LOCUS       NM_012841               4926 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus DCC netrin 1 receptor (Dcc), mRNA.
ACCESSION   NM_012841
VERSION     NM_012841.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4926)
  AUTHORS   Chua,J.Y., Ng,S.J., Yagensky,O., Wanker,E.E. and Chua,J.J.E.
  TITLE     FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and
            Dendrite Development
  JOURNAL   eNeuro 8 (2) (2021)
   PUBMED   33771901
  REMARK    GeneRIF: FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon
            and Dendrite Development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4926)
  AUTHORS   Wang,X., Chen,Q., Yi,S., Liu,Q., Zhang,R., Wang,P., Qian,T. and
            Li,S.
  TITLE     The microRNAs let-7 and miR-9 down-regulate the axon-guidance genes
            Ntn1 and Dcc during peripheral nerve regeneration
  JOURNAL   J Biol Chem 294 (10), 3489-3500 (2019)
   PUBMED   30626732
  REMARK    GeneRIF: miRs let-7 and miR-9 are involved in regulating neuron
            pathfinding and extend our understanding of the regulatory pathways
            active during peripheral nerve regeneration
            Erratum:[J Biol Chem. 2019 Apr 26;294(17):6695. doi:
            10.1074/jbc.AAC119.008724.. PMID: 31028164]
REFERENCE   3  (bases 1 to 4926)
  AUTHORS   DeGeer,J., Boudeau,J., Schmidt,S., Bedford,F., Lamarche-Vane,N. and
            Debant,A.
  TITLE     Tyrosine phosphorylation of the Rho guanine nucleotide exchange
            factor Trio regulates netrin-1/DCC-mediated cortical axon outgrowth
  JOURNAL   Mol Cell Biol 33 (4), 739-751 (2013)
   PUBMED   23230270
  REMARK    GeneRIF: Trio(Y2622) phosphorylation is essential for the
            regulation of the DCC/Trio signaling complex in cortical neurons
            during netrin-1-mediated axon outgrowth.
REFERENCE   4  (bases 1 to 4926)
  AUTHORS   Horn,K.E., Glasgow,S.D., Gobert,D., Bull,S.J., Luk,T., Girgis,J.,
            Tremblay,M.E., McEachern,D., Bouchard,J.F., Haber,M., Hamel,E.,
            Krimpenfort,P., Murai,K.K., Berns,A., Doucet,G., Chapman,C.A.,
            Ruthazer,E.S. and Kennedy,T.E.
  TITLE     DCC expression by neurons regulates synaptic plasticity in the
            adult brain
  JOURNAL   Cell Rep 3 (1), 173-185 (2013)
   PUBMED   23291093
  REMARK    GeneRIF: DCC activation of Src is required for NMDAR-dependent
            long-term potentiation and certain forms of learning and memory.
REFERENCE   5  (bases 1 to 4926)
  AUTHORS   Huang,C.Y., Chu,D., Hwang,W.C. and Tsaur,M.L.
  TITLE     Coexpression of high-voltage-activated ion channels Kv3.4 and
            Cav1.2 in pioneer axons during pathfinding in the developing rat
            forebrain
  JOURNAL   J Comp Neurol 520 (16), 3650-3672 (2012)
   PUBMED   22473424
REFERENCE   6  (bases 1 to 4926)
  AUTHORS   Keino-Masu,K., Masu,M., Hinck,L., Leonardo,E.D., Chan,S.S.,
            Culotti,J.G. and Tessier-Lavigne,M.
  TITLE     Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
  JOURNAL   Cell 87 (2), 175-185 (1996)
   PUBMED   8861902
REFERENCE   7  (bases 1 to 4926)
  AUTHORS   Miyake,S., Nagai,K., Yoshino,K., Oto,M., Endo,M. and Yuasa,Y.
  TITLE     Point mutations and allelic deletion of tumor suppressor gene DCC
            in human esophageal squamous cell carcinomas and their relation to
            metastasis
  JOURNAL   Cancer Res 54 (11), 3007-3010 (1994)
   PUBMED   8187090
REFERENCE   8  (bases 1 to 4926)
  AUTHORS   Cho,K.R., Oliner,J.D., Simons,J.W., Hedrick,L., Fearon,E.R.,
            Preisinger,A.C., Hedge,P., Silverman,G.A. and Vogelstein,B.
  TITLE     The DCC gene: structural analysis and mutations in colorectal
            carcinomas
  JOURNAL   Genomics 19 (3), 525-531 (1994)
   PUBMED   8188295
REFERENCE   9  (bases 1 to 4926)
  AUTHORS   Fearon,E.R., Cho,K.R., Nigro,J.M., Kern,S.E., Simons,J.W.,
            Ruppert,J.M., Hamilton,S.R., Preisinger,A.C., Thomas,G.,
            Kinzler,K.W. et al.
  TITLE     Identification of a chromosome 18q gene that is altered in
            colorectal cancers
  JOURNAL   Science 247 (4938), 49-56 (1990)
   PUBMED   2294591
REFERENCE   10 (bases 1 to 4926)
  AUTHORS   Tanaka,S., Tamura,K. and Mizuno,Y.
  TITLE     [Clinical consideration with special reference to autopsy cases of
            malignant tumor in the oral cavity, treated with Bleomycin
            (author's transl)]
  JOURNAL   Hiroshima Daigaku Shigaku Zasshi 8 (2), 168-175 (1975)
   PUBMED   69641
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012841.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U68725.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-423               JAXUCZ010000018.1  68247252-68247674   c
            424-744             JAXUCZ010000018.1  67848436-67848756   c
            745-1029            JAXUCZ010000018.1  67723156-67723440   c
            1030-1180           JAXUCZ010000018.1  67701584-67701734   c
            1181-1317           JAXUCZ010000018.1  67699300-67699436   c
            1318-1472           JAXUCZ010000018.1  67571552-67571706   c
            1473-1593           JAXUCZ010000018.1  67568768-67568888   c
            1594-1750           JAXUCZ010000018.1  67483626-67483782   c
            1751-1905           JAXUCZ010000018.1  67460666-67460820   c
            1906-2054           JAXUCZ010000018.1  67435054-67435202   c
            2055-2193           JAXUCZ010000018.1  67433864-67434002   c
            2194-2243           JAXUCZ010000018.1  67427801-67427850   c
            2244-2385           JAXUCZ010000018.1  67342528-67342669   c
            2386-2496           JAXUCZ010000018.1  67332727-67332837   c
            2497-2691           JAXUCZ010000018.1  67306725-67306919   c
            2692-2787           JAXUCZ010000018.1  67271474-67271569   c
            2788-3020           JAXUCZ010000018.1  67266386-67266618   c
            3021-3159           JAXUCZ010000018.1  67262141-67262279   c
            3160-3267           JAXUCZ010000018.1  67257849-67257956   c
            3268-3462           JAXUCZ010000018.1  67254167-67254361   c
            3463-3495           JAXUCZ010000018.1  67248889-67248921   c
            3496-3561           JAXUCZ010000018.1  67229859-67229924   c
            3562-3724           JAXUCZ010000018.1  67223092-67223254   c
            3725-3951           JAXUCZ010000018.1  67212774-67213000   c
            3952-4068           JAXUCZ010000018.1  67207703-67207819   c
            4069-4224           JAXUCZ010000018.1  67192369-67192524   c
            4225-4437           JAXUCZ010000018.1  67185732-67185944   c
            4438-4580           JAXUCZ010000018.1  67152544-67152686   c
            4581-4926           JAXUCZ010000018.1  67149179-67149524   c
FEATURES             Location/Qualifiers
     source          1..4926
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1-q12.2"
     gene            1..4926
                     /gene="Dcc"
                     /note="DCC netrin 1 receptor"
                     /db_xref="GeneID:25311"
                     /db_xref="RGD:2492"
     exon            1..423
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..4670
                     /gene="Dcc"
                     /note="colorectal tumor suppressor; netrin receptor DCC;
                     deleted in colorectal carcinoma; tumor suppressor protein
                     DCC; putative colorectal tumor suppressor"
                     /codon_start=1
                     /product="netrin receptor DCC precursor"
                     /protein_id="NP_036973.1"
                     /db_xref="GeneID:25311"
                     /db_xref="RGD:2492"
                     /translation="MENSLGCVWVPKLAFVLFGASLLSAHLQVTGFQIKPFTSLHFVS
                     EPSDAVTMRGGNVLLNCSAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSLLIQNI
                     LHSRHHKPDEGLYQCEASLGDSGSIISRTAKVMVAGPLRFLSQTESITAFMGDTVLLK
                     CEVIGDPMPTIHWQKNQQDLNPIPGDSRVVVLPSGALQISRLQPGDSGVYRCSARNPA
                     STRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRG
                     EEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAELTVLVPPWFL
                     NHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVK
                     SDEGFYQCVAENEAGNAQSSAQLIVPKPAIPSSSILPSAPRDVVPVLVSSRFVRLSWR
                     PPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEW
                     GPGESSQPIKVATQPELQVPGPVENLHAVSASPTSILITWEPPAYANGPVQGYRLFCT
                     EVSTGKEQNIEVDGLSYKLEGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSA
                     PPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYL
                     FTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNC
                     IIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKA
                     FNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGVQAVALT
                     HEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNT
                     MYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLE
                     ANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNAKGV
                     GPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHG
                     SVTPQKNSNLLVITVVTVGVLTVLVVVIVAVICTRRSSAQQRKKRATHSASKRKGSQK
                     DLRPPDLWIHHEEMEMKNIEKPAGTDPAGRGSPIQSCQDLTPVSHSQSESQMGSKSAS
                     HSGQDTEEAGSSMSTLERSLAARRATRTKLMIPMEAQSNNPAVVSAIPVPTLESAQYP
                     GILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRTVSEGPTAQQQPMLPPAQPEHPS
                     SEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVK
                     TASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQ
                     LNAITGSAF"
     exon            424..744
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1029
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1180
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1317
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1472
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1593
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1750
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1905
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2054
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2193
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2243
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2385
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2496
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2691
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2787
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..3020
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3159
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3267
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3462
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3495
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3561
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3724
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..3951
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4068
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4224
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4437
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            4438..4580
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
     exon            4581..4926
                     /gene="Dcc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagctgtc tcccctttgc tcgctctctc tgcttccttg agttagttct ccaaggtgtt
       61 accggggttc gggtgctctt ggaccgaatg gaactttttg ctgcctcgtc ttgctgctga
      121 ttgtgtccct ggacaagaaa aaaaggcttc gcaggcaaaa gaggcgcagg ggaggtggag
      181 aaagaggtgg aggaagagga cgaggaggaa gaggaggagg aagcctaagg ggctcggcgc
      241 gggtgtgtgc atgtgtgcat gcgtgtgtga gtgcatgtgt gtgagtgcca ccgctgccca
      301 ggacccccgg ccccgaaggt gttggctgaa atatggagaa tagtcttgga tgtgtctggg
      361 tacccaagct ggcttttgta ctcttcggag cttccttgct cagcgcgcat cttcaagtca
      421 cgggtttcca aattaaacct ttcacgtcac ttcattttgt gtctgaacct tctgatgctg
      481 tcacaatgcg gggaggaaac gtcctgctca actgctctgc agagtctgac cgcggagtcc
      541 cagtcatcaa gtggaagaaa gatggcctta tcctggcctt gggaatggat gacagaaagc
      601 agcaacttcc taatgggtct ctgttgatac aaaacatact tcattccaga caccataaac
      661 cggatgaagg actttaccaa tgcgaggcat ccttaggaga ctctggctca attattagtc
      721 ggacagcaaa agttatggta gcaggaccac tgaggttcct ctcccagaca gaatctatca
      781 cagccttcat gggagataca gtgttactta agtgtgaagt cattggggac cccatgccaa
      841 caatacactg gcagaagaat caacaagacc tcaacccgat cccaggagac tcgcgtgtgg
      901 tcgtcttgcc ctccggagca ttgcagatca gccgacttca accaggagac agtggagtct
      961 accgatgctc agctcggaat ccagccagca caagaacagg aaatgaagcc gaagtcagga
     1021 ttttatcaga cccaggcctg cataggcagc tgtattttct gcagagacca tccaatgtga
     1081 tagccattga agggaaagat gctgtcctgg agtgttgtgt ttctggctat cctccaccaa
     1141 gtttcacctg gttacggggc gaggaggtca tccaactcag gtctaaaaag tattcgttgt
     1201 tgggtgggag caatttgctc atctctaatg tgacagatga tgacagtggg acctatacgt
     1261 gcgttgtcac atataagaat gagaatatta gtgcctctgc agagctcacg gtcttggttc
     1321 cgccatggtt tttaaatcac ccttccaacc tctatgccta tgaaagcatg gacattgagt
     1381 ttgaatgtgc agtgtccggg aagcctgtgc ccactgtgaa ttggatgaag aatggagatg
     1441 tggtgattcc tagtgattac tttcagatag tgggaggaag caacttacga atccttgggg
     1501 tggtgaaatc agatgaaggc ttttatcaat gtgtggctga aaatgaggct ggcaatgccc
     1561 aaagtagtgc ccagctgatt gtccccaagc ctgccatccc aagctccagc atcctccctt
     1621 ctgctcccag agatgtggtc cctgtcttgg tttctagtcg ctttgtccgt ttgagctggc
     1681 gtccacctgc cgaagccaaa ggaaacattc aaacattcac agtctttttc tccagagagg
     1741 gtgacaacag ggagcgagct ttgaatacaa cccagcctgg gtcccttcag cttactgtgg
     1801 gaaacttgaa accagaagcc atgtatacct tcagagttgt tgcctacaat gagtggggac
     1861 caggggagag ctctcaaccc atcaaggtgg ccactcagcc tgagttgcaa gttccagggc
     1921 cagtagaaaa cctgcacgct gtatctgcct ctcctacctc aattcttatt acatgggaac
     1981 cccctgccta tgcaaatggt ccggttcaag gttacagatt gttttgcact gaggtgtcta
     2041 caggaaaaga acagaatata gaggttgatg gactatctta taaactggaa ggcctgaaaa
     2101 aattcacgga atatactctt cgattccttg cttataatcg ttatggtccg ggagtgtcta
     2161 ccgatgacat aacagtcgtt acactttcag atgtgccaag tgctccacct cagaacgtct
     2221 ctctggaagt ggttaattca aggagtatca aagtaagctg gctccctcct ccatcgggaa
     2281 cacaaaatgg atttattact ggctataaaa ttcgacacag aaagactacc cgcaggggtg
     2341 agatggaaac actggaaccc aataacctct ggtacctctt cacaggattg gagaagggga
     2401 gtcagtacag tttccaagtg tcagccatga ctgtcaatgg cactggacca ccttctaact
     2461 ggtacacagc agaaacccca gagaacgact tagacgagtc tcaagttcct gaccagccaa
     2521 gttctctcca tgtgaggccc cagacaaact gcatcatcat gagttggact ccacctctca
     2581 acccaaacat cgtggtgaga ggctatatta tcggatatgg tgttggcagc ccttatgccg
     2641 agacagtgcg tgtagacagt aagcagcggt actattccat cgagaggctg gagtcgagtt
     2701 ctcattatgt aatctcctta aaagctttca acaatgctgg agaaggtgtc cctctctacg
     2761 aaagtgccac tacccgttcc ataacagacc ccactgaccc cgttgattat tatcctttgc
     2821 ttgatgattt ccccacctcg ggcccagatg tctccacccc catgctccca ccagtaggtg
     2881 tgcaggctgt ggctcttacc cacgaggctg tgagggtcag ctgggcagac aactctgtcc
     2941 cgaagaacca gaagacatcc gacgttcggc tttacacggt tcggtggagg accagctttt
     3001 ccgccagtgc caagtacaag tcagaagaca caacgtctct cagctacaca gcgactggcc
     3061 tcaagccaaa taccatgtat gagttctcag tcatggtgac aaagaacaga aggtcaagca
     3121 cgtggagcat gactgcacac gccaccacct acgaagctgc cccaacttct gctcccaagg
     3181 atttgacagt cattactcgt gaggggaagc ctcgtgctgt cattgtgagc tggcagcctc
     3241 ccttggaagc caatgggaaa atcaccgctt acatcttgtt ttataccttg gacaagaata
     3301 tacccatcga tgactggatt atggagacta tcagcggtga ccggcttacc catcagatca
     3361 tggatctgag cctggacact atgtattact ttcgaattca agcacggaac gctaaaggcg
     3421 tggggcccct ctcggatccc atcctcttca ggactttgaa agtggaacac cctgacaaaa
     3481 tggctaatga ccaaggtcgt catggagatg gaggttattg gccagttgat actaacttga
     3541 ttgatagaag cactctcaac gaaccaccca ttggacaaat gcacccccca catggcagtg
     3601 taactcctca aaagaacagc aacctgcttg tcataaccgt ggtcaccgtg ggcgttctca
     3661 ccgtgttggt tgtggtcatt gtagcagtga tttgtacccg gcgctcttca gcccagcaaa
     3721 ggaagaaacg ggccacgcac agtgcgagca agaggaaggg cagtcagaag gacctccggc
     3781 ctccggatct ttggatacat catgaagaaa tggaaatgaa aaatatcgag aagccggccg
     3841 gaaccgaccc tgcaggaaga ggctccccca tccagagttg ccaagacctc acaccagtca
     3901 gccacagcca gtcagaaagc cagatgggaa gcaaaagtgc ctcccattca ggtcaagata
     3961 ccgaggaggc agggagctcc atgtctactc tagaaaggtc ccttgcagca cgccgggcca
     4021 ccaggaccaa gctcatgatt cccatggagg cccagtccaa taatcctgct gtcgtgagtg
     4081 ccatccctgt accaacccta gaaagtgccc agtatccagg aatcctcccg tctcccacat
     4141 gtggatatcc gcatccacag ttcactctcc ggccagtacc attcccaaca ctgtctgtgg
     4201 accgaggttt cggagcagga agaactgtga gtgaaggacc aacagcacaa caacaaccca
     4261 tgctgccccc agctcagcct gaacatccca gcagcgaaga agcccccagc agaaccatcc
     4321 ctacagcctg tgtgcggcca actcacccac tccgaagttt tgcaaaccct ttgctacctc
     4381 cacctatgag tgcaatagaa ccaaaagtcc cttacacacc gcttttgtcg cagccaggac
     4441 ccacccttcc caagactcat gttaaaacgg cctcccttgg gctagcagga aaggcaaggt
     4501 cccctttgct tcccgtgtct gtgccaacag cccctgaagt gtctgaagag agtcacaagc
     4561 caacagagga tccagccagt gtatatgaac aggatgactt gagtgaacaa atggcgagtt
     4621 tggaagggct aatgaagcaa ctcaatgcca tcacaggctc cgccttttga catgcattgc
     4681 caaaccgttg agatcttctg ggaactttac agcataccaa ttatccataa acagcacacc
     4741 tgtgtccaaa aactctaaac cagtgtacag gtccaccatc tggaccatcc agttaagaaa
     4801 catctgaagc acttcagaag aaatctgtaa cccatcctag atggacatca ggaatcaaaa
     4861 caaagatggt catgaggtcc cgaagatgca tcttaactac aaagtcaagg ctgaagctgc
     4921 ctgcag
//
