LOCUS       NP_001101014            3291 aa            linear   ROD 03-APR-2024
DEFINITION  protocadherin-16 precursor [Rattus norvegicus].
ACCESSION   NP_001101014 XP_001075461 XP_219128
VERSION     NP_001101014.2
DBSOURCE    REFSEQ: accession NM_001107544.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 3291)
  AUTHORS   Durst,R., Sauls,K., Peal,D.S., deVlaming,A., Toomer,K., Leyne,M.,
            Salani,M., Talkowski,M.E., Brand,H., Perrocheau,M., Simpson,C.,
            Jett,C., Stone,M.R., Charles,F., Chiang,C., Lynch,S.N.,
            Bouatia-Naji,N., Delling,F.N., Freed,L.A., Tribouilloy,C., Le
            Tourneau,T., LeMarec,H., Fernandez-Friera,L., Solis,J.,
            Trujillano,D., Ossowski,S., Estivill,X., Dina,C., Bruneval,P.,
            Chester,A., Schott,J.J., Irvine,K.D., Mao,Y., Wessels,A.,
            Motiwala,T., Puceat,M., Tsukasaki,Y., Menick,D.R., Kasiganesan,H.,
            Nie,X., Broome,A.M., Williams,K., Johnson,A., Markwald,R.R.,
            Jeunemaitre,X., Hagege,A., Levine,R.A., Milan,D.J., Norris,R.A. and
            Slaugenhaupt,S.A.
  TITLE     Mutations in DCHS1 cause mitral valve prolapse
  JOURNAL   Nature 525 (7567), 109-113 (2015)
   PUBMED   26258302
REFERENCE   2  (residues 1 to 3291)
  AUTHORS   Bagherie-Lachidan,M., Reginensi,A., Pan,Q., Zaveri,H.P.,
            Scott,D.A., Blencowe,B.J., Helmbacher,F. and McNeill,H.
  TITLE     Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the
            nephron progenitor pool
  JOURNAL   Development 142 (15), 2564-2573 (2015)
   PUBMED   26116661
REFERENCE   3  (residues 1 to 3291)
  AUTHORS   Cappello,S., Gray,M.J., Badouel,C., Lange,S., Einsiedler,M.,
            Srour,M., Chitayat,D., Hamdan,F.F., Jenkins,Z.A., Morgan,T.,
            Preitner,N., Uster,T., Thomas,J., Shannon,P., Morrison,V., Di
            Donato,N., Van Maldergem,L., Neuhann,T., Newbury-Ecob,R.,
            Swinkells,M., Terhal,P., Wilson,L.C., Zwijnenburg,P.J.,
            Sutherland-Smith,A.J., Black,M.A., Markie,D., Michaud,J.L.,
            Simpson,M.A., Mansour,S., McNeill,H., Gotz,M. and Robertson,S.P.
  TITLE     Mutations in genes encoding the cadherin receptor-ligand pair DCHS1
            and FAT4 disrupt cerebral cortical development
  JOURNAL   Nat Genet 45 (11), 1300-1308 (2013)
   PUBMED   24056717
REFERENCE   4  (residues 1 to 3291)
  AUTHORS   Mao,Y., Mulvaney,J., Zakaria,S., Yu,T., Morgan,K.M., Allen,S.,
            Basson,M.A., Francis-West,P. and Irvine,K.D.
  TITLE     Characterization of a Dchs1 mutant mouse reveals requirements for
            Dchs1-Fat4 signaling during mammalian development
  JOURNAL   Development 138 (5), 947-957 (2011)
   PUBMED   21303848
REFERENCE   5  (residues 1 to 3291)
  AUTHORS   Ishiuchi,T., Misaki,K., Yonemura,S., Takeichi,M. and Tanoue,T.
  TITLE     Mammalian Fat and Dachsous cadherins regulate apical membrane
            organization in the embryonic cerebral cortex
  JOURNAL   J Cell Biol 185 (6), 959-967 (2009)
   PUBMED   19506035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 1, 2009 this sequence version replaced NP_001101014.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3291
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     Protein         1..3291
                     /product="protocadherin-16 precursor"
                     /note="dachsous 1; protein dachsous homolog 1;
                     protocadherin-16; protocadherin 16 dachsous-like"
                     /calculated_mol_wt=342362
     sig_peptide     1..35
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D4ACX8.2)"
                     /calculated_mol_wt=3638
     mat_peptide     36..3291
                     /product="Protocadherin-16. /id=PRO_0000429046"
                     /note="propagated from UniProtKB/Swiss-Prot (D4ACX8.2)"
                     /calculated_mol_wt=342362
     Region          43..133
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(47..48,102,104,129,131..132)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          144..245
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(148..149,208,210,241,243..244)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          254..352
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(260..261,315,317,348,350..351)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          368..462
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(371..372,425,427,458,460..461)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            396
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D4ACX8.2)"
     Region          476..568
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(478..479,531,533,564,566..567)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          577..675
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(583..584,639,641,671,673..674)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          683..775
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          788..884
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(795..796,847,849,880,882..883)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          894..984
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          951..971
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4ACX8.2)"
     Region          998..1095
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1005..1006,1055,1057,1091,1093..1094)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          1108..1201
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1110..1111,1164,1166,1197,1199..1200)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          1218..1306
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          1356..1427
                     /region_name="CA"
                     /note="Cadherin repeats; smart00112"
                     /db_xref="CDD:214520"
     Region          1438..1535
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1440..1441,1495,1497,1531,1533..1534)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          1544..1637
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1549..1550,1601,1603,1634,1636..1637)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          1646..1740
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1653..1654,1703,1705,1736,1738..1739)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            1711
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D4ACX8.2)"
     Region          1750..1844
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1755..1756,1807,1809,1840,1842..1843)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          1852..1949
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1859..1860,1911,1913,1945,1947..1948)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          1976..2052
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          2067..2160
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2072..2073,2126,2128,2156,2158..2159)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          2168..2266
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2175..2176,2229,2231,2262,2264..2265)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          2275..2365
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2280..2281,2331,2333,2361,2363..2364)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            2354
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D4ACX8.2)"
     Region          2374..2471
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2380..2381,2434,2436,2467,2469..2470)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          2479..2591
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2486..2487,2554,2556,2587,2589..2590)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            2562
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (D4ACX8.2)"
     Region          2599..2695
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2606..2607,2659,2661,2691,2693..2694)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          2705..2801
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          2810..2916
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            2934..2954
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (D4ACX8.2)"
     Region          2978..3033
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4ACX8.2)"
     Site            3048
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:E9PVD3; propagated from
                     UniProtKB/Swiss-Prot (D4ACX8.2)"
     Region          3051..3080
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4ACX8.2)"
     Region          3226..3291
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4ACX8.2)"
     CDS             1..3291
                     /gene="Dchs1"
                     /gene_synonym="Pcdh16"
                     /coded_by="NM_001107544.2:115..9990"
                     /db_xref="GeneID:308912"
                     /db_xref="RGD:1309878"
ORIGIN      
        1 mqeelsvals cpgmkslgtl lpllvllgtt vpgirgqags ldlqideeqp agtligdisa
       61 glppgtappp myfisaqegs gvgtdldide hsgvvctarv ldrerrdryr ftavtpdgat
      121 vevtvrvadi ndhapafpqa raalqipeht algtryplep ahdadagrlg tqgyalsgdg
      181 agetfrletr pgpggapvpe lviageldre nrshymlqle aydggspprr aqalldvtll
      241 dindhapafn qsryhavvse slapgspvlq vfasdadaga ngavtyeinr rqsegdgpfs
      301 idahtgflkl erpldfeqrr vhelvvqard ggahpelgsa fvtvhvrdan dnqpsmtvif
      361 lsadgsprvs eaappgqlva risvsdpddg dfahvnvsle ggeghfalst qdsviylvcv
      421 arrldreerd vynlrvtatd sgspplraea afvlhvtdvn dnapafdrql yrpeplpeva
      481 lpgsfvvrvt ardpdqgtng qvtyslapgt hthwfsidpt sgiittaatl dyelepqpql
      541 ivvatdgglp plvssatvsv alqdvndnep qfqrtfynas lpegtqpgtc flqvtatdad
      601 sgpfgllsys lgaglgasgs ppfridahsg evcttrildr dqgpssfdft vtaidggglk
      661 smvyvkvfva dendnppqfy preyaaslsa qstpgtavlr vhahdpdqgp hgrlsyhila
      721 gnspplfald ahsglltvaw plgrransvv qleigaqdgg glqaepiarv nisivpgtpt
      781 ppifeqlqyv fsvpedvapg tsvgvvqahn ppgrlgpvtl tlsggdprgl fsldsasgll
      841 ktlrpldrel lgpvlelevr agsgtppvfs aarirvlldd vndnspafpa pedtvllpqn
      901 tapgtpvytl raldpdsgan srvtfsllag gdglftvdpt tghvrlmgpl gppggpphel
      961 eveaqdggsp prtshfrlrv viqdlgihgl aprfdsptyr vdlpsgtttg tqilqvqaqa
     1021 pdgspvtyhl aadgasnpfg lesqsgwlwv raaldresqe lytlkvmavs gskaelgqqt
     1081 gtatvrvvil nqndhsprls eeptflavae nqppgtsvgr vfatdkdsgp ngrltyslqq
     1141 lsedskafri hpqtgevttl qtldreqqss fqllvqvqda gspprsatgt vhvavldlnd
     1201 nsptflqasg aaggglpiqv pdrvppgtlv ttlqakdpde gengtilytl tgsgselfsl
     1261 hphtgelhta asliraerph yvltlsahdq gspprsaslq llvqvlpstr mvespdlvea
     1321 dsaatvpvvl tvtaaeglrp gsllgsvapq epasmgvlty tlvggadpeg tfaldsasgr
     1381 lylarvldfe sgpawraltv raegpggaga rlmrvqvrvq denehapafa rdplalalpe
     1441 npepgatlyt frasdadgpg pnsdvryrll rqeppvpalr ldartgalsa prgldrettp
     1501 allliveatd rpanasrrka trvsarvfvt dendnapvfa spsrmrlped qppgpaalhv
     1561 vardpdlgea arvsyrlaag gdghfrlhat tgalsvvrpl dreqraehvl tvvasdhgsp
     1621 prsstqlltv svvdvndeap afpqqeynvi lrensppgts lltlkatdpd lgangqvtyg
     1681 gvsgesfsld pnsgvlttlr aldreeqeei nltvyardrg lppllthitv rvtvedendh
     1741 sptfgnthls levpegqdpq tlttlrasdp dgglngqlqy rilggdpsga faldltsgef
     1801 gttrpldrev epafqlqiea rdggqpalsa tllvtvtvld andhapafpv psysvevped
     1861 apvgtlllql qahdpdegdn grvmyylgag tagafllept sgelstatal drehcasyaf
     1921 svtavdgaaa gplsttvpit vtvrdvndha pafptsplrl rlprpgpsln kptlalatlr
     1981 aedrdagana silyrlagtp ppgttvdsyt geirvarspa algprdrvlf ivatdlgrpa
     2041 rsatgvvivg iqgepergpr fpranneavl renappgtpv ispkavhsgg sngpitysil
     2101 sgnergifsi qpstgtitvq saegldfetn prlrlvlqae sggafafsvl tltlqdandn
     2161 aprflqphyv aflpesrple gpllqveadd ldqgsggqis yslaasqpar glfhvdpatg
     2221 titttaildr eiwaetrlvl matdrgspal vgsatltvmv idtndnrpti pqpwelrvse
     2281 dallgseiaq vtgndvdsgp vlwyvlspsg pqdpfsigry ggrvsltgpl dfeqcdhyhl
     2341 qllahdgphe ghanltvlve dvndnvpifs qslyqvmmle htppgsails vsatdrdsga
     2401 nghisyhlas paegfsvdtn ngtlfttvga malghegpgv vdvvleardh gapgrsaqat
     2461 vhvqlkdqnd hapsftlphy rvavsedlpp gstlltleai dadgsrshat vdysiisgnr
     2521 grvfqleprl aevgdgvgpg pqalgclvll epldfesltq ynltvtaadr gqpprssavp
     2581 vtvtvldvnd nppvftrasy rvtvpedmpv gaellhveas dadpgphglv hftlssgdpl
     2641 glfeldensg alrlahpldc etqaqhqlvv qaadpagthf alvpvtvevq dvndhgpafp
     2701 lsllstslae nqppgtlvtt lhamdgdagt fgrlrytlle avpgpegrea fslnsstgel
     2761 rarvpfdyeh tgsfrllvga adagnlsasv tvsvlitged eydpvflaps fhfqvpegaq
     2821 rghslghvqa tdedggadgl vlyslatssp yfginqttga lylrvdsrap gsgtatsggg
     2881 grtrreapre lrlevvargp lpgsrsatvp vtvdithtal glapdlnlll vgavaaslgv
     2941 vvvlalaalv lglvrarsrk aeaapgpmsq tapiassslq klgreppspp psehlyhqtl
     3001 psyggpgagg pyprggsldp shssgrgsae aaeddeirmi nefprvasva sslaargpds
     3061 giqqdadgls dtsceppapd twykgrkagl llpgagatly reegppatat aflggcglsp
     3121 aptgdygfpa dgkpcvagal taivageeel rgsynwdyll swcpqfqpla svfteiarlk
     3181 dearpcppap ridppplita vahpgaksvp pkpastaatr aifppashrs pishegslss
     3241 aamspsfsps lsplaarspv vspfgvaqgp sasalstesg leppddtelr i
//
