LOCUS       NM_013158               2252 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus dopamine beta-hydroxylase (Dbh), mRNA.
ACCESSION   NM_013158
VERSION     NM_013158.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2252)
  AUTHORS   Kato,K., Fushuku,S. and Yamamoto,Y.
  TITLE     Age-related changes in immunoreactivity for dopamine
            beta-hydroxylase in carotid body glomus cells in spontaneously
            hypertensive rats
  JOURNAL   Auton Neurosci 205, 50-56 (2017)
   PUBMED   28473232
  REMARK    GeneRIF: Study revealed age-related changes in tyrosine hydroxylase
            and DBH immunoreactivities in the carotid body glomus cells of
            spontaneously hypertensive (SHR/Izm) and Wistar Kyoto (WKY/Izm)
            rats at 4, 8, 12, and 16 weeks of age using immunohistochemistry.
            DBH age-dependently increased in the glomus cells of SHR/Izm in
            contrast to WKY/Izm.
REFERENCE   2  (bases 1 to 2252)
  AUTHORS   Murtazina,A.R., Nikishina,Y.O., Bondarenko,N.S., Sapronova,A.Y.,
            Volina,E.V. and Ugrumov,M.V.
  TITLE     Gene expression and content of enzymes of noradrenaline synthesis
            in the rat organ of Zuckerkandl at the critical period of
            morphogenesis
  JOURNAL   Dokl Biochem Biophys 474 (1), 200-203 (2017)
   PUBMED   28726094
  REMARK    GeneRIF: tyrosine hydroxylase and dopamine beta-hydroxylase-was
            evaluated in the organ of Zuckerkandl of rats in the critical
            period of morphogenesis
REFERENCE   3  (bases 1 to 2252)
  AUTHORS   Pravenec,M., Landa,V., Zidek,V., Mlejnek,P., Silhavy,J., Mir,S.A.,
            Vaingankar,S.M., Wang,J. and Kurtz,T.W.
  TITLE     Effects of transgenic expression of dopamine beta hydroxylase (Dbh)
            gene on blood pressure in spontaneously hypertensive rats
  JOURNAL   Physiol Res 65 (6), 1039-1044 (2016)
   PUBMED   27959576
  REMARK    GeneRIF: genetically determined decreases in adrenal expression and
            activity of DBH do not represent primary determinants of increased
            blood pressure in the SHR model
REFERENCE   4  (bases 1 to 2252)
  AUTHORS   Cubells,J.F., Schroeder,J.P., Barrie,E.S., Manvich,D.F., Sadee,W.,
            Berg,T., Mercer,K., Stowe,T.A., Liles,L.C., Squires,K.E.,
            Mezher,A., Curtin,P., Perdomo,D.L., Szot,P. and Weinshenker,D.
  TITLE     Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully
            Rescues Noradrenergic Function in Dopamine beta-Hydroxylase
            Knockout Mice
  JOURNAL   PLoS One 11 (5), e0154864 (2016)
   PUBMED   27148966
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2252)
  AUTHORS   Vendelboe,T.V., Harris,P., Zhao,Y., Walter,T.S., Harlos,K., El
            Omari,K. and Christensen,H.E.
  TITLE     The crystal structure of human dopamine beta-hydroxylase at 2.9 A
            resolution
  JOURNAL   Sci Adv 2 (4), e1500980 (2016)
   PUBMED   27152332
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2252)
  AUTHORS   Thomas,S.A. and Palmiter,R.D.
  TITLE     Thermoregulatory and metabolic phenotypes of mice lacking
            noradrenaline and adrenaline
  JOURNAL   Nature 387 (6628), 94-97 (1997)
   PUBMED   9139828
REFERENCE   7  (bases 1 to 2252)
  AUTHORS   Thomas,S.A., Matsumoto,A.M. and Palmiter,R.D.
  TITLE     Noradrenaline is essential for mouse fetal development
  JOURNAL   Nature 374 (6523), 643-646 (1995)
   PUBMED   7715704
REFERENCE   8  (bases 1 to 2252)
  AUTHORS   Kobayashi,K., Morita,S., Mizuguchi,T., Sawada,H., Yamada,K.,
            Nagatsu,I., Fujita,K. and Nagatsu,T.
  TITLE     Functional and high level expression of human dopamine
            beta-hydroxylase in transgenic mice
  JOURNAL   J Biol Chem 269 (47), 29725-29731 (1994)
   PUBMED   7961964
REFERENCE   9  (bases 1 to 2252)
  AUTHORS   McMahon,A., Geertman,R. and Sabban,E.L.
  TITLE     Rat dopamine beta-hydroxylase: molecular cloning and
            characterization of the cDNA and regulation of the mRNA by
            reserpine
  JOURNAL   J Neurosci Res 25 (3), 395-404 (1990)
   PUBMED   2325165
REFERENCE   10 (bases 1 to 2252)
  AUTHORS   Lamouroux,A., Vigny,A., Faucon Biguet,N., Darmon,M.C., Franck,R.,
            Henry,J.P. and Mallet,J.
  TITLE     The primary structure of human dopamine-beta-hydroxylase: insights
            into the relationship between the soluble and the membrane-bound
            forms of the enzyme
  JOURNAL   EMBO J 6 (13), 3931-3937 (1987)
   PUBMED   3443096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013158.2.
            
            Sequence Note: This sequence has been modified as follows: removed
            34 bp suspected to be vector contamination from the 3' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.10847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050745, SAMN17050746
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               JAXUCZ010000003.1  30886328-30886681
            355-501             JAXUCZ010000003.1  30888860-30889006
            502-759             JAXUCZ010000003.1  30890853-30891110
            760-936             JAXUCZ010000003.1  30891817-30891993
            937-1039            JAXUCZ010000003.1  30893020-30893122
            1040-1206           JAXUCZ010000003.1  30895001-30895167
            1207-1350           JAXUCZ010000003.1  30897437-30897580
            1351-1389           JAXUCZ010000003.1  30897854-30897892
            1390-1449           JAXUCZ010000003.1  30898276-30898335
            1450-1577           JAXUCZ010000003.1  30901067-30901194
            1578-1737           JAXUCZ010000003.1  30901591-30901750
            1738-2252           JAXUCZ010000003.1  30902799-30903313
FEATURES             Location/Qualifiers
     source          1..2252
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..2252
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /note="dopamine beta-hydroxylase"
                     /db_xref="GeneID:25699"
                     /db_xref="RGD:2489"
     exon            1..354
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1872
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /EC_number="1.14.17.1"
                     /note="dopamine beta-monooxygenase; Dopamine beta
                     hydroxylase (dopamine beta-monooxygenase)"
                     /codon_start=1
                     /product="dopamine beta-hydroxylase precursor"
                     /protein_id="NP_037290.3"
                     /db_xref="GeneID:25699"
                     /db_xref="RGD:2489"
                     /translation="MQPHLSHQPCWSLPSPSVREAASMYGTAVAIFLVILVAALQGSE
                     PPESPFPYHIPLDPEGTLELSWNVSYDQEIIHFQLQVQGPRAGVLFGMSDRGEMENAD
                     LVMLWTDGDRTYFADAWSDQKGQIHLDTHQDYQLLQAQRVSNSLSLLFKRPFVTCDPK
                     DYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQQVQLLKPEVSTPAMPADVQTMD
                     IRAPDVLIPSTETTYWCYITELPLHFPRHHIIMYEAIVTEGNEALVHHMEVFQCTNES
                     EAFPMFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGVPFGGSGSSRFLRLE
                     VHYHNPRNIQGRRDSSGIRLHYTASLRPNEAGIMELGLVYTPLMAIPPQETTFVLTGY
                     CTDRCTQMALPKSGIRIFASQLHTHLTGRKVITVLARDGQQREVVNRDNHYSPHFQEI
                     RMLKNAVTVHQGDVLITSCTYNTENRTMATVGGFGILEEMCVNYVHYYPKTELELCKS
                     AVDDGFLQKYFHIVNRFGNEEVCTCPQASVPQQFASVPWNSFNRDMLKALYNYAPISV
                     HCNKTSAVRFPGNWNLQPLPKITSAVEEPDPRCPIRQTRGPAGPFVVITTEADTE"
     exon            355..501
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /inference="alignment:Splign:2.1.0"
     exon            502..759
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /inference="alignment:Splign:2.1.0"
     exon            760..936
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1039
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1206
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1350
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1389
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1449
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1577
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1737
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..2252
                     /gene="Dbh"
                     /gene_synonym="DOPBHY"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagccatgc agcctcacct cagccaccag ccttgctgga gcctccccag ccccagcgtc
       61 cgtgaggcgg cttccatgta tggcactgct gtggccatct tcctggtcat cctggtggct
      121 gcactgcagg gctcggagcc tccggagagc cccttccctt accacatccc cctggaccct
      181 gaagggactt tagagctctc gtggaacgtc agctatgacc aggagatcat ccacttccag
      241 ctccaggtgc aagggccgag ggctggggtc ctgttcggaa tgtcggatcg aggtgagatg
      301 gagaacgcag acctcgtcat gctctggact gacggggaca ggacctactt tgcggacgcc
      361 tggagtgacc agaaagggca gatccatctg gatacccatc aggactacca gctgctccag
      421 gcacagaggg tgtcaaacag cctatccctg ctcttcaaga ggccctttgt cacctgcgac
      481 cccaaggatt atgtcattga ggatgacact gtccatctag tgtatgggat cctggaggag
      541 ccattccagt ccctggaggc catcaacacc tcaggcctac atacgggact acagcaggtg
      601 cagcttctga agcctgaggt ctccactcca gccatgcctg cggatgtaca aaccatggat
      661 atccgggctc ctgacgtcct catccccagc actgagacca catactggtg ctatatcact
      721 gagctacccc tacacttccc ccgacaccac atcatcatgt atgaggccat tgtcacggag
      781 ggcaatgagg ccctggtgca ccacatggag gtcttccaat gtacaaatga gtctgaggcc
      841 ttccccatgt tcaacggacc ctgcgactcc aagatgaaac ctgacagact caactactgt
      901 cgccacgtgc tggcggcatg ggccctgggc gccaaggcat tttactaccc agaagaagcc
      961 ggtgtcccct ttgggggctc aggatcctcc cggtttctcc gactggaagt tcattaccac
     1021 aatccacgga atatacaagg ccggcgcgac tcctctggca tccgtctaca ctacacagct
     1081 agtctccgac ccaatgaggc aggcatcatg gagcttggac tggtgtacac gcccttgatg
     1141 gccatccccc ctcaggagac cacctttgtt ttgactggct actgcacaga caggtgcacc
     1201 cagatggcac tgccgaaatc tggaatccgc atctttgcct cacagctcca cacgcacctg
     1261 accggcagga aggtgattac tgtgctcgcc agggatggcc aacagaggga agtggtgaac
     1321 agagacaacc actacagccc ccactttcag gagatcagaa tgctgaagaa tgctgtgact
     1381 gtccaccagg gggatgtcct catcacttcg tgcacataca acacagaaaa caggacaatg
     1441 gccacagtgg gggggtttgg aatcttggag gagatgtgcg tcaactacgt ccactactac
     1501 cccaaaacag agctggagct ctgcaagagt gccgtggatg atggcttcct gcagaaatac
     1561 ttccacatag taaaccggtt cggcaatgag gaggtctgca cctgccctca ggcctctgtc
     1621 ccccagcagt tcgcctctgt gccctggaac tctttcaatc gtgatatgct caaggctttg
     1681 tataactatg cccctatctc tgtgcactgt aacaagacct ctgccgtccg cttcccgggt
     1741 aactggaacc tgcagcctct gcctaagatc acttccgcag tggaagaacc cgacccacgc
     1801 tgccccatcc gacagactcg gggacccgcc ggccccttcg ttgtcatcac cacggaggca
     1861 gacactgagt aattgttctt cagcctctcc tcgttttgtc cctactgggc tcactccagc
     1921 tctgcgcacc ccacatgaag acccccttcc atagaatagt gctgttcacc taggaggaag
     1981 ggggtatcac cttggagaca cctgcacggc tgcatcccat gaggtctgac tggacagagc
     2041 agctctggac atcatcactg ctggctccac agagggacaa ctcaatgtgg gagtccagat
     2101 tcaactccac aggacctccc ttgcctccag aacagcctta ccaggctggg tgcagacttc
     2161 ccaagcctca cagtcctgac cctgttggcc ctctggtggt aacttgtgtt ggtgtatgcc
     2221 atgacaacac tgtttaaata gtcctttgca ga
//
