LOCUS       NM_001271346            1839 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus damage specific DNA binding protein 2 (Ddb2),
            mRNA.
ACCESSION   NM_001271346 XM_002726233 XM_002729197
VERSION     NM_001271346.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1839)
  AUTHORS   Compe,E. and Egly,J.M.
  TITLE     TFIIH: when transcription met DNA repair
  JOURNAL   Nat Rev Mol Cell Biol 13 (6), 343-354 (2012)
   PUBMED   22572993
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2012 Jul;13(7):476]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1839)
  AUTHORS   Lan,L., Nakajima,S., Kapetanaki,M.G., Hsieh,C.L., Fagerburg,M.,
            Thickman,K., Rodriguez-Collazo,P., Leuba,S.H., Levine,A.S. and
            Rapic-Otrin,V.
  TITLE     Monoubiquitinated histone H2A destabilizes photolesion-containing
            nucleosomes with concomitant release of UV-damaged DNA-binding
            protein E3 ligase
  JOURNAL   J Biol Chem 287 (15), 12036-12049 (2012)
   PUBMED   22334663
REFERENCE   3  (bases 1 to 1839)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
REFERENCE   4  (bases 1 to 1839)
  AUTHORS   Yoon,T., Chakrabortty,A., Franks,R., Valli,T., Kiyokawa,H. and
            Raychaudhuri,P.
  TITLE     Tumor-prone phenotype of the DDB2-deficient mice
  JOURNAL   Oncogene 24 (3), 469-478 (2005)
   PUBMED   15558025
REFERENCE   5  (bases 1 to 1839)
  AUTHORS   Groisman,R., Polanowska,J., Kuraoka,I., Sawada,J., Saijo,M.,
            Drapkin,R., Kisselev,A.F., Tanaka,K. and Nakatani,Y.
  TITLE     The ubiquitin ligase activity in the DDB2 and CSA complexes is
            differentially regulated by the COP9 signalosome in response to DNA
            damage
  JOURNAL   Cell 113 (3), 357-367 (2003)
   PUBMED   12732143
REFERENCE   6  (bases 1 to 1839)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
REFERENCE   7  (bases 1 to 1839)
  AUTHORS   Nichols,A.F., Ong,P. and Linn,S.
  TITLE     Mutations specific to the xeroderma pigmentosum group E Ddb-
            phenotype
  JOURNAL   J Biol Chem 271 (40), 24317-24320 (1996)
   PUBMED   8798680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Sep 19, 2012 this sequence version replaced
            XM_002726233.2, XM_002729197.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.388695.1,
                                           SRR26643293.17683.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               JAXUCZ010000003.1  97663147-97663443   c
            298-434             JAXUCZ010000003.1  97661766-97661902   c
            435-626             JAXUCZ010000003.1  97661057-97661248   c
            627-772             JAXUCZ010000003.1  97648110-97648255   c
            773-872             JAXUCZ010000003.1  97646709-97646808   c
            873-1050            JAXUCZ010000003.1  97646449-97646626   c
            1051-1193           JAXUCZ010000003.1  97646063-97646205   c
            1194-1358           JAXUCZ010000003.1  97641766-97641930   c
            1359-1404           JAXUCZ010000003.1  97641588-97641633   c
            1405-1839           JAXUCZ010000003.1  97640923-97641357   c
FEATURES             Location/Qualifiers
     source          1..1839
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1839
                     /gene="Ddb2"
                     /note="damage specific DNA binding protein 2"
                     /db_xref="GeneID:100362121"
                     /db_xref="RGD:1310164"
     exon            1..297
                     /gene="Ddb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1469
                     /gene="Ddb2"
                     /codon_start=1
                     /product="DNA damage-binding protein 2"
                     /protein_id="NP_001258275.1"
                     /db_xref="GeneID:100362121"
                     /db_xref="RGD:1310164"
                     /translation="MAPKKCPETQKSPDVAVLLKSKSRRSPQELEPEAKKLFVQGPVS
                     SRKCESCCLLAELSSLQIPPRSSSIVRDLYQQKLGKATWPSLQQGLQKSFLHSLASYR
                     VFQKAAPFDRRTTSLAWHPTHPSTLAVGSKGGDIMIWNFGIKDKPIFLKGIGAGGSIT
                     GLKFNHLNTNQFFASSMEGTTRLQDFKGNILRIYTSSNSCKVWFCSLDVSAKSRVVVT
                     GDNMGHVILTNTDGKELWNLRMHKKKVAHVALNPCCDWLLATASIDQTVKIWDLRQIK
                     GKDSFLFSLPHRHPVNSACFSPDGARLLTTDQNNEIRVYSASQWDSPLSLISHPHRHF
                     QHLTPIKATWHSRHNLIVVGRYPDPNLKSCVPYELRTIDVFDGSSGKMMCQLYDPGYS
                     GITSLNEFNPMGDTLASTMGYHILIWSPEEDGSLKDHERL"
     exon            298..434
                     /gene="Ddb2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..626
                     /gene="Ddb2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..772
                     /gene="Ddb2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..872
                     /gene="Ddb2"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1050
                     /gene="Ddb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1193
                     /gene="Ddb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1358
                     /gene="Ddb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1404
                     /gene="Ddb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1839
                     /gene="Ddb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaagtaaag cagccctagg agagtttggc gcgaagttgt ctgtgccaag ctacctgcga
       61 cgacggcgct ccttcgtacg tagtcccttc ctgtttttct ccttcgaggc ttttcaggtc
      121 ttgcttcgtt attttgccat agagcttggt atctcttcac cgagtacgtc atggctccca
      181 agaaatgccc agaaacccag aagtcccccg acgttgcggt gctcctcaag agcaaaagcc
      241 gcagaagtcc tcaggagctg gagcccgaag ccaagaagct gtttgtgcag ggtcccgttt
      301 ctagtaggaa atgtgagtcg tgctgccttc tggcagagtt gtccagcttg cagatccctc
      361 cgaggagcag cagcattgtc cgggatcttt accagcagaa gttgggcaaa gccacctggc
      421 cgtcactaca gcagggtctc cagaagtcct ttttgcactc tctagcttct taccgggtat
      481 tccaaaaagc tgcccccttt gacaggagga caacgtcctt ggcatggcac ccgactcatc
      541 ccagtacttt ggctgtgggc tccaaagggg gagatattat gatctggaac tttggcataa
      601 aggacaaacc catcttcctt aaagggattg gagctggagg aagcatcact gggctgaagt
      661 ttaatcatct caataccaac cagttttttg cctcctcaat ggagggaaca accaggctgc
      721 aggattttaa aggcaacatt ctcagaattt ataccagctc aaactcttgc aaggtctggt
      781 tttgcagcct tgatgtttct gccaagagcc gagtggtggt tacaggagac aatatgggac
      841 acgtgatcct gacgaacaca gatggcaagg agctttggaa cctcagaatg cacaaaaaga
      901 aagtagccca tgtggccctg aacccctgct gtgattggct tctggccaca gcctccatag
      961 atcaaacagt gaaaatttgg gacctgcgcc aaattaaagg gaaagacagc ttcctcttct
     1021 cactgcctca caggcatcct gtcaattcag cttgttttag ccccgatgga gctcggctcc
     1081 tgactactga ccagaacaat gagattcggg tttactctgc ctcccagtgg gatagccccc
     1141 tgagtctgat ctcccaccct caccgccatt ttcagcacct cacacccatc aaggcgacct
     1201 ggcattcacg gcacaacctc attgttgtgg gccgataccc agatcctaat cttaaaagtt
     1261 gtgttcccta tgaactaagg acaatagatg tgtttgatgg aagctcgggg aagatgatgt
     1321 gtcagctcta tgatccagga tattccggta ttacttcgct caatgagttc aatcctatgg
     1381 gagacacact ggcttctact atgggttatc atattctcat ttggagccca gaggaagatg
     1441 ggtcattgaa agaccatgaa agactatgaa gatggtgtgg gacagcaaca cctgaccctg
     1501 cctatgggag caggttctgt gagagaagtg gtagctgttt gttcacaggc cagaagtacc
     1561 caactctcag tgtgggagta ggggtgctgg tggcatggga tactgtatgg aactaggata
     1621 ctgacatgtt actgctctag attttgcttc agaaaattaa agagtaaacc agctaccctc
     1681 agggtccctg ctgtgtctag cctggagacc aagttcatgc tagagccaag gtactttcct
     1741 tttttctgat gtatagtagc agaataacca gggaattttt aaatttttat gttcattttg
     1801 acataaccaa taaaagcata tcttttgtat tgagaccta
//
