LOCUS       NM_001004239            1675 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dynactin subunit 2 (Dctn2), mRNA.
ACCESSION   NM_001004239 XM_216906
VERSION     NM_001004239.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1675)
  AUTHORS   Staples,C.J., Myers,K.N., Beveridge,R.D., Patil,A.A., Howard,A.E.,
            Barone,G., Lee,A.J., Swanton,C., Howell,M., Maslen,S., Skehel,J.M.,
            Boulton,S.J. and Collis,S.J.
  TITLE     Ccdc13 is a novel human centriolar satellite protein required for
            ciliogenesis and genome stability
  JOURNAL   J Cell Sci 127 (Pt 13), 2910-2919 (2014)
   PUBMED   24816561
REFERENCE   2  (bases 1 to 1675)
  AUTHORS   Papal,S., Cortese,M., Legendre,K., Sorusch,N., Dragavon,J.,
            Sahly,I., Shorte,S., Wolfrum,U., Petit,C. and El-Amraoui,A.
  TITLE     The giant spectrin betaV couples the molecular motors to
            phototransduction and Usher syndrome type I proteins along their
            trafficking route
  JOURNAL   Hum Mol Genet 22 (18), 3773-3788 (2013)
   PUBMED   23704327
REFERENCE   3  (bases 1 to 1675)
  AUTHORS   Ohbayashi,N., Maruta,Y., Ishida,M. and Fukuda,M.
  TITLE     Melanoregulin regulates retrograde melanosome transport through
            interaction with the RILP-p150Glued complex in melanocytes
  JOURNAL   J Cell Sci 125 (Pt 6), 1508-1518 (2012)
   PUBMED   22275436
REFERENCE   4  (bases 1 to 1675)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   5  (bases 1 to 1675)
  AUTHORS   Gorbea,C., Pratt,G., Ustrell,V., Bell,R., Sahasrabudhe,S.,
            Hughes,R.E. and Rechsteiner,M.
  TITLE     A protein interaction network for Ecm29 links the 26 S proteasome
            to molecular motors and endosomal components
  JOURNAL   J Biol Chem 285 (41), 31616-31633 (2010)
   PUBMED   20682791
REFERENCE   6  (bases 1 to 1675)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1675)
  AUTHORS   Fumoto,K., Hoogenraad,C.C. and Kikuchi,A.
  TITLE     GSK-3beta-regulated interaction of BICD with dynein is involved in
            microtubule anchorage at centrosome
  JOURNAL   EMBO J 25 (24), 5670-5682 (2006)
   PUBMED   17139249
REFERENCE   8  (bases 1 to 1675)
  AUTHORS   Schroer,T.A.
  TITLE     Dynactin
  JOURNAL   Annu Rev Cell Dev Biol 20, 759-779 (2004)
   PUBMED   15473859
  REMARK    Review article
REFERENCE   9  (bases 1 to 1675)
  AUTHORS   Abe,T.K., Tanaka,H., Iwanaga,T., Odani,S. and Kuwano,R.
  TITLE     The presence of the 50-kDa subunit of dynactin complex in the nerve
            growth cone
  JOURNAL   Biochem Biophys Res Commun 233 (2), 295-299 (1997)
   PUBMED   9144527
REFERENCE   10 (bases 1 to 1675)
  AUTHORS   Echeverri,C.J., Paschal,B.M., Vaughan,K.T. and Vallee,R.B.
  TITLE     Molecular characterization of the 50-kD subunit of dynactin reveals
            function for the complex in chromosome alignment and spindle
            organization during mitosis
  JOURNAL   J Cell Biol 132 (4), 617-633 (1996)
   PUBMED   8647893
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079042.1.
            
            On Sep 10, 2004 this sequence version replaced XM_216906.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079042.1, SRR8487226.140273.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1675
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1675
                     /gene="Dctn2"
                     /note="dynactin subunit 2"
                     /db_xref="GeneID:299850"
                     /db_xref="RGD:1303182"
     exon            1..146
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1319
                     /gene="Dctn2"
                     /note="dynactin 2 (p50)"
                     /codon_start=1
                     /product="dynactin subunit 2"
                     /protein_id="NP_001004239.1"
                     /db_xref="GeneID:299850"
                     /db_xref="RGD:1303182"
                     /translation="MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELSSTSVE
                     HIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGDYEMLGEGLGVKETPQQK
                     YQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGP
                     DAAINLADPDGALAKRLLLQLEATKSSKGSSGGKSTGGTPPDSSLVTYELHSRPEQDK
                     FSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMETVELLQAKVNALDLAV
                     LDQVEARLQSVLGKVNEIAKHKASVEDADTQNKVHQLYETIQRWSPVASTLPELVQRL
                     VTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTMRENLATVEGNFAS
                     IDARMKKLGK"
     exon            147..215
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     exon            216..312
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..374
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..473
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..634
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..782
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     exon            783..848
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..887
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     exon            888..965
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1037
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1140
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1232
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1652
                     /gene="Dctn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccccttat cgtcgcctag ccggggaccc ggacccagcc tctcccccac tcggtcaccg
       61 gcccggctcc tccaaggccc cggttccccc agccccgctt cgccgccgcc atggcggacc
      121 ctaaatacgc cgatctcccc ggcattgcca ggaacgagcc agatgtttat gaaaccagcg
      181 acctacctga ggatgatcaa gcagagtttg atgcggagga gctgagcagc acaagtgtgg
      241 aacacatcat cgtcaacccc aacgctgcct atgacaagtt caaggacaag agagtaggga
      301 caaaggggct tgatttctca gatcgcattg gaaagaccaa gaggacagga tatgagtctg
      361 gagactatga aatgcttgga gagggtctgg gagtaaagga gacaccacag cagaagtacc
      421 aacgactact gcatgaagtc caggagctga caacggaggt ggagaagatc aagacaacag
      481 tgaaggagtc agccactgag gagaagctca cccctgtggt gctggctaaa cagctggccg
      541 ctctgaagca gcagctggta gcttcccacc tggagaagct tctgggacca gatgctgcca
      601 tcaacctcgc tgacccagat ggagccctag ctaagcgctt actgctgcag ctggaagcaa
      661 ccaagagcag caaaggcagc tcagggggaa agagcacagg tggcactccc ccagatagca
      721 gccttgtcac ttacgaactc cactcacggc ctgagcagga caagttctcg caagctgcca
      781 aagttgcaga actcgagaag cgcctgacag agctggaggc cactgtccgc tgtgatcagg
      841 atgctcagaa tcccctttct gcaggtctac agggagcctg ccttatggaa acggtagaac
      901 tgttacaggc caaagtgaac gccctggacc ttgcagttct ggaccaagta gaggctcgac
      961 tgcagagtgt cctgggaaag gtgaatgaga ttgctaagca caaggcatct gtggaggacg
     1021 cagacacaca gaataaggtg caccagctct atgagaccat ccagcgctgg agccctgtgg
     1081 cctccactct ccctgagctg gtacagagac ttgtcaccat caagcagctt catgagcaag
     1141 ctatgcagtt tggtcagctc ctgacacact tggataccac ccagcagatg atggcgagtt
     1201 ctcttaagga caatactgcc ctcctgaccc aggttcagac aacgatgcgt gaaaacttgg
     1261 ccacagttga ggggaatttt gccagcattg atgctcgtat gaagaagctg ggaaagtgag
     1321 cgccactggg agttggggag ctggggtaac ccttgcccct gagctttgtc agacacttcc
     1381 acagagcttc cccttgacca tactcatagt cccatcccac ctgacaaggg caagggttct
     1441 tcttgcatgt ggggtgcaca ccctcccctg aggaagagtg ggagctggga gctatcacgg
     1501 gatgaggttg tgggcccagc cacatgccag ctcttgtcca gtaagtgctt gcctgctgtg
     1561 ggagaggact ggatcctgtc ctcacacagc tctgtggctg attctaatac tgtacaaccg
     1621 tctctgacca ttaaatgatg ttgtaccgtg gaaaaaaaaa aaaaaaaaaa aaaaa
//
