LOCUS       NM_001107162            2225 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus DDB1 and CUL4 associated factor 15 (Dcaf15),
            mRNA.
ACCESSION   NM_001107162 XM_001068441 XM_222457
VERSION     NM_001107162.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2225)
  AUTHORS   Faust TB, Yoon H, Nowak RP, Donovan KA, Li Z, Cai Q, Eleuteri NA,
            Zhang T, Gray NS and Fischer ES.
  TITLE     Structural complementarity facilitates E7820-mediated degradation
            of RBM39 by DCAF15
  JOURNAL   Nat Chem Biol 16 (1), 7-14 (2020)
   PUBMED   31686031
REFERENCE   2  (bases 1 to 2225)
  AUTHORS   Pech MF, Fong LE, Villalta JE, Chan LJ, Kharbanda S, O'Brien JJ,
            McAllister FE, Firestone AJ, Jan CH and Settleman J.
  TITLE     Systematic identification of cancer cell vulnerabilities to natural
            killer cell-mediated immune surveillance
  JOURNAL   Elife 8, e47362 (2019)
   PUBMED   31452512
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2225)
  AUTHORS   Uehara T, Minoshima Y, Sagane K, Sugi NH, Mitsuhashi KO, Yamamoto
            N, Kamiyama H, Takahashi K, Kotake Y, Uesugi M, Yokoi A, Inoue A,
            Yoshida T, Mabuchi M, Tanaka A and Owa T.
  TITLE     Selective degradation of splicing factor CAPERalpha by anticancer
            sulfonamides
  JOURNAL   Nat Chem Biol 13 (6), 675-680 (2017)
   PUBMED   28437394
REFERENCE   4  (bases 1 to 2225)
  AUTHORS   Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y,
            Williams NS and Nijhawan D.
  TITLE     Anticancer sulfonamides target splicing by inducing RBM39
            degradation via recruitment to DCAF15
  JOURNAL   Science 356 (6336) (2017)
   PUBMED   28302793
  REMARK    Erratum:[Science. 2017 May 26;356(6340):null. PMID: 28546157]
REFERENCE   5  (bases 1 to 2225)
  AUTHORS   Jin J, Arias EE, Chen J, Harper JW and Walter JC.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_222457.4, XM_001068441.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2225
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /note="DDB1 and CUL4 associated factor 15"
                     /db_xref="GeneID:304653"
                     /db_xref="RGD:1304881"
     exon            1..166
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1834
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 15"
                     /protein_id="NP_001100632.1"
                     /db_xref="GeneID:304653"
                     /db_xref="RGD:1304881"
                     /translation="MAPSSKSERNSGAGSAGGGPGGTGGKRAVGRRREHVLKQLERVK
                     ISGQLSPRLFRKLPPRVCVSLKNIVDEDFLYAGHIFLGFSKCGRYVLSYTSSSGDDDF
                     SFYIYHLYWWEFNVHSKLKLVRQVRLFQDEEIYSDLYLTVCEWPSDASKVIVFGFNTR
                     SANGMLMNMMMMSDENHRDIYISTVAVPPRGRCAACQDASRAHPGDPSAQCLQHGFML
                     HTKYQVVYPFPTFQPAFQLKKDQVVLLNTSYSLVACAVSVHSAGDSSFCQILYDHTAL
                     PPAPPSSPGPWSPEAPAFPSLGVEVAPAQPSGAPEPSPAIAKAKEFVADIFRRAKEAK
                     GSVLEEARLPSGLGPSNSRCRPSLELPAPSGEVVPRASPPAAEPTAPEPGYINYTKLH
                     YVLQSGEGTEPEDEFEDDKISLPFVVTDLRGRNLRPMRERTDMQGQYLTVEQLTLDFE
                     YVINEVIRHDATWGHQFCSFSDYDIVILEVCPETNQVLINIGLLLLAFPAPTEEGQLR
                     PKTYHTSLKVAWDLNTGIFETVSVGDLTEVKGQTSGSVWSSYRKSCVDMVMKWLVPES
                     SGRYVNRMTNEALHKGCSLKVLADSERYTWIVL"
     exon            167..264
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
     exon            265..400
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
     exon            401..507
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
     exon            508..647
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
     exon            648..818
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1250
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1342
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1471
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1557
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1662
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1778
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..2225
                     /gene="Dcaf15"
                     /gene_synonym="RGD1304881"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggttgctc cggaagtgga ggaagggggt gaaaatggcg cccagctcga aatcggagcg
       61 gaacagcggg gccgggagcg ccggcggcgg ccctgggggc accggaggga agcgggccgt
      121 ggggcggcgg cgggaacacg ttctcaagca gctggagcga gtcaagatca gtgggcagct
      181 ctcacctcgt cttttccgga agctaccccc cagggtctgt gtgtccctca agaacatcgt
      241 agacgaggac tttctctacg caggccatat cttcctggga ttttccaagt gtggccgcta
      301 tgtcctctcc tacaccagca gcagtgggga tgacgacttc tccttctaca tatatcacct
      361 ctactggtgg gagttcaacg tccacagcaa gctcaagctg gtccggcagg tgcggctctt
      421 ccaggatgag gagatctaca gtgacctgta cctgaccgtg tgtgagtggc ctagcgacgc
      481 ttccaaggtc atcgtgtttg gtttcaacac ccgctcagcc aacgggatgc tcatgaacat
      541 gatgatgatg agcgatgaga accatcgtga catctacatc agcactgtgg ctgtgccacc
      601 tcggggccgc tgtgctgcct gccaggatgc cagtcgtgcc cacccagggg acccaagcgc
      661 acagtgcctg cagcatggct tcatgctgca caccaaatac caggtggtgt accctttccc
      721 cacctttcaa cccgccttcc aactcaagaa ggatcaggtg gtgctgctca acaccagcta
      781 ctctctggtg gcctgcgctg tctccgtcca ctcagcaggt gacagcagtt tctgccaaat
      841 cctgtatgac cacacagctt tgccccccgc cccacccagt tctccaggac cttggagccc
      901 tgaggctcct gccttcccca gccttggtgt tgaagtggcc ccagcccagc cctctggagc
      961 ccctgagccc tcaccagcca ttgccaaggc caaggagttt gtggctgaca tcttccgcag
     1021 ggccaaagag gccaagggta gtgtcttgga ggaagctcgg ctgccctctg gtttggggcc
     1081 ctcaaacagc cgctgccgcc catctttaga gctgccagcc ccaagtgggg aagtggtacc
     1141 cagggccagc cctcctgctg cagagcccac agccccggag cctggctaca tcaattacac
     1201 caagctgcac tatgtgttac agtctgggga agggacagag cctgaggatg agtttgagga
     1261 tgacaagatc tctctaccct ttgtggtaac tgatctccgc ggccgcaact tacggcccat
     1321 gcgagagcgg acagacatgc agggccagta cctgacagtg gagcagctta cactggactt
     1381 cgagtatgtc atcaatgagg ttatccgcca cgatgccact tggggtcacc agttctgctc
     1441 tttcagtgac tatgacatag tcatcctgga ggtctgccca gaaaccaacc aggtcctgat
     1501 caacattggc ctgctgctct tggccttccc agctcccact gaagagggcc agcttcgacc
     1561 aaagacgtat cacaccagtc tcaaagtggc ctgggacctc aacacgggca tctttgagac
     1621 agtcagcgtg ggtgatctaa ctgaggtcaa aggacagacc agtggcagtg tctggagctc
     1681 ctaccgaaag agctgcgtgg acatggtcat gaagtggctg gtgccagaga gcagtggccg
     1741 ctatgtgaac aggatgacta acgaggcact gcacaaaggg tgctcactga aggttctggc
     1801 agacagtgag cggtacactt ggattgtgct gtgagggctg gactgccctg gaccctgact
     1861 ccaactacct ccacggcccg gagggagagg accaccttcc tgggctggcc ctacgagggt
     1921 cacaaccggc actagtgtta ggttgcggga tgggactggt gcagcagcct ctggtggccc
     1981 gagagtctgg atgtgtcttt atttatgcct atttaagttg ggaaagggca gagagaggag
     2041 ccccttaggc ctggcctgcc ccagcgcagc ctagtcctgc tccctgtgct ccagcccttt
     2101 tccttggctg caagtgtagc cctctaggag gccagtggtt ccagcctccc tcacctaggg
     2161 tgggaaccct gtggccactt cgccttgttc ctcatgtact aaatgcttta tttctgacct
     2221 ggctg
//
