LOCUS       NM_138892                672 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus dCTP pyrophosphatase 1 (Dctpp1), mRNA.
ACCESSION   NM_138892
VERSION     NM_138892.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 672)
  AUTHORS   Requena,C.E., Perez-Moreno,G., Ruiz-Perez,L.M., Vidal,A.E. and
            Gonzalez-Pacanowska,D.
  TITLE     The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and
            cleansing of the dNTP pool in human cells
  JOURNAL   Biochem J 459 (1), 171-180 (2014)
   PUBMED   24467396
REFERENCE   2  (bases 1 to 672)
  AUTHORS   Nonaka,M., Tsuchimoto,D., Sakumi,K. and Nakabeppu,Y.
  TITLE     Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate
            pyrophosphohydrolase that prefers 5-iodocytosine
  JOURNAL   FEBS J 276 (6), 1654-1666 (2009)
   PUBMED   19220460
REFERENCE   3  (bases 1 to 672)
  AUTHORS   Wu,B., Liu,Y., Zhao,Q., Liao,S., Zhang,J., Bartlam,M., Chen,W. and
            Rao,Z.
  TITLE     Crystal structure of RS21-C6, involved in nucleoside triphosphate
            pyrophosphohydrolysis
  JOURNAL   J Mol Biol 367 (5), 1405-1412 (2007)
   PUBMED   17320107
REFERENCE   4  (bases 1 to 672)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY029335.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY029335.1, FM060364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..672
                     /gene="Dctpp1"
                     /gene_synonym="RS21-C6; Rs21c6; Xtp3tpa"
                     /note="dCTP pyrophosphatase 1"
                     /db_xref="GeneID:192252"
                     /db_xref="RGD:620933"
     exon            1..154
                     /gene="Dctpp1"
                     /gene_synonym="RS21-C6; Rs21c6; Xtp3tpa"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..566
                     /gene="Dctpp1"
                     /gene_synonym="RS21-C6; Rs21c6; Xtp3tpa"
                     /EC_number="3.6.1.12"
                     /function="might be involved in inducing TCR-CD3 complex
                     expression"
                     /note="dCTPase 1; deoxycytidine-triphosphatase 1;
                     XTP3-transactivated gene A protein homolog;
                     XTP3-transactivated protein A"
                     /codon_start=1
                     /product="dCTP pyrophosphatase 1"
                     /protein_id="NP_620247.1"
                     /db_xref="GeneID:192252"
                     /db_xref="RGD:620933"
                     /translation="MSQAGTGVCGNGGQEDSAAAGPFSFSPEPTLEDIRRLHAEFAAE
                     RDWEQFHQPRNLLLALVGEVGELAELFQWKSDAEPGPQAWQPKERAALQEELSDVLIY
                     LVALAARCHVDLPRAVISKMDTNRQRYPVHLSRGSACKYTDLPRGTLSENEAVGSGDP
                     ASELGNQAST"
     exon            155..265
                     /gene="Dctpp1"
                     /gene_synonym="RS21-C6; Rs21c6; Xtp3tpa"
                     /inference="alignment:Splign:2.1.0"
     exon            266..647
                     /gene="Dctpp1"
                     /gene_synonym="RS21-C6; Rs21c6; Xtp3tpa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctctgaacg tggcgcggag tttgctcccg cgcggctggg actggtgggc ggaatgtccc
       61 aagctggtac cggtgtgtgc ggtaatgggg ggcaagaaga ctctgctgct gccggcccgt
      121 tcagcttcag cccagagccc acgcttgagg acatccgacg cctccatgca gagtttgctg
      181 ctgagcggga ctgggaacag ttccaccagc ctcggaacct gctcctagcc ttggtgggag
      241 aagtgggcga gctggcagaa ctctttcagt ggaagtctga cgcagagcct ggtcctcagg
      301 catggcagcc aaaggagaga gcagcccttc aggaggagct tagtgacgtc ctcatctacc
      361 tggtggcatt agcagcccgt tgtcatgtgg acttacctcg agcagtaatc tccaaaatgg
      421 acaccaaccg ccaacgttac ccagtccatc tgtcccgggg ctctgcctgc aagtacacag
      481 acttgccccg tgggaccctc tctgaaaacg aggctgtggg gtctggagac cctgcctctg
      541 agttgggaaa ccaggcttcc acctagaaaa acagtgctag tctggtcttt tttaagtcat
      601 agatctgggc ctggtgtttt ctctctcatt aaaataacgt aaggcaaaaa aaaaaaaaaa
      661 aaaaaaaaaa aa
//
