LOCUS       NM_012543               1660 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus D-box binding PAR bZIP transcription factor
            (Dbp), transcript variant 1, mRNA.
ACCESSION   NM_012543
VERSION     NM_012543.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1660)
  AUTHORS   Jiang,H., Li,J., He,X., Xue,J., Liang,S., Liu,S., Gao,F., Qu,N.,
            Liu,H. and Chen,L.
  TITLE     D-site binding protein regulates cell proliferation through
            mediating cell cycle progression in rat mesangial cells
  JOURNAL   Tissue Cell 61, 35-43 (2019)
   PUBMED   31759405
  REMARK    GeneRIF: DBP effectively inhibits the proliferation of mesangial
            cells through G1 phase arrest.
REFERENCE   2  (bases 1 to 1660)
  AUTHORS   Harbour,V.L., Weigl,Y., Robinson,B. and Amir,S.
  TITLE     Phase differences in expression of circadian clock genes in the
            central nucleus of the amygdala, dentate gyrus, and suprachiasmatic
            nucleus in the rat
  JOURNAL   PLoS One 9 (7), e103309 (2014)
   PUBMED   25068868
  REMARK    GeneRIF: Data show that the expression of clock genes Per2, Bmal1
            and Dbp follow a diurnal rhythm in the central nucleus of the
            amygdala, dentate gyrus, and suprachiasmatic nucleu but the phase
            and amplitude of the rhythms of each gene vary across the 3
            regions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1660)
  AUTHORS   Huang,X.M., Chen,W.L., Yuan,J.P., Yang,Y.H., Mei,Q.H. and
            Huang,L.X.
  TITLE     Altered diurnal variation and localization of clock proteins in the
            remnant kidney of 5/6 nephrectomy rats
  JOURNAL   Nephrology (Carlton) 18 (8), 555-562 (2013)
   PUBMED   23738784
  REMARK    GeneRIF: The localization and diurnal variation of BMAL1, DBP and
            PER2 are changed in remnant kidney of 5/6 nephrectomy rats and are
            involved in diurnal rhythm of renal function.
REFERENCE   4  (bases 1 to 1660)
  AUTHORS   Yamajuku,D., Shibata,Y., Kitazawa,M., Katakura,T., Urata,H.,
            Kojima,T., Takayasu,S., Nakata,O. and Hashimoto,S.
  TITLE     Cellular DBP and E4BP4 proteins are critical for determining the
            period length of the circadian oscillator
  JOURNAL   FEBS Lett 585 (14), 2217-2222 (2011)
   PUBMED   21635892
  REMARK    GeneRIF: Data show that knockdown of DBP, D-box positive regulator,
            led to a short-period phenotype, and overexpression of DBP produced
            a long-period rhythm, while knockdown and overexpression of E4BP4,
            D-box negative regulator, had the opposite effect of DBP.
REFERENCE   5  (bases 1 to 1660)
  AUTHORS   Xu,Z., Kaga,S., Tsubomizu,J., Fujisaki,J., Mochiduki,A., Sakai,T.,
            Tsukamura,H., Maeda,K., Inoue,K. and Adachi,A.A.
  TITLE     Circadian transcriptional factor DBP regulates expression of Kiss1
            in the anteroventral periventricular nucleus
  JOURNAL   Mol Cell Endocrinol 339 (1-2), 90-97 (2011)
   PUBMED   21458520
  REMARK    GeneRIF: Dbp and estrogen regulate the expression of Kiss1 in the
            anteroventral periventricular nucleus
REFERENCE   6  (bases 1 to 1660)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 1660)
  AUTHORS   Brown,S.A., Zumbrunn,G., Fleury-Olela,F., Preitner,N. and
            Schibler,U.
  TITLE     Rhythms of mammalian body temperature can sustain peripheral
            circadian clocks
  JOURNAL   Curr Biol 12 (18), 1574-1583 (2002)
   PUBMED   12372249
  REMARK    GeneRIF: natural body temperature rhythms can affect circadian gene
            expression
REFERENCE   8  (bases 1 to 1660)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   9  (bases 1 to 1660)
  AUTHORS   Brown,S.A. and Schibler,U.
  TITLE     The ins and outs of circadian timekeeping
  JOURNAL   Curr Opin Genet Dev 9 (5), 588-594 (1999)
   PUBMED   10508692
  REMARK    Review article
REFERENCE   10 (bases 1 to 1660)
  AUTHORS   Mueller,C.R., Maire,P. and Schibler,U.
  TITLE     DBP, a liver-enriched transcriptional activator, is expressed late
            in ontogeny and its tissue specificity is determined
            posttranscriptionally
  JOURNAL   Cell 61 (2), 279-291 (1990)
   PUBMED   2331750
  REMARK    Erratum:[Cell. 1991 May 31;65(5):915.. PMID: 2040017]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 18, 2014 this sequence version replaced NM_012543.2.
            
            Summary: The protein encoded by this gene is a member of the Par
            bZIP transcription factor family and binds to specific sequences in
            the promoters of several genes, such as albumin, Cyp2a4, and
            Cyp2a5. The encoded protein can bind DNA as a homo- or heterodimer
            and is involved in the regulation of some circadian rhythym genes.
            Three transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087668.1, J03179.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               JAXUCZ010000001.1  105312256-105312795
            541-951             JAXUCZ010000001.1  105313638-105314048
            952-1163            JAXUCZ010000001.1  105315292-105315503
            1164-1660           JAXUCZ010000001.1  105316709-105317205
FEATURES             Location/Qualifiers
     source          1..1660
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1660
                     /gene="Dbp"
                     /note="D-box binding PAR bZIP transcription factor"
                     /db_xref="GeneID:24309"
                     /db_xref="RGD:2491"
     exon            1..540
                     /gene="Dbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..1379
                     /gene="Dbp"
                     /note="isoform 1 is encoded by transcript variant 1; d
                     site-binding protein; albumin D box-binding protein;
                     albumin D-element-binding protein; d site albumin
                     promoter-binding protein 1; D site albumin promoter
                     binding protein; D site of albumin promoter (albumin
                     D-box) binding protein"
                     /codon_start=1
                     /product="D site-binding protein isoform 1"
                     /protein_id="NP_036675.1"
                     /db_xref="GeneID:24309"
                     /db_xref="RGD:2491"
                     /translation="MARPLSDRTPGPLLLGGPAGAPPGGGALLGLRSLLQGNSKPKEP
                     ASCLLKEKERKATLPSAPVPGPVLETAGPADAPTGAVSGGGSPRGRSGPVAGPSLFAP
                     LLWERTLPFGDVEYVDLDAFLLEHGLPPSPPPPGGLSPAPSPARTPAPSPGPGSCSSS
                     SPRSSPGHAPARATLGAAGGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIP
                     GHETFDPRRHRFSEEELKPQPIMKKARKVQVPEEQKDEKYWSRRYKNNEAAKRSRDAR
                     RLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGTL"
     exon            541..951
                     /gene="Dbp"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1163
                     /gene="Dbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1660
                     /gene="Dbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggtgcaca cctctgggtg cagattgcaa agctcctttc tttgcgagaa gtgcaaaatt
       61 ggctagagcc agagtctcgc ccacctggta cagaaggagc gcgcgcctgt gtcccttggg
      121 gacccacagt tgcaaagaga cagctgcttg atttggtcac ccactcgccc agactatagg
      181 agcctcccgg gacactcttg agttgcacct ttctgcagag cagactgttt gagcccccgc
      241 agtgctcgta ggatttgaag cgttctgata ctggaggctt gctcgccgcg ctcgcccgac
      301 tctgggacac attcgtccga gccacaggag tgtgcgggtg actgacatat catctcttcg
      361 actctccatg agctcatgaa cctgggagca ggtgcccgga aatggcgcgg cctctgagcg
      421 acaggacccc gggccccctg ctgctgggtg gcccggctgg ggccccccct ggcgggggag
      481 cgctgcttgg gctgaggagc cttctgcagg gaaacagcaa gcccaaagaa ccggccagct
      541 gtctcctgaa ggaaaaggag cgcaaggcaa ctctgccctc agcccccgtc ccgggacccg
      601 tcctggaaac ggcgggccca gcggatgccc caactggggc ggttagtggc ggtgggtccc
      661 ctcgggggcg ctcagggcct gtggctggcc cgagtctttt tgcgccgctg ctgtgggaac
      721 gcactttgcc tttcggggac gtggaatacg tggacctgga cgccttcttg ctggagcacg
      781 ggctaccgcc gagcccgccg ccccccgggg gcctgtcgcc ggcaccctct ccagcgcgca
      841 ctcccgcgcc ctcccccggg cccggctctt gcagctcctc ttccccccgc tcctcgcccg
      901 ggcacgcccc cgcgcgggcc actctgggag ccgccggcgg ccaccgcgca ggcttgacct
      961 ctagggacac acccagtcct gtggacccag acaccgtgga ggtgctaatg acctttgaac
     1021 ctgatccggc tgatcttgcc ctgtcaagca ttccaggcca tgagactttt gaccctcgga
     1081 ggcaccgctt ctcagaggag gaattgaagc ctcagccaat catgaagaag gcaaggaaag
     1141 tccaggtgcc cgaggaacag aaggatgaga agtactggag ccggaggtac aagaacaatg
     1201 aagcagccaa gaggtcgaga gacgcaagaa gactcaagga gaaccagata tctgtgcggg
     1261 cagccttcct ggagaaggaa aacgccctat tgcggcagga ggtggtggct gtgcggcagg
     1321 agctgtccca ctaccgtgct gtgctttcac gctaccaggc ccaacacggg acactgtgag
     1381 gccacttcca ccctgccagg gcagagtcct gttccttgtt cagacttaca cctgacaccc
     1441 cccttcctcc ttgtcccatg gccaatggtc tggccagcta ggtgcccagg aacgtcatga
     1501 tgcagacaaa tacatttata tttttaagaa aaagctagcc ttcccccacc tcccttgtgg
     1561 gggtggggag ggtcctgtgt gcacttttag cacgtcgagg aacccatcca tccaaccgcc
     1621 tccatcaaca caatcctgaa taaatcttga gaacccagga
//
