LOCUS       NM_080891               2483 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus death-domain associated protein (Daxx), mRNA.
ACCESSION   NM_080891
VERSION     NM_080891.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2483)
  AUTHORS   Chen,C., Sun,X., Xie,W., Chen,S., Hu,Y., Xing,D., Xu,J., Chen,X.,
            Zhao,Z., Han,Z., Xue,X., Shen,X. and Lin,K.
  TITLE     Opposing biological functions of the cytoplasm and nucleus DAXX
            modified by SUMO-2/3 in gastric cancer
  JOURNAL   Cell Death Dis 11 (7), 514 (2020)
   PUBMED   32641734
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2483)
  AUTHORS   Wu,C., Ding,H., Wang,S., Li,Y., Liu,S.B., Wang,X., Zheng,J.,
            Xue,T., Amin,H.M., Song,Y.H. and Zhou,J.
  TITLE     DAXX inhibits cancer stemness and epithelial-mesenchymal transition
            in gastric cancer
  JOURNAL   Br J Cancer 122 (10), 1477-1485 (2020)
   PUBMED   32203224
REFERENCE   3  (bases 1 to 2483)
  AUTHORS   Liu,Y., Guo,F., Zhu,X., Guo,W., Fu,T. and Wang,W.
  TITLE     Death Domain-Associated Protein Promotes Colon Cancer Metastasis
            through Direct Interaction with ZEB1
  JOURNAL   J Cancer 11 (3), 750-758 (2020)
   PUBMED   31942198
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2483)
  AUTHORS   LaFramboise,W.A., Pai,R.K., Petrosko,P., Belsky,M.A., Dhir,A.,
            Howard,P.G., Becich,M.J., Holtzman,M.P., Ahrendt,S.A.,
            Pingpank,J.F., Zeh,H.J., Dhir,R., Bartlett,D.L. and Choudry,H.A.
  TITLE     Discrimination of low- and high-grade appendiceal mucinous
            neoplasms by targeted sequencing of cancer-related variants
  JOURNAL   Mod Pathol 32 (8), 1197-1209 (2019)
   PUBMED   30962504
REFERENCE   5  (bases 1 to 2483)
  AUTHORS   Ziv,E., Rice,S.L., Filtes,J., Yarmohammadi,H., Boas,F.E.,
            Erinjeri,J.P., Petre,E.N., Brody,L.A., Brown,K.T., Covey,A.M.,
            Getrajdman,G.I., Maybody,M., Raj,N., Sofocleous,C.T., Solomon,S.B.
            and Reidy-Lagunes,D.
  TITLE     DAXX Mutation Status of Embolization-Treated Neuroendocrine Tumors
            Predicts Shorter Time to Hepatic Progression
  JOURNAL   J Vasc Interv Radiol 29 (11), 1519-1526 (2018)
   PUBMED   30342802
REFERENCE   6  (bases 1 to 2483)
  AUTHORS   Li,H., Leo,C., Zhu,J., Wu,X., O'Neil,J., Park,E.J. and Chen,J.D.
  TITLE     Sequestration and inhibition of Daxx-mediated transcriptional
            repression by PML
  JOURNAL   Mol Cell Biol 20 (5), 1784-1796 (2000)
   PUBMED   10669754
REFERENCE   7  (bases 1 to 2483)
  AUTHORS   Zhong,S., Salomoni,P., Ronchetti,S., Guo,A., Ruggero,D. and
            Pandolfi,P.P.
  TITLE     Promyelocytic leukemia protein (PML) and Daxx participate in a
            novel nuclear pathway for apoptosis
  JOURNAL   J Exp Med 191 (4), 631-640 (2000)
   PUBMED   10684855
REFERENCE   8  (bases 1 to 2483)
  AUTHORS   Li,R., Pei,H., Watson,D.K. and Papas,T.S.
  TITLE     EAP1/Daxx interacts with ETS1 and represses transcriptional
            activation of ETS1 target genes
  JOURNAL   Oncogene 19 (6), 745-753 (2000)
   PUBMED   10698492
REFERENCE   9  (bases 1 to 2483)
  AUTHORS   Everett,R.D., Earnshaw,W.C., Pluta,A.F., Sternsdorf,T.,
            Ainsztein,A.M., Carmena,M., Ruchaud,S., Hsu,W.L. and Orr,A.
  TITLE     A dynamic connection between centromeres and ND10 proteins
  JOURNAL   J Cell Sci 112 (Pt 20), 3443-3454 (1999)
   PUBMED   10504293
REFERENCE   10 (bases 1 to 2483)
  AUTHORS   Michaelson,J.S., Bader,D., Kuo,F., Kozak,C. and Leder,P.
  TITLE     Loss of Daxx, a promiscuously interacting protein, results in
            extensive apoptosis in early mouse development
  JOURNAL   Genes Dev 13 (15), 1918-1923 (1999)
   PUBMED   10444590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC128729.1.
            
            On Sep 12, 2009 this sequence version replaced NM_080891.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128729.1, SRR8487226.83983.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2483
                     /gene="Daxx"
                     /note="death-domain associated protein"
                     /db_xref="GeneID:140926"
                     /db_xref="RGD:621227"
     exon            1..80
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            81..303
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2289
                     /gene="Daxx"
                     /note="Fas death domain-associated protein"
                     /codon_start=1
                     /product="death domain-associated protein 6"
                     /protein_id="NP_543167.2"
                     /db_xref="GeneID:140926"
                     /db_xref="RGD:621227"
                     /translation="MATDDSIIVLDDDDEDEAAAQPGPSNPASNPVSPGPEASGPSES
                     HGDGGSSNSGSRKCYKLENEKLFEEFLELCKMQTSDHPEVVPFLHKLQQRAQSAFLAS
                     AEFRNILSRVLSRSRNRPAKLYVYINELCTVLKAHSIKKKLNLAPAASAESSGDNPPT
                     DPPSDLTNTETTASEASRTRGSRRQIQRLEQLLALYVAEIQRLQEKELDLSELDDPDS
                     SYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKP
                     GPDTFPDYGDVLRAVEKAATRHSLGLPRQQLQLLAQDAFRDVGVRLQERRHLDLIYNF
                     GCHLTDDYRPGVDPALTDPTLARRLRENRTLAMSRLDEVISKYAMMQDKSEEGERQKR
                     RARLLATSQSSDLPKASSDSGEGPSGVASQEDPTTPKAETEDEEDDEESDDEEEEEEE
                     EEEEATEDEDEDLEQLQEDQDDEEEEEGDNEDDKSPTSPSPIFRRRNSAPTEGLRSPE
                     EQQERGLTGTPASPLEASPGLPSTDAESSGEQLQERLLAGESPVSQLSELDMEALPEE
                     TIPSPEERGISSSRRKSDSSLPTILENGAAMVTSTSFNGRVSSHPCRDASPPSKRFRK
                     EKKQLGPGPLENSYVKKQTMAQQDSGWKISVLSTPSSPLASVGPVADSSTRVDSPSHE
                     LVTSSLCNPSPSLILQTPQSQSPRPCIYKTSVATQCDPEEIIVLSDSD"
     exon            304..1129
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1338
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1531
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..2006
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2229
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2453
                     /gene="Daxx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggggaaa ggaaggcgga gggaactttg cgaggatttg tgatccgcgc tgaggggagc
       61 ctcgagagac cgtttctgag ggggatttga tcccccatgg ccaccgatga cagcatcatt
      121 gtgcttgacg atgatgatga agatgaagca gctgctcagc caggaccctc caacccagcc
      181 tctaatcctg tctcaccagg accagaagcc tctggtccct ctgagtccca tggggatgga
      241 gggagcagta actcaggtag caggaagtgc tacaagttgg agaatgagaa gctgtttgaa
      301 gagttccttg aactgtgtaa gatgcagaca tcggaccacc ctgaggtggt tccgttcctc
      361 cacaaactgc agcagcgtgc tcagtccgct tttctggcct ctgcagagtt ccgcaacatc
      421 ctctccaggg ttctgtctcg gtctcggaac cggccagcga agctctacgt ctacattaac
      481 gagctctgca ctgtccttaa agctcattcc atcaagaaga agttgaactt agctcccgca
      541 gcctcagcgg aatcatcggg tgataaccct cccacagatc ccccgtctga ccttacaaac
      601 accgaaacca ctgcctctga ggcctcaagg actcgaggct cccggaggca gatccagcgc
      661 ttggagcagc tgctggcact gtatgtcgca gagatacagc ggctgcagga aaaggagttg
      721 gatctgtcag aactggatga tcccgactcc tcctatttgc aggaggcccg cttgaagcgg
      781 aaactgatcc gcctctttgg gcggctgtgc gagttgaagg actgctcttc tctgactggg
      841 agggtcatag agcagcgaat tccttaccga ggcactcgat acccagaggt caacaggcgc
      901 atcgagcggc tcatcaacaa gccggggcct gacacgtttc cggactatgg agatgtgctg
      961 agagcggtgg agaaggcggc gacccggcac agtctgggcc ttcccagaca gcagcttcag
     1021 ctcctggctc aggatgcctt ccgggatgtg ggtgtcaggt tacaggagcg ccgccacctg
     1081 gatctcatct ataactttgg ctgccacctc acagatgact ataggccagg cgttgacccc
     1141 gcactcaccg atcccacatt ggctcgccgc cttcgggaga atcgaacctt ggccatgagc
     1201 cggctggatg aggtcatctc caagtatgcc atgatgcaag acaagagtga ggagggggag
     1261 agacagaaga gacgggcccg gctcttagcc acttcccaat cttcagacct ccccaaagcc
     1321 tcctcggatt ccggtgaggg tcctagtgga gtggcatccc aggaggaccc tactaccccc
     1381 aaggctgaga ccgaggatga ggaagacgat gaggaaagtg atgatgaaga ggaggaagag
     1441 gaagaggagg aggaggaggc caccgaagat gaagatgagg atttagaaca gttgcaggag
     1501 gatcaggatg atgaagagga ggaggaagga gataatgaag acgataaaag tcccacatcc
     1561 ccttcgccca ttttccgcag aaggaactca gcacccacag aagggctcag gtccccggag
     1621 gagcagcagg agagaggact gacggggacg ccagcatccc cgctggaagc atccccgggc
     1681 cttcccagca ccgatgctga aagcagcggc gagcagctcc aggagcggct cctggcagga
     1741 gagagtcccg tgtcccagct ttctgagcta gacatggaag ctctgcctga ggagaccatc
     1801 ccttcccctg aggaaagggg catttcctct tccaggagaa agtcagacag ttccctcccc
     1861 accatcttgg aaaatggggc agctatggtt acctctacgt ccttcaatgg gcgtgtctct
     1921 tctcaccctt gtcgagatgc cagtccccca agcaagagat ttcggaagga aaagaagcaa
     1981 ctgggacctg ggccgttaga aaacagctat gtaaaaaagc agacgatggc acagcaggac
     2041 agtgggtgga agataagtgt cctgtctact ccgtcctccc ccttggcctc tgtgggtcct
     2101 gttgctgatt cctccacgag ggtggactct cccagccatg agctggtaac cagctccctg
     2161 tgcaaccctt ctccatccct gatactccag actccccagt ctcagtctcc ccggccttgt
     2221 atttataaga cgagtgtggc cacccagtgc gatcccgagg agatcatcgt gctctcagac
     2281 tctgattagc agtccctgca tccagaaggg tttctaatgg ctgttagaag atgacggagc
     2341 aaatgatgga cagagctcct cccgttttgg tggtgtttct tttgacaaaa aatcagatgt
     2401 tttaagtttt acacagacac attaataaac aatgaatttc ttttcttatt gtaaaaaaaa
     2461 aaaaaaaaaa aaaaaaaaaa aaa
//
