LOCUS       NM_171995               4260 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus damage-specific DNA binding protein 1 (Ddb1),
            mRNA.
ACCESSION   NM_171995 XM_342024
VERSION     NM_171995.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4260)
  AUTHORS   Liu,Y., Qu,H.Q., Chang,X., Qu,J., Mentch,F.D., Nguyen,K., Tian,L.,
            Glessner,J., Sleiman,P.M.A. and Hakonarson,H.
  TITLE     Mutation burden analysis of six common mental disorders in African
            Americans by whole genome sequencing
  JOURNAL   Hum Mol Genet 31 (22), 3769-3776 (2022)
   PUBMED   35642741
REFERENCE   2  (bases 1 to 4260)
  AUTHORS   Faust,T.B., Yoon,H., Nowak,R.P., Donovan,K.A., Li,Z., Cai,Q.,
            Eleuteri,N.A., Zhang,T., Gray,N.S. and Fischer,E.S.
  TITLE     Structural complementarity facilitates E7820-mediated degradation
            of RBM39 by DCAF15
  JOURNAL   Nat Chem Biol 16 (1), 7-14 (2020)
   PUBMED   31686031
REFERENCE   3  (bases 1 to 4260)
  AUTHORS   Mo,Y., Lin,R., Liu,P., Tan,M., Xiong,Y., Guan,K.L. and Yuan,H.X.
  TITLE     SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3
            ligase complexes
  JOURNAL   FEBS J 284 (21), 3619-3636 (2017)
   PUBMED   28886238
REFERENCE   4  (bases 1 to 4260)
  AUTHORS   Tong,X., Zhang,D., Charney,N., Jin,E., VanDommelen,K., Stamper,K.,
            Gupta,N., Saldate,J. and Yin,L.
  TITLE     DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven
            Gluconeogenesis in Liver
  JOURNAL   Diabetes 66 (10), 2571-2582 (2017)
   PUBMED   28790135
  REMARK    Erratum:[Diabetes. 2017 Dec;66(12):3144. doi: 10.2337/db17-er12e..
            PMID: 28993340]
REFERENCE   5  (bases 1 to 4260)
  AUTHORS   Uehara,T., Minoshima,Y., Sagane,K., Sugi,N.H., Mitsuhashi,K.O.,
            Yamamoto,N., Kamiyama,H., Takahashi,K., Kotake,Y., Uesugi,M.,
            Yokoi,A., Inoue,A., Yoshida,T., Mabuchi,M., Tanaka,A. and Owa,T.
  TITLE     Selective degradation of splicing factor CAPERalpha by anticancer
            sulfonamides
  JOURNAL   Nat Chem Biol 13 (6), 675-680 (2017)
   PUBMED   28437394
REFERENCE   6  (bases 1 to 4260)
  AUTHORS   Wertz,I.E., O'Rourke,K.M., Zhang,Z., Dornan,D., Arnott,D.,
            Deshaies,R.J. and Dixit,V.M.
  TITLE     Human De-etiolated-1 regulates c-Jun by assembling a CUL4A
            ubiquitin ligase
  JOURNAL   Science 303 (5662), 1371-1374 (2004)
   PUBMED   14739464
REFERENCE   7  (bases 1 to 4260)
  AUTHORS   Groisman,R., Polanowska,J., Kuraoka,I., Sawada,J., Saijo,M.,
            Drapkin,R., Kisselev,A.F., Tanaka,K. and Nakatani,Y.
  TITLE     The ubiquitin ligase activity in the DDB2 and CSA complexes is
            differentially regulated by the COP9 signalosome in response to DNA
            damage
  JOURNAL   Cell 113 (3), 357-367 (2003)
   PUBMED   12732143
REFERENCE   8  (bases 1 to 4260)
  AUTHORS   Sun,N.K., Lu,H.P. and Chao,C.C.
  TITLE     Identification of rat DDB1, a putative DNA repair protein, and
            functional correlation with its damaged-DNA recognition activity
  JOURNAL   J Biomed Sci 9 (4), 371-380 (2002)
   PUBMED   12145536
  REMARK    GeneRIF: role in UV-damaged-DNA recognition activity in mammalian
            tissues and cell lines
REFERENCE   9  (bases 1 to 4260)
  AUTHORS   Chen,X., Zhang,Y., Douglas,L. and Zhou,P.
  TITLE     UV-damaged DNA-binding proteins are targets of CUL-4A-mediated
            ubiquitination and degradation
  JOURNAL   J Biol Chem 276 (51), 48175-48182 (2001)
   PUBMED   11673459
REFERENCE   10 (bases 1 to 4260)
  AUTHORS   Martinez,E., Palhan,V.B., Tjernberg,A., Lymar,E.S., Gamper,A.M.,
            Kundu,T.K., Chait,B.T. and Roeder,R.G.
  TITLE     Human STAGA complex is a chromatin-acetylating transcription
            coactivator that interacts with pre-mRNA splicing and DNA
            damage-binding factors in vivo
  JOURNAL   Mol Cell Biol 21 (20), 6782-6795 (2001)
   PUBMED   11564863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1, FM035228.1, FN804617.1, CB777486.1, CV111529.1,
            FN805433.1, FM065862.1, FM131388.1, FM101956.1 and CV108212.1.
            
            On Nov 10, 2012 this sequence version replaced NM_171995.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2437783.1,
                                           SRR26360194.1155074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               JAXUCZ010000001.1  216677810-216677983
            175-786             FM035228.1         1-612
            787-934             FN804617.1         539-686
            935-1090            JAXUCZ010000001.1  216685318-216685473
            1091-1174           JAXUCZ010000001.1  216686268-216686351
            1175-1291           JAXUCZ010000001.1  216687034-216687150
            1292-1394           JAXUCZ010000001.1  216687697-216687799
            1395-1470           JAXUCZ010000001.1  216691606-216691681
            1471-1555           JAXUCZ010000001.1  216691780-216691864
            1556-1799           CB777486.1         1-244
            1800-2522           CV111529.1         1-723
            2523-2761           FN805433.1         239-477
            2762-3202           FM065862.1         188-628
            3203-3573           FM131388.1         310-680
            3574-3666           FM101956.1         340-432
            3667-4260           CV108212.1         1-594
FEATURES             Location/Qualifiers
     source          1..4260
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..4260
                     /gene="Ddb1"
                     /note="damage-specific DNA binding protein 1"
                     /db_xref="GeneID:64470"
                     /db_xref="RGD:621889"
     exon            1..230
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..3592
                     /gene="Ddb1"
                     /note="damage-specific DNA binding protein 1, 127kDa"
                     /codon_start=1
                     /product="DNA damage-binding protein 1"
                     /protein_id="NP_741992.2"
                     /db_xref="GeneID:64470"
                     /db_xref="RGD:621889"
                     /translation="MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVV
                     TAEGLRPVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIIT
                     RAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLE
                     ELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASM
                     VIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDM
                     EGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLV
                     KLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRN
                     GIGIHEHASIDLPGIKGLWPLRSDPSRETDDTLVLSFVGQTRVLMLNGEEVEETELMG
                     FVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQGKNISVASCNSSQV
                     VVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLGESNGLSPLCAIGLWTDISA
                     RILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLS
                     DRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPL
                     NSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRI
                     EVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFGEEVEVHNLLIIDQHT
                     FEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDG
                     KLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTECNHYNNIMALYL
                     KTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAF
                     NLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLF
                     GTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGF
                     IDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH"
     exon            231..379
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..496
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..718
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..833
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..931
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1090
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1174
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1291
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1394
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1470
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1579
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1758
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1922
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2030
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2238
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2334
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2446
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2570
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2735
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2830
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..3001
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3111
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3281
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3384
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3508
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3509..4245
                     /gene="Ddb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcccgtgat cctctgcgcc tggcctctct ggcctgcaac gtgtcttagg ggcggaggca
       61 acagccacgg agttggctgc gtgagggtgg gggttctcag tctcttcgct cgtgcccatc
      121 tccctgtcgt cgctctaggc gccccacggg ccggcccaag gacctcaata tgtcgtacaa
      181 ctacgtcgta acggcgcaga agcctaccgc agtgaacggc tgtgtgaccg gacactttac
      241 ttcagcggaa gacttgaacc tgttgattgc taaaaacaca agattagaga tctatgtggt
      301 caccgcagaa ggcctacggc cagtcaaaga ggtggggatg tatgggaaga tcgcagttat
      361 ggagctcttc agacccaagg gggagagtaa agacctgctg ttcatcttga ctgctaagta
      421 caatgcctgc atcctggagt ataagcagag tggtgaaagc attgatatca ttacaagggc
      481 ccatggcaat gtccaggacc gtattggtcg cccctcagag actggcatca ttggcatcat
      541 tgaccctgag tgccgtatga ttggcctccg actctacgat ggccttttca aggtcattcc
      601 actagaccga gacaataaag agctcaaggc ctttaacatc cgcctagaag aattgcatgt
      661 catcgatgtc aagttcctgt atggttgtca agcgcctacc atttgctttg tctaccagga
      721 tcctcagggg cggcacgtga aaacctatga ggtgtctctt cgggagaagg agttcaacaa
      781 gggcccttgg aagcaggaga atgtagaagc cgaagcttca atggtgatcg cagtcccgga
      841 gccttttgga ggtgccatca tcattggaca ggagtcaatt acctatcaca atggtgataa
      901 atacctggca atcgctcctc ctatcattaa gcaaagcact attgtgtgcc ataaccgggt
      961 ggatcctaat ggctcacggt accttctggg agatatggaa ggacggcttt tcatgctgct
     1021 cttagagaag gaggagcaga tggatggcac cgtcaccctc aaggaccttc gagtggaact
     1081 ccttggagag acctccattg cagagtgcct aacatatctt gataacggtg ttgtgtttgt
     1141 cgggtctcgc ctgggtgatt cccagctcgt aaagctcaat gtcgacagca atgaacaagg
     1201 ctcctatgta gtggctatgg aaacctttac caacttagga cccattgtgg atatgtgtgt
     1261 ggtggacctg gagaggcagg gacagggtca gctggtcact tgctctggag ctttcaagga
     1321 aggttccttg cggatcatcc ggaacggaat tggaatccat gagcatgcca gcattgactt
     1381 accaggcatc aaaggtttat ggccactgcg gtctgaccca agtcgggaga ctgatgacac
     1441 tttggtactc tcttttgtgg gccagacaag agttctcatg ctaaatggag aggaagtgga
     1501 agaaacagaa ttgatgggct ttgtggacga tcagcagact ttcttttgcg gcaatgtggc
     1561 tcatcagcag cttatccaga tcacctcagc gtctgtaagg ttggtctctc aagagcccaa
     1621 agctttggtc agcgagtgga aggagcccca gggcaagaac atcagtgtgg cctcctgtaa
     1681 cagcagccag gtggtagttg ctgtgggaag ggcactatac tatcttcaga tccatcctca
     1741 ggagctccgg caaatcagcc acacagagat ggaacatgaa gtggcttgct tggatatcac
     1801 cccactagga gagagcaatg gcctgtcccc actttgtgcc attggtctct ggacagatat
     1861 ttcagctcgt atcttgaagc tcccatcctt tgaactactg cacaaggaga tgctgggtgg
     1921 agagatcatc cctcgatcta tcctgatgac cacttttgag agcagccact acctcctttg
     1981 tgccttggga gatggggctc tcttctactt tgggctcaac atagagacag gcttactgag
     2041 tgaccgtaaa aaggtgactt tgggtaccca gcccacggtg ttgaggacat tccgttctct
     2101 ttctaccacc aacgtctttg cttgctcaga ccggcccact gtcatctata gcagcaatca
     2161 taagttggtc ttctccaatg ttaacctcaa ggaggtgaac tatatgtgtc ctctcaactc
     2221 agatggctat cctgacagtc tggcattggc caataacagc actctcacca ttggcaccat
     2281 cgatgagatc cagaaactcc atattcgcac ggttcctctc tatgaatctc ccaggaagat
     2341 ctgttatcag gaagtgtctc agtgctttgg ggtcctttcc agccgcattg aagttcaaga
     2401 taccagtgga ggcactactg ctttgaggcc cagtgctagc acccaggccc tgtccagcag
     2461 cgtcagctcc agcaagctct tctctagtag tacggctcct cacgagacct cctttggaga
     2521 agaggtggaa gtgcacaacc tcctcatcat tgaccagcat acttttgaag tgcttcatgc
     2581 ccatcagttt ctacaaaatg agtatgccct cagcctggtc tcctgcaaat tgggtaaaga
     2641 ccccaacaca tacttcattg tgggcacagc catggtatat cctgaagagg cggagcccaa
     2701 acagggtcgt attgtggtct tccagtattc ggatggaaaa ctacagactg tggccgaaaa
     2761 ggaagtaaag ggggctgtgt actctatggt ggagtttaat gggaagctgc ttgctagcat
     2821 caacagcacg gtgcggctct atgaatggac cacagaaaag gaacttcgca ctgagtgcaa
     2881 tcactacaac aacatcatgg ccctgtacct gaagaccaag ggcgacttca tcctggtggg
     2941 cgacctcatg cgatcagtgc tactgcttgc ctacaagcct atggaaggaa actttgaaga
     3001 gattgcccga gactttaatc ccaactggat gagtgcagtg gagatcttgg atgatgacaa
     3061 ttttctggga gctgagaatg cctttaactt gtttgtgtgt cagaaggaca gtgctgccac
     3121 cactgatgag gagcggcagc acctacagga ggttggtctc ttccacctgg gcgagtttgt
     3181 caatgtgttc tgccatggct ccctagttat gcagaatctg ggcgagactt ctacccctac
     3241 ccagggctcg gtgctctttg gcacagtcaa cggcatgata gggctggtga cctcactgtc
     3301 ggagagctgg tacaacctcc tgttggacat gcagaaccga ctcaataagg tcatcaaaag
     3361 tgtgggcaag attgagcact ccttctggag atcctttcac actgagcgaa agacagaacc
     3421 agccacaggc ttcatcgatg gtgacctgat tgaaagtttc ctagatatca gccgccccaa
     3481 gatgcaggag gttgtggcaa acttgcagta tgatgatggc agtggtatga agcgggaggc
     3541 aactgcagat gacctcatca aagtcgtgga ggagctaact cggatccatt agccaaggaa
     3601 caggatttct tttcctggcc ctccctaaag gcgctgccct cctgtcctcc cctccttttc
     3661 ccacccttgt tttcttggca tgggaggctt ttccctaagc cacctgcccc tagaaccaca
     3721 gatgacctgt gtggaaacag ggctttttat aactaaaacc agttcactag agacctagga
     3781 atgggctgaa agtggaatat tttctccctg gatttttacc agccatcacc ttggaccacc
     3841 aagccttgaa tggtgttgcc agttggctcc tcctggggag gacttttgtc actcttcggc
     3901 caagaagcag ctctgtgcac ctgtgtgtgg tgtctcacac tcatgctctg tcctctgctg
     3961 tcttatgtag gttgtgggtg tggggaggtc gaggtaggga agagggtcgg gagggttcat
     4021 tgtcttgagg gcttcctttg ctttcttctc ttgcctctga gaacatcagc ctggaggtct
     4081 gtcaggccgt gggctgcctg agtggaaacc ttggatggtg gataattccc aagccacagc
     4141 ccttctgtct cggggaactc ccttcttcac agagaaggag gtgggggctg tgaattggtt
     4201 gttagtttct gaattttacc aaataaagta gaatctaaga agaaaaaaaa aaaaaaaaaa
//
