LOCUS       NM_024129               1639 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus decorin (Dcn), mRNA.
ACCESSION   NM_024129 XM_343201
VERSION     NM_024129.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1639)
  AUTHORS   Hassan,G.M. and Ebrahim,R.H.
  TITLE     The myokine decorin improves the cardiac function in a rat model of
            isoprenaline-induced myocardial infarction
  JOURNAL   Can J Physiol Pharmacol 101 (6), 286-293 (2023)
   PUBMED   36917819
  REMARK    GeneRIF: The myokine decorin improves the cardiac function in a rat
            model of isoprenaline-induced myocardial infarction.
REFERENCE   2  (bases 1 to 1639)
  AUTHORS   Gaspar,R., Gomori,K., Kiss,B., Szantai,A., Paloczi,J., Varga,Z.V.,
            Pipis,J., Varadi,B., Agg,B., Csont,T., Ferdinandy,P., Bartekova,M.
            and Gorbe,A.
  TITLE     Decorin Protects Cardiac Myocytes against Simulated
            Ischemia/Reperfusion Injury
  JOURNAL   Molecules 25 (15), 3426 (2020)
   PUBMED   32731559
  REMARK    GeneRIF: Decorin Protects Cardiac Myocytes against Simulated
            Ischemia/Reperfusion Injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1639)
  AUTHORS   Lai,J., Chen,F., Chen,J., Ruan,G., He,M., Chen,C., Tang,J. and
            Wang,D.W.
  TITLE     Overexpression of decorin promoted angiogenesis in diabetic
            cardiomyopathy via IGF1R-AKT-VEGF signaling
  JOURNAL   Sci Rep 7, 44473 (2017)
   PUBMED   28290552
  REMARK    GeneRIF: overexpression of decorin ameliorated diabetic
            cardiomyopathy and promoted angiogenesis through the IGF1R-AKT-VEGF
            signaling pathway in vivo and in vitro.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1639)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   5  (bases 1 to 1639)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   6  (bases 1 to 1639)
  AUTHORS   De Cosmo,S., Tassi,V., Thomas,S., Piras,G.P., Trevisan,R., Cavallo
            Perin,P., Bacci,S., Zucaro,L., Cisternino,C., Trischitta,V. and
            Viberti,G.C.
  TITLE     The Decorin gene 179 allelic variant is associated with a slower
            progression of renal disease in patients with type 1 diabetes
  JOURNAL   Nephron 92 (1), 72-76 (2002)
   PUBMED   12187087
REFERENCE   7  (bases 1 to 1639)
  AUTHORS   Schaefer,L., Raslik,I., Grone,H.J., Schonherr,E., Macakova,K.,
            Ugorcakova,J., Budny,S., Schaefer,R.M. and Kresse,H.
  TITLE     Small proteoglycans in human diabetic nephropathy: discrepancy
            between glomerular expression and protein accumulation of decorin,
            biglycan, lumican, and fibromodulin
  JOURNAL   FASEB J 15 (3), 559-561 (2001)
   PUBMED   11259366
REFERENCE   8  (bases 1 to 1639)
  AUTHORS   Asundi,V.K. and Dreher,K.L.
  TITLE     Molecular characterization of vascular smooth muscle decorin:
            deduced core protein structure and regulation of gene expression
  JOURNAL   Eur J Cell Biol 59 (2), 314-321 (1992)
   PUBMED   1493796
REFERENCE   9  (bases 1 to 1639)
  AUTHORS   Abramson,S.R. and Woessner,J.F. Jr.
  TITLE     cDNA sequence for rat dermatan sulfate proteoglycan-II (decorin)
  JOURNAL   Biochim Biophys Acta 1132 (2), 225-227 (1992)
   PUBMED   1390895
REFERENCE   10 (bases 1 to 1639)
  AUTHORS   Kokenyesi,R. and Woessner,J.F. Jr.
  TITLE     Purification and characterization of a small dermatan sulphate
            proteoglycan implicated in the dilatation of the rat uterine cervix
  JOURNAL   Biochem J 260 (2), 413-419 (1989)
   PUBMED   2764879
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083750.1.
            
            On Oct 11, 2004 this sequence version replaced XM_343201.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083750.1, FQ228702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1639
                     /gene="Dcn"
                     /note="decorin"
                     /db_xref="GeneID:29139"
                     /db_xref="RGD:61895"
     exon            1..26
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            27..246
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1115
                     /gene="Dcn"
                     /note="dermatan sulfate proteoglycan-II (decorin); DSPG;
                     PG40; PG-S2; bone proteoglycan II"
                     /codon_start=1
                     /product="decorin precursor"
                     /protein_id="NP_077043.1"
                     /db_xref="GeneID:29139"
                     /db_xref="RGD:61895"
                     /translation="MKATLVLFLLAQVSWAGPFEQRGLFDFMLEDEASGIIPYDPDNP
                     LISMCPYRCQCHLRVVQCSDLGLDKVPWEFPPDTTLLDLQNNKITEIKEGAFKNLKDL
                     HTLILVNNKISKISPEAFKPLVKLERLYLSKNHLKELPEKLPKTLQELRLHDNEITKL
                     KKSVFNGLNRMIVIELGGNPLKNSGIENGALQGMKGLGYIRISDTNITAIPQGLPTSI
                     SELHLDGNKIAKVDAASLKGMSNLSKLGLSFNSITVVENGSLANVPHLRELHLDNNKL
                     LRVPAGLAQHKYVQVVYLHNNNISEVGQHDFCLPSYQTRKTSYTAVSLYSNPVRYWQI
                     HPHTFRCVFGRSTIQLGNYK"
     exon            247..359
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            360..573
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            574..687
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            688..781
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            782..920
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1618
                     /gene="Dcn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggtggcaa atacccggat taaaaggtgg tgaaaacgca tgagacaacc atgaaggcaa
       61 ctctcgtctt attccttctg gcgcaagtct cttgggctgg accatttgag cagagaggat
      121 tatttgactt catgctagaa gatgaggcct ctggcataat cccttacgac cctgacaatc
      181 ccctgatatc tatgtgcccc taccgatgcc aatgccatct ccgagtggtg cagtgttctg
      241 atctgggtct ggacaaagta ccctgggaat ttccacctga cacaacattg ctagacctgc
      301 aaaacaacaa aataacagag atcaaagagg gggcctttaa gaacctgaag gacttgcata
      361 ccttgatcct tgtcaacaac aagatcagca agatcagccc agaggcattt aaacctctag
      421 tgaagttgga aaggctttat ctgtctaaga accacctaaa ggagctgccc gaaaaattgc
      481 ccaaaacact ccaggagctt cgactccacg acaatgagat caccaaactg aagaaatctg
      541 tgttcaatgg actgaaccgt atgattgtca tagaactggg cggcaaccca ctgaaaaact
      601 ctgggattga aaatggagcc ttgcagggaa tgaagggtct cggatacatc cgcatctcag
      661 acaccaacat aactgctatt cctcaaggtc tgcccacttc tatcagtgaa ctgcatctgg
      721 atggcaacaa gatcgccaaa gttgatgcag ccagcctgaa aggaatgtct aatttgtcta
      781 agctgggttt gagcttcaat agcatcaccg ttgtggaaaa tggcagtctg gctaatgttc
      841 ctcatctgag ggagctccac ttggacaaca acaaactcct cagagtgcct gctgggctgg
      901 cacagcataa atatgtccag gtcgtctacc ttcataacaa caacatctcc gaagttgggc
      961 agcatgactt ctgcctccct tcataccaga ctaggaagac ttcctacact gccgtgagtc
     1021 tttatagcaa ccctgtccgg tattggcaaa ttcacccaca caccttcaga tgtgtcttcg
     1081 ggcgctctac cattcaactt gggaactaca agtaactccc aaacagcctc atttttataa
     1141 tcgggaacaa aaaaaccaat ctgtcaatat tattgctaaa aagaaaaaaa tattttgaaa
     1201 aagaaagaat gctagattct ggaaattcaa gtatagcgcg gatgcctttc ccgtatgact
     1261 tatcatgcat caagccaaat atacagattg aataattacc tacaataaaa atattttatc
     1321 tgtagtattc agaatcactt ttaaaatttt ctgtagatgt gaactgaggt atcgaagtct
     1381 ggtgtaatca tagatgtcaa catttaataa agctaaaagg aacagaatac aaagtcttct
     1441 gtaattcata gagctaaatt gactcttttg acataaagtc aaatgtagaa ctctagcaat
     1501 gtattaatct cctttattat tggtaaagtc ttatttgaat atctaagttc aacatgggct
     1561 atgtaaaatt ttcactgtca tactgaaaaa caataaaatt taaaaaatgc attcaaaaaa
     1621 aaaaaaaaaa aaaaaaaaa
//
