LOCUS       NM_022297               2687 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus dimethylarginine dimethylaminohydrolase 1
            (Ddah1), mRNA.
ACCESSION   NM_022297 XM_345298
VERSION     NM_022297.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2687)
  AUTHORS   Wu,M., Li,T., Li,G., Niu,B., Wu,T., Yan,L., Wang,S., He,S.,
            Huang,C., Tong,W., Li,N. and Jiang,J.
  TITLE     LncRNA DANCR deficiency promotes high glucose-induced endothelial
            to mesenchymal transition in cardiac microvascular cells via the
            FoxO1/DDAH1/ADMA signaling pathway
  JOURNAL   Eur J Pharmacol 950, 175732 (2023)
   PUBMED   37116560
  REMARK    GeneRIF: LncRNA DANCR deficiency promotes high glucose-induced
            endothelial to mesenchymal transition in cardiac microvascular
            cells via the FoxO1/DDAH1/ADMA signaling pathway.
REFERENCE   2  (bases 1 to 2687)
  AUTHORS   Zhao,Y., Zhang,M., Dou,Y., Du,K., Liu,X. and Zhao,Y.
  TITLE     DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia
            via the ROS/FOXO1/APR1 Pathway
  JOURNAL   Oxid Med Cell Longev 2022, 2350857 (2022)
   PUBMED   35509834
  REMARK    GeneRIF: DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral
            Ischemia via the ROS/FOXO1/APR1 Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2687)
  AUTHORS   Zhao,Y., Ma,X., Zhou,Y., Xie,J., Liu,X. and Zhao,Y.
  TITLE     DDAH-1, via regulation of ADMA levels, protects against
            ischemia-induced blood-brain barrier leakage
  JOURNAL   Lab Invest 101 (7), 808-823 (2021)
   PUBMED   33574439
  REMARK    GeneRIF: DDAH-1, via regulation of ADMA levels, protects against
            ischemia-induced blood-brain barrier leakage.
            Erratum:[Lab Invest. 2021 Oct;101(10):1411-1413. doi:
            10.1038/s41374-021-00588-4.. PMID: 34341461]
REFERENCE   4  (bases 1 to 2687)
  AUTHORS   Zhao,Y., Zhou,Y., Ma,X., Liu,X., Zhao,Y. and Liu,X.
  TITLE     DDAH-1 via HIF-1 target genes improves cerebral ischemic tolerance
            after hypoxic preconditioning and middle cerebral artery
            occlusion-reperfusion
  JOURNAL   Nitric Oxide 95, 17-28 (2020)
   PUBMED   31870966
  REMARK    GeneRIF: DDAH-1 via HIF-1 target genes improves cerebral ischemic
            tolerance after hypoxic preconditioning and middle cerebral artery
            occlusion-reperfusion.
REFERENCE   5  (bases 1 to 2687)
  AUTHORS   Wang,D., Li,H., Weir,E.K., Xu,Y., Xu,D. and Chen,Y.
  TITLE     Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates
            monocrotaline-induced pulmonary oxidative stress, pulmonary
            arterial hypertension and right heart failure in rats
  JOURNAL   Int J Cardiol 295, 14-20 (2019)
   PUBMED   31402164
REFERENCE   6  (bases 1 to 2687)
  AUTHORS   Valkonen,V.P., Tuomainen,T.P. and Laaksonen,R.
  TITLE     DDAH gene and cardiovascular risk
  JOURNAL   Vasc Med 10 Suppl 1, S45-S48 (2005)
   PUBMED   16444868
  REMARK    Review article
REFERENCE   7  (bases 1 to 2687)
  AUTHORS   Kostourou,V., Troy,H., Murray,J.F., Cullis,E.R., Whitley,G.S.,
            Griffiths,J.R. and Robinson,S.P.
  TITLE     Overexpression of dimethylarginine dimethylaminohydrolase enhances
            tumor hypoxia: an insight into the relationship of hypoxia and
            angiogenesis in vivo
  JOURNAL   Neoplasia 6 (4), 401-411 (2004)
   PUBMED   15256062
  REMARK    GeneRIF: Transfected into glioma cells in nude mice increases cell
            hypoxia and points to an inverse relationship of tumor oxygenation
            and angiogenesis in vivo.
REFERENCE   8  (bases 1 to 2687)
  AUTHORS   Mishima,T., Hamada,T., Ui-Tei,K., Takahashi,F., Miyata,Y.,
            Imaki,J., Suzuki,H. and Yamashita,K.
  TITLE     Expression of DDAH1 in chick and rat embryos
  JOURNAL   Brain Res Dev Brain Res 148 (2), 223-232 (2004)
   PUBMED   14766200
  REMARK    GeneRIF: The DDAH1 mRNA expression in the embryonic spinal cord,
            which was especially strong in the ventral horn and dorsal root
            ganglion (DRG). DDAH1 was also detected in the brain, kidney,
            digestive tract, and in other tissues.
REFERENCE   9  (bases 1 to 2687)
  AUTHORS   Kostourou,V., Robinson,S.P., Cartwright,J.E. and Whitley,G.S.
  TITLE     Dimethylarginine dimethylaminohydrolase I enhances tumour growth
            and angiogenesis
  JOURNAL   Br J Cancer 87 (6), 673-680 (2002)
   PUBMED   12237779
  REMARK    GeneRIF: dimethylarginine dimethylaminohydrolase plays a pivotal
            role in tumour growth and the development of the tumour vasculature
            by regulating the concentration of nitric oxide and altering
            vascular endothelial cell growth factor production.
REFERENCE   10 (bases 1 to 2687)
  AUTHORS   Kimoto,M., Sasakawa,T., Tsuji,H., Miyatake,S., Oka,T., Nio,N. and
            Ogawa,T.
  TITLE     Cloning and sequencing of cDNA encoding NG,NG-dimethylarginine
            dimethylaminohydrolase from rat kidney
  JOURNAL   Biochim Biophys Acta 1337 (1), 6-10 (1997)
   PUBMED   9003431
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022297.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.11110.1,
                                           SRR26643298.13925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               JAXUCZ010000002.1  237327812-237328223
            413-512             JAXUCZ010000002.1  237417839-237417938
            513-586             JAXUCZ010000002.1  237423563-237423636
            587-706             JAXUCZ010000002.1  237424453-237424572
            707-850             JAXUCZ010000002.1  237455600-237455743
            851-2687            JAXUCZ010000002.1  237457805-237459641
FEATURES             Location/Qualifiers
     source          1..2687
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..2687
                     /gene="Ddah1"
                     /note="dimethylarginine dimethylaminohydrolase 1"
                     /db_xref="GeneID:64157"
                     /db_xref="RGD:70968"
     exon            1..412
                     /gene="Ddah1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..967
                     /gene="Ddah1"
                     /EC_number="3.5.3.18"
                     /note="NG,NG dimethylarginine dimethylaminohydrolase;
                     DDAHI; DDAH-1; dimethylargininase-1"
                     /codon_start=1
                     /product="N(G),N(G)-dimethylarginine
                     dimethylaminohydrolase 1"
                     /protein_id="NP_071633.1"
                     /db_xref="GeneID:64157"
                     /db_xref="RGD:70968"
                     /translation="MAGLSHPSVFGRATHAVVRAPPESLCRHALRRSQGEEVDFARAE
                     RQHQLYVGVLGSKLGLQVVQLPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEV
                     DMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKD
                     YAVSTVPVADSLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDM
                     AANCIYLNIPSKGHVLLHRTPEEYPESAKVYEKLKDHLLIPVSNSEMEKVDGLLTCCS
                     VFINKKTDS"
     exon            413..512
                     /gene="Ddah1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..586
                     /gene="Ddah1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..706
                     /gene="Ddah1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..850
                     /gene="Ddah1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..2687
                     /gene="Ddah1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagccgccg ggcgctcgca ggctcgcagg ctcgcaggtt gggcgcgcgc tgctctcggg
       61 aagacccggc caccgagcca aaccccgccg ccgcctctcc gcgcgagcca tggccggcct
      121 cagccacccc tcggtcttcg gccgggccac ccacgccgtg gtgcgggctc cgcccgagtc
      181 cctgtgccgc cacgcgctga ggcgctccca gggcgaagag gtggatttcg ctcgcgctga
      241 gcgccagcac cagctctacg tgggcgtgct gggcagcaag ctggggctgc aggtggtgca
      301 gctgccggcc gacgagagcc tgcctgactg cgtgttcgtg gaggacgtgg ccgtggtgtg
      361 cgaggagacc gccctcatca cccgccccgg ggcgcctagc cgcaggaagg aggttgacat
      421 gatgaaagag gctttggaaa aacttcagct caacatagta gagatgaaag atgaaaatgc
      481 aaccttagat ggtggggacg tcctattcac aggcagagag ttttttgtgg gcctttccaa
      541 aaggacaaat caacgaggtg ctgagatctt ggctgatact ttcaaggact acgcagtttc
      601 cacagtcccc gtggccgatt ctttgcattt aaagagtttc tgcagcatgg ctggccccaa
      661 cctgatcgca atagggtcca gtgaatctgc gcagaaggcc ctcaagatca tgcaacagat
      721 gagtgaccac cgttatgaca agctcactgt accggacgac atggccgcca actgtatata
      781 tttaaatatc cccagcaaag ggcatgtctt gctgcaccga accccagaag agtacccaga
      841 aagcgcaaag gtttatgaga agctcaagga ccatctactg atccctgtga gcaattctga
      901 gatggaaaag gtggacggct tgctcacctg ctgctccgtt tttattaaca agaagacaga
      961 ctcttgagcg gaagagtccc tcccgagcgg ccggcgagtg gcctaggcca ggctgatgat
     1021 ggctctgtac ccattcctcc tgtttccttt gacaatctac tgtgccacta actcttgttt
     1081 acaaagaatt ccaatcttaa tcgcctcatt tccccacacc cccctcttcc tcacggggcc
     1141 ccctaacctg tgcacacatt tgctcaatga actaagcaac ctaggaaata cagaactaac
     1201 gaatcattgg aatgtgattg atagcgtgga ggcactcact ccagcctctg tgtccttagt
     1261 gtgggaatag tttagatgca gggcatcctg aaggactgac ctcctgggca gacagataaa
     1321 caagcaaggg actttctttg cttcatgagt tgcgtttggt tcctgtgaga gtcctgagaa
     1381 cgtggatttt ttcccattcc cctctcttct cacctctaaa acactttctt ccaggtcttc
     1441 ctttggcctt cctcacttct ttcgtaatca ccttgaacct ggatttatcc aaggtctcga
     1501 actctggata ccctcctaac gtccaccctg tctacgtgca gtcctctcct cctcacagcc
     1561 acaacttctg ccaccaccag caaatcagag tggctggttg gagacgaggg acctcacaga
     1621 ggcacatcct gacagggttt cccattagca cacctaggaa ggtaaattca ggtggttgat
     1681 acaggatgtt agatacagaa gcctagaaac acccccatgg gtacatctca gagagactga
     1741 gtcactgcca tgattttgcc tcatgactgg tcctatagga gcgtggagga aagtctttct
     1801 ccaccccacc acctccccct ttttcagctt ccttctgact caaccttgta tctaccccct
     1861 tagaatcacc atgattttga aaagtcattt ccttcaaaaa aaggcagaac atctaatgat
     1921 tgttgacggt ctggtaagag ctagagggaa ctgcctccac ccaaggccta ggagcacaat
     1981 caggaaatgg ttcctaaagt caacttcaaa caatgtgtga gtctcctttg aaatatccat
     2041 gactgtttac tgtggaattc aaccgaaact tcaaattaca caactttcag cagacgcagg
     2101 tctctcacag ggaacaatac cacagcaaag gaattccttt cttgaaagct gaaacaggcc
     2161 aaggacatgg taccttacaa ggcacggtga cccagccagg catctcatca aacttctggt
     2221 cacttctacc ttggctgtat agcctgcagt ctgtcattcg atatttaaag ttggggagac
     2281 aaaggctatg tcagctctag ctctccttac ctctctttgt gatcagtgtt tcttctagtg
     2341 aaggcaagag agactgggcc tcatctcgtc cccctcagtg gccggaagtg agaaaatcaa
     2401 gacttccttt accgcccttc tcttagttgg caacctctct gaagaggtct ccatctctcc
     2461 cttgctgtct aactctagac tcatatcgca tgccaatatc taactgtaca ccctgtgaat
     2521 gaaccatatc ctggtcactg tcacatttca cagcgtatca caggtgaaca gttatgcctt
     2581 ctccagggca agggaatatg agacagttgc ctaaattcat aaagaaaaat tgttctcagc
     2641 cattatggtt gccttgaggg gttaaagttg accccaccta cactagc
//
