LOCUS       NM_031024               2679 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus drebrin 1 (Dbn1), mRNA.
ACCESSION   NM_031024
VERSION     NM_031024.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2679)
  AUTHORS   Poobalasingam,T., Bianco,F., Oozeer,F. and Gordon-Weeks,P.R.
  TITLE     The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive
            neuritogenesis in embryonic cortical neurons
  JOURNAL   J Neurochem 160 (2), 185-202 (2022)
   PUBMED   34478582
  REMARK    GeneRIF: The drebrin/EB3 pathway regulates cytoskeletal dynamics to
            drive neuritogenesis in embryonic cortical neurons.
REFERENCE   2  (bases 1 to 2679)
  AUTHORS   Yao,N., Li,J., Liu,H., Wan,J., Liu,W. and Zhang,M.
  TITLE     The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic
            Sequestering Mechanism of ZMYND8 by Drebrin
  JOURNAL   Structure 25 (11), 1657-1666 (2017)
   PUBMED   28966017
REFERENCE   3  (bases 1 to 2679)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2679)
  AUTHORS   Chen,H., Li,M.W.M. and Yan Cheng,C.
  TITLE     Drebrin and Spermatogenesis
  JOURNAL   Adv Exp Med Biol 1006, 291-312 (2017)
   PUBMED   28865027
  REMARK    GeneRIF: These data are carefully evaluated in light of other
            recent findings herein regarding the role of drebrin in actin
            filament organization at the ES.
REFERENCE   5  (bases 1 to 2679)
  AUTHORS   Shirao,T., Koganezawa,N., Yamazaki,H., Hanamura,K. and Imamura,K.
  TITLE     Localization of Drebrin: Light Microscopy Study
  JOURNAL   Adv Exp Med Biol 1006, 105-118 (2017)
   PUBMED   28865017
  REMARK    GeneRIF: In the adult brain, drebrin is mainly localized in
            dendritic spines, but in some nuclei, drebrin can be detected in
            neuronal somata as well as dendritic spines. The fact that the
            developmental changes in drebrin expression highly correlate in
            time with the sensitive period of visual cortical plasticity in
            kittens suggests that synaptic plasticity depends on drebrin.
            Review article
REFERENCE   6  (bases 1 to 2679)
  AUTHORS   Sasaki,Y., Hayashi,K., Shirao,T., Ishikawa,R. and Kohama,K.
  TITLE     Inhibition by drebrin of the actin-bundling activity of brain
            fascin, a protein localized in filopodia of growth cones
  JOURNAL   J Neurochem 66 (3), 980-988 (1996)
   PUBMED   8769857
REFERENCE   7  (bases 1 to 2679)
  AUTHORS   Harigaya,Y., Shoji,M., Shirao,T. and Hirai,S.
  TITLE     Disappearance of actin-binding protein, drebrin, from hippocampal
            synapses in Alzheimer's disease
  JOURNAL   J Neurosci Res 43 (1), 87-92 (1996)
   PUBMED   8838578
REFERENCE   8  (bases 1 to 2679)
  AUTHORS   Saruki,N.
  TITLE     [The changes of central nervous synapses after transient cerebral
            ischemia]
  JOURNAL   Masui 44 (12), 1639-1647 (1995)
   PUBMED   8583659
REFERENCE   9  (bases 1 to 2679)
  AUTHORS   Ikeda,K., Shirao,T., Toda,M., Asada,H., Toya,S. and Uyemura,K.
  TITLE     Effect of a neuron-specific actin-binding protein, drebrin A, on
            cell-substratum adhesion
  JOURNAL   Neurosci Lett 194 (3), 197-200 (1995)
   PUBMED   7478237
REFERENCE   10 (bases 1 to 2679)
  AUTHORS   Shirao,T., Kojima,N. and Obata,K.
  TITLE     Cloning of drebrin A and induction of neurite-like processes in
            drebrin-transfected cells
  JOURNAL   Neuroreport 3 (1), 109-112 (1992)
   PUBMED   1611026
  REMARK    Erratum:[Neuroreport 1992 Mar;3(3):following 285]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031024.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59267.1, SRR26360194.2027069.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000017.1  9155856-9155994
            140-195             JAXUCZ010000017.1  9160374-9160429
            196-308             JAXUCZ010000017.1  9161008-9161120
            309-383             JAXUCZ010000017.1  9161323-9161397
            384-530             JAXUCZ010000017.1  9161516-9161662
            531-608             JAXUCZ010000017.1  9161815-9161892
            609-760             JAXUCZ010000017.1  9162119-9162270
            761-824             JAXUCZ010000017.1  9162348-9162411
            825-884             JAXUCZ010000017.1  9165922-9165981
            885-1008            JAXUCZ010000017.1  9166078-9166201
            1009-1146           JAXUCZ010000017.1  9166968-9167105
            1147-1317           JAXUCZ010000017.1  9167424-9167594
            1318-2000           JAXUCZ010000017.1  9168008-9168690
            2001-2106           JAXUCZ010000017.1  9168981-9169086
            2107-2679           JAXUCZ010000017.1  9169256-9169828
FEATURES             Location/Qualifiers
     source          1..2679
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2679
                     /gene="Dbn1"
                     /note="drebrin 1"
                     /db_xref="GeneID:81653"
                     /db_xref="RGD:70885"
     exon            1..139
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..2177
                     /gene="Dbn1"
                     /note="developmentally-regulated brain protein; drebrin E"
                     /codon_start=1
                     /product="drebrin"
                     /protein_id="NP_112286.1"
                     /db_xref="GeneID:81653"
                     /db_xref="RGD:70885"
                     /translation="MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLA
                     ASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHV
                     AKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVG
                     TTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDARLRFEQERMEQERQEQ
                     EERERRYREREQQIEEHRRKQQSLEAEEAKRRLKDQSIFGDQRDEEEESQMKKSESEV
                     EEAAAIIAQRPDNPREFFRQQERVASASGGSCDAPSPFNHRPGRPYCPFIKASDSGPS
                     SSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTAST
                     PITEQIERALDEVTSSQPPPPPPPPPPAQEAQESAPRLDGEEVCKEAKVAAAPQVWAG
                     CAEEPPRAQEPPLLQSSPTEDLMCTESPEQAVLAASPEPDASVTSVADAHAADTIETT
                     TATTATTIADNVTPAAASLIDLWPGNGEEASTPQAEPRVPTPPSGAEASLAEVPLLNE
                     AAQEPLPPVGEGCANLLNFDELPEPPATFCDPEEEAEGEPLAASQVLTMPSALEEVDQ
                     VLEQELEPEPHLLTNGETTQKEGTQQASEGYFSQSQEEEFAQSEEPCAKAPPPVFYNK
                     PPEIDITCWDADPVPEEEEGFEGGD"
     exon            140..195
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            196..308
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..383
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..530
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..608
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..760
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..824
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..884
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1008
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1146
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1317
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..2000
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2106
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2679
                     /gene="Dbn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggtccgc ccgtgcgtgc gtctgtccgt tcggcctccg tccggcccgc agcatggccg
       61 gcgtcagctt cagcggccac cgcctggagc tgctggcggc gtacgaggag gtgatccggg
      121 aggagagtgc agccgactgg gctctgtaca cttacgaaga tggctcagat gacctcaagc
      181 ttgcagcatc aggagaagga ggcttgcagg agctttcagg ccacttcgag aaccagaaag
      241 tgatgtacgg tttctgcagc gtcaaggact cccaggctgc cttgccaaaa tatgtgctca
      301 tcaactgggt tggtgaggat gtgcctgatg cccgaaaatg tgcttgtgcc agccatgtgg
      361 ccaaggtggc tgaattcttc cagggcgttg acgtaattgt gaatgccagc agtgtggagg
      421 atatcgatgc tggcgccatt gggcagcggc tctccaatgg actggctcgg ctctctagcc
      481 cagtgctgca ccgcctgcgc cttcgggagg atgagaatgc tgagccggtg ggcaccacct
      541 accagaagac ggatgcggcc gtggagatga agcggattaa ccgtgagcag ttttgggagc
      601 aggccaagaa ggaggaggag ctgcggaagg aggaggagcg gaagaaggct ttggacgcca
      661 ggctcaggtt tgagcaggag cggatggagc aggagcggca ggagcaggag gaacgggaac
      721 ggcgctaccg agagcgggag cagcagatcg aggagcacag gaggaaacag cagagtctgg
      781 aagctgaaga ggccaagagg aggttaaagg atcagtctat ctttggtgat cagcgagatg
      841 aagaggaaga gtcccagatg aagaagtcgg aatctgaggt ggaggaggca gctgccatca
      901 ttgcccagcg gcctgataac ccacgggagt tcttcagaca gcaggaacga gtggcttcag
      961 cctctggtgg cagctgtgac gcaccctcgc ccttcaacca ccgaccaggt cgtccgtact
     1021 gccctttcat aaaggcatcg gacagtgggc cttcctcctc ctcctcttcc tcctcttccc
     1081 ctccacggac tccctttccc tatatcacct gccaccgcac cccaaacctc tcttcctccc
     1141 tcccatgcag tcacctggac agccaccgga ggatggcgcc cactcccatt cccacccgga
     1201 gcccatctga ttccagcaca gcctccaccc ccatcacgga gcagatcgag agggccctgg
     1261 atgaggtcac atcctcgcag cctccacccc cacctccacc acccccacca gctcaagagg
     1321 cccaggagtc tgctcccaga ctggacggtg aagaggtctg caaggaggcc aaagtagcag
     1381 cagctcctca ggtctgggct ggctgtgcag aggagcctcc tcgggcacag gaacctcccc
     1441 tgttgcaaag cagccccacg gaggacttga tgtgcacaga atctcctgag caggctgtcc
     1501 tggcggcctc tccagagcct gatgcctctg tcacctcagt agctgatgct catgcagctg
     1561 acaccatcga gaccaccact gccactactg ccaccactat tgccgacaac gtcacccctg
     1621 ccgccgccag cctcattgat ctgtggcctg gtaacgggga agaggcctca acgcctcagg
     1681 ctgaacccag ggtgcccacc ccaccctcag gtgctgaggc ctccctggca gaggtgcctc
     1741 tgttgaatga ggcagctcag gagccgctgc caccagtggg cgaaggctgt gccaaccttc
     1801 ttaatttcga tgagctgcca gaacctccag ccaccttctg tgacccagag gaggaagccg
     1861 aaggagagcc gctggctgcc tcccaggtcc taactatgcc ctcagcccta gaggaggtag
     1921 atcaggtgtt ggagcaggag ttggagccag aacctcatct gctgaccaat ggagagacca
     1981 ctcagaagga ggggacccag caggccagcg aaggatactt cagtcagtca caggaggaag
     2041 aattcgccca atcagaagag ccatgtgcaa aggctccacc tcctgtattc tacaacaagc
     2101 ctccagaaat cgacatcacc tgctgggatg cagacccagt tcctgaagag gaagagggct
     2161 tcgagggtgg tgattagtag tggcgactgc cccctggctg ccctcgccaa ggctgcccac
     2221 ctgcagtggc ctctggccag ccggcttgca gcgccagcat tagcagcagc cccgcctggc
     2281 tcccactctg gattccggca ctggccgggg acctgtctgc ttctctaccc acagggcctg
     2341 acttttacag cttttctctt ttttttaaaa gttgatagac ttgtacaatt gactggtttt
     2401 cctcccgttg gtagttgaaa caatgttgca gattccaccc ccttcctgcc cagaccagat
     2461 tgtagcttag tccttcctgc tcagctgacc agggtggagg cctcaccctg cttgggacct
     2521 ggtgggggtc gggggttctg gtgggaaaat gttccccccc atcacttttc ctagttttat
     2581 gtttcttgga aaaaaaatat cactttgtat tctctatcca gggcttcaga tattttgcac
     2641 gaaatttaaa acatggcaat aaatggctcg tgggctctg
//
