LOCUS       NM_053379               8827 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus doublecortin (Dcx), mRNA.
ACCESSION   NM_053379
VERSION     NM_053379.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8827)
  AUTHORS   Skalbania,J., Palasz,A., Blaszczyk,I., Suszka-Switek,A.,
            Krzystanek,M., Tulcanaz,K.P., Worthington,J.J. and
            Mordecka-Chamera,K.
  TITLE     Chlorpromazine affects the numbers of Sox-2, Musashi1 and
            DCX-expressing cells in the rat brain subventricular zone
  JOURNAL   Pharmacol Rep 73 (4), 1164-1169 (2021)
   PUBMED   33843023
  REMARK    GeneRIF: Chlorpromazine affects the numbers of Sox-2, Musashi1 and
            DCX-expressing cells in the rat brain subventricular zone.
REFERENCE   2  (bases 1 to 8827)
  AUTHORS   Cilingir-Kaya,O.T., Moore,C., Meshul,C.K., Gursoy,D., Onat,F. and
            Sirvanci,S.
  TITLE     Neurogenesis is Enhanced in Young Rats with Genetic Absence
            Epilepsy: An Immuno-electron Microscopic Study
  JOURNAL   Turk Neurosurg 31 (4), 623-633 (2021)
   PUBMED   33978223
REFERENCE   3  (bases 1 to 8827)
  AUTHORS   Tan,J., Wu,Z., Liu,J., Zhang,W., Yuan,W. and Peng,H.
  TITLE     MicroRNA-203-mediated inhibition of doublecortin underpins
            cardioprotection conferred by sevoflurane in rats after myocardial
            ischaemia-reperfusion injury
  JOURNAL   J Cell Mol Med 24 (17), 9825-9838 (2020)
   PUBMED   32783282
  REMARK    GeneRIF: MicroRNA-203-mediated inhibition of doublecortin underpins
            cardioprotection conferred by sevoflurane in rats after myocardial
            ischaemia-reperfusion injury.
REFERENCE   4  (bases 1 to 8827)
  AUTHORS   Pretsch,G., Sanadgol,N., Smidak,R., Lubec,J., Korz,V., Hoger,H.,
            Zappe,K., Cichna-Markl,M. and Lubec,G.
  TITLE     Doublecortin and IGF-1R protein levels are reduced in spite of
            unchanged DNA methylation in the hippocampus of aged rats
  JOURNAL   Amino Acids 52 (4), 543-553 (2020)
   PUBMED   32236698
  REMARK    GeneRIF: Doublecortin and IGF-1R protein levels are reduced in
            spite of unchanged DNA methylation in the hippocampus of aged rats.
REFERENCE   5  (bases 1 to 8827)
  AUTHORS   Silva-Pena,D., Garcia-Marchena,N., Alen,F., Araos,P., Rivera,P.,
            Vargas,A., Garcia-Fernandez,M.I., Martin-Velasco,A.I.,
            Villanua,M.A., Castilla-Ortega,E., Santin,L., Pavon,F.J.,
            Serrano,A., Rubio,G., Rodriguez de Fonseca,F. and Suarez,J.
  TITLE     Alcohol-induced cognitive deficits are associated with decreased
            circulating levels of the neurotrophin BDNF in humans and rats
  JOURNAL   Addict Biol 24 (5), 1019-1033 (2019)
   PUBMED   30277635
REFERENCE   6  (bases 1 to 8827)
  AUTHORS   Corbo,J.C., Deuel,T.A., Long,J.M., LaPorte,P., Tsai,E.,
            Wynshaw-Boris,A. and Walsh,C.A.
  TITLE     Doublecortin is required in mice for lamination of the hippocampus
            but not the neocortex
  JOURNAL   J Neurosci 22 (17), 7548-7557 (2002)
   PUBMED   12196578
REFERENCE   7  (bases 1 to 8827)
  AUTHORS   Arvidsson,A., Collin,T., Kirik,D., Kokaia,Z. and Lindvall,O.
  TITLE     Neuronal replacement from endogenous precursors in the adult brain
            after stroke
  JOURNAL   Nat Med 8 (9), 963-970 (2002)
   PUBMED   12161747
REFERENCE   8  (bases 1 to 8827)
  AUTHORS   Aigner,L., Fluegel,D., Dietrich,J., Ploetz,S. and Winkler,J.
  TITLE     Isolated lissencephaly sequence and double-cortex syndrome in a
            German family with a novel doublecortin mutation
  JOURNAL   Neuropediatrics 31 (4), 195-198 (2000)
   PUBMED   11071144
REFERENCE   9  (bases 1 to 8827)
  AUTHORS   Kato,M., Kimura,T., Lin,C., Ito,A., Kodama,S., Morikawa,T., Soga,T.
            and Hayasaka,K.
  TITLE     A novel mutation of the doublecortin gene in Japanese patients with
            X-linked lissencephaly and subcortical band heterotopia
  JOURNAL   Hum Genet 104 (4), 341-344 (1999)
   PUBMED   10369164
REFERENCE   10 (bases 1 to 8827)
  AUTHORS   des Portes,V., Francis,F., Pinard,J.M., Desguerre,I., Moutard,M.L.,
            Snoeck,I., Meiners,L.C., Capron,F., Cusmai,R., Ricci,S., Motte,J.,
            Echenne,B., Ponsot,G., Dulac,O., Chelly,J. and Beldjord,C.
  TITLE     doublecortin is the major gene causing X-linked subcortical laminar
            heterotopia (SCLH)
  JOURNAL   Hum Mol Genet 7 (7), 1063-1070 (1998)
   PUBMED   9618162
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000021.1.
            
            On Sep 30, 2010 this sequence version replaced NM_053379.2.
            
            Summary: This gene encodes a member of the doublecortin family. The
            protein encoded by this gene contains two doublecortin domains,
            which bind microtubules and regulate microtubule polymerization. In
            the developing cortex, cortical neurons must migrate over long
            distances to reach the site of their final differentiation. The
            encoded protein appears to direct neuronal migration by regulating
            the organization and stability of microtubules. Studies in knockout
            mice lacking this gene suggest that this gene has a cortical role
            in nuclear translocation and positioning of the mitotic spindle in
            radial glial mitotic division. This gene is essential for neuronal
            migration, differentiation, and plasticity, is required for
            hippocampal development and also plays a role in dendrites
            development.[provided by RefSeq, Sep 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000021.1  112304118-112304161 c
            45-430              JAXUCZ010000021.1  112301978-112302363 c
            431-771             JAXUCZ010000021.1  112294232-112294572 c
            772-874             JAXUCZ010000021.1  112251300-112251402 c
            875-1012            JAXUCZ010000021.1  112249841-112249978 c
            1013-1107           JAXUCZ010000021.1  112242447-112242541 c
            1108-8827           JAXUCZ010000021.1  112227455-112235174 c
FEATURES             Location/Qualifiers
     source          1..8827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq33-q34"
     gene            1..8827
                     /gene="Dcx"
                     /note="doublecortin"
                     /db_xref="GeneID:84394"
                     /db_xref="RGD:620670"
     exon            1..44
                     /gene="Dcx"
                     /inference="alignment:Splign:2.1.0"
     exon            45..430
                     /gene="Dcx"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1164
                     /gene="Dcx"
                     /codon_start=1
                     /product="neuronal migration protein doublecortin"
                     /protein_id="NP_445831.3"
                     /db_xref="GeneID:84394"
                     /db_xref="RGD:620670"
                     /translation="MELDFGHFDERDKASRNMRGSRMNGLPSPTHSAHCSFYRTRTLQ
                     ALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVR
                     YIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQ
                     SLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAI
                     KLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKG
                     NPSATAGPKASPTPQKTSAKSPGPMRRSKSPADSGNDQDANGTSSSQLSTPKSKQSPI
                     STPTSPGSLRKHKDLYLPLSLDDSDSLGDSM"
     exon            431..771
                     /gene="Dcx"
                     /inference="alignment:Splign:2.1.0"
     exon            772..874
                     /gene="Dcx"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1012
                     /gene="Dcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1107
                     /gene="Dcx"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..8827
                     /gene="Dcx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttttcttt ctcacagcat ctccacccaa ccagcagaaa accggttgct gtggttccac
       61 caaaatatgg aacttgattt tggacatttt gacgaacgag acaaagcatc tagaaatatg
      121 agagggtcac ggatgaatgg acttccaagt cccactcata gtgctcactg tagcttctac
      181 agaaccagaa ccttgcaggc attaagtaat gagaagaagg ccaagaaggt acgtttctac
      241 cgcaatgggg accgttactt caaggggatt gtgtacgctg tttcttctga ccgttttcgt
      301 agttttgatg cattgctggc tgacctgact cgatccttgt ccgacaacat caacctgcct
      361 cagggagtgc gctacattta cactattgat ggatccagaa agattggaag catggatgaa
      421 ctggaagaag gggaaagcta tgtctgttcc tcagacaact tctttaaaaa ggttgagtat
      481 accaagaatg tcaatcccaa ctggtcggtc aatgtaaaga catcagccaa catgaaagcg
      541 ccccagtcct tggctagcag caacagtgct caagccagag agaacaagga cttcgtgcgc
      601 cccaaacttg tgaccatcat tcgcagtggg gtgaagcctc ggaaggcggt gcgtgtgctt
      661 ctcaacaaga aaacagccca ctctttcgag caggtcctca ctgacatcac agaagcgatc
      721 aaactggaaa ccggagttgt caaaaaactc tatacccttg atggaaagca ggtcacctgt
      781 ctccatgatt tctttggtga tgatgatgtg ttcattgctt gtggccctga aaagttccgc
      841 tatgctcaag atgacttctc cttggatgag aatgaatgca gagtcatgaa agggaatcca
      901 tctgccacag ctggcccaaa agcttcccca acacctcaaa agacatctgc taaaagccca
      961 ggcccaatgc gccgcagcaa gtctccagct gactcaggta acgaccaaga cgcaaatgga
     1021 acttctagca gtcagctctc aacacctaag tcgaagcagt ctcctatctc tacacccaca
     1081 agccctggaa gtctgcggaa gcacaaggac ttgtacctgc cactgtcatt ggatgactct
     1141 gattcacttg gcgattccat gtgaaagatg ataggctaaa tcaaagccga ttattatagc
     1201 agaatacttt cgctcaagtg accaacaagg ctattggtgc ttagacattt ttgttgttat
     1261 tgttgctttt caaaacactc tgtagtatgt agggtttatt ttcttgtgac ttctcttctg
     1321 ggccactaat tcacatttac caataagaga tagattgata accatctttt gagtgacttt
     1381 tccagaactg caaaatgtgc tagtccatga cctttctact gaatgcttag gggcctttgt
     1441 attttcccca ttcaatttgt gcagaaacta gtctttcttc tctagaaggc tgtttacgta
     1501 cacatcgctt aaaatgttta tgtgtggggg aaaactttca tatgcagatc taaaagtgaa
     1561 aaacctaagt gtcccttgcc tctgtatctt cagaatgctg gaggatctca ggagagtggc
     1621 aagtcagatc cttggcctca ctcgttgctc ttaattgagc ctccagtgta ttgtctagca
     1681 ttcattctgg ctgttgagat ggagaaacac cagcgacttc caatgtgaca ccatgtgctt
     1741 aaggctgtgg tatcagactg gctgcaagag atgaggtaga atttagggga aaaactgccc
     1801 aaatttcagt aggatttaca taaagcacag tggattcctg gtcaactcct ctactgggga
     1861 aattttggaa tcaatcaata attgattagt ttggggtaca tgatgtcaca tacatgatcc
     1921 caccaggagg ctttctaatg tacacgttag tacatgaacc gcatggtatc catctagctc
     1981 tgttctattg aatgccttgt aaacaaccaa cactacaaac actgtgagaa tttgttttca
     2041 ggtctgacac cttttggtcg ctttttatag caagaaacca tatccatttt ttataataac
     2101 tcaagtctgt atttcaggag caaaactctt cgggctcctt ttttataagc tggtgatttt
     2161 tttcctttgt ctaaaaaaca cgagtagaaa attgaccaaa aaaatgcaga agaatactgt
     2221 agtttagaaa tcatgctctc actgccaaac agaaagctcc gggagaaaac tcaacgacta
     2281 gaggccaatt caatagaatc aggtttttga taccttttta acagttacac tttcagtact
     2341 aatttcaatg tggaccagac attctaatta tattttaaat gaaatgttat ggcatatttt
     2401 aagtaagtct tttttatcta taatcctaat atttcatact taagatacag agacctttca
     2461 cttgacttta acatttagaa aggatttctc tttattaagg attgctcact tgaaataact
     2521 gtctttgagg tacaggtttt taaaattact ttttctctgt aatcatagcc catgatagcc
     2581 aagacaacta aatttaggtg aaagccatgc atgccaattc tgtgtttgat ttttagtaga
     2641 taggcagatt tcctttactt ctttgtcatt gttcagatag cttgaaagat gcagcgttca
     2701 aagccaacat gtcgtttggc tgctgaatga catgcagctg tcccttcatt ctaagtaaaa
     2761 tgagtgtggg gttcgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2821 gtgtgtgtgt gtctaggctg cttcacaatt aggaaatact gcacaagaca actcaacgtg
     2881 gattgatgac aacttggtgg cattgctgat gcgcaggggg aagtaggatg gcaggggtag
     2941 cgagagcccc cttgataaat ttcagatgtc cttaattact agattacaag aaacattttc
     3001 ggttttggtt caggagaagg gggatgatga gagctctggt ttctgctcaa actgctcatt
     3061 gaagagccca aaatgatgag gttttgctct tcccccctct ttattggtaa gcccacatga
     3121 aatgattaag aaacccattt taatcagccc ctattttttc tagaagctca gtgatttctt
     3181 agtgcctccc agagcatttg agttaattag ggaaaattgg ttatttggga tggatagaaa
     3241 ttgtggtagg aggtctattt ttaacctctg ggccagatcc tccagcacac tctatgttgg
     3301 tctttgagca aatcccatgt tgtcccaagt attcatttaa gacgagacat gcagatccta
     3361 ctgaaagagt aggagcaaag agaattcaac agtcctcatg cccaggcccc ttggttctct
     3421 gagtatttct ctacttgtag cataatatag cacaagaaag tactgtgggc atatctttag
     3481 aatattctta gaacaaacat tcttttataa caacagtgtc ctttctgctt ttctttgagc
     3541 taactacaag gaaaccttta caaaacactt tttatttata tacaggaaca gttacatata
     3601 aaaaatattt ttaactgcta ttttgtgtgg tataattgaa aactcaagtc tccaataatt
     3661 tcattttaaa ttggctgaaa ttcaagtaaa ttgttttcag aaataagctc ctacaccccc
     3721 caaattcatt ctcagttttt cctaatacag ttttactact ttagtcccat cgagttcagt
     3781 gtgcatggtc agcaagcatt tgccaccact tcccataaca cctccccctc tctctttttc
     3841 tctttctctc tgtctctctg tctctctcac gcgcgtgtgc gcgcgcgctc acacacacac
     3901 acacacacac acacacacac acacacacac catgttgctt gttcctacct cctgactttt
     3961 cttccccaca gaaatagaaa taggggcata aaaagggaaa tgtatatatg ggggctgggt
     4021 tgaacaacta acttcgtaag tagtgctaag tagaattaaa gcgagagaaa agcttctttt
     4081 ctcatcactg ttttggaaag gatagccatt agcatgactg ctttgtgtcc ttgcggactt
     4141 tagtattagc ctagactgag ttatagcatt ttctagctgg aaggaagatt aagatcacat
     4201 catctgctcc aaatttttca ttttcttaag gccaggaaac agaccaagat gtaaagtgat
     4261 ttccccctaa ggtcacacag ctgcccattg gcagtgctgg gattagaacc tacacctctg
     4321 ggctcatatt ccggggtatt ttcccaacta gccagtattg tcttttgtga ggttgctgaa
     4381 aattctttcc cagggtcatg ttgcatcctg gatctatatg ctactttgct ggtctcagca
     4441 agaaatccac acagcaatct aatctggccc ttcctcctca ttttcacatt acttcatcca
     4501 catggcctgt caacagcgcc aaggagaggg atgcattgaa atgttgggca ccagaaggtg
     4561 gctgccctac cttgaggaat cttctaaatg gccctctgaa ctcctacttt atccacgtag
     4621 aatggaaaat gactactttg tcccttatcg gcttccttca atgtcatggc acacatgttc
     4681 ctcccaggat atggaagtgg ttacttgttt ctgggacaga gaaaataaga aatgaagaac
     4741 agagcaatag ctttgtttat tctgactttc taagatgact tttttatcat ttaaaaatta
     4801 gtctggctat ctttcctact aataacgatt tcctttaaaa tatggtagtg agccaagcca
     4861 gagaaagata atcaagtctc gtatttgtcc tgaatctcta tgtcctcata gccacgctcc
     4921 ctggtgcaaa caattttcag gtttaaacaa gttgattttg tttactaaat tgtgccctgg
     4981 ctgacactga atatttgtat ctataccaaa aatagcacag tgactttaca cattatgttc
     5041 tctctctcta tgtagcttat ttctgtggct ttccatgaca gaagttaggg caacgtgatc
     5101 tgtacgtgtt agtttctttg catcaaggaa ctaacaaata ttgactgaat tctaaaagaa
     5161 ctcttactag acttacccaa gttcaggaac ttctctatct tttcttctct ccagttggga
     5221 gtgaccaagg aatcgtaaag tgggtgtgta tcttctatat cctaggatca tctagcctaa
     5281 gtttaaggca actagcccaa tgcttgattt gtataaaatt gtgtatccat caccggtctc
     5341 ctcaatatcc tacatagaga ttttcccagt tcctctcaca ttagattcca aatggatttc
     5401 ccatttagaa aacagagaag gaactaagcc ctatctcctt ggaatgggag cagtcacatg
     5461 tccatgggtc cccaatgaac ttctgtgatg gtgagaatat ttcaggagag gagactgcct
     5521 tgggaacagc tatagcaaga gacttctcca gcagaaaccc gatgacggca tagctttact
     5581 gacttccttc atgatctagt ttgcatagga tctttctctt ttcttccttt attcttcttt
     5641 ttttggaatt tattggagcc tgttcttggg cacatggggc catttggacc catacctagg
     5701 cctcagttat atattgcctt cgctttttaa gaggattagg cttctagatt caaactggtt
     5761 ttctaagtag ggaaggtgta ttttgaaagt catacggggc acaggagggc tgatggtcct
     5821 attatttaga gctggaaccc tgagatggca aaggatgagt actgacctag gcatttagaa
     5881 tacgtcaggg ctgatctgga gtttagaggc tgtcatgctt ctgcctctgg cctactaaaa
     5941 ccacatgtgt agtgcaactc acaattctgg gaatcatgta ggatttcctc ttctttcaat
     6001 catggccacc tggagcaaga ataggccact gacttttcag gctttccttt tgattagaga
     6061 ggcctctatc tgccttgggt gcaaaatgaa gtttcattag ccatcacacc aaaggcttct
     6121 tagtggtcac ttgtatgccc cctctttcag gattgatgta gagctcctgc tttggccaaa
     6181 ctggtgtgag attggctatc tttgggaagt gaagtgtttc ttaagctgtt tggagtcaaa
     6241 atattctgta attagaagtg attttgcccc tctttagcat acctggggtt agggaagtag
     6301 agaattctca attgaaagta agtcactttc ctgcttgggt aataaggcca ggtgagttgc
     6361 aaaaggtcaa agagaacaca aaagtcagaa gacaaagtct tgtaatctaa agcaaagacc
     6421 cgaaggtttc agaatgtctc aagtctgggc aataattcaa ggaaataaat ggctatttgt
     6481 cattccattt cctgttttct ttctctattt agatgcctat atttgttctc agtttcgact
     6541 ctgttatcaa tttctcattc cgtagcaaaa acatccattc tttgacgtgt gcggcacttc
     6601 ctcctcttgg aattctttgc accttcccac ctcacaactg ggcatatgca gcttcatagt
     6661 ctgttaagtt ttgccttggg attgaaggga aataattttc catttcgaca attcctggtt
     6721 ctacccaagt tcagtcacaa gtaggttggt agaaatcaac ctgattctgg ccctttcttc
     6781 ttttctgttt tagtctcagc agatcttttc aaacgttgtc ctttcggctc atgaatgtta
     6841 ggtatttacc ttctaagcaa gcattgtaca gaacactttc tgcttctttt gaaatgtcat
     6901 tttgtgaaca gattgtaatg tgctcagata aataatcagc tgaacaggaa aagagtctac
     6961 ccatctattc aaattggcaa actattgtta gttggtttct ttaaatttgc tcatagtttt
     7021 gaaaagctgc aatataatat catgagagac cacagataat tgttcctgtc atttggttgg
     7081 gctgaataga gactgggggt gggggtgggg gtggggaagc aggaacgatt tgtttaaact
     7141 tttaccacta ttcattaagc tctctctgtt ataacattat gatctgtgtt tgccacttat
     7201 tgaattattt aagctaagct ggtaggcaat taaaattaat ttaagtcaaa aagtatctaa
     7261 cacatctagg ctaaagaaaa aaaatactta gttgaaatgt atttgtcctt ccaatattag
     7321 atttacctaa acattttcct tttaacatca actgttcatg atccaggact gtctgtccat
     7381 gtatgtcctg taaattagca ggcttaagtc tactgattaa ttcaacagag ttcagaatcc
     7441 ctggggatgt caatgtcact gcttggcaat accatatgta ttgcctattt tttccagtga
     7501 cttttctttc taagttctct taaagaggtt tgcgaaagta agaagttaag ctaaaatata
     7561 tccaatgttt ggtagtgtat catattgcag cattaaacca acaacccttt atgacttata
     7621 cacagctaat gcatggtttg agagtggatt ttgcattttt catgtgcagt aaattattta
     7681 aaatgttttt ggtcaccttt ttgtgccatt aaacttgtac agaaaatgct cttatggcca
     7741 ttttcaaagg gagaaagttt aaaatggaaa cagcccaccc tttctgccct atagctgtag
     7801 ttagaattga gtacgtgtag aaaaacggct gtaattggtg gttgtagtgt tagagtttgt
     7861 tagctggcta gtgactacct ttggagagta aatgcatggt cttgtacatc acatttctta
     7921 aataactctt tttaacctcg gaaaagaata tattattcca tgtggccctc ttccctccct
     7981 ccactccctg ctcccagata tcttaccatt aactgtaaat aaccgattta ggggccaaga
     8041 attcctgcca agtaaagtca gaaacgagca aaaaaaccaa ggggcgtgtg tgaagagaat
     8101 tttacaacaa tttctcagaa gtcattgacc atttctaaag gaaaggcacg gttatcaaag
     8161 cttcagctgt ctttgaccta aaaatcagag gcaaattggg agggtctttg gctgccagat
     8221 tacagtatag aattgaataa ttcttagaat catacaaccc aaggatgtcc ctgatccctg
     8281 cactagttgt gaggtatttg gatgcatcaa aggtgtgttg acctatattt attggggaca
     8341 aaagaaaagc aaatgtgcaa cgaatgctca ggggtttcag ctaggcccca gtcagcaaaa
     8401 gcaaggaggt gagtttagat agatgcattg tctgtttccc aggcaatgct tagactttga
     8461 gtgatacaaa ggcagtgttt caagaagaca ctctcttctt tggtttgctg ttctctcttg
     8521 gactggtatg tttggcaagg cccatgtaag ctggttagag caggtctttt atctccccca
     8581 ccataatttg atgagggctc tttggtttga ggacttcaag gctgtctaga gaagttcccc
     8641 catgtgtgtg aggtgttgtg aactgtgaac actgtacatc ttcagtgttc aatacagggc
     8701 agccaaagag ctgctcttgc aatctttttt ggctctcaag ctctgttctc catcgaattc
     8761 tcatttctgt gtacatttgc aagatgtgtg taatgtcatt ttccaaaaat aaaatttgat
     8821 ttcaata
//
