LOCUS       NM_001389222            4086 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DNA cross-link repair 1B (Dclre1b), transcript
            variant 1, mRNA.
ACCESSION   NM_001389222 XM_006233078
VERSION     NM_001389222.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4086)
  AUTHORS   Andreev,D.E., O'Connor,P.B., Zhdanov,A.V., Dmitriev,R.I.,
            Shatsky,I.N., Papkovsky,D.B. and Baranov,P.V.
  TITLE     Oxygen and glucose deprivation induces widespread alterations in
            mRNA translation within 20 minutes
  JOURNAL   Genome Biol 16 (1), 90 (2015)
   PUBMED   25943107
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4086)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   3  (bases 1 to 4086)
  AUTHORS   Sengerova,B., Allerston,C.K., Abu,M., Lee,S.Y., Hartley,J.,
            Kiakos,K., Schofield,C.J., Hartley,J.A., Gileadi,O. and McHugh,P.J.
  TITLE     Characterization of the human SNM1A and SNM1B/Apollo DNA repair
            exonucleases
  JOURNAL   J Biol Chem 287 (31), 26254-26267 (2012)
   PUBMED   22692201
REFERENCE   4  (bases 1 to 4086)
  AUTHORS   Wu,P., van Overbeek,M., Rooney,S. and de Lange,T.
  TITLE     Apollo contributes to G overhang maintenance and protects
            leading-end telomeres
  JOURNAL   Mol Cell 39 (4), 606-617 (2010)
   PUBMED   20619712
REFERENCE   5  (bases 1 to 4086)
  AUTHORS   Ye,J., Lenain,C., Bauwens,S., Rizzo,A., Saint-Leger,A., Poulet,A.,
            Benarroch,D., Magdinier,F., Morere,J., Amiard,S., Verhoeyen,E.,
            Britton,S., Calsou,P., Salles,B., Bizard,A., Nadal,M., Salvati,E.,
            Sabatier,L., Wu,Y., Biroccio,A., Londono-Vallejo,A.,
            Giraud-Panis,M.J. and Gilson,E.
  TITLE     TRF2 and apollo cooperate with topoisomerase 2alpha to protect
            human telomeres from replicative damage
  JOURNAL   Cell 142 (2), 230-242 (2010)
   PUBMED   20655466
REFERENCE   6  (bases 1 to 4086)
  AUTHORS   Touzot,F., Callebaut,I., Soulier,J., Gaillard,L., Azerrad,C.,
            Durandy,A., Fischer,A., de Villartay,J.P. and Revy,P.
  TITLE     Function of Apollo (SNM1B) at telomere highlighted by a splice
            variant identified in a patient with Hoyeraal-Hreidarsson syndrome
  JOURNAL   Proc Natl Acad Sci U S A 107 (22), 10097-10102 (2010)
   PUBMED   20479256
REFERENCE   7  (bases 1 to 4086)
  AUTHORS   Liu,L., Akhter,S., Bae,J.B., Mukhopadhyay,S.S., Richie,C.T., Liu,X.
            and Legerski,R.
  TITLE     SNM1B/Apollo interacts with astrin and is required for the prophase
            cell cycle checkpoint
  JOURNAL   Cell Cycle 8 (4), 628-638 (2009)
   PUBMED   19197158
REFERENCE   8  (bases 1 to 4086)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   9  (bases 1 to 4086)
  AUTHORS   Chen,Y., Yang,Y., van Overbeek,M., Donigian,J.R., Baciu,P., de
            Lange,T. and Lei,M.
  TITLE     A shared docking motif in TRF1 and TRF2 used for differential
            recruitment of telomeric proteins
  JOURNAL   Science 319 (5866), 1092-1096 (2008)
   PUBMED   18202258
REFERENCE   10 (bases 1 to 4086)
  AUTHORS   Lenain,C., Bauwens,S., Amiard,S., Brunori,M., Giraud-Panis,M.J. and
            Gilson,E.
  TITLE     The Apollo 5' exonuclease functions together with TRF2 to protect
            telomeres from DNA repair
  JOURNAL   Curr Biol 16 (13), 1303-1310 (2006)
   PUBMED   16730175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 30, 2020 this sequence version replaced XM_006233078.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.477319.1,
                                           SRR26643429.9574.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117, SAMN16676811
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-489               JAXUCZ010000002.1  194006352-194006840 c
            490-655             JAXUCZ010000002.1  194005497-194005662 c
            656-838             JAXUCZ010000002.1  194004837-194005019 c
            839-4086            JAXUCZ010000002.1  193998350-194001597 c
FEATURES             Location/Qualifiers
     source          1..4086
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4086
                     /gene="Dclre1b"
                     /note="DNA cross-link repair 1B"
                     /db_xref="GeneID:310745"
                     /db_xref="RGD:1310343"
     exon            1..489
                     /gene="Dclre1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1926
                     /gene="Dclre1b"
                     /EC_number="3.5.2.6"
                     /note="SNM1 homolog B; DNA cross-link repair 1B protein;
                     beta-lactamase MBLAC2"
                     /codon_start=1
                     /product="5' exonuclease Apollo"
                     /protein_id="NP_001376151.1"
                     /db_xref="GeneID:310745"
                     /db_xref="RGD:1310343"
                     /translation="MNGVVIPQTPIAVDFWSLRRAGTARLFFLSHMHCDHTVGLSSTW
                     ARPLYCSPITAHLLHRRLQVSKQWIRALEIGESHVLPLDEIGQETMTVTLIDANHCPG
                     SVMFLFEGYFGTILYTGDFRYTPSMLKEPALTLGKQIHTLYLDNTNCNPALVLPSRQE
                     ATQQIIQLIRQFPQHNIKIGLYSLGKESLLEQLALEFQTWVVLSPQRLELVQLLGLAD
                     VFTVEEEAGRIHAVDHMEICHSAMLQWNQTHPTIAIFPTSRKIRSPHPSIYSIPYSDH
                     SSYSELRAFVAALRPCQVVPIVREQPCGEFFQDSLSPRLSMPLIPHSVQQYMSSSSRK
                     TNVFWQLERRLKRPRTQGVVFESPEEKADQVKVDRDSKKHKKESLSPWAGCLSRLCPH
                     PLQARKQLFPDFCRKEGDEPVLFCDSNKMATVLTAPLELSVQLQPVDEFPFPETREEI
                     GLGSPLWSGGGSGSPTRGKQSNGMGCGSPPTHISRTTHLTPESGGLALKYLLTPVDFL
                     QAGFSSRNFDQQVEKHQRVQCNNPAVMNTVDDV"
     exon            490..655
                     /gene="Dclre1b"
                     /inference="alignment:Splign:2.1.0"
     exon            656..838
                     /gene="Dclre1b"
                     /inference="alignment:Splign:2.1.0"
     exon            839..4086
                     /gene="Dclre1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccccgccg ccgcgcgcgc tttgacaaag ttgcggactg ggcctaagct cccgcgcacg
       61 ggtgtgagta atgctctccg ggcttcttcc gcgttgggcg cttccaccct ggctgtcccg
      121 agcgcggcca ccctcttttt cttcaccctg tctacttctt ccatttctgg gatggttttc
      181 ctttagggct tctggccttg ttcttgaatc cacatgtcgt tgggacgctg tcgtggaagc
      241 ctcacccagg agtgcagttc ccgcgaagac cccactgggt gactcctcaa ctctgccacc
      301 atgaacgggg tcgtaatccc ccaaacaccc atcgctgtgg atttttggag cctgcgccgt
      361 gctggtaccg cgcggctctt cttcttatcc cacatgcact gtgaccacac ggtgggcctg
      421 tctagcactt gggcacggcc cctctactgc tctcccatca ctgcccacct cttgcatcgt
      481 cgcctgcagg tgtctaagca gtggatccga gctctggaga ttggtgagag ccatgtatta
      541 cctctagatg aaattggaca agaaaccatg actgtaaccc tcatagatgc caatcactgt
      601 cctggttctg tcatgtttct ctttgaagga tactttggaa caattctcta cacaggtgat
      661 tttcgatata caccgtccat gctgaaggag cctgctctga cactagggaa acagattcat
      721 actttatatc tagacaacac caattgcaac ccagcccttg ttcttccttc ccgacaggaa
      781 gctactcaac agattatcca gctaatccga cagttccccc aacacaacat aaagattggc
      841 ctctatagtc taggaaaaga atcactgctg gagcagctag cccttgagtt tcagacctgg
      901 gtggtattga gtcctcaacg cctggagttg gtacagctgc tgggcctggc agacgtgttc
      961 acagtggagg aagaagctgg gcgaatccac gctgtggacc acatggaaat ctgccattcg
     1021 gccatgcttc agtggaacca gacccacccc accattgcta ttttccccac aagccggaaa
     1081 atacgaagcc ctcaccccag catctacagc atcccttact ctgaccattc atcctactct
     1141 gagcttcgag catttgttgc agctctgagg ccttgccagg tggtgcccat agtccgtgaa
     1201 cagccttgtg gagagttttt tcaggatagc ttgagtccta gactctctat gcctctgatt
     1261 ccacactctg tgcaacaata catgagttcc tcctcgagga aaacaaatgt gttttggcag
     1321 ttagaaagga ggctaaagag gccaagaacc cagggtgttg tgtttgaatc ccctgaggag
     1381 aaagctgatc aggttaaagt tgacagagac tcaaagaaac acaaaaaaga aagcctctcc
     1441 ccctgggctg ggtgcctttc gaggctttgc ccccatcctc tgcaggccag gaagcagttg
     1501 ttcccagatt tctgcagaaa agaaggtgat gagccagttc ttttctgtga ctccaacaag
     1561 atggcgactg tgttgactgc cccattggaa ctttcagtgc agttacagcc tgtagatgag
     1621 tttccctttc cagaaaccag ggaggaaatt ggcttagggt ccccattgtg gtcaggggga
     1681 ggcagtggct caccaacgag agggaagcaa agcaatggca tgggctgtgg ttctccccca
     1741 actcacatta gcagaaccac tcatctaact cctgagtccg ggggcctggc gttaaaatac
     1801 cttcttactc cagtggattt cctccaagca gggttctcct ccaggaactt tgaccagcaa
     1861 gtggaaaaac accagagagt gcagtgtaac aatcctgcag ttatgaacac agtggatgat
     1921 gtctagtggc aagagttggc ttggtgtctt cctttacaga atcctgtggc tcactctgag
     1981 tggctcttct aaagcttttt atgaagtcct ggtgcctaag aaacccttag ttttatagta
     2041 catttattgc ttaattttat tatatttaag aaacagtttt cattatataa actattcagt
     2101 gttcataagc acattgaaag ttcttagaag ttccatagca atttaatttg ttccacttgg
     2161 tttaacccag tttttctcaa ccctttatca gcatcaagtt tgtttgtttt tttgttttgt
     2221 tagagtctga atcaaaaaga atcaggcttg tcccgttgtc atttcctttg ttatatccca
     2281 gtccccaagt tcccatcacc ctttttccag ataaaagtct acattattta ttttcagact
     2341 gtaatttata gtgctggagg ataaagtggg ggtgcagagc agcatgttct aaccctgact
     2401 gtcactgact cgctgtgaca tgaccctacc caagtaactt cctgtctctg cctcttggag
     2461 tgaacaggaa accatgaaaa ggcattgaaa cagtgttagg aaaataacac cttcctcctg
     2521 cgtgaagggg tttagtaact gtcatgagac ctccatctgg aacatagccg tttggaggtt
     2581 agacaccacg caccatggtg gcgcatggga caagctgaac attaaggttt agaacatgtc
     2641 agtgctactg gatgcttgca gacactgctt tgttaaagct acagaagatc aaatgtgctg
     2701 ccagatatcc tctgatggtt cacatagctg ggattttccc ccccaccccc acaagtttga
     2761 attagggagc cagagcacag agcttgtttg ttttagtatc caggggagag agaccaagga
     2821 gccagctggc tggaacgggt cagagtatgc agttctaccc tgccctgctc ataacctgac
     2881 aaaatgccaa accaataagc aagacagctg atagcagagc catgaggaaa tgtgctctgg
     2941 gagggtgcag gcaaggagca gcttaggcct ggaaccatga gcagtaacaa taaagaaagt
     3001 cgcctcaccc ttgggaagga gggaggagct ctgctacttt gggagggaga agtggagttt
     3061 attgagcaaa ataagacttt gctctcggac acactgtact cagttctgtt tttgtcagtg
     3121 accttcctat aaacctctaa gggcttcata ggaactgcag caggtgaggc atgtggttca
     3181 acaggaaacc tagacattgg ctggaatcca gggcacatgg caaattgttt gaatagatga
     3241 gccttactca gctgcaatgt gggggctgag atatctacct cccatgattg ctatgcagac
     3301 tattggtaaa attccctagc tcattgcctg gcacatgaca gtatttcaaa tattggtttt
     3361 cgtagctaaa agtctagctc tggtaggatg ggtgcttagc aaactgaaat tctggattct
     3421 atcctgagtg ccaaaaaaag aggcaatctt caaaacaatt ttctatgaaa acacaaagtt
     3481 aaatgttttc cacgtagact agttgatggg catttttcta gtctttctga ggatatgtgt
     3541 aaaatctgta cattttcaga agtaggatat ttcacacatg tgcacacaca caaagggtgc
     3601 agaacagatg gccaagtggt taagagctct taatgtgctg ctcttgaaga cctgactttg
     3661 gttcccagca ccttcattgg gttgatcata actcaagttc caggggtctt tcaccttctg
     3721 acctctgtga ataactgcac aaaaacttgt atggtctcac acaatacaca taaataaaaa
     3781 tttttaaata atgttttgaa gggggccagg gagatggctc agtgggtaaa agcacttgtc
     3841 acacaaactg gtgaactaga ttcaatcccc agaacccaca taaaagtgaa ggagaactga
     3901 gtcaataaag ctgtcctcca gctggttgcc atgcttgcct atgaacaata ctaaaagggg
     3961 ggccataaga taacactgta tatgattcct taattcctta attggaactc aaagtgccat
     4021 tataaaaaat gctttgttaa taggatgtaa ctacatgtta ataaatcatt ctcatattat
     4081 tcaaca
//
