LOCUS       NM_001009691            3969 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus doublecortin-like kinase 2 (Dclk2), transcript
            variant 2, mRNA.
ACCESSION   NM_001009691 XM_227490
VERSION     NM_001009691.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3969)
  AUTHORS   Dijkmans,T.F., van Hooijdonk,L.W., Fitzsimons,C.P. and
            Vreugdenhil,E.
  TITLE     The doublecortin gene family and disorders of neuronal structure
  JOURNAL   Cent Nerv Syst Agents Med Chem 10 (1), 32-46 (2010)
   PUBMED   20236041
  REMARK    Review article
REFERENCE   2  (bases 1 to 3969)
  AUTHORS   Kerjan,G., Koizumi,H., Han,E.B., Dube,C.M., Djakovic,S.N.,
            Patrick,G.N., Baram,T.Z., Heinemann,S.F. and Gleeson,J.G.
  TITLE     Mice lacking doublecortin and doublecortin-like kinase 2 display
            altered hippocampal neuronal maturation and spontaneous seizures
  JOURNAL   Proc Natl Acad Sci U S A 106 (16), 6766-6771 (2009)
   PUBMED   19342486
REFERENCE   3  (bases 1 to 3969)
  AUTHORS   Tuy,F.P., Saillour,Y., Kappeler,C., Chelly,J. and Francis,F.
  TITLE     Alternative transcripts of Dclk1 and Dclk2 and their expression in
            doublecortin knockout mice
  JOURNAL   Dev Neurosci 30 (1-3), 171-186 (2008)
   PUBMED   18075264
REFERENCE   4  (bases 1 to 3969)
  AUTHORS   Reiner,O., Coquelle,F.M., Peter,B., Levy,T., Kaplan,A., Sapir,T.,
            Orr,I., Barkai,N., Eichele,G. and Bergmann,S.
  TITLE     The evolving doublecortin (DCX) superfamily
  JOURNAL   BMC Genomics 7, 188 (2006)
   PUBMED   16869982
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3969)
  AUTHORS   Ohmae,S., Takemoto-Kimura,S., Okamura,M., Adachi-Morishima,A.,
            Nonaka,M., Fuse,T., Kida,S., Tanji,M., Furuyashiki,T., Arakawa,Y.,
            Narumiya,S., Okuno,H. and Bito,H.
  TITLE     Molecular identification and characterization of a family of
            kinases with homology to Ca2+/calmodulin-dependent protein kinases
            I/IV
  JOURNAL   J Biol Chem 281 (29), 20427-20439 (2006)
   PUBMED   16684769
REFERENCE   6  (bases 1 to 3969)
  AUTHORS   Edelman,A.M., Kim,W.Y., Higgins,D., Goldstein,E.G., Oberdoerster,M.
            and Sigurdson,W.
  TITLE     Doublecortin kinase-2, a novel doublecortin-related protein kinase
            associated with terminal segments of axons and dendrites
  JOURNAL   J Biol Chem 280 (9), 8531-8543 (2005)
   PUBMED   15611072
  REMARK    GeneRIF: Doublecortin kinase-2 is associated with terminal segments
            of axons and dendrites
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000002.1.
            
            On Oct 1, 2010 this sequence version replaced NM_001009691.2.
            
            Summary: This gene encodes a member of the protein kinase
            superfamily and the doublecortin family. The protein encoded by
            this gene contains two N-terminal doublecortin domains, which bind
            microtubules and regulate microtubule polymerization, a C-terminal
            serine/threonine protein kinase domain, which shows substantial
            homology to Ca2+/calmoduline-dependent protein kinase, and a
            serine/proline-rich domain in between the doublecortin and the
            protein kinase domains, which mediates multiple protein-protein
            interactions. The microtubule-polymerizing activity of the encoded
            protein is independent of its protein kinase activity. Mouse
            studies show that this gene and the DCX gene, another family
            member, share function in the establishment of hippocampal
            organization and that their absence results in a severe epileptic
            phenotype and lethality, as described in human patients with
            lissencephaly. Alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Sep
            2010].
            
            Transcript Variant: This variant (2) is an exon-5-containing
            transcript (PMIDs:15611072 and 18075264). It encodes the longer
            isoform (b).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY673998.1, AY674000.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1029              JAXUCZ010000002.1  174635164-174636192 c
            1030-1361           JAXUCZ010000002.1  174622443-174622774 c
            1362-1464           JAXUCZ010000002.1  174554532-174554634 c
            1465-1566           JAXUCZ010000002.1  174550189-174550290 c
            1567-1614           JAXUCZ010000002.1  174549247-174549294 c
            1615-1709           JAXUCZ010000002.1  174544228-174544322 c
            1710-1785           JAXUCZ010000002.1  174536077-174536152 c
            1786-1894           JAXUCZ010000002.1  174535218-174535326 c
            1895-1952           JAXUCZ010000002.1  174533734-174533791 c
            1953-2072           JAXUCZ010000002.1  174527164-174527283 c
            2073-2219           JAXUCZ010000002.1  174526805-174526951 c
            2220-2353           JAXUCZ010000002.1  174519992-174520125 c
            2354-2431           JAXUCZ010000002.1  174519537-174519614 c
            2432-2528           JAXUCZ010000002.1  174514242-174514338 c
            2529-2609           JAXUCZ010000002.1  174513658-174513738 c
            2610-2726           JAXUCZ010000002.1  174512429-174512545 c
            2727-3360           JAXUCZ010000002.1  174507269-174507902 c
            3361-3969           JAXUCZ010000002.1  174506660-174507268 c
FEATURES             Location/Qualifiers
     source          1..3969
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3969
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /note="doublecortin-like kinase 2"
                     /db_xref="GeneID:310698"
                     /db_xref="RGD:1308384"
     exon            1..1029
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     CDS             609..2912
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /EC_number="2.7.11.1"
                     /note="isoform b is encoded by transcript variant 2;
                     serine/threonine-protein kinase DCLK2; caMK-like CREB
                     regulatory kinase 2; doublecortin-like and CAM kinase-like
                     2; doublecortin kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase DCLK2 isoform b"
                     /protein_id="NP_001009691.3"
                     /db_xref="GeneID:310698"
                     /db_xref="RGD:1308384"
                     /translation="MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSISGPKGNGL
                     IPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDAL
                     LIELTRSLSDNVNLPQGVRTIYTVDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKN
                     VNPNWSVNIKGGTTRTLAVASAKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKK
                     TAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKYRYA
                     QDDFVLDHSECRVLKSSYSRASAAKYSGSRSPGLSRRSKSPASVKRAGHSSAYSTAKS
                     PVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAQGRSSSNVNGGPELDRCMSPE
                     GVNGNRCSESFTLLEKYRIGKVIGDGNFAVVKECMDRSTGKEFALKIIDKAKCCGKEH
                     LIENEVSILRRVKHPNIIMLVEEMETTTELFLVMELVKGGDLFDAITSSTKYTERDGS
                     AMVYNLASALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTV
                     CGTPTYVAPEIIAETGYGLKVDVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGK
                     LEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWVSDDASQENNMQAEVTG
                     KLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQVFCSKHCRDSSKSSREQTSAREAPP
                     PPESPRPPGPPATSGCDPAGTWRRHRD"
     exon            1030..1361
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1464
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1566
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1614
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1709
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1785
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1894
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1952
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2072
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2219
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2353
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2431
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2528
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2609
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2726
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..3969
                     /gene="Dclk2"
                     /gene_synonym="CL2; CLICK-II; CLICK2; Dck2; RGD1308384"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacccgtgg gcgtgcgcgc gtgggaggcg gctgcactct tcctgagggg gcccagcggc
       61 tccagaggat tccccggtcc agccgggacg cgcaccggcc gtggactggg ccagggcgcg
      121 cgcgaggaag cggcggcggc gggaacccgg gaccccaggc cgcgcaagac agccccgagg
      181 cgcctcgccc acgctcgcgc ccctcccccc tccgcttcct tcttctgctc agcgcgccgg
      241 agagcgcagg ccggatgcga acccgggcca gcctaaggtc gttcaacttg gcggctcccg
      301 gcctgctgcc cgcgcgctac ttgtgaggcg tggccgggtg aaggaggcgc ttggggggcg
      361 tggggctccc cagctggcgg cggcgaccga gagggcgctc gggacaatga gctgggcagc
      421 tgcgcgctgc ggccgccttt agctggcaga gcgggtccac ctgcgagcat ggcccggatg
      481 ccggagccag gtgtcccgct gctttaaggc cggaccgagc gcctagatcg cggcgcgctg
      541 ctgccggggc ggcggggacg ttcttttatt aattcattta tttgtggaga cctctccgag
      601 cagccgcgat ggccagcacc aggagcattg agctggaaca ttttgaagaa cgggacaaaa
      661 ggccgcggcc agggtcgcgg agaggagctc ccagctcctc cgggggcagc agcatctctg
      721 gccccaaggg caacgggctc atccccagcc cggcgcacag tgctcactgc agcttctacc
      781 gcacgcggac cttgcaggcc ctcagctcgg agaagaaggc caagaaggcg cggttctacc
      841 ggaatgggga ccgctacttc aaaggcctgg tctttgcgat ctccagcgac cgtttccgtt
      901 ccttcgatgc gctcctcata gagctcaccc gctcgctgtc tgacaatgtg aacctgcccc
      961 agggcgtccg cacaatctac accgtagacg gcagccggaa ggtcaccagc ctggacgagc
     1021 tgctggaagg tgaaagttac gtgtgtgcct ccaacgaacc attccgtaaa gttgactaca
     1081 ccaaaaacgt taacccgaac tggtctgtga acatcaaggg tggtactacc cgcaccttgg
     1141 ccgtggcctc ggccaagagt gaggtgaaag aaagcaagga cttcatcaaa cccaagctcg
     1201 tgactgtgat tcgaagtggg gtgaagccta gaaaggccgt gcgcatcctt ctgaataaaa
     1261 agactgccca ttcctttgag caggtcctaa cggatatcac cgaagccatt aaactagact
     1321 ccggcgtggt gaagaggctg tgcaccctgg atggaaagca ggttacttgt ctgcaagact
     1381 tttttggaga cgatgatgtt tttattgcat gtggacctga aaaatatcgt tatgcccaag
     1441 atgactttgt cctggatcat agtgagtgcc gtgtcctgaa gtcatcttat tctcgggcct
     1501 cagctgctaa gtattctgga tccagaagcc cagggctctc ccgccgcagc aagtcaccag
     1561 cttcagtaaa gagggctggc cactccagtg cctattctac agccaaatcc ccagtgaatg
     1621 gaactcccag cagccagctt tccactccta agtccaccaa gtcctccagc tcctctccaa
     1681 ccagcccggg aagtttcaga ggactgaagc agatttctgc tcagggcaga tcttcttcca
     1741 atgtaaacgg tgggcccgaa cttgaccgtt gcatgagtcc tgaaggcgtg aatggaaaca
     1801 ggtgctccga gtcattcact cttctggaga aatacagaat cgggaaggtc atcggagacg
     1861 gcaactttgc cgtagttaaa gaatgtatgg acaggtccac tggaaaggag tttgcattaa
     1921 agattattga caaagccaaa tgctgtggaa aggaacatct gattgagaac gaagtgtcaa
     1981 tcctgcgccg ggtgaagcac cccaacatca tcatgctggt tgaggagatg gaaacaacaa
     2041 ctgagctctt cctagtgatg gaactggtca aaggtggaga tctcttcgac gcgatcactt
     2101 cttcaaccaa gtacaccgag agagatggca gtgccatggt gtacaaccta gccagcgccc
     2161 tcagatacct gcacggcctc agcatcgtgc acagagatat caaacctgag aatctgctgg
     2221 tgtgcgaata cccagacgga accaagtcgc tgaagctggg agactttggg ctggcgacgg
     2281 tggttgaagg cccgttgtac acagtctgtg gcaccccaac ttacgtggca cccgagatca
     2341 ttgctgaaac aggttacggc ctgaaggtgg atgtttgggc agctggtgtg attacgtaca
     2401 ttcttctctg tggattccca ccgttccgga gtgagaacaa cctccaggag gatctctttg
     2461 accagatctt ggccggaaag ctggagtttc cagctcccta ctgggacaac attacagact
     2521 ctgccaagga gttaatcagt caaatgcttc aggtaaacgt tgaagctcgc tgtactgcgg
     2581 gagaaattct gagtcacccc tgggtgtcag atgatgcatc ccaggagaat aatatgcaag
     2641 ccgaggttac aggtaaacta aaacagcact ttaataatgc gctccccaaa cagaacagca
     2701 ccaccactgg ggtctccgtt atcatgaaca cggctctaga taaagagggg caggttttct
     2761 gcagcaagca ctgtcgggac agcagcaaat catccaggga gcagacctca gcccgggagg
     2821 ccccgccccc accggagtct cccaggcccc ctggtcctcc agccacctct ggctgtgatc
     2881 ctgccgggac ctggcgtcgc catcgagact gaactgtgtg tccacaggcc aaagccgctc
     2941 tctcaccgtg ccaggaaggc cgctcctcac caggccccat cacctcctca ctgaaagagc
     3001 ccttctctcc tgactgctgc tttgacagtt tgttggcatg ttcagtcgct gcctgagaac
     3061 agaactgagg cgtcctggag ccagtgtgca gcatggcctc atgcactttg ggctctgccc
     3121 tttctagtta ctggctgtgt caagcaagct gtgccagtca tggggacaga tttggagtga
     3181 cttgttttaa atcatctgtg ttttagtcca gtagacactt ggccgctttc cccagagagt
     3241 gtgcaacttc atctggaact acatcgtttt tatagaaatg cattggatga attaggattc
     3301 tccttatcga aggacgctcc caagtgctcc ctcaggacac aactatccgt tctgtgagag
     3361 gcaacatggt ctcttcctct acttagtggg tttgaggcac ttgacttctg aatagaagtg
     3421 agtccttgag agggtcagca gctgcctctg ggattcctga ctttgggaac tgcattctga
     3481 tgcctcagga agcagatccc ctcccgcagg gtgcagggct cacagaccta gcagacatgc
     3541 cctcagtttc ccctgacttc ccctatgtgt gttttaggaa atgctaatgg agttggcctg
     3601 tgggctgtgg aatgtgcagc agctcttggc agagcagggt cagctctgct gtgtcatcac
     3661 cagggtctcc tctcacctct gctctttgtc acgagcaggc agaaagccat ttgctgcagg
     3721 tctgctgaga cccagcgggg actggggcgc atggtgctcc ttgaatgtcc tgtgaccaat
     3781 cttctggaag gctgctggca gtttttcctg ttttccacca ccccactctt tttaataatt
     3841 gtacatataa ctgtatttgt tttacttgct tgtcttcgaa acgggtggac cccgcagttc
     3901 actctcactg ttaggttttg ccttctccag gtatccccaa cctgcaataa acccttcctc
     3961 ttcagaaaa
//
