LOCUS       NM_031853                593 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus diazepam binding inhibitor (Dbi), mRNA.
ACCESSION   NM_031853 XM_001055495
VERSION     NM_031853.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 593)
  AUTHORS   Bourzam,A., Hamdi,Y., Bahdoudi,S., Duraisamy,K., El Mehdi,M.,
            Basille-Dugay,M., Dlimi,O., Kharrat,M., Vejux,A., Lizard,G.,
            Ghrairi,T., Lefranc,B., Vaudry,D., Boutin,J.A., Leprince,J. and
            Masmoudi-Kouki,O.
  TITLE     Octadecaneuropeptide, ODN, Promotes Cell Survival against
            6-OHDA-Induced Oxidative Stress and Apoptosis by Modulating the
            Expression of miR-34b, miR-29a, and miR-21in Cultured Astrocytes
  JOURNAL   Cells 13 (14), 1188 (2024)
   PUBMED   39056770
  REMARK    GeneRIF: Octadecaneuropeptide, ODN, Promotes Cell Survival against
            6-OHDA-Induced Oxidative Stress and Apoptosis by Modulating the
            Expression of miR-34b, miR-29a, and miR-21in Cultured Astrocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 593)
  AUTHORS   Ghouili,I., Bahdoudi,S., Morin,F., Amri,F., Hamdi,Y., Coly,P.M.,
            Walet-Balieu,M.L., Leprince,J., Zekri,S., Vaudry,H., Vaudry,D.,
            Castel,H., Amri,M., Tonon,M.C. and Masmoudi-Kouki,O.
  TITLE     Endogenous Expression of ODN-Related Peptides in Astrocytes
            Contributes to Cell Protection Against Oxidative Stress:
            Astrocyte-Neuron Crosstalk Relevance for Neuronal Survival
  JOURNAL   Mol Neurobiol 55 (6), 4596-4611 (2018)
   PUBMED   28698967
  REMARK    GeneRIF: astrocytes produce authentic ODN, notably in a moderate
            oxidative stress situation, and this glio- and neuro-protective
            agent may form part of the brain defense mechanisms against
            oxidative stress injury.
REFERENCE   3  (bases 1 to 593)
  AUTHORS   Yoshihara,E., Iwahashi,K., Waga,C., Murayama,O., Ohtani,N.,
            Narita,S., Nagahori,K., Numajiri,M. and Onozawa,Y.
  TITLE     Relationship between alcohol dependence and the DBI rs2276596 (C/A)
            polymorphism in Japanese
  JOURNAL   Nihon Arukoru Yakubutsu Igakkai Zasshi 49 (1), 39-44 (2014)
   PUBMED   24818357
REFERENCE   4  (bases 1 to 593)
  AUTHORS   Lanfray,D., Arthaud,S., Ouellet,J., Compere,V., Do Rego,J.L.,
            Leprince,J., Lefranc,B., Castel,H., Bouchard,C.,
            Monge-Roffarello,B., Richard,D., Pelletier,G., Vaudry,H.,
            Tonon,M.C. and Morin,F.
  TITLE     Gliotransmission and brain glucose sensing: critical role of
            endozepines
  JOURNAL   Diabetes 62 (3), 801-810 (2013)
   PUBMED   23160530
  REMARK    GeneRIF: Data suggest that neuroglia play important role in glucose
            sensing in hypothalamus and may regulate energy balance/appetite
            control through production/secretion of endozepines (diazepam
            binding inhibitor and processing product, octadecaneuropeptide).
REFERENCE   5  (bases 1 to 593)
  AUTHORS   Ludewig,A.H., Nitz,I., Klapper,M. and Doring,F.
  TITLE     Identification of a novel human Acyl-CoA binding protein isoform
            with a unique C-terminal domain
  JOURNAL   IUBMB Life 63 (7), 547-552 (2011)
   PUBMED   21698759
REFERENCE   6  (bases 1 to 593)
  AUTHORS   Mandrup,S., Hummel,R., Ravn,S., Jensen,G., Andreasen,P.H.,
            Gregersen,N., Knudsen,J. and Kristiansen,K.
  TITLE     Acyl-CoA-binding protein/diazepam-binding inhibitor gene and
            pseudogenes. A typical housekeeping gene family
  JOURNAL   J Mol Biol 228 (3), 1011-1022 (1992)
   PUBMED   1469708
REFERENCE   7  (bases 1 to 593)
  AUTHORS   Slobodyansky,E., Guidotti,A., Wambebe,C., Berkovich,A. and Costa,E.
  TITLE     Isolation and characterization of a rat brain
            triakontatetraneuropeptide, a posttranslational product of diazepam
            binding inhibitor: specific action at the Ro 5-4864 recognition
            site
  JOURNAL   J Neurochem 53 (4), 1276-1284 (1989)
   PUBMED   2769267
REFERENCE   8  (bases 1 to 593)
  AUTHORS   Knudsen,J., Hojrup,P., Hansen,H.O., Hansen,H.F. and Roepstorff,P.
  TITLE     Acyl-CoA-binding protein in the rat. Purification, binding
            characteristics, tissue concentrations and amino acid sequence
  JOURNAL   Biochem J 262 (2), 513-519 (1989)
   PUBMED   2803267
REFERENCE   9  (bases 1 to 593)
  AUTHORS   Gray,P.W.
  TITLE     Molecular biology of diazepam binding inhibitor
  JOURNAL   Neuropharmacology 26 (7B), 863-865 (1987)
   PUBMED   2821429
REFERENCE   10 (bases 1 to 593)
  AUTHORS   Ferrero,P., Santi,M.R., Conti-Tronconi,B., Costa,E. and Guidotti,A.
  TITLE     Study of an octadecaneuropeptide derived from diazepam binding
            inhibitor (DBI): biological activity and presence in rat brain
  JOURNAL   Proc Natl Acad Sci U S A 83 (3), 827-831 (1986)
   PUBMED   3456171
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1986 Apr;83(8):2776. doi:
            10.1073/pnas.83.8.2776.. PMID: 3458238]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M14201.1 and BC084717.1.
            
            On Feb 9, 2008 this sequence version replaced NM_031853.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M14201.1, CF977190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132294, SAMD00132297
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               M14201.1           1-113
            114-593             BC084717.1         1-480
FEATURES             Location/Qualifiers
     source          1..593
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q11"
     gene            1..593
                     /gene="Dbi"
                     /gene_synonym="Acbp; Acoabp3; Ep; Odn; RNACOABP3; Ttn"
                     /note="diazepam binding inhibitor"
                     /db_xref="GeneID:25045"
                     /db_xref="RGD:2490"
     exon            1..126
                     /gene="Dbi"
                     /gene_synonym="Acbp; Acoabp3; Ep; Odn; RNACOABP3; Ttn"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..381
                     /gene="Dbi"
                     /gene_synonym="Acbp; Acoabp3; Ep; Odn; RNACOABP3; Ttn"
                     /EC_number="3.4.17.3"
                     /note="GABA receptor modulator; diazepam binding
                     inhibitor-like; octadecaneuropeptide; endozepine;
                     triakontatetraneuropeptide; LRRGT00046; diazepam binding
                     inhibitor (GABA receptor modulator, acyl-CoA binding
                     protein); diazepam binding inhibitor (GABA receptor
                     modulator, acyl-Coenzyme A binding protein); Diazepam
                     binding inhibitor (GABA receptor modulator, acyl-Coenxyme
                     A binding protein); diazepam binding inhibitor, acyl-CoA
                     binding protein"
                     /codon_start=1
                     /product="acyl-CoA-binding protein"
                     /protein_id="NP_114054.1"
                     /db_xref="GeneID:25045"
                     /db_xref="RGD:2490"
                     /translation="MSQADFDKAAEEVKRLKTQPTDEEMLFIYSHFKQATVGDVNTDR
                     PGLLDLKGKAKWDSWNKLKGTSKENAMKTYVEKVEELKKKYGI"
     exon            127..244
                     /gene="Dbi"
                     /gene_synonym="Acbp; Acoabp3; Ep; Odn; RNACOABP3; Ttn"
                     /inference="alignment:Splign:2.1.0"
     exon            245..307
                     /gene="Dbi"
                     /gene_synonym="Acbp; Acoabp3; Ep; Odn; RNACOABP3; Ttn"
                     /inference="alignment:Splign:2.1.0"
     exon            308..566
                     /gene="Dbi"
                     /gene_synonym="Acbp; Acoabp3; Ep; Odn; RNACOABP3; Ttn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtaggaac gcgggggttg tgcttttaaa ggcgctagcc ggtacgctct ggaacttgat
       61 tgcttccctc ttctgagctt gctcccgcgc tttcagcatc caggtcacct cgccagtatg
      121 tctcaggctg atttcgacaa agccgctgag gaggtgaagc gcctcaagac tcagccaact
      181 gatgaagaga tgctgttcat ctacagccac ttcaaacaag ctactgtggg cgatgtaaac
      241 acagatcggc cggggctgtt ggacctcaag ggcaaagcca agtgggactc gtggaacaag
      301 ctgaaaggaa cttccaagga aaatgccatg aagacctatg tggaaaaggt agaagagcta
      361 aagaagaaat atggaatata aacgaccaga tttggtggcc agccacatgt gtgacataat
      421 acctgtgagg acataatgcc ttggtgtttt ttttttttct aatgtagatg acatggctct
      481 gatatgttag ggccagagtt aattactgct cctccttcct ttggagtttt tacctgaaat
      541 caattaaaag tacatttgtt actctaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
