LOCUS       NM_134387                852 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus dicarbonyl and L-xylulose reductase (Dcxr), mRNA.
ACCESSION   NM_134387
VERSION     NM_134387.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 852)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 852)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 852)
  AUTHORS   Fong,K.W., Leung,J.W., Li,Y., Wang,W., Feng,L., Ma,W., Liu,D.,
            Songyang,Z. and Chen,J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
REFERENCE   4  (bases 1 to 852)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 852)
  AUTHORS   Matsunaga,T., Arakaki,M., Kamiya,T., Endo,S., El-Kabbani,O. and
            Hara,A.
  TITLE     Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of
            9,10-phenanthrenequinone leading to apoptosis in human endothelial
            cells
  JOURNAL   Chem Biol Interact 181 (1), 52-60 (2009)
   PUBMED   19442656
REFERENCE   6  (bases 1 to 852)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 852)
  AUTHORS   Ishikura,S., Isaji,T., Usami,N., Nakagawa,J., El-Kabbani,O. and
            Hara,A.
  TITLE     Identification of amino acid residues involved in substrate
            recognition of L-xylulose reductase by site-directed mutagenesis
  JOURNAL   Chem Biol Interact 143-144, 543-550 (2003)
   PUBMED   12604240
REFERENCE   8  (bases 1 to 852)
  AUTHORS   Nakagawa,J., Ishikura,S., Asami,J., Isaji,T., Usami,N., Hara,A.,
            Sakurai,T., Tsuritani,K., Oda,K., Takahashi,M., Yoshimoto,M.,
            Otsuka,N. and Kitamura,K.
  TITLE     Molecular characterization of mammalian dicarbonyl/L-xylulose
            reductase and its localization in kidney
  JOURNAL   J Biol Chem 277 (20), 17883-17891 (2002)
   PUBMED   11882650
  REMARK    GeneRIF: Dcxr is highly expressed in kidney and liver
            (dicarbonyl/L-xylulose reductase)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jun 3, 2021 this sequence version replaced NM_134387.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB061719.1, FQ233401.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000010.1  106506555-106506619 c
            66-163              JAXUCZ010000010.1  106506376-106506473 c
            164-318             JAXUCZ010000010.1  106505743-106505897 c
            319-361             JAXUCZ010000010.1  106505615-106505657 c
            362-461             JAXUCZ010000010.1  106505430-106505529 c
            462-526             JAXUCZ010000010.1  106505284-106505348 c
            527-644             JAXUCZ010000010.1  106505077-106505194 c
            645-852             JAXUCZ010000010.1  106504730-106504937 c
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..852
                     /gene="Dcxr"
                     /gene_synonym="glb"
                     /note="dicarbonyl and L-xylulose reductase"
                     /db_xref="GeneID:171408"
                     /db_xref="RGD:620031"
     exon            1..65
                     /gene="Dcxr"
                     /gene_synonym="glb"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..748
                     /gene="Dcxr"
                     /gene_synonym="glb"
                     /EC_number="1.1.1.10"
                     /note="XR; diacetyl/L-xylulose reductase; dicarbonyl
                     L-xylulose reductase"
                     /codon_start=1
                     /product="L-xylulose reductase"
                     /protein_id="NP_599214.1"
                     /db_xref="GeneID:171408"
                     /db_xref="RGD:620031"
                     /translation="MDLGLAGRRALVTGAGKGIGRSTVLALQAAGAQVVAVSRTREDL
                     DSLVRECPGVEPVCVDLADWEATEQALSNVGPVDLLVNNAAVATLQPFLEVTKEACDT
                     SFNVNFRAVVQVSQIVARGMIARGVPGAIVNVSSQASQRALTNHTVYCSTKGALDMLT
                     KVMALELGPHKIRVNAVNPTVVMTPMGRANWSDPHKAKVMLDRIPLGKFAEVENVVDT
                     ILFLLSNRSSMTTGSALPVDGGFLAT"
     exon            66..163
                     /gene="Dcxr"
                     /gene_synonym="glb"
                     /inference="alignment:Splign:2.1.0"
     exon            164..318
                     /gene="Dcxr"
                     /gene_synonym="glb"
                     /inference="alignment:Splign:2.1.0"
     exon            319..361
                     /gene="Dcxr"
                     /gene_synonym="glb"
                     /inference="alignment:Splign:2.1.0"
     exon            362..461
                     /gene="Dcxr"
                     /gene_synonym="glb"
                     /inference="alignment:Splign:2.1.0"
     exon            462..526
                     /gene="Dcxr"
                     /gene_synonym="glb"
                     /inference="alignment:Splign:2.1.0"
     exon            527..644
                     /gene="Dcxr"
                     /gene_synonym="glb"
                     /inference="alignment:Splign:2.1.0"
     exon            645..852
                     /gene="Dcxr"
                     /gene_synonym="glb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactggggc accatggacc tgggtcttgc aggtcggcgg gcgctggtca ccggcgcggg
       61 caaaggcatc gggcgcagca ctgtgctggc tttgcaggcg gctggtgcac aggttgtggc
      121 ggtgagtcgg acgcgagagg acctggacag cctggtccgg gagtgtcctg gtgtggagcc
      181 tgtgtgtgtg gacctggccg actgggaggc cacagaacag gccctaagca atgtgggacc
      241 ggtggacctt ctggtgaaca atgctgctgt ggctacgttg cagcccttcc tggaggtcac
      301 caaggaggcc tgtgacacgt ccttcaacgt gaattttcgg gctgtcgtcc aggtgtcgca
      361 gattgtggcc aggggcatga tagctcgggg agttccaggg gccattgtga atgtctccag
      421 ccaggcctcc cagcgtgcac tgaccaacca taccgtctac tgttccacca agggtgcttt
      481 agacatgttg accaaggtga tggccctaga gcttgggccc cacaagatcc gtgtgaatgc
      541 agtaaacccc acagtagtga tgacacccat gggccgggcc aactggagtg acccgcacaa
      601 agctaaggtc atgctggatc gtatcccact tggcaagttt gctgaggtgg agaacgtggt
      661 agacaccatc ctcttcctgc tgagcaaccg aagtagcatg actactggtt ccgctttgcc
      721 agtggatggg ggcttcctgg ctacctaagc cctccctacc aatactctgc tcaactcatg
      781 ttcagaacat cgtgccctcc atccctccaa taaagctctc tgcccagcct gtgtgctgat
      841 tctccaccca aa
//
