LOCUS       NM_001170469            1621 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus decapping mRNA 2 (Dcp2), mRNA.
ACCESSION   NM_001170469 XM_001055777 XM_225963
VERSION     NM_001170469.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1621)
  AUTHORS   Mauer,J., Luo,X., Blanjoie,A., Jiao,X., Grozhik,A.V., Patil,D.P.,
            Linder,B., Pickering,B.F., Vasseur,J.J., Chen,Q., Gross,S.S.,
            Elemento,O., Debart,F., Kiledjian,M. and Jaffrey,S.R.
  TITLE     Reversible methylation of m6Am in the 5' cap controls mRNA
            stability
  JOURNAL   Nature 541 (7637), 371-375 (2017)
   PUBMED   28002401
REFERENCE   2  (bases 1 to 1621)
  AUTHORS   Shukla,S., Schmidt,J.C., Goldfarb,K.C., Cech,T.R. and Parker,R.
  TITLE     Inhibition of telomerase RNA decay rescues telomerase deficiency
            caused by dyskerin or PARN defects
  JOURNAL   Nat Struct Mol Biol 23 (4), 286-292 (2016)
   PUBMED   26950371
REFERENCE   3  (bases 1 to 1621)
  AUTHORS   Jonas,S. and Izaurralde,E.
  TITLE     The role of disordered protein regions in the assembly of decapping
            complexes and RNP granules
  JOURNAL   Genes Dev 27 (24), 2628-2641 (2013)
   PUBMED   24352420
  REMARK    Review article
REFERENCE   4  (bases 1 to 1621)
  AUTHORS   Song,M.G., Li,Y. and Kiledjian,M.
  TITLE     Multiple mRNA decapping enzymes in mammalian cells
  JOURNAL   Mol Cell 40 (3), 423-432 (2010)
   PUBMED   21070968
REFERENCE   5  (bases 1 to 1621)
  AUTHORS   James,V., Zhang,Y., Foxler,D.E., de Moor,C.H., Kong,Y.W.,
            Webb,T.M., Self,T.J., Feng,Y., Lagos,D., Chu,C.Y., Rana,T.M.,
            Morley,S.J., Longmore,G.D., Bushell,M. and Sharp,T.V.
  TITLE     LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for
            microRNA-mediated gene silencing
  JOURNAL   Proc Natl Acad Sci U S A 107 (28), 12499-12504 (2010)
   PUBMED   20616046
REFERENCE   6  (bases 1 to 1621)
  AUTHORS   Mullen,T.E. and Marzluff,W.F.
  TITLE     Degradation of histone mRNA requires oligouridylation followed by
            decapping and simultaneous degradation of the mRNA both 5' to 3'
            and 3' to 5'
  JOURNAL   Genes Dev 22 (1), 50-65 (2008)
   PUBMED   18172165
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000018.1.
            
            On or before Dec 20, 2009 this sequence version replaced
            XM_001055777.1, XM_225963.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.59672.1,
                                           SRR26643298.73932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               JAXUCZ010000018.1  37001615-37001800
            187-338             JAXUCZ010000018.1  37009511-37009662
            339-466             JAXUCZ010000018.1  37013535-37013662
            467-565             JAXUCZ010000018.1  37014297-37014395
            566-718             JAXUCZ010000018.1  37019198-37019350
            719-831             JAXUCZ010000018.1  37019445-37019557
            832-939             JAXUCZ010000018.1  37019639-37019746
            940-1072            JAXUCZ010000018.1  37024016-37024148
            1073-1183           JAXUCZ010000018.1  37026299-37026409
            1184-1235           JAXUCZ010000018.1  37035384-37035435
            1236-1621           JAXUCZ010000018.1  37037564-37037949
FEATURES             Location/Qualifiers
     source          1..1621
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..1621
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /note="decapping mRNA 2"
                     /db_xref="GeneID:291604"
                     /db_xref="RGD:1562909"
     exon            1..186
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1399
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /EC_number="3.6.1.62"
                     /note="mRNA-decapping enzyme 2; DCP2 decapping enzyme
                     homolog; m7GpppN-mRNA hydrolase-like; mRNA-decapping
                     enzyme 2-like"
                     /codon_start=1
                     /product="m7GpppN-mRNA hydrolase"
                     /protein_id="NP_001163940.1"
                     /db_xref="GeneID:291604"
                     /db_xref="RGD:1562909"
                     /translation="METKRLEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHW
                     FYLDFYMQNTPGLPQCGIRDFAKAVFSHCPFLLPQGEDVEKILDEWKEYKMGVPTYGA
                     IILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKD
                     DYIELRINDQLARLYIIPGVPKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKL
                     GLAPNKFFMAIPFIRPLRDWLSRRFGDSSDSDNGFSSAGSTPARPTVEKLSRTKFRHS
                     QQLFPEGSPSDQWVKHRQPLQQKHSNHTEVSDLCKAKNQNMRGNGRKQYQDSPNQKKR
                     VNGIHGQPTKQQNPLMKCEKKLHPRKLQDNFETDAACDLPCSGEDPLVEHAEGHSVAC
                     NGHCKFPFSSRTFLSFKFDQNAIMKILDL"
     exon            187..338
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /inference="alignment:Splign:2.1.0"
     exon            339..466
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /inference="alignment:Splign:2.1.0"
     exon            467..565
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /inference="alignment:Splign:2.1.0"
     exon            566..718
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /inference="alignment:Splign:2.1.0"
     exon            719..831
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /inference="alignment:Splign:2.1.0"
     exon            832..939
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1072
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1183
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1235
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1621
                     /gene="Dcp2"
                     /gene_synonym="RGD1562909"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccccctcg cctcggccca gcctctgggt acgagcagag ggttccactg tccgcgggac
       61 ctcagctcct tgcttctcta cggtgccggc tgcgcggagc cgggatgccc tgcgcctgct
      121 gcgggtcctc actatggaga ccaaacgcct ggaaattccc ggcagcgtcc tggatgatct
      181 ctgcagccga tttattttgc atattcccag tgaggaaaga gacaatgcaa tccgagtgtg
      241 cttccagatt gaactcgccc attggtttta cttggatttc tacatgcaga acacaccagg
      301 attacctcag tgtgggataa gagactttgc caaagctgtc ttcagtcact gtccatttct
      361 gctgccacaa ggtgaagacg tggaaaagat tctggatgaa tggaaggaat ataaaatggg
      421 agtaccaact tatggtgcaa ttattctcga tgagacactg gagaatgtac tgctggttca
      481 ggggtacctg gcaaagtcag gttggggatt tccaaaagga aaagtaaata aagaagaagc
      541 acctcatgac tgtgcagcta gagaggtctt cgaggaaact ggttttgaca taaaagacta
      601 tatttgtaag gatgattaca ttgaacttcg aatcaatgac cagcttgctc gcttgtacat
      661 cattccagga gttccaaaag acacaaaatt taaccccaaa accagaagag aaattaggaa
      721 tattgagtgg ttctccattg agaagttgcc atgtcataga aacgacatga ctcccaagtc
      781 caagctcggc ttggcgccca ataagttttt tatggccatc ccctttatca gaccactacg
      841 ggactggctg tctcgaaggt tcggagattc ctctgacagt gataatggtt tttcctcagc
      901 tggtagcaca ccagctagac ccaccgtgga aaaactgagt cgaacgaaat tccgccacag
      961 ccagcagctg ttccctgaag gttctcctag tgaccaatgg gtaaagcaca ggcagccgct
     1021 gcaacagaag cacagtaacc acacggaggt gtcggacctt tgcaaagcaa agaatcaaaa
     1081 tatgagagga aatggcagaa aacagtatca agattcacct aatcaaaaga agagagtgaa
     1141 cggaattcac ggtcagccaa caaagcagca gaatcctttg atgaaatgtg aaaagaagct
     1201 ccatccacga aagcttcagg acaactttga gacagatgcc gcatgtgatt tgccttgttc
     1261 tggtgaagac ccactggtag aacatgctga gggacattct gtagcatgca atggacattg
     1321 caaattccca ttttcatcca gaacctttct gagtttcaag tttgaccaaa acgctataat
     1381 gaaaatcttg gacctttgat ccagcaagtg tattgccgaa gtcccagtat ctgagacctg
     1441 ttgcatgtga gtgggtgtct cctcgagcct tacctttctc aggtatttga aagaaatgca
     1501 gggaggcaat gtttctaaag agattttctg tacagaagag aaactagaaa gaaacacaag
     1561 tttgcactgt aagtgcattt agaacttttt atatggattt accatttcag tgtttggaac
     1621 c
//
