LOCUS       NM_001106110            6788 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus doublecortin domain containing 2 (Dcdc2), mRNA.
ACCESSION   NM_001106110 XM_001070222 XM_225316
VERSION     NM_001106110.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6788)
  AUTHORS   Mascheretti,S., Trezzi,V., Giorda,R., Boivin,M., Plourde,V.,
            Vitaro,F., Brendgen,M., Dionne,G. and Marino,C.
  TITLE     Complex effects of dyslexia risk factors account for ADHD traits:
            evidence from two independent samples
  JOURNAL   J Child Psychol Psychiatry 58 (1), 75-82 (2017)
   PUBMED   27501527
REFERENCE   2  (bases 1 to 6788)
  AUTHORS   Girard,M., Bizet,A.A., Lachaux,A., Gonzales,E., Filhol,E.,
            Collardeau-Frachon,S., Jeanpierre,C., Henry,C., Fabre,M.,
            Viremouneix,L., Galmiche,L., Debray,D., Bole-Feysot,C.,
            Nitschke,P., Pariente,D., Guettier,C., Lyonnet,S., Heidet,L.,
            Bertholet,A., Jacquemin,E., Henrion-Caude,A. and Saunier,S.
  TITLE     DCDC2 Mutations Cause Neonatal Sclerosing Cholangitis
  JOURNAL   Hum Mutat 37 (10), 1025-1029 (2016)
   PUBMED   27319779
REFERENCE   3  (bases 1 to 6788)
  AUTHORS   Che,A., Truong,D.T., Fitch,R.H. and LoTurco,J.J.
  TITLE     Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances
            Glutamatergic Synaptic Transmission Between Layer 4 Neurons in
            Mouse Neocortex
  JOURNAL   Cereb Cortex 26 (9), 3705-3718 (2016)
   PUBMED   26250775
REFERENCE   4  (bases 1 to 6788)
  AUTHORS   Zhang,Y., Li,J., Song,S., Tardif,T., Burmeister,M.,
            Villafuerte,S.M., Su,M., McBride,C. and Shu,H.
  TITLE     Association of DCDC2 Polymorphisms with Normal Variations in
            Reading Abilities in a Chinese Population
  JOURNAL   PLoS One 11 (4), e0153603 (2016)
   PUBMED   27100778
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6788)
  AUTHORS   Grati,M., Chakchouk,I., Ma,Q., Bensaid,M., Desmidt,A., Turki,N.,
            Yan,D., Baanannou,A., Mittal,R., Driss,N., Blanton,S., Farooq,A.,
            Lu,Z., Liu,X.Z. and Masmoudi,S.
  TITLE     A missense mutation in DCDC2 causes human recessive deafness
            DFNB66, likely by interfering with sensory hair cell and supporting
            cell cilia length regulation
  JOURNAL   Hum Mol Genet 24 (9), 2482-2491 (2015)
   PUBMED   25601850
REFERENCE   6  (bases 1 to 6788)
  AUTHORS   Wilcke,A., Weissfuss,J., Kirsten,H., Wolfram,G., Boltze,J. and
            Ahnert,P.
  TITLE     The role of gene DCDC2 in German dyslexics
  JOURNAL   Ann Dyslexia 59 (1), 1-11 (2009)
   PUBMED   19238550
REFERENCE   7  (bases 1 to 6788)
  AUTHORS   Burbridge,T.J., Wang,Y., Volz,A.J., Peschansky,V.J., Lisann,L.,
            Galaburda,A.M., Lo Turco,J.J. and Rosen,G.D.
  TITLE     Postnatal analysis of the effect of embryonic knockdown and
            overexpression of candidate dyslexia susceptibility gene homolog
            Dcdc2 in the rat
  JOURNAL   Neuroscience 152 (3), 723-733 (2008)
   PUBMED   18313856
  REMARK    GeneRIF: These results support the claim that knockdown of Dcdc2
            expression results in neuronal migration disorders similar to those
            seen in the brains of dyslexics.
REFERENCE   8  (bases 1 to 6788)
  AUTHORS   Wang,Y., Paramasivam,M., Thomas,A., Bai,J., Kaminen-Ahola,N.,
            Kere,J., Voskuil,J., Rosen,G.D., Galaburda,A.M. and Loturco,J.J.
  TITLE     DYX1C1 functions in neuronal migration in developing neocortex
  JOURNAL   Neuroscience 143 (2), 515-522 (2006)
   PUBMED   16989952
REFERENCE   9  (bases 1 to 6788)
  AUTHORS   Reiner,O., Coquelle,F.M., Peter,B., Levy,T., Kaplan,A., Sapir,T.,
            Orr,I., Barkai,N., Eichele,G. and Bergmann,S.
  TITLE     The evolving doublecortin (DCX) superfamily
  JOURNAL   BMC Genomics 7, 188 (2006)
   PUBMED   16869982
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6788)
  AUTHORS   Meng,H., Smith,S.D., Hager,K., Held,M., Liu,J., Olson,R.K.,
            Pennington,B.F., DeFries,J.C., Gelernter,J., O'Reilly-Pol,T.,
            Somlo,S., Skudlarski,P., Shaywitz,S.E., Shaywitz,B.A.,
            Marchione,K., Wang,Y., Paramasivam,M., LoTurco,J.J., Page,G.P. and
            Gruen,J.R.
  TITLE     DCDC2 is associated with reading disability and modulates neuronal
            development in the brain
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17053-17058 (2005)
   PUBMED   16278297
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18763]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000017.1.
            
            On Feb 14, 2008 this sequence version replaced NM_001106110.1.
            
            Summary: This gene encodes a member of the doublecortin family. The
            protein encoded by this gene contains two doublecortin domains. The
            doublecortin domain has been demonstrated to bind tubulin and
            enhance microtubule polymerization. Knockdown of this gene
            expression results in neuronal migration disorders similar to those
            seen in the brains of dyslexics. [provided by RefSeq, Sep 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.71894.1,
                                           SRR26643287.33768.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               JAXUCZ010000017.1  40458458-40458790   c
            334-388             JAXUCZ010000017.1  40453573-40453627   c
            389-465             JAXUCZ010000017.1  40406516-40406592   c
            466-597             JAXUCZ010000017.1  40406275-40406406   c
            598-744             JAXUCZ010000017.1  40401861-40402007   c
            745-799             JAXUCZ010000017.1  40399496-40399550   c
            800-959             JAXUCZ010000017.1  40388761-40388920   c
            960-1060            JAXUCZ010000017.1  40307675-40307775   c
            1061-1363           JAXUCZ010000017.1  40282824-40283126   c
            1364-6788           JAXUCZ010000017.1  40274009-40279433   c
FEATURES             Location/Qualifiers
     source          1..6788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..6788
                     /gene="Dcdc2"
                     /note="doublecortin domain containing 2"
                     /db_xref="GeneID:291130"
                     /db_xref="RGD:1310227"
     exon            1..333
                     /gene="Dcdc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1468
                     /gene="Dcdc2"
                     /codon_start=1
                     /product="doublecortin domain-containing protein 2"
                     /protein_id="NP_001099580.2"
                     /db_xref="GeneID:291130"
                     /db_xref="RGD:1310227"
                     /translation="MNGPSPRSSHLSQPVVKSVLVYRNGDPFFAGRRVVIHEKKVSSF
                     DIFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIESGGNYVAGGQEAFKKLNYLDI
                     GEIKKRPMEAVNTEVKPVIHSKINVSARFRKALHEPCTIFLIANGDLISPASRLLIPR
                     KALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKRL
                     PYSELLFDKSAMRRPYGQKASSLPPMVGSRKSKGSGNYRQSKSTIGSSDNSSPQPLKR
                     KGKKDSNSEKPTKVKQSVKSKNSHQAIPDNDEGIFKAGAERSETRGAAEVQEDEDTQV
                     EVPVDQRPAEIVDEEEDGEKTSKDANQKDDFSAMNGEAEDRAGSKVADAPEEEEGIPD
                     QGEKKASPSRVNGGTDEENGEELDQVTEELQPTVDEKGKAEGDNSAQDEAGLDAQRPP
                     RPEVTVTSPQENEGNESNKASSAVA"
     exon            334..388
                     /gene="Dcdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            389..465
                     /gene="Dcdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            466..597
                     /gene="Dcdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..744
                     /gene="Dcdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..799
                     /gene="Dcdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..959
                     /gene="Dcdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1060
                     /gene="Dcdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1363
                     /gene="Dcdc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..6788
                     /gene="Dcdc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggtggac tgcttgaggg cccggcgtcc cgcggggaag atgaacggtc ccagccccag
       61 gtccagccac ctgtcgcagc cggtggtgaa gagtgtgctg gtgtaccgca atggggaccc
      121 gttcttcgcc gggcgccgcg tcgtcattca cgagaagaag gtgtccagct tcgacatctt
      181 cctcaaggaa gtgaccggcg gtgtgcaggc tccctttggg gcagttagga acatctacac
      241 cccgaggacg ggccaccgca tccggaagct ggaccagata gagagcgggg gcaactacgt
      301 ggctgggggc caggaagctt tcaagaaact caactacttg gacataggag aaatcaagaa
      361 aagaccaatg gaagctgtta atactgaggt gaagcctgtc atccacagca aaatcaacgt
      421 gtctgcccga ttcaggaagg cgctgcatga gccctgtacc attttcttga ttgcaaatgg
      481 agacctcata agcccagctt ctcgcctcct catcccaaga aaagctttaa atcagtggga
      541 tcacgtacta caaatggtca cagaaaaaat aactcttcgg agtggggctg tccacaggct
      601 gtatacatta gaaggaaaac tggttgagag tggagcagag ctggagaacg ggcagtttta
      661 tgtggccgtc ggcagagata agtttaagag actaccgtac agtgagttac tttttgacaa
      721 gtcagcaatg agaaggcctt atggtcagaa agcttcttca ctacctccca tggttggatc
      781 caggaagtct aaagggagcg ggaattaccg acaatctaag tcaaccattg gctccagtga
      841 taactcatct cctcagcctc tgaagaggaa agggaagaaa gactcaaatt cagaaaaacc
      901 cacgaaagtg aaacaaagtg tgaagtcgaa gaattcccac caagcaattc cagacaacga
      961 tgaaggcatt ttcaaagctg gagcagagag atctgaaacg aggggggcag cagaagttca
     1021 ggaagatgaa gacactcagg ttgaggtacc agtggaccag aggccagcag aaatagttga
     1081 tgaggaagaa gatggagaga aaacaagcaa agatgccaac cagaaggatg acttttcagc
     1141 aatgaacggt gaggctgaag acagagcggg gagtaaagta gccgatgccc ctgaggagga
     1201 ggagggaatc ccagaccaag gggagaagaa ggcaagtccc tctcgggtaa atggtggcac
     1261 tgacgaagag aatggtgagg aattggacca ggttaccgag gagcttcagc caacagtgga
     1321 tgagaaagga aaggctgaag gagacaacag tgcacaagat gaggctggtt tagatgctca
     1381 aagaccacca agaccagaag tgacagtcac cagccctcaa gagaacgaag ggaatgaatc
     1441 aaacaaagcc tcttctgctg tggcatagat ggtttaaagc agagaatact tgggatgtga
     1501 gagcatgcga agctatgata cttgaataat gagcacagca tctctttatg tagaatatgg
     1561 caatatggtg gagaccctac ctgttgcatt ttaaaaatag aagctacatg aagggaaaga
     1621 ttaggtcatt tgtaactcaa taacttatgt ttatgacagg tgtttaaaaa ttcctttaga
     1681 agaacaaaat aagagagaga cagaggggat ttgtacctta agacagcagt tggctacctg
     1741 tgtttgtaag ggggaagaca tgggctagct cccattagat accttattat agacttggaa
     1801 gcaagaatac tgtcagcttg ttctaaagca tttatctaga aacatataga cttttaaaag
     1861 attggtaata ggaagcatgt attatgttct taaagcaata aactgttgtt gaacaaattg
     1921 caatttagtt tcagagataa tttggagatg gcaatagatc tgaacattct gaagctgatg
     1981 acattccttc cttcctccag ccaaggttca ctctgggtaa agtcagaaca cagcctaaag
     2041 tgtgacctgg tcggaggaaa tgcttctaga gaaccttggt gattcatgac aggtgtgtgg
     2101 gatgtggctg ccatactctc aggcaggagc cagaaagcct gatctagaca gcctgtgggt
     2161 tttcactggt ctgttttcac tgtgtccgtc ctgggaataa agcctttcct tcttctgtat
     2221 gctgttggaa aactcaatag tggttaagat taaattcttt tcctgattta aaaaatgaac
     2281 ttttattaaa cacaaagaaa cagaaaggga agcaaaaagt agaagagttt atgaccatcc
     2341 agttccttag ctactttgtc ttataccacg gttgtcatgg ttgcttagag acattatgtc
     2401 catctgtcca tccactcatc catctgcttg tctgtccatc catctgtctg tcagtccttc
     2461 cacctgccca tgtatctcct aagcttttag actttcaaga gacttttagc ctgtcaagca
     2521 gattctctct ctctttctat atatatatat atatacatat atatatatgt atatagatat
     2581 atatttgaaa gatttccata gcttccactt tcagtttgtg gatagataac taacgtgcat
     2641 ccaccctgtg aggtacagat gaaggaaaaa taattatgtt agtttgatga ccatactatg
     2701 atcatactat ggtgtctctc cctctaaata cagaaataat atttttctca ctttaaggaa
     2761 tatattttta ctcagataga aagtgaaaac tgcaagattt tagattgtag tgcctttgta
     2821 agactcatta ctattgtaag tctattttcc cctccagatt tcacaaccaa ccatctggga
     2881 acaaaatagt tgggagttat atatactaaa gtaatgtaga aaatagatgt atttttttcc
     2941 caaagctatt ttgattcttc catgaataaa agtatgaaca gagcttatga catcatggtg
     3001 tttgagggga tcatgacaca gggcctggga atctgggagg atggacttta actgggtcac
     3061 agtctgggcg gcactttctg tgcacacact tacttttacc acacatggac tgccagcagc
     3121 catcttgcac tgttagcaaa acagagatgc tctccttctg atgtaacatt ccagcatctg
     3181 ggattagatt caaatatctt acaaaagtgg aatataagaa ttttcaacta agtctcaaac
     3241 tgattctctt tctcactgtg aagagtgtgt ctccttaagg aagcatcatt ctttgcccct
     3301 ctccccttca tttcactgtg gcacttgggt ttcaggggct ctcttgccag ctgtcttaat
     3361 gaggcgcaac actgatactt tacatgaaaa ataaactttg agatcataac atttcaagaa
     3421 ggttataggc atagtaacaa tcatagaatg ttgaaataaa tggggacatc atcttctcct
     3481 gtgcatgcat ggggcccaaa catgtgactt aaatcaagat catcttcata tgttgtctag
     3541 acaaatatgt aatcctttac tggggattaa aactgtaggc ataactgtga aggtgacctt
     3601 catagatgtt ggagttcagt tcatatctta aatgtggtgg tctcctctgt ggaaattggg
     3661 tacctatgac aggccaggtc cacatgtaag tgagacttac tgacaaattt gggaattata
     3721 cataaagcac atgtgaatga ggtcttggtg aagggtcatg tatcattcat acgaaggctc
     3781 ctggatatat acctgcaatg tgttgctttg aagtgtcagt tctttgcaat ttcttagttt
     3841 taaattttaa ggacacttat gatcatctgc tgatggaatt ggagcattga tagttttgca
     3901 cttgactaga agtgactttg actaaagtca ccttcagatg agagggatgc gttacatgtt
     3961 ttggcatctg ttgaagccac tgttgcatgt ccatcaactt tctgttacta tgaccacagg
     4021 gcagccccct actctctatg ttttcctggg gtcttgagga gacttgctat ttaagacatt
     4081 tttcttgcac tctattttta aatgtcagaa tgccagactc ataggaagag catgataagg
     4141 tcatgtatcc agtcttattc tatctttatg caccacatca tacatgtggc ttagcatcag
     4201 tcatatatct ctgtgggcat acagttgtga attgatgctg atatctttcc tagggtagtc
     4261 ccagggtagt cccagggaag tcccagggta gtcccagggt aggcctaggg tagccccagt
     4321 gtagtcccag tgtagttcca gtgtagttct agggtagtcc cagagtagtt ctagggtagt
     4381 cctagagtag ggctcaaacc ctagaaactt cagatttttc tctagaggga tggcaagatg
     4441 acttagcagc tgaagtgccc ctaccaaacc taatgtccta tactgtggca tgtacatacc
     4501 aaagccatcc ctaagacaga cagacagact ggcagacaga cagacagact ggcagacaga
     4561 cagacagaca gacagacaca cacacacaca aacgagggga agggaagggg agagagagag
     4621 agagagagag agagagagag agagagagag agagagcgag agcgctaaat aataagtata
     4681 agtgctttgt tttctttagg caatctgctt tatacacaga ggttgaactt ccctggttta
     4741 gagaagataa tgtgcttaaa gcatggctgc tgtaaggcac agcaactccc atctgtaatc
     4801 ccacaacttg gaagctggtg gtagaatcaa gaattaaagg tcagcctagt ttacatggta
     4861 tgtttgaagt taacctttgc aacatgaggc ccctgtctcc aaaacactca tttgaccaac
     4921 caagcaaccc atctacctac ccaccccaag ctaaagctaa acttgccacc acaaaaaaat
     4981 aggaaggatg ttcagtatgt tgctagaagg tatatccatg atgctaacat gtcttgtaaa
     5041 gaatcaactc tacccttcta ctgttgttgt caaagtagca aaagcaaagt aaattaatct
     5101 ccgaggagaa aaccccacat cagaacgggt tccaatcaga agaaaacaca tacccaaaac
     5161 acatgtctat cagtacctcc acgtgtacac tcgtacactc tcaggcatta agaagcactc
     5221 ctcactgctc tgcacagaga aaggctccca cgtggggaga agcagagctg acagtgtgag
     5281 agcaaatagc aagagactac tgttatcagc gtcagtattg ctttactggg acaagagata
     5341 tatttcccca ataagacagt taccagcgtc acttaaagta agcatggtgg catatgacta
     5401 ttactccagt gctccagagg tagaggcaga gggtcagaag ttgaaggtca ttctcagctg
     5461 cactgtgaga tccaggccag tgctagctct aagaggccca tctaaaacaa aaagaggagg
     5521 agatgccaag gttagtttta gttacatttt taaaaatgag ggatgcgcac cttgttgcct
     5581 gaactgataa caggctacta cagtttctgc ggcagcctaa gtaccgtgta gactatttgg
     5641 tggggggagc agggagaaaa tccgggactc ctccttgtat ccagaaacca ggtagaacac
     5701 agagtgactc taatacagtg tcaccccggg caggaaccag tttctgaaga atagtctgct
     5761 tttctaacca gagacactta gcgttctttg tcactgatta gcatgaccac aaacataggc
     5821 tttggctttt gacacatacc ctggtctata gacagctctg gcttttggac tgtatatttt
     5881 gttccatgaa gtttgaaagt caggtgggga atgaaacaat ttctccatat gttgaacaag
     5941 aaagtaagta ttgtttttaa agagatctga aagagatgtg tgattaggag aaaattaaaa
     6001 ataataatga taaaagcact tataaaaccc aaggggacta atggaactct gcccatgtga
     6061 gccaattagc tgccaacttt gctctgaaaa tgtgaccaat gaattctatg ccgcttcatc
     6121 tgctgaaatg gatggcttaa ccgactgctt caggtattgt caaaaaagac gggggaggtt
     6181 ggggtcagcg tcagaggact gcagcagctc tgttgctttc gtgttctccg tacagttccc
     6241 atggctaaca tgcacagact aatgggtaat tcttttaggc attatgtgaa gattaaatta
     6301 agctcatagt ttctgtggca tttgttacat ttagaatgtc tttatgtaag gaaaatatgc
     6361 attttggtca atttatgaga tgtagctttc acttctaaag tgcttgtgca cctgtcctgt
     6421 cctgtgagga ggtgggtgtt ttatgtagta tcatccctgc tcacagtgcc atgtgtcact
     6481 gtgtcacttc atgtgggaaa cctttctgta gatttttcca tgaacatgac agagatgcag
     6541 actcatgaag acacaactca tgagagtgta cctctgtttg gatgtagcat agatgttgag
     6601 ctcattatgt attgttttta caatttatat gcatgtttat ttgataaaaa tcgagatcta
     6661 ttaaaattgc tatttcttta ttgtacgaga tatttttaga gaaccacagg ttccgaggtt
     6721 ttgcaatgct aatggtgtgt attttgtata cagacaacca cggaaataaa tgtatcattt
     6781 tacaaaga
//
