LOCUS       NM_001191800            3249 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus doublecortin-like kinase 3 (Dclk3), mRNA.
ACCESSION   NM_001191800 XM_236661
VERSION     NM_001191800.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3249)
  AUTHORS   Dijkmans,T.F., van Hooijdonk,L.W., Fitzsimons,C.P. and
            Vreugdenhil,E.
  TITLE     The doublecortin gene family and disorders of neuronal structure
  JOURNAL   Cent Nerv Syst Agents Med Chem 10 (1), 32-46 (2010)
   PUBMED   20236041
  REMARK    Review article
REFERENCE   2  (bases 1 to 3249)
  AUTHORS   Bailey,M.J., Coon,S.L., Carter,D.A., Humphries,A., Kim,J.S.,
            Shi,Q., Gaildrat,P., Morin,F., Ganguly,S., Hogenesch,J.B.,
            Weller,J.L., Rath,M.F., Moller,M., Baler,R., Sugden,D.,
            Rangel,Z.G., Munson,P.J. and Klein,D.C.
  TITLE     Night/day changes in pineal expression of >600 genes: central role
            of adrenergic/cAMP signaling
  JOURNAL   J Biol Chem 284 (12), 7606-7622 (2009)
   PUBMED   19103603
  REMARK    GeneRIF: Dclk3 is expressed in the pineal gland at levels >16-fold
            greater than the median expression level in other tissues; in
            addition, expression exhibits a >10-fold increase at night.
REFERENCE   3  (bases 1 to 3249)
  AUTHORS   Reiner,O., Coquelle,F.M., Peter,B., Levy,T., Kaplan,A., Sapir,T.,
            Orr,I., Barkai,N., Eichele,G. and Bergmann,S.
  TITLE     The evolving doublecortin (DCX) superfamily
  JOURNAL   BMC Genomics 7, 188 (2006)
   PUBMED   16869982
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3249)
  AUTHORS   Ohmae,S., Takemoto-Kimura,S., Okamura,M., Adachi-Morishima,A.,
            Nonaka,M., Fuse,T., Kida,S., Tanji,M., Furuyashiki,T., Arakawa,Y.,
            Narumiya,S., Okuno,H. and Bito,H.
  TITLE     Molecular identification and characterization of a family of
            kinases with homology to Ca2+/calmodulin-dependent protein kinases
            I/IV
  JOURNAL   J Biol Chem 281 (29), 20427-20439 (2006)
   PUBMED   16684769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XM_236661.5.
            
            Summary: This gene encodes a member of the protein kinase
            superfamily and the doublecortin family. Differently from the other
            two closely related family members (DCLK1 and DCLK2), the protein
            encoded by this gene contains only one N-terminal doublecortin
            domain and is unable to bind microtubules and to regulate
            microtubule polymerization. The protein contains a C-terminal
            serine/threonine protein kinase domain, which shows substantial
            homology to Ca2+/calmoduline-dependent protein kinase, and a
            serine/proline-rich domain in between the doublecortin and the
            protein kinase domains, which mediates multiple protein-protein
            interactions. [provided by RefSeq, Sep 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.31073.1,
                                           SRR26643298.46980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000008.1  120279916-120280003
            89-1929             JAXUCZ010000008.1  120309442-120311282
            1930-2062           JAXUCZ010000008.1  120325563-120325695
            2063-2230           JAXUCZ010000008.1  120327747-120327914
            2231-3249           JAXUCZ010000008.1  120331344-120332362
FEATURES             Location/Qualifiers
     source          1..3249
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3249
                     /gene="Dclk3"
                     /gene_synonym="Dcamkl3; RGD1309232"
                     /note="doublecortin-like kinase 3"
                     /db_xref="GeneID:316023"
                     /db_xref="RGD:1309232"
     CDS             1..2424
                     /gene="Dclk3"
                     /gene_synonym="Dcamkl3; RGD1309232"
                     /EC_number="2.7.11.1"
                     /note="doublecortin and CaM kinase-like 3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase DCLK3"
                     /protein_id="NP_001178729.1"
                     /db_xref="GeneID:316023"
                     /db_xref="RGD:1309232"
                     /translation="MPAAPVLRPPPPPATPAPPAPSRPAPAISGHRGPCDHSLKCLSS
                     KISERKLPGSWLPSGRGPLEKPVLGPRGAVMPMFSPQSSLHSVRAEHSPLKPRVVTVV
                     KLGVQPLRKATLLLNRRSVQTFEQLLSDISEALGFPRWKNDRVRKLFTLKGREVKSVS
                     DFFREGDAFIAMGKEPLTLKSIQLAMEELYPKNRALALAPHSRVPSPRLRSRLPSKLL
                     KGSHRCGEAGSYGEVMGNKAVIRHQGKTSTELAPEDKARAQKKWVGGKQESENGGLPS
                     PREATQEETHASGEKHLGVEIEKTSGEIVRCEKCKRETELQLGLQRGQCPPGTSELDL
                     GRGQKRDSEKLVRTKSCRRASEAKSTDGEEGWKGDSHRGSPRDPPQELRRPNNNSDKK
                     ESRGSEAQESHPQGVAKAQKDLMEGLPAVEEGAVDARRDSRHTCRIKHAAWLRREQQA
                     EPPQLPRTRGEEKEAEHEKKSGGLGGRRMLEKESKTKPEENRPERPSGRKLRPTGIIS
                     ADVEKHYDIGRVIGDGNFAIVKECKHRETRQAYAMKIIDKSQLKGKEDIVDSEILIIQ
                     SLSHPNIVKLHEVYETEAEIYLIMEYVQGGDLFDAIIESVKFPEPDAAVMITDLCKAL
                     VHMHDKKIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPE
                     ILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGQFEFLSPYWDN
                     ISDAAKDLVRNLLVVDPKKRYTAHQVLHHPWIGMVGHPSTVNPQKEESPSSEGRFQSQ
                     HKKVAEHVS"
     exon            1..88
                     /gene="Dclk3"
                     /gene_synonym="Dcamkl3; RGD1309232"
                     /inference="alignment:Splign:2.1.0"
     exon            89..1929
                     /gene="Dclk3"
                     /gene_synonym="Dcamkl3; RGD1309232"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2062
                     /gene="Dclk3"
                     /gene_synonym="Dcamkl3; RGD1309232"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2230
                     /gene="Dclk3"
                     /gene_synonym="Dcamkl3; RGD1309232"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..3249
                     /gene="Dclk3"
                     /gene_synonym="Dcamkl3; RGD1309232"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccagccg cgccggtcct gcgccctccg ccgccaccgg cgacccctgc cccgccggca
       61 cccagccgcc ctgcgcctgc tatctcgggc catcggggtc cgtgtgacca ttctctaaaa
      121 tgcttaagct cgaagatctc tgagagaaag ttgccaggct cctggctgcc ttcgggacga
      181 ggacctctgg agaagccagt cctggggcca cgtggtgccg tcatgccgat gttcagccct
      241 cagagtagcc tccactcagt ccgcgcagag cacagcccac tgaagcccag ggtggttacg
      301 gtggtgaagc tgggcgtgca gcccctccgc aaggccaccc tgctcctcaa caggcggtca
      361 gtgcagacct ttgagcagct cctgtcggac atctctgaag ccttgggctt cccgcgatgg
      421 aagaatgacc gtgtgcggaa gctgttcacc ctcaagggca gggaggtcaa gagtgtgtct
      481 gacttcttcc gggagggcga tgctttcata gccatgggca aagagccact gacattgaag
      541 agtatccagt tggctatgga ggaactgtat cctaagaacc gcgcccttgc cctggcccct
      601 catagtagag tcccctcccc aaggctaaga agcaggcttc ccagcaagct tctgaaagga
      661 agtcaccgct gtggggaggc aggaagctat ggtgaggtaa tggggaacaa ggcagtcatt
      721 aggcaccagg gcaagacttc cacagagctg gccccagaag acaaggcaag ggcccagaag
      781 aagtgggtag gagggaaaca ggaatcagaa aatggtggcc tgccgtcacc tagagaagcc
      841 actcaggagg agacgcatgc aagtggggag aagcacctcg gggtggagat tgaaaagacc
      901 tcgggggaga ttgtcaggtg tgagaagtgt aagagagaaa cagagctgca gttgggccta
      961 cagagggggc agtgccctcc gggaaccagt gagctggacc tggggagggg ccagaagagg
     1021 gattccgaga agttggtcag gaccaagagc tgcaggaggg cttctgaggc aaagtctaca
     1081 gatggagagg aagggtggaa gggtgacagc caccggggca gccccaggga tccccctcag
     1141 gaactgagga ggcccaacaa caactcagac aagaaagaga gcagaggctc agaagctcag
     1201 gaaagtcacc ctcagggcgt ggccaaggcc cagaaggacc tcatggaagg tctgccagct
     1261 gtagaggagg gggcggtgga cgcgaggaga gattccaggc acacatgcag gattaagcat
     1321 gctgcctggc tccggagaga gcagcaggct gaacccccac agctccccag aacccgaggg
     1381 gaggagaagg aagcagagca tgagaagaag tcaggtggtc tgggagggag gaggatgcta
     1441 gaaaaggagt ctaagacgaa gccggaagag aaccggccgg aacgacccag tggccggaag
     1501 ctgaggccca cgggcatcat ctcagcggat gtggagaagc actatgacat aggtcgggtc
     1561 attggggatg ggaattttgc catcgtgaag gaatgcaagc accgagagac caggcaggct
     1621 tacgccatga agattattga caaatcccag ctgaagggta aggaggacat tgtggacagt
     1681 gagattttaa ttatccagag tctctctcac cccaacatag tgaaactgca tgaggtctac
     1741 gaaacagagg cagagatcta cctgatcatg gagtacgtgc agggagggga ccttttcgat
     1801 gccatcatcg aaagtgtgaa gtttccagag cctgacgctg cagttatgat cacagacttg
     1861 tgtaaggccc tcgtccacat gcatgacaag aagatcgtcc accgggacct gaagccggaa
     1921 aacctcctgg ttcagcgaaa tgaagacaag tctaccacct tgaagctggc tgactttggc
     1981 ctggccaaac atgtggtgag gcctatattt actgtgtgtg ggacgccaac atatgtagct
     2041 cctgagattc tttctgagaa aggttacggc ctggaggtgg acatgtgggc cgcaggtgtg
     2101 atcctataca tcctcttgtg tggcttccct cctttccgaa gtcctgagag ggaccaagac
     2161 gagctcttca acatcatcca gctgggccag tttgagttcc tctctcctta ctgggacaac
     2221 atttctgatg ctgccaaaga tctggtgaga aatttgctgg tagtggaccc caagaagcgg
     2281 tacacggccc accaggtcct acatcatccc tggattggga tggtggggca ccccagcaca
     2341 gtgaacccac agaaggagga gtcccccagc agcgagggtc gcttccagag ccagcacaag
     2401 aaggttgcag agcacgtgtc gtaacctgcc tgggacatct gtccagtttg gtctccttga
     2461 ggacagagaa gagaggggac gtctgcgagc aagatcatgc aagacacttc tccacagatc
     2521 tagggaaaga gaagagccac ctgtcatagt ctaaagagtg tttagaaagc aacaacctaa
     2581 tgttgaatga tgtatgatat ttttagattt gtatatctga agtctttaat actttttttt
     2641 gggtaagaat tgccacgaat gaggagtttt gataataacg atgaattctg ttttcttctt
     2701 gaagtcgagt tcatggtggg ctacatgagt gtgtttcaca tctctcaagc tcccccacac
     2761 agtgaatgag gtgattcttg gcttttctat cacaataaaa cacgatgaat aacagagaaa
     2821 gatctgcctt gttcaatggt ggggagagct gggaaagtag ttcgacacag ctgtatttta
     2881 acctttgaca aagagaccaa tacatgtggt tctacaaact gaaattccgt gaaaaaacaa
     2941 aaaacaaccc aacacttttt ttttttttat gaatctgcgg gctgactgat tagaatttca
     3001 cgattttgga gaactggaat gtacagattg agagccaaaa tttactttgg gttatctccc
     3061 atcccattaa tagtcatgta tcacccaact gtatgtatga cctgacagac agagctgttg
     3121 gaacgtagta actcagctgg gcactggctc ctactaaccc aaagctaaga ctgagagcat
     3181 tcaaagccgg ccgaagagat ttccccactt cgctgtcagc cgcctgcctg atcacgccac
     3241 cagtatgaa
//
