LOCUS       NP_001014253             591 aa            linear   ROD 02-MAY-2024
DEFINITION  DDB1- and CUL4-associated factor 8 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001014253 XP_344174
VERSION     NP_001014253.1
DBSOURCE    REFSEQ: accession NM_001014231.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 591)
  AUTHORS   Wu,F., Wang,S., Xing,J., Li,M. and Zheng,C.
  TITLE     Characterization of nuclear import and export signals determining
            the subcellular localization of WD repeat-containing protein 42A
            (WDR42A)
  JOURNAL   FEBS Lett 586 (8), 1079-1085 (2012)
   PUBMED   22500989
REFERENCE   2  (residues 1 to 591)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 20, 2005 this sequence version replaced XP_344174.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085957.1, SRR26360186.901292.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     Protein         1..591
                     /product="DDB1- and CUL4-associated factor 8 isoform 1"
                     /note="WD repeat-containing protein 42A; WD repeat domain
                     42A"
                     /calculated_mol_wt=66025
     Region          1..140
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Site            22
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Region          39..50
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:Q5TAQ9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Site            99
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Site            123
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Site            124
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Region          183..500
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          185..224
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Site            order(186,204,208,214..215,228..229,249,253,259..260,
                     275..276,294,299,305..306,322,343,347,353..354,373..374,
                     398,402,408..409,424..425,445,450,456..457,469..470,489,
                     493,499..500)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          192..228
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Site            198
                     /site_type="methylation"
                     /note="Omega-N-methylarginine, by PRMT1.
                     /evidence=ECO:0000250|UniProtKB:Q5TAQ9; propagated from
                     UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Region          228..269
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Region          234..275
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          275..315
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Region          280..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          323..363
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Region          329..377
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          379..418
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Region          384..423
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          426..466
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Region          431..468
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          470..509
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2M6.1)"
     Region          475..499
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          552..591
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2M6.1)"
     CDS             1..591
                     /gene="Dcaf8"
                     /gene_synonym="RGD1308513; Wdr42a"
                     /coded_by="NM_001014231.2:302..2077"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:364050"
                     /db_xref="RGD:1308513"
ORIGIN      
        1 msskrpstdg rrdlangsls sspeemsgae egretssgie veasdlslsl tgddggpnrt
       61 stesrgtdte ssgeekdsds medtghysin denrvhghsd eeeeeeqprh rvqrkrasrd
      121 qdssdderal edwvssetta lprprwqalp alrerelgss arfvyeacga rvfvqrfrlq
      181 hgleghtgcv ntlhfnqrgt wlasgsddlk vvvwdwvrrq pvldfesghk snvfqakflp
      241 nsgdstlamc ardgqvrvae lsatqccknt krvaqhkgas hklalepdsp ctflsageda
      301 vvftidlrqd rpasklvvtk ekekkvglyt iyvnpanthq favggrdqfv riydqrkide
      361 nenngvlkkf cphhlvnses kanitclvys hdgtellasy ndediylfns shsdgaqyik
      421 rykghrnnat vkgvnfygpk sefvvsgsdc ghiflwekss cqiiqfmegd kggvvnclep
      481 hphlpvlats gldhdvkiwa ptaeastelt glkdvikknk rerdedslhh tdlfdshmlw
      541 flmhhlrqrr hhrrwrepgv gatdadsdes psssdtsdee egpdrvqcmp s
//
