LOCUS       NM_001107544           10462 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dachsous cadherin-related 1 (Dchs1), mRNA.
ACCESSION   NM_001107544 XM_001075461 XM_219128
VERSION     NM_001107544.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10462)
  AUTHORS   Durst,R., Sauls,K., Peal,D.S., deVlaming,A., Toomer,K., Leyne,M.,
            Salani,M., Talkowski,M.E., Brand,H., Perrocheau,M., Simpson,C.,
            Jett,C., Stone,M.R., Charles,F., Chiang,C., Lynch,S.N.,
            Bouatia-Naji,N., Delling,F.N., Freed,L.A., Tribouilloy,C., Le
            Tourneau,T., LeMarec,H., Fernandez-Friera,L., Solis,J.,
            Trujillano,D., Ossowski,S., Estivill,X., Dina,C., Bruneval,P.,
            Chester,A., Schott,J.J., Irvine,K.D., Mao,Y., Wessels,A.,
            Motiwala,T., Puceat,M., Tsukasaki,Y., Menick,D.R., Kasiganesan,H.,
            Nie,X., Broome,A.M., Williams,K., Johnson,A., Markwald,R.R.,
            Jeunemaitre,X., Hagege,A., Levine,R.A., Milan,D.J., Norris,R.A. and
            Slaugenhaupt,S.A.
  TITLE     Mutations in DCHS1 cause mitral valve prolapse
  JOURNAL   Nature 525 (7567), 109-113 (2015)
   PUBMED   26258302
REFERENCE   2  (bases 1 to 10462)
  AUTHORS   Bagherie-Lachidan,M., Reginensi,A., Pan,Q., Zaveri,H.P.,
            Scott,D.A., Blencowe,B.J., Helmbacher,F. and McNeill,H.
  TITLE     Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the
            nephron progenitor pool
  JOURNAL   Development 142 (15), 2564-2573 (2015)
   PUBMED   26116661
REFERENCE   3  (bases 1 to 10462)
  AUTHORS   Cappello,S., Gray,M.J., Badouel,C., Lange,S., Einsiedler,M.,
            Srour,M., Chitayat,D., Hamdan,F.F., Jenkins,Z.A., Morgan,T.,
            Preitner,N., Uster,T., Thomas,J., Shannon,P., Morrison,V., Di
            Donato,N., Van Maldergem,L., Neuhann,T., Newbury-Ecob,R.,
            Swinkells,M., Terhal,P., Wilson,L.C., Zwijnenburg,P.J.,
            Sutherland-Smith,A.J., Black,M.A., Markie,D., Michaud,J.L.,
            Simpson,M.A., Mansour,S., McNeill,H., Gotz,M. and Robertson,S.P.
  TITLE     Mutations in genes encoding the cadherin receptor-ligand pair DCHS1
            and FAT4 disrupt cerebral cortical development
  JOURNAL   Nat Genet 45 (11), 1300-1308 (2013)
   PUBMED   24056717
REFERENCE   4  (bases 1 to 10462)
  AUTHORS   Mao,Y., Mulvaney,J., Zakaria,S., Yu,T., Morgan,K.M., Allen,S.,
            Basson,M.A., Francis-West,P. and Irvine,K.D.
  TITLE     Characterization of a Dchs1 mutant mouse reveals requirements for
            Dchs1-Fat4 signaling during mammalian development
  JOURNAL   Development 138 (5), 947-957 (2011)
   PUBMED   21303848
REFERENCE   5  (bases 1 to 10462)
  AUTHORS   Ishiuchi,T., Misaki,K., Yonemura,S., Takeichi,M. and Tanoue,T.
  TITLE     Mammalian Fat and Dachsous cadherins regulate apical membrane
            organization in the embryonic cerebral cortex
  JOURNAL   J Cell Biol 185 (6), 959-967 (2009)
   PUBMED   19506035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 1, 2009 this sequence version replaced NM_001107544.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1893              JAXUCZ010000001.1  169534747-169536639 c
            1894-2082           JAXUCZ010000001.1  169529502-169529690 c
            2083-2314           JAXUCZ010000001.1  169529178-169529409 c
            2315-2551           JAXUCZ010000001.1  169528814-169529050 c
            2552-3577           JAXUCZ010000001.1  169527565-169528590 c
            3578-3771           JAXUCZ010000001.1  169527174-169527367 c
            3772-3868           JAXUCZ010000001.1  169526860-169526956 c
            3869-4026           JAXUCZ010000001.1  169526600-169526757 c
            4027-4888           JAXUCZ010000001.1  169525546-169526407 c
            4889-5128           JAXUCZ010000001.1  169525211-169525450 c
            5129-5254           JAXUCZ010000001.1  169524961-169525086 c
            5255-5464           JAXUCZ010000001.1  169524237-169524446 c
            5465-6343           JAXUCZ010000001.1  169522214-169523092 c
            6344-6457           JAXUCZ010000001.1  169521982-169522095 c
            6458-6669           JAXUCZ010000001.1  169521613-169521824 c
            6670-6824           JAXUCZ010000001.1  169521370-169521524 c
            6825-6955           JAXUCZ010000001.1  169521044-169521174 c
            6956-7239           JAXUCZ010000001.1  169520679-169520962 c
            7240-7378           JAXUCZ010000001.1  169520192-169520330 c
            7379-10462          JAXUCZ010000001.1  169516762-169519845 c
FEATURES             Location/Qualifiers
     source          1..10462
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..10462
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /note="dachsous cadherin-related 1"
                     /db_xref="GeneID:308912"
                     /db_xref="RGD:1309878"
     exon            1..1893
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..9990
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /note="dachsous 1; protein dachsous homolog 1;
                     protocadherin-16; protocadherin 16 dachsous-like"
                     /codon_start=1
                     /product="protocadherin-16 precursor"
                     /protein_id="NP_001101014.2"
                     /db_xref="GeneID:308912"
                     /db_xref="RGD:1309878"
                     /translation="MQEELSVALSCPGMKSLGTLLPLLVLLGTTVPGIRGQAGSLDLQ
                     IDEEQPAGTLIGDISAGLPPGTAPPPMYFISAQEGSGVGTDLDIDEHSGVVCTARVLD
                     RERRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQIPEHTALGTRYPLEP
                     AHDADAGRLGTQGYALSGDGAGETFRLETRPGPGGAPVPELVIAGELDRENRSHYMLQ
                     LEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQVFASDA
                     DAGANGAVTYEINRRQSEGDGPFSIDAHTGFLKLERPLDFEQRRVHELVVQARDGGAH
                     PELGSAFVTVHVRDANDNQPSMTVIFLSADGSPRVSEAAPPGQLVARISVSDPDDGDF
                     AHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDVYNLRVTATDSGSPPLRAEA
                     AFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAP
                     GTHTHWFSIDPTSGIITTAATLDYELEPQPQLIVVATDGGLPPLVSSATVSVALQDVN
                     DNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGASGSPPFR
                     IDAHSGEVCTTRILDRDQGPSSFDFTVTAIDGGGLKSMVYVKVFVADENDNPPQFYPR
                     EYAASLSAQSTPGTAVLRVHAHDPDQGPHGRLSYHILAGNSPPLFALDAHSGLLTVAW
                     PLGRRANSVVQLEIGAQDGGGLQAEPIARVNISIVPGTPTPPIFEQLQYVFSVPEDVA
                     PGTSVGVVQAHNPPGRLGPVTLTLSGGDPRGLFSLDSASGLLKTLRPLDRELLGPVLE
                     LEVRAGSGTPPVFSAARIRVLLDDVNDNSPAFPAPEDTVLLPQNTAPGTPVYTLRALD
                     PDSGANSRVTFSLLAGGDGLFTVDPTTGHVRLMGPLGPPGGPPHELEVEAQDGGSPPR
                     TSHFRLRVVIQDLGIHGLAPRFDSPTYRVDLPSGTTTGTQILQVQAQAPDGSPVTYHL
                     AADGASNPFGLESQSGWLWVRAALDRESQELYTLKVMAVSGSKAELGQQTGTATVRVV
                     ILNQNDHSPRLSEEPTFLAVAENQPPGTSVGRVFATDKDSGPNGRLTYSLQQLSEDSK
                     AFRIHPQTGEVTTLQTLDREQQSSFQLLVQVQDAGSPPRSATGTVHVAVLDLNDNSPT
                     FLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGSGSELFSLHP
                     HTGELHTAASLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSTRMVESPDLVEA
                     DSAATVPVVLTVTAAEGLRPGSLLGSVAPQEPASMGVLTYTLVGGADPEGTFALDSAS
                     GRLYLARVLDFESGPAWRALTVRAEGPGGAGARLMRVQVRVQDENEHAPAFARDPLAL
                     ALPENPEPGATLYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGL
                     DRETTPALLLIVEATDRPANASRRKATRVSARVFVTDENDNAPVFASPSRMRLPEDQP
                     PGPAALHVVARDPDLGEAARVSYRLAAGGDGHFRLHATTGALSVVRPLDREQRAEHVL
                     TVVASDHGSPPRSSTQLLTVSVVDVNDEAPAFPQQEYNVILRENSPPGTSLLTLKATD
                     PDLGANGQVTYGGVSGESFSLDPNSGVLTTLRALDREEQEEINLTVYARDRGLPPLLT
                     HITVRVTVEDENDHSPTFGNTHLSLEVPEGQDPQTLTTLRASDPDGGLNGQLQYRILG
                     GDPSGAFALDLTSGEFGTTRPLDREVEPAFQLQIEARDGGQPALSATLLVTVTVLDAN
                     DHAPAFPVPSYSVEVPEDAPVGTLLLQLQAHDPDEGDNGRVMYYLGAGTAGAFLLEPT
                     SGELSTATALDREHCASYAFSVTAVDGAAAGPLSTTVPITVTVRDVNDHAPAFPTSPL
                     RLRLPRPGPSLNKPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVA
                     RSPAALGPRDRVLFIVATDLGRPARSATGVVIVGIQGEPERGPRFPRANNEAVLRENA
                     PPGTPVISPKAVHSGGSNGPITYSILSGNERGIFSIQPSTGTITVQSAEGLDFETNPR
                     LRLVLQAESGGAFAFSVLTLTLQDANDNAPRFLQPHYVAFLPESRPLEGPLLQVEADD
                     LDQGSGGQISYSLAASQPARGLFHVDPATGTITTTAILDREIWAETRLVLMATDRGSP
                     ALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVL
                     SPSGPQDPFSIGRYGGRVSLTGPLDFEQCDHYHLQLLAHDGPHEGHANLTVLVEDVND
                     NVPIFSQSLYQVMMLEHTPPGSAILSVSATDRDSGANGHISYHLASPAEGFSVDTNNG
                     TLFTTVGAMALGHEGPGVVDVVLEARDHGAPGRSAQATVHVQLKDQNDHAPSFTLPHY
                     RVAVSEDLPPGSTLLTLEAIDADGSRSHATVDYSIISGNRGRVFQLEPRLAEVGDGVG
                     PGPQALGCLVLLEPLDFESLTQYNLTVTAADRGQPPRSSAVPVTVTVLDVNDNPPVFT
                     RASYRVTVPEDMPVGAELLHVEASDADPGPHGLVHFTLSSGDPLGLFELDENSGALRL
                     AHPLDCETQAQHQLVVQAADPAGTHFALVPVTVEVQDVNDHGPAFPLSLLSTSLAENQ
                     PPGTLVTTLHAMDGDAGTFGRLRYTLLEAVPGPEGREAFSLNSSTGELRARVPFDYEH
                     TGSFRLLVGAADAGNLSASVTVSVLITGEDEYDPVFLAPSFHFQVPEGAQRGHSLGHV
                     QATDEDGGADGLVLYSLATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGRTRRE
                     APRELRLEVVARGPLPGSRSATVPVTVDITHTALGLAPDLNLLLVGAVAASLGVVVVL
                     ALAALVLGLVRARSRKAEAAPGPMSQTAPIASSSLQKLGREPPSPPPSEHLYHQTLPS
                     YGGPGAGGPYPRGGSLDPSHSSGRGSAEAAEDDEIRMINEFPRVASVASSLAARGPDS
                     GIQQDADGLSDTSCEPPAPDTWYKGRKAGLLLPGAGATLYREEGPPATATAFLGGCGL
                     SPAPTGDYGFPADGKPCVAGALTAIVAGEEELRGSYNWDYLLSWCPQFQPLASVFTEI
                     ARLKDEARPCPPAPRIDPPPLITAVAHPGAKSVPPKPASTAATRAIFPPASHRSPISH
                     EGSLSSAAMSPSFSPSLSPLAARSPVVSPFGVAQGPSASALSTESGLEPPDDTELRI"
     exon            1894..2082
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2314
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2551
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..3577
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3771
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..3868
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..4026
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            4027..4888
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            4889..5128
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            5129..5254
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            5255..5464
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            5465..6343
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            6344..6457
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            6458..6669
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            6670..6824
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            6825..6955
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            6956..7239
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            7240..7378
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            7379..10462
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagggagc ccaaactaca gctagaaccc aagttggatc cgatccaaac cctgaaatca
       61 agctgggcta ggagtctggt gtggagctga agtttcagct ggactggccc tgccatgcag
      121 gaggagctaa gtgttgcact ctcctgccct ggcatgaaga gcctcgggac tctgttacca
      181 ctgctggtgc tgttgggaac tacagtgcca ggaatccggg gtcaggctgg gagcctggac
      241 ctacagatag atgaggaaca accagcaggc acactgattg gcgacatcag tgcagggctc
      301 ccaccaggca cagctcctcc tcccatgtac tttatctctg cccaggaggg cagtggcgta
      361 ggcacagacc tcgatattga tgagcacagt ggggtggtct gtacagctcg agtcctggac
      421 cgtgagcgga gagaccgtta ccgcttcact gcagtcactc ccgatggcgc caccgttgaa
      481 gttacggtga gagtagctga tatcaacgac catgcaccag ctttccctca ggctcgggct
      541 gccctgcaga tacctgaaca tacagctctt ggcacacgct acccactgga gcctgctcat
      601 gatgcagacg ccggacgact aggaacccaa gggtatgcgc tatctggtga tggggctgga
      661 gagacctttc gactggagac acgtcctggt cctggtggag ctccagtgcc tgagctggtc
      721 attgctgggg aactggaccg ggagaaccgc tcacactaca tgttgcagct cgaggcctat
      781 gatggtggct cacccccacg gagagcccag gccctgctag atgtgacact tctggatatc
      841 aatgaccatg ccccagcttt caatcaaagc cgataccatg ctgtggtatc tgagagtctg
      901 gcccctggaa gtcctgtctt gcaggtgttt gcatctgatg ctgatgctgg tgcaaatggg
      961 gctgtgactt atgagatcaa caggagacag agtgaaggtg atgggccctt ctccattgat
     1021 gctcacacag ggtttctgaa actggagcgc ccactggact ttgaacaaag gcgagttcat
     1081 gaactggtgg tgcaggcaag ggatggtggg gctcacccag agctgggttc agcttttgtg
     1141 acagtgcatg tgcgagatgc caatgacaat cagccctcca tgactgtcat cttcctgagt
     1201 gctgatggct ccccccgggt gtctgaggct gccccaccgg gacaacttgt tgctcgaatc
     1261 tctgtgtcag atccggatga tggtgacttt gcccacgtca atgtgtccct ggaaggtgga
     1321 gagggccact ttgccctgag cacccaagac agtgtcatct atctagtgtg tgtggctcga
     1381 aggctggatc gggaggagag ggatgtctat aacttgcgag tcacggccac cgactcaggc
     1441 tcaccaccac ttcgggctga agctgccttt gtgctacatg tcactgatgt caatgacaac
     1501 gcacctgcgt ttgaccgcca gctctaccga cctgagcctc tgcctgaagt cgcattgccc
     1561 ggcagctttg tggtacgggt gactgcccgg gatcctgacc aaggcaccaa tggtcaggtc
     1621 acttacagtc tggctcctgg cactcacact cactggttct ccattgatcc tacgtcaggc
     1681 atcatcacca cagctgccac attggactat gaactagaac ctcagccaca gcttattgtg
     1741 gtggccacag atgggggcct gcccccttta gtctcctctg ccacagttag tgtggcctta
     1801 caagacgtga atgacaatga gccccagttc cagaggactt tctacaatgc ctcgctgcct
     1861 gaaggcaccc agcccggaac ctgtttcctg caggtaacag ccacagatgc cgacagtggc
     1921 ccatttggcc tcctctccta ttccttgggt gctgggcttg gagcttctgg gtctccccca
     1981 ttccgcattg atgcccacag tggtgaggtg tgtaccaccc ggatcctgga ccgtgaccag
     2041 ggaccttcaa gctttgactt cacagtgaca gccatcgatg ggggaggtct caagtccatg
     2101 gtgtacgtga aggtgtttgt ggcagacgag aatgacaacc cacctcagtt ttacccacgg
     2161 gagtacgctg ccagcctgag tgctcagagc accccaggca cagctgtgct gagggtgcac
     2221 gcccatgacc ctgaccaggg accccatggg cggctttcct accacatcct ggctggcaac
     2281 agcccgccac tctttgcatt ggatgcacac tcaggactgc tgacagtagc ctggccctta
     2341 ggcagacggg ctaattctgt ggtgcagctg gagatcgggg ctcaggatgg aggtggtctg
     2401 caggcagaac ctattgcccg agtcaacatc agcattgtgc ctggaacccc cacaccacct
     2461 atatttgagc aactacagta tgttttttct gtgccagagg atgtggcacc aggcaccagt
     2521 gttggcgtag tccaggcaca caacccacca ggtcgcttag ggcctgtgac cctcacccta
     2581 tcaggtgggg acccccgagg gctcttctcc ctagattcag cctcggggct attaaaaaca
     2641 cttcgtcctc tggaccggga gcttctggga cctgtcctag agctagaggt tcgagcaggc
     2701 agcggaaccc ccccagtttt ctctgctgct cggatccgtg tgcttctgga tgatgtgaac
     2761 gataactctc ctgccttccc tgcacctgaa gacactgtgt tgttgccaca aaacactgct
     2821 ccagggactc ctgtctatac actgcgtgct ctagatcccg actcgggagc taacagtcga
     2881 gtcaccttta gtctacttgc tggaggtgat ggattgttca ctgtggaccc taccacgggc
     2941 cacgtccggc tcatgggacc tctagggcct ccagggggac caccccatga gttggaagtg
     3001 gaggcccagg atggaggctc cccaccacgc accagccact ttcgacttcg tgtggtgata
     3061 caggatttgg gaatccatgg gttggctcca cgatttgaca gccctaccta ccgagtggac
     3121 ttgccttcag gcactaccac tggaactcag atcttgcaag tgcaggccca ggcaccagat
     3181 gggagccccg tcacttacca tcttgcagca gatggagcca gtaacccctt tggcctggag
     3241 tcacagagtg ggtggctgtg ggtacgggca gcattagacc gtgagtccca ggagttatac
     3301 acattgaagg tgatggctgt atctggttcc aaagctgaat tggggcaaca gacaggcaca
     3361 gccacagtga gggtcgttat cctcaaccaa aatgaccaca gtccccgctt gtctgaagag
     3421 cccacctttc tggctgtagc agagaaccaa cccccaggga ccagtgtagg ccgagtcttt
     3481 gccactgaca aagactcagg tcctaatggg cgtctgacct acagccttca acagctttca
     3541 gaagacagca aggccttccg catccacccc cagactggag aagtgactac actccaaacc
     3601 ctggaccgag agcaacagag cagcttccag ctcctggtcc aggtgcagga tgcgggcagt
     3661 ccacctcgca gcgccacagg cactgtgcat gtcgcggtgc ttgacctcaa cgacaacagt
     3721 cctaccttcc tgcaggcttc aggggctgct ggtggaggtc tccctatcca ggtaccagac
     3781 cgagtgcctc caggaacact ggtgacaact ctgcaggcca aagatccaga tgagggggag
     3841 aatgggacca tcctatacac cctaactggt tctggctctg agctcttctc tctgcatcct
     3901 cacacggggg agctgcacac tgcggcatct ctgattagag ctgagaggcc tcactatgtg
     3961 ctaactctta gcgctcacga ccagggcagc ccccctcgaa gtgccagcct ccaactgctc
     4021 gtacaggtgc ttccctcgac tcgtatggtg gagtcaccag atctcgtaga agctgactca
     4081 gcggcaacag tgcctgtagt actgacagtt acagcagctg aggggcttcg acctggatcc
     4141 ctgttaggtt cggtggcccc gcaggagcca gctagtatgg gcgtactcac ctatactctg
     4201 gttggtggag ccgaccccga gggcaccttc gctctggact cagcctcagg tcgcctgtac
     4261 ttggcccgtg tcttggactt tgagtctggg ccggcttggc gcgcgctcac ggtgcgcgcc
     4321 gaggggccgg gaggtgcagg agcgcggctg atgagagtgc aggtgcgcgt gcaagacgag
     4381 aacgagcacg cgcccgcttt tgcacgcgac cccctggcac tggcgctacc tgagaaccct
     4441 gagcccggcg ccacgctgta tactttccgt gcttcagacg cggatggccc aggtcccaac
     4501 agtgacgtgc gataccgcct gctgaggcag gaacccccgg ttcccgccct gcgcttggac
     4561 gcgcgcaccg gggcgctcag cgctcctcgt ggtctggatc gggagaccac acccgcgctg
     4621 ttgctgatcg tggaagccac agacagacca gccaatgcca gccgccgcaa ggcaacgcgc
     4681 gtctcggcgc gggtctttgt cacggatgaa aatgacaacg cccctgtctt cgcctcacca
     4741 tcacggatgc gcctcccaga ggatcagcct cctgggcctg cggcgctgca cgtggtagct
     4801 cgggatccag atctggggga ggctgcccgt gtgtcctatc gtcttgcggc tggaggggat
     4861 ggccacttcc ggctacatgc gaccactgga gcgctgtccg tggtgcggcc cttggaccgt
     4921 gaacagcgag ctgagcatgt actgacagtg gtggcctcgg accatggctc gccgccacgt
     4981 tcatccactc agctcctgac tgtcagtgtt gttgacgtca acgacgaggc acccgctttc
     5041 cctcagcagg agtacaacgt catccttcgt gagaacagtc cgcctggcac ttctctgctc
     5101 acactgaagg caactgaccc tgaccttggg gccaatgggc aagtgactta tgggggtgtc
     5161 tctggcgaga gcttctctct ggacccaaac agtggagttc ttacgactct gagggctctg
     5221 gaccgggagg agcaggagga gatcaatttg acagtatatg cccgggacag gggcttgcca
     5281 cccctgttaa ctcacatcac agtgcgagtg actgtggaag atgagaatga ccatagtcca
     5341 acttttggga acacccatct ctccctggaa gtgccagaag gccaggaccc ccaaaccctt
     5401 accacactac gagcctctga tccggatggg ggactcaacg gacagctcca gtaccgcatc
     5461 cttggtgggg acccttcagg agcctttgca ctagatctca cttctgggga gtttggcacc
     5521 acgaggccac tagaccggga ggtagagcct gcattccagc tgcagataga ggccagagat
     5581 ggaggccagc cagcccttag tgcgaccttg cttgtgacag tgacagtgct ggatgccaat
     5641 gaccatgcgc cagcctttcc tgtgccttct tattctgtag aggtacctga ggatgcacct
     5701 gtcgggaccc tactgctgca actacaggct catgacccgg atgaggggga caatggccgt
     5761 gtgatgtact acctgggtgc aggtacagca ggggccttcc tgctggagcc tacctctggg
     5821 gaactgagca cagccacagc cttggacaga gagcactgtg ccagctacgc cttttctgtg
     5881 actgcagtgg atggtgcagc tgctgggcct ctgagcacta cagtaccaat caccgtcacg
     5941 gtgcgtgatg tcaatgatca cgcacccgct ttccccacca gtcctctgcg cctccgccta
     6001 ccccgcccag gtcctagcct caacaaacca accctggctc tggccacgct tcgagctgaa
     6061 gatcgagatg ctggtgccaa tgcctccatt ctataccggc tggcaggcac accaccacct
     6121 ggcaccactg tggactctta cactggtgaa atccgtgtgg ctcgatcccc tgcggctctt
     6181 ggacctcggg atcgtgtcct cttcatcgtg gctactgacc ttggccgccc agctcgctct
     6241 gccactggtg tggtcattgt tgggatacaa ggagagcctg agcgtggacc ccgctttccc
     6301 agagctaata atgaggctgt gctccgtgaa aatgcaccac cagggactcc agttatctcc
     6361 ccaaaggctg tccattcagg aggctcaaat ggaccaatta cctatagcat tctcagtggg
     6421 aatgagagag ggattttctc catccaacct agcacaggaa ccatcacagt tcagtcagca
     6481 gaggggcttg actttgagac aaacccacgg ctacgactgg tgctacaggc agagagtgga
     6541 ggagcctttg ctttctcggt gctgaccctg acccttcaag atgccaatga caatgctccc
     6601 cgtttcctgc agcctcacta cgtggctttc ctgccagagt cccgaccctt ggaagggccc
     6661 ctgctgcagg tggaagcaga cgacctggat caaggctctg gaggacagat ctcctacagt
     6721 ctggctgcat cccagccagc acggggcttg ttccatgtag acccagccac aggcactatc
     6781 actaccacag ccatcctgga ccgggaaatc tgggctgaaa cacggctggt actgatggcc
     6841 acagacagag gaagcccagc attggtgggc tcagctaccc tgacagtgat ggtcatcgat
     6901 accaatgaca atcgccccac catcccccag ccctgggagc tccgcgtgtc agaagatgca
     6961 ctgctgggct cagagatcgc acaggtgact gggaatgatg tggattctgg accagtgcta
     7021 tggtatgtgc tgagcccatc tggaccccag gatcccttca gtattggccg atatggagga
     7081 cgtgtctccc tcacgggccc cctggacttt gagcaatgtg accactacca cctacagctg
     7141 ctggcacatg atgggcctca tgagggccat gccaacctca cagtgcttgt ggaagatgtc
     7201 aatgacaatg tacccatctt ctcacagagc ctctaccagg taatgatgtt agagcacacc
     7261 cctcctggca gcgccattct ctccgtctct gccactgaca gagactcagg tgccaatggt
     7321 cacatatcct accatctggc ttcccctgct gagggcttca gtgtcgacac taacaatgga
     7381 actctgttca caacagtggg agcaatggcc ttgggccatg aggggccagg agtggtagat
     7441 gtggtgctgg aagcacgaga ccatggggct ccaggccggt cagcacaggc cacggtgcat
     7501 gtgcagctga aagaccagaa tgaccatgcc ccaagcttca cgttgccaca ctaccgtgtt
     7561 gctgtgtctg aagatttacc ccctggttcc accctgctca ccctggaggc catagatgct
     7621 gatggaagcc gcagccatgc tactgtagac tacagcatta tcagtggcaa tcggggccga
     7681 gttttccagc tggaaccccg cctggctgag gttggggacg gtgttgggcc aggtccccag
     7741 gctttgggct gcctagtgtt gcttgagcct ctagactttg aaagcctgac acagtacaat
     7801 ttaactgtga ccgcagctga ccggggacag ccaccccgca gttcagccgt gcccgtgact
     7861 gtcactgtac tggatgtcaa tgacaaccca cctgtcttta ctcgagcatc ctaccgtgtg
     7921 acagtacctg aggacatgcc tgttggagct gagctattgc atgtggaggc ctctgatgct
     7981 gaccctggac ctcatggcct tgtgcatttc acccttagct cgggtgatcc tttaggcctc
     8041 tttgagctgg atgagaactc gggtgctctg aggctggccc accctctgga ctgcgaaacc
     8101 caggctcaac atcagcttgt ggtgcaggca gctgaccctg ctggaacaca ctttgctctg
     8161 gtaccggtga cagttgaggt ccaggatgtg aatgaccatg gtccagcctt cccattgagc
     8221 ctgctcagta ctagccttgc tgagaatcag cctccaggca ctcttgtgac cacgctacat
     8281 gcaatggatg gggatgctgg gacttttggt agactccgat acacactgtt ggaggcagtg
     8341 ccagggcccg agggtcgtga ggcattctca ctgaacagct caacagggga attgcgggca
     8401 cgggtacctt ttgactatga gcacacagga agcttccgtc tactagtggg cgctgctgat
     8461 gctgggaatc tctcggcttc tgtcaccgtg tcggtgctga tcactggaga agatgaatat
     8521 gaccctgtat tcctggctcc atctttccat ttccaagtgc ctgaaggtgc ccagcgtggc
     8581 cacagcctgg gccatgtgca ggccacagat gaggacggag gtgctgatgg tctggtgctc
     8641 tattcgctgg ctacctcttc cccctatttt ggtatcaacc agacaacagg tgctttgtac
     8701 ttgcgagtgg acagtcgggc accaggaagt ggaacagcca cctctggggg tgggggccgg
     8761 acccgacgtg aagcaccgcg ggagttaagg ctggaggtag tagcgagagg gcctctgcct
     8821 ggatcgcgga gtgccacagt gcctgtgact gtggatatta cccacactgc tctaggcctg
     8881 gcacctgacc tcaacttgct attggttggg gctgtggcag cttctttggg agttgtggtg
     8941 gtgctggccc tggcagctct tgtcctgggc cttgttcggg cacggagccg caaggctgag
     9001 gcagcccctg gcccaatgtc acagacagca cccatagcca gtagctcttt acagaaactg
     9061 ggtcgggaac cccccagtcc accaccctct gaacacctgt atcatcagac tcttcccagc
     9121 tatggtgggc caggagctgg aggtccctac ccccgtggtg gctccttgga cccttcacat
     9181 tcaagtggcc gaggctcagc agaggctgca gaggatgatg agatacgcat gatcaacgag
     9241 tttccccgtg tggccagtgt ggcctcctcc ctggccgccc gaggccctga ctcgggcatc
     9301 cagcaggatg cagatggact gagtgacacg tcttgcgagc ctcctgcccc tgacacctgg
     9361 tacaagggca ggaaggcagg gctgctgctg ccaggcgcag gagccactct gtaccgagag
     9421 gaggggcctc cagccactgc tacagccttc ctggggggct gtggcctgag ccctgcaccc
     9481 actggggact atggcttccc agcagatggg aagccatgtg tagctggagc gctgacggcc
     9541 atcgtggctg gtgaggaaga gctccgtggc agctataact gggactacct gttgagctgg
     9601 tgccctcagt tccagcctct ggccagtgtc ttcacagaga ttgctcggct caaggatgaa
     9661 gcccgtccat gtcctcccgc tccccgtatt gacccaccac ccctcatcac tgctgtggcc
     9721 cacccaggag ccaagtctgt tcccccaaag cctgcaagca cggctgccac ccgggccatc
     9781 ttcccaccag cctctcaccg ctcccctatc agccatgaag gctccctctc ctcagctgcc
     9841 atgtccccca gcttctcacc ctcactgtct cctttggctg ctcgctctcc tgttgtctca
     9901 ccattcgggg tagcccaggg cccctcagct tcagcactca gcacagagtc tggcctggag
     9961 cctcccgatg acacagagct gcgcatctag ctgtggccct aactgggccc cgacctggga
    10021 cacgtccagt gtccccaaag caggccccat tctcagcctg ccctgggcag cctcggacca
    10081 tgactggcca tggggaggcc accaccagtc cccagctctc caccccaaac tcttgtagtt
    10141 gggacaggtc ccacatttct ccacagtccc ctcagcacta ggaccacaaa gggcctgttg
    10201 gtcactgacc tgtggccaga tccagtgtgg agagaaataa gaaagaggca accgccttgg
    10261 gttctcttca gccaagactt cctgccctgc accagcaccc tgcgatggag ctgagacttt
    10321 atttattggg gggtaggggg atggaggagg tccctccaac ctgtttgggc ctaactcttg
    10381 ggttcttctg acgtccctgc ccctgcccag aacaagtgcc aattctcact ctggagcctt
    10441 aataaactgc agtttgtatc ca
//
