LOCUS       NM_147145               2162 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DNA cross-link repair 1C (Dclre1c), mRNA.
ACCESSION   NM_147145
VERSION     NM_147145.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2162)
  AUTHORS   Volk,T., Pannicke,U., Reisli,I., Bulashevska,A., Ritter,J.,
            Bjorkman,A., Schaffer,A.A., Fliegauf,M., Sayar,E.H., Salzer,U.,
            Fisch,P., Pfeifer,D., Di Virgilio,M., Cao,H., Yang,F.,
            Zimmermann,K., Keles,S., Caliskaner,Z., Guner,S.U., Schindler,D.,
            Hammarstrom,L., Rizzi,M., Hummel,M., Pan-Hammarstrom,Q., Schwarz,K.
            and Grimbacher,B.
  TITLE     DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from
            atypical severe combined immunodeficiency to mere antibody
            deficiency
  JOURNAL   Hum Mol Genet 24 (25), 7361-7372 (2015)
   PUBMED   26476407
REFERENCE   2  (bases 1 to 2162)
  AUTHORS   Craxton,A., Somers,J., Munnur,D., Jukes-Jones,R., Cain,K. and
            Malewicz,M.
  TITLE     XLS (c9orf142) is a new component of mammalian DNA double-stranded
            break repair
  JOURNAL   Cell Death Differ 22 (6), 890-897 (2015)
   PUBMED   25941166
REFERENCE   3  (bases 1 to 2162)
  AUTHORS   Lee,B.S., Gapud,E.J., Zhang,S., Dorsett,Y., Bredemeyer,A.,
            George,R., Callen,E., Daniel,J.A., Osipovich,O., Oltz,E.M.,
            Bassing,C.H., Nussenzweig,A., Lees-Miller,S., Hammel,M., Chen,B.P.
            and Sleckman,B.P.
  TITLE     Functional intersection of ATM and DNA-dependent protein kinase
            catalytic subunit in coding end joining during V(D)J recombination
  JOURNAL   Mol Cell Biol 33 (18), 3568-3579 (2013)
   PUBMED   23836881
REFERENCE   4  (bases 1 to 2162)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   5  (bases 1 to 2162)
  AUTHORS   Rooney,S., Alt,F.W., Lombard,D., Whitlow,S., Eckersdorff,M.,
            Fleming,J., Fugmann,S., Ferguson,D.O., Schatz,D.G. and Sekiguchi,J.
  TITLE     Defective DNA repair and increased genomic instability in
            Artemis-deficient murine cells
  JOURNAL   J Exp Med 197 (5), 553-565 (2003)
   PUBMED   12615897
REFERENCE   6  (bases 1 to 2162)
  AUTHORS   Rooney,S., Sekiguchi,J., Zhu,C., Cheng,H.L., Manis,J., Whitlow,S.,
            DeVido,J., Foy,D., Chaudhuri,J., Lombard,D. and Alt,F.W.
  TITLE     Leaky Scid phenotype associated with defective V(D)J coding end
            processing in Artemis-deficient mice
  JOURNAL   Mol Cell 10 (6), 1379-1390 (2002)
   PUBMED   12504013
REFERENCE   7  (bases 1 to 2162)
  AUTHORS   Ma,Y., Pannicke,U., Schwarz,K. and Lieber,M.R.
  TITLE     Hairpin opening and overhang processing by an Artemis/DNA-dependent
            protein kinase complex in nonhomologous end joining and V(D)J
            recombination
  JOURNAL   Cell 108 (6), 781-794 (2002)
   PUBMED   11955432
REFERENCE   8  (bases 1 to 2162)
  AUTHORS   Moshous,D., Callebaut,I., de Chasseval,R., Corneo,B.,
            Cavazzana-Calvo,M., Le Deist,F., Tezcan,I., Sanal,O., Bertrand,Y.,
            Philippe,N., Fischer,A. and de Villartay,J.P.
  TITLE     Artemis, a novel DNA double-strand break repair/V(D)J recombination
            protein, is mutated in human severe combined immune deficiency
  JOURNAL   Cell 105 (2), 177-186 (2001)
   PUBMED   11336668
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083546.1.
            
            On Dec 7, 2007 this sequence version replaced NM_147145.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083546.1, AF395746.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2162
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..2162
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /note="DNA cross-link repair 1C"
                     /db_xref="GeneID:259171"
                     /db_xref="RGD:708574"
     exon            1..132
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..2120
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /note="SNM1-like protein; DNA cross-link repair 1C
                     protein"
                     /codon_start=1
                     /product="protein artemis"
                     /protein_id="NP_671486.2"
                     /db_xref="GeneID:259171"
                     /db_xref="RGD:708574"
                     /translation="MSSFQGQMEEYPTISIDRFDRENLKARAYFLSHCHKDHMKGLRA
                     PSMKRRLECSLKVFLYCSPVTKELLLTSPKYKFWENRIIAIEIETPTQVSLVDEASGE
                     KEEVVVTLLPAGHCPGSVMFLFQGSNGTVLYTGDFRLAKGEVSRMELLHSGGRVKDIQ
                     SVYLDTTFCDPRFYQIPSREECLRGVLELVRSWITRSPKHVVWLNCKAAYGYEYLFTN
                     LSEELGVQVHVDKLDMFKNMPDILHHLTTDRNTQIHACRHPKAEEYFQWNKLPCGMAS
                     KTKTVLHTISIKPSTMWFGERTRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYICP
                     VNAYPNVIPIGLTVDKVMDFLKPLCRSSQCAEPKYKPLGKLKRARTVHLDSEEDDDLF
                     DDPLLTHSRRKVPYQVTLHPEVFSMKALPLDQPELGQSPGCCKAESMPSPSLANFVDC
                     DESNSDSEGELETPPSLQGGLGPTTLPQQNADPDVDVPRWEVFFKRKDEITDECLENL
                     PSSIETGGSQSPKRFSDSPKLGSDSDGESTHISSQNSSQSTHITDQGSQGWDSQCDTV
                     LLSSQEKSGGDSTSLNKDTYKPKPKDSISASQIEQNALCPQDTHCDLKSGAEVNGVPC
                     IEEPDTVSGRKSSPEKTSLTSTQADSQSSSDFEIPSTPEAELPKPEHLQFLYGKLATG
                     ESIVLKKENVHSQIFK"
     exon            133..184
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            185..269
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            270..329
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            330..385
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            386..487
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            488..560
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            561..701
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            702..803
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            804..940
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            941..995
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1084
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1179
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..2138
                     /gene="Dclre1c"
                     /gene_synonym="Snm1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtttctagt cttccctggc gctatgagtt ctttccaggg acagatggag gaatatccaa
       61 ccatctccat tgaccgcttc gacagagaga acctgaaagc ccgtgcctac ttcctttcgc
      121 actgccacaa ggatcacatg aaaggattaa gggctccttc catgaaaaga aggctggaat
      181 gcagtttgaa ggtcttcctg tactgttctc cagtcactaa ggagctgctc ttaaccagcc
      241 caaagtacaa gttctgggaa aaccgaatta tagcaattga aattgaaact cctacccagg
      301 tatctttagt tgatgaggca tcgggtgaga aggaagaagt tgttgtgact ctcttaccag
      361 ctggtcactg cccaggttca gttatgtttc tatttcaggg cagtaatgga actgtcttat
      421 acacaggaga cttcagactg gcgaaaggag aagtttccag aatggagctt ctgcactctg
      481 ggggcagagt aaaagacatc caaagtgtat atttagacac cactttctgt gacccaaggt
      541 tttatcaaat tccaagtcgt gaggagtgct tgaggggcgt tctggagctg gttcggagct
      601 ggatcacgag gagtccgaag cacgtcgtgt ggctgaactg caaggccgcc tacggctatg
      661 agtacttatt caccaacctg agtgaggagc tgggagtcca ggttcatgtg gacaagctgg
      721 acatgtttaa aaacatgcct gatatcctgc accatctcac aacggatcga aacacccaga
      781 tccacgcctg ccgccacccg aaggcagaag agtattttca gtggaataag ttaccctgtg
      841 gcatggcttc caaaactaaa actgtactcc acacaatcag catcaagcca tctaccatgt
      901 ggtttggaga gaggaccaga aaaacaaacg tgattgtgag aaccggagag agctcataca
      961 gagcttgctt ctctttccac tcctcctaca gtgagattaa agattttttg agctacatct
     1021 gcccagtgaa tgcgtatcca aatgtcattc cgatcggcct cactgtggat aaggtcatgg
     1081 actttttaaa gcctctgtgc cgctcttccc aatgtgctga accaaagtac aagcccctcg
     1141 ggaaactgaa gagagctaga acagttcacc ttgactcaga ggaagatgat gatctctttg
     1201 atgaccctct actaacacat tcaaggcgca aagttccgta ccaagtaact cttcaccctg
     1261 aggtattttc aatgaaggca ctaccgctag atcagcctga actgggacaa agccccggat
     1321 gctgtaaagc agagagtatg ccgagtcctt ctttggccaa ctttgtggac tgtgacgagt
     1381 ccaacagtga cagtgaagga gagttagaga ccccgccttc tctgcaggga ggtctcggcc
     1441 ccacaacact cccacagcaa aacgctgatc cggatgtgga tgtacctcgg tgggaagtat
     1501 tcttcaaaag aaaagatgaa atcacagatg aatgtttgga aaacttacct tcctccatag
     1561 agacaggggg atcgcagtca ccaaagcgtt tcagtgactc accaaagctg ggcagtgact
     1621 ctgatggaga atccacccat atctcttccc agaattcatc tcagtcaacc cacataacgg
     1681 atcaaggaag ccaaggctgg gacagccagt gtgataccgt tttgttatct tcccaagaga
     1741 aaagtggtgg ggatagcacc tctttgaaca aggataccta caaaccaaaa cccaaagata
     1801 gtatttctgc ctcccaaata gaacagaatg cactttgtcc acaggatact cactgtgatt
     1861 tgaaaagcgg agctgaagta aatggagtcc cttgtattga agaaccagac actgtgagtg
     1921 gcaggaaatc ttcacctgag aaaacatcgc taaccagcac acaggcagac tcacagagct
     1981 cctctgactt tgaaatcccc tcaactccag aagctgagct tcccaagcca gagcatttac
     2041 agttcttata tggaaagctg gcaacaggtg agagtatagt gttgaaaaaa gaaaatgttc
     2101 actcccagat atttaaataa aactcattct agcaaggaaa aaaaaaaaaa aaaaaaaaaa
     2161 aa
//
