LOCUS       NM_212532               1320 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DDAH family member 2, ADMA-independent (Ddah2),
            transcript variant 1, mRNA.
ACCESSION   NM_212532 XM_215315
VERSION     NM_212532.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Xiao,H.B., Sui,G.G., Lu,X.Y. and Sun,Z.L.
  TITLE     Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher
            PRMT1 in LPS-Induced Endometritis Rats
  JOURNAL   Inflammation 41 (1), 299-306 (2018)
   PUBMED   29119338
  REMARK    GeneRIF: Higher levels of asymmetric dimethylarginine are
            associated with lower DDAH2 and higher PRMT1 in LPS-induced
            endometritis rat model.
REFERENCE   2  (bases 1 to 1320)
  AUTHORS   Zhou,R., Ma,P., Xiong,A., Xu,Y., Wang,Y. and Xu,Q.
  TITLE     Protective effects of low-dose rosuvastatin on
            isoproterenol-induced chronic heart failure in rats by regulation
            of DDAH-ADMA-NO pathway
  JOURNAL   Cardiovasc Ther 35 (2) (2017)
   PUBMED   27957828
  REMARK    GeneRIF: Low-dose rosuvastatin exerted cardioprotective effects on
            isoproterenol-induced heart failure in rats by modulating
            DDAH-ADMA-NO pathway.
REFERENCE   3  (bases 1 to 1320)
  AUTHORS   Wu,Y., Zhang,J.J., Li,T.B., Liu,W.Q., Li,L.S., Luo,X.J.,
            Jiang,J.L., Ma,Q.L., Yang,Z.C. and Peng,J.
  TITLE     Phosphorylation of Nonmuscle Myosin Light Chain Promotes
            Endothelial Injury in Hyperlipidemic Rats Through a Mechanism
            Involving Downregulation of Dimethylarginine Dimethylaminohydrolase
            2
  JOURNAL   J Cardiovasc Pharmacol Ther 21 (6), 536-548 (2016)
   PUBMED   26911182
  REMARK    GeneRIF: Suppression of DDAH2 expression might account for, at
            least partially, the vascular endothelial dysfunction in
            hyperlipidemia, and nmMLC20 plays a role in suppression of DDAH2
            expression in a phosphorylation-dependent manner.
REFERENCE   4  (bases 1 to 1320)
  AUTHORS   Zheng,J., Wang,K., Jin,P., Dong,C., Yuan,Q., Li,Y. and Yang,Z.
  TITLE     The association of adipose-derived dimethylarginine
            dimethylaminohydrolase-2 with insulin sensitivity in experimental
            type 2 diabetes mellitus
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 45 (8), 641-648 (2013)
   PUBMED   23702602
  REMARK    GeneRIF: findings suggested that in the development of type 2
            diabetes mellitus, local DDAH-2 in adipocytes might play an
            important role in regulating insulin sensitivity
REFERENCE   5  (bases 1 to 1320)
  AUTHORS   Chen,X.M., Xia,J., Zhou,T., Yuan,Q., Zhang,W.F., Hu,C.P., Li,Y.J.
            and Jiang,J.L.
  TITLE     Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid
            arthritis in rats
  JOURNAL   Int Immunopharmacol 16 (2), 322-331 (2013)
   PUBMED   23619555
  REMARK    GeneRIF: The DDAH/asymmetric dimethylarginine pathway participates
            in the pathogenesis of rheumatoid arthritis and may be mediated by
            cortistatin.
REFERENCE   6  (bases 1 to 1320)
  AUTHORS   Sakurada,M., Shichiri,M., Imamura,M., Azuma,H. and Hirata,Y.
  TITLE     Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2
            via cyclic GMP induction in endothelial cells
  JOURNAL   Hypertension 52 (5), 903-909 (2008)
   PUBMED   18824664
  REMARK    GeneRIF: DDAH-2-ADMA/MMA-endothelial NO synthase regulatory pathway
            and NO-induced cGMP constitute a positive feedback loop that
            ultimately serves to maintain NO levels in the endothelial
            environment
REFERENCE   7  (bases 1 to 1320)
  AUTHORS   Wang,D., Gill,P.S., Chabrashvili,T., Onozato,M.L., Raggio,J.,
            Mendonca,M., Dennehy,K., Li,M., Modlinger,P., Leiper,J.,
            Vallance,P., Adler,O., Leone,A., Tojo,A., Welch,W.J. and
            Wilcox,C.S.
  TITLE     Isoform-specific regulation by N(G),N(G)-dimethylarginine
            dimethylaminohydrolase of rat serum asymmetric dimethylarginine and
            vascular endothelium-derived relaxing factor/NO
  JOURNAL   Circ Res 101 (6), 627-635 (2007)
   PUBMED   17673667
  REMARK    GeneRIF: Endothelium-derived relaxing factor is metabolized by
            DDAH-2, which is strongly expressed in blood vessels.
REFERENCE   8  (bases 1 to 1320)
  AUTHORS   Sasaki,A., Doi,S., Mizutani,S. and Azuma,H.
  TITLE     Roles of accumulated endogenous nitric oxide synthase inhibitors,
            enhanced arginase activity, and attenuated nitric oxide synthase
            activity in endothelial cells for pulmonary hypertension in rats
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 292 (6), L1480-L1487 (2007)
   PUBMED   17322279
  REMARK    GeneRIF: The DDAH activity and DDAH1, but not DDAH2, protein
            expression were significantly reduced in pulmonary artery
            endothelial cells of rats given monocrotaline
REFERENCE   9  (bases 1 to 1320)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   10 (bases 1 to 1320)
  AUTHORS   Leiper,J.M., Santa Maria,J., Chubb,A., MacAllister,R.J.,
            Charles,I.G., Whitley,G.S. and Vallance,P.
  TITLE     Identification of two human dimethylarginine
            dimethylaminohydrolases with distinct tissue distributions and
            homology with microbial arginine deiminases
  JOURNAL   Biochem J 343 Pt 1 (Pt 1), 209-214 (1999)
   PUBMED   10493931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO385374.1 and BC097930.1.
            
            On Sep 30, 2009 this sequence version replaced NM_212532.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097930.1, FQ213713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132295, SAMD00132298
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CO385374.1         1-10
            11-1320             BC097930.1         1-1310
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1320
                     /gene="Ddah2"
                     /note="DDAH family member 2, ADMA-independent"
                     /db_xref="GeneID:294239"
                     /db_xref="RGD:1302955"
     exon            1..184
                     /gene="Ddah2"
                     /inference="alignment:Splign:2.1.0"
     exon            185..544
                     /gene="Ddah2"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1105
                     /gene="Ddah2"
                     /EC_number="3.5.3.18"
                     /note="n(G),N(G)-dimethylarginine dimethylaminohydrolase
                     2; DDAH-2; DDAHII; dimethylargininase-2; inactive
                     dimethylarginine dimethylaminohydrolase 2; inactive
                     N(G),N(G)-dimethylarginine dimethylaminohydrolase 2"
                     /codon_start=1
                     /product="putative hydrolase DDAH2"
                     /protein_id="NP_997697.1"
                     /db_xref="GeneID:294239"
                     /db_xref="RGD:1302955"
                     /translation="MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQRE
                     HGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDG
                     VRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFA
                     VSTVPVSGASHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAAS
                     DCLFLRPGLPGTTPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKVGAGLSSLC
                     LVLSTRPHC"
     exon            545..644
                     /gene="Ddah2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..718
                     /gene="Ddah2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..838
                     /gene="Ddah2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..988
                     /gene="Ddah2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1294
                     /gene="Ddah2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagaccat cgcgcccccg ccccatcgcc gtacgtgagc tcgcctaccc tgggaacccc
       61 tcaaaagccc gagctatcgg tctctcctgc ttgaagactc aagctcccat cttcatcaac
      121 tctctcctct gggggtgggg ccaaggccga aatcacaagg ctgcaggagt ggaggtggcc
      181 gctgacaagt gaagtaaaga gaaaaaaaca aaacggcttg gctggaaagg gcttctgtgt
      241 ggatgtgatg gggacgccgg gggaggggct gggtcgctgt tcccatgccc tgatccgggg
      301 tgtccccgag agcttggcat ccggggaagg tgctggcgct ggtcttccgg ctctggatct
      361 ggctaaagct caaagggagc atggagtact aggaggtaaa ctgaggcaac gactaggtct
      421 gcagcttctt gaactgcctc ctgaggaatc actgccgctg ggaccactgc ttggtgacac
      481 ggctgtgatc caaggagaca cggctctaat cacaaggccc tggagcccag cgcgtaggcc
      541 tgaggttgat ggagtccgca aagctctcca ggacttgggg ctcagaattg tggagatggg
      601 ggatgagaac gctacgctgg acggcaccga cgtcctcttc accggccggg agtttttcgt
      661 aggcctctcc aagtggacca atcatcgagg agctgagatc gtggcagaca cgttccggga
      721 cttcgctgtc tctacggtac cggtctctgg cgcctcgcat ctgcgcggcc tctgtggcat
      781 gggaggacct cgcacggtgg tggctggaag cagtgaggct gcccaaaaag ccgtcagggc
      841 aatggcagca ctgactgatc acccctacgc ctctctgacc ctcccagatg acgcagcgag
      901 tgactgtctc tttctgcgtc ctgggttgcc tggtaccaca cctttccttc tgcaccgcgg
      961 aggtggggac ctgcccaaca gccaggaggc tctgcaaaag ctctctgacg tcaccctggt
     1021 acctgtgtcc tgctcggaac tggagaaggt tggagctggc ctcagctccc tctgcctggt
     1081 gctcagcaca cgcccccact gctgagggct gggtttgggg ctccaattag ctaggaatag
     1141 agccgtctag ggagtagaat caggtaatag aggctgggta gtcgtgggag atgccccagg
     1201 atagggaagg acttagtatg ggacaaagac taggagccag tgggtgagtc ttctctgtca
     1261 aaaccaataa aataaaattg gccttttaga taagaaaaaa aaaaaaaaaa aaaaaaaaaa
//
