LOCUS       NM_022546               1515 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus death-associated protein kinase 3 (Dapk3), mRNA.
ACCESSION   NM_022546
VERSION     NM_022546.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1515)
  AUTHORS   Turner,S.R., Al-Ghabkari,A., Carlson,D.A., Chappellaz,M.,
            Sutherland,C., Haystead,T.A.J., Cole,W.C. and MacDonald,J.A.
  TITLE     Death-associated protein kinase 3 regulates the myogenic reactivity
            of cerebral arteries
  JOURNAL   Exp Physiol 108 (7), 986-997 (2023)
   PUBMED   37084168
  REMARK    GeneRIF: Death-associated protein kinase 3 regulates the myogenic
            reactivity of cerebral arteries.
REFERENCE   2  (bases 1 to 1515)
  AUTHORS   Li,K.X., Du,Q., Wang,H.P. and Sun,H.J.
  TITLE     Death-associated protein kinase 3 deficiency alleviates vascular
            calcification via AMPK-mediated inhibition of endoplasmic reticulum
            stress
  JOURNAL   Eur J Pharmacol 852, 90-98 (2019)
   PUBMED   30851272
  REMARK    GeneRIF: DAPK3 modulated VSMC calcification through AMPK-mediated
            ERS signaling
REFERENCE   3  (bases 1 to 1515)
  AUTHORS   El-Mas,M.M. and Abdel-Rahman,A.A.
  TITLE     Estrogen modulation of the ethanol-evoked myocardial oxidative
            stress and dysfunction via DAPK3/Akt/ERK activation in male rats
  JOURNAL   Toxicol Appl Pharmacol 287 (3), 284-292 (2015)
   PUBMED   26111663
  REMARK    GeneRIF: Estrogen promotes ethanol-evoked myocardial oxidative
            stress and left ventricular dysfunction via DAPK3/Akt/ERK
            activation in male rats.
REFERENCE   4  (bases 1 to 1515)
  AUTHORS   Nehru,V., Almeida,F.N. and Aspenstrom,P.
  TITLE     Interaction of RhoD and ZIP kinase modulates actin filament
            assembly and focal adhesion dynamics
  JOURNAL   Biochem Biophys Res Commun 433 (2), 163-169 (2013)
   PUBMED   23454120
REFERENCE   5  (bases 1 to 1515)
  AUTHORS   Arif,A., Chatterjee,P., Moodt,R.A. and Fox,P.L.
  TITLE     Heterotrimeric GAIT complex drives transcript-selective translation
            inhibition in murine macrophages
  JOURNAL   Mol Cell Biol 32 (24), 5046-5055 (2012)
   PUBMED   23071094
REFERENCE   6  (bases 1 to 1515)
  AUTHORS   Page,G., Kogel,D., Rangnekar,V. and Scheidtmann,K.H.
  TITLE     Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP
            kinase and Par-4 results in cytoplasmic retention and apoptosis
  JOURNAL   Oncogene 18 (51), 7265-7273 (1999)
   PUBMED   10602480
REFERENCE   7  (bases 1 to 1515)
  AUTHORS   Page,G., Lodige,I., Kogel,D. and Scheidtmann,K.H.
  TITLE     AATF, a novel transcription factor that interacts with Dlk/ZIP
            kinase and interferes with apoptosis
  JOURNAL   FEBS Lett 462 (1-2), 187-191 (1999)
   PUBMED   10580117
REFERENCE   8  (bases 1 to 1515)
  AUTHORS   Murata-Hori,M., Suizu,F., Iwasaki,T., Kikuchi,A. and Hosoya,H.
  TITLE     ZIP kinase identified as a novel myosin regulatory light chain
            kinase in HeLa cells
  JOURNAL   FEBS Lett 451 (1), 81-84 (1999)
   PUBMED   10356987
REFERENCE   9  (bases 1 to 1515)
  AUTHORS   Kogel,D., Plottner,O., Landsberg,G., Christian,S. and
            Scheidtmann,K.H.
  TITLE     Cloning and characterization of Dlk, a novel serine/threonine
            kinase that is tightly associated with chromatin and phosphorylates
            core histones
  JOURNAL   Oncogene 17 (20), 2645-2654 (1998)
   PUBMED   9840928
REFERENCE   10 (bases 1 to 1515)
  AUTHORS   Kawai,T., Matsumoto,M., Takeda,K., Sanjo,H. and Akira,S.
  TITLE     ZIP kinase, a novel serine/threonine kinase which mediates
            apoptosis
  JOURNAL   Mol Cell Biol 18 (3), 1642-1651 (1998)
   PUBMED   9488481
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022546.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ006971.1, BC062076.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000007.1  9183196-9183272     c
            78-176              JAXUCZ010000007.1  9182273-9182371     c
            177-537             JAXUCZ010000007.1  9177565-9177925     c
            538-667             JAXUCZ010000007.1  9177357-9177486     c
            668-716             JAXUCZ010000007.1  9177222-9177270     c
            717-743             JAXUCZ010000007.1  9176839-9176865     c
            744-896             JAXUCZ010000007.1  9176071-9176223     c
            897-942             JAXUCZ010000007.1  9175561-9175606     c
            943-1515            JAXUCZ010000007.1  9174904-9175476     c
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1515
                     /gene="Dapk3"
                     /gene_synonym="Dapkl"
                     /note="death-associated protein kinase 3"
                     /db_xref="GeneID:64391"
                     /db_xref="RGD:621766"
     exon            1..77
                     /gene="Dapk3"
                     /gene_synonym="Dapkl"
                     /inference="alignment:Splign:2.1.0"
     exon            78..176
                     /gene="Dapk3"
                     /gene_synonym="Dapkl"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1461
                     /gene="Dapk3"
                     /gene_synonym="Dapkl"
                     /EC_number="2.7.11.1"
                     /note="dlk; ZIP-kinase; DAP kinase 3; DAP-like kinase;
                     Death-associated like kinase; MYPT1 kinase"
                     /codon_start=1
                     /product="death-associated protein kinase 3"
                     /protein_id="NP_071991.1"
                     /db_xref="GeneID:64391"
                     /db_xref="RGD:621766"
                     /translation="MSTFRQEDVEDHYEMGEELGSGQFAIVRKCQQKGTGMEYAAKFI
                     KKRRLPSSRRGVSREEIEREVSILREIRHPNIITLHDVFENKTDVVLILELVSGGELF
                     DFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKHAASPRIKLI
                     DFGIAHRIEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFL
                     GETKQETLTNISAVNYDFDEEYFSSTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK
                     VRRREDGARKPERRRLRAARLREYSLKSHSSMPRNTSYASFERFSRVLEDVAAAEQGL
                     RELQRGRRQCRERVCALRVAAEQREARCRDGSAGLGRDLRRLRTELGRTEALRTRAQE
                     EARAALLGAGGLKRRLCRLENRYDALAAQVAAEVQFVRDLVRALEQERLQAECGVR"
     exon            177..537
                     /gene="Dapk3"
                     /gene_synonym="Dapkl"
                     /inference="alignment:Splign:2.1.0"
     exon            538..667
                     /gene="Dapk3"
                     /gene_synonym="Dapkl"
                     /inference="alignment:Splign:2.1.0"
     exon            668..716
                     /gene="Dapk3"
                     /gene_synonym="Dapkl"
                     /inference="alignment:Splign:2.1.0"
     exon            717..743
                     /gene="Dapk3"
                     /gene_synonym="Dapkl"
                     /inference="alignment:Splign:2.1.0"
     exon            744..896
                     /gene="Dapk3"
                     /gene_synonym="Dapkl"
                     /inference="alignment:Splign:2.1.0"
     exon            897..942
                     /gene="Dapk3"
                     /gene_synonym="Dapkl"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1515
                     /gene="Dapk3"
                     /gene_synonym="Dapkl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaacccgca gggtttgcac cggaggctct cgcgggggcc tcgctggcgc tgggcgggga
       61 ctcgcgggct gaggacgctc ctgtgtcccc agaatcctgc agaaggacag cgccatgtcc
      121 acgttcaggc aggaggacgt tgaggaccat tatgagatgg gagaggagct tggcagcggc
      181 cagttcgcca tcgtgcgcaa gtgccagcag aagggcaccg gcatggagta cgcggccaag
      241 ttcataaaga agcggcgcct gccgtccagc cggcgcggtg tgagccgtga ggagatcgag
      301 cgcgaggtga gcatcctgcg cgagatccgc caccccaaca tcatcacgct gcacgatgtg
      361 ttcgagaaca agacagatgt ggtgctgatc ttggagctgg tgtccggcgg cgaacttttc
      421 gactttctgg ctgagaagga gtcactgaca gaggatgagg ccacgcagtt cctcaagcag
      481 atcctggacg gtgtccacta cctgcactcc aagcgcatcg cgcactttga cctgaagccg
      541 gagaacatca tgttgctgga caagcatgca gccagcccac gcattaagct catcgacttt
      601 ggcatcgcgc acaggatcga ggccggtagc gagttcaaga acatctttgg cacgccagag
      661 ttcgtcgccc ctgagattgt aaactatgaa ccacttggct tggaagctga tatgtggagc
      721 atcggcgtca tcacctacat cctcctgagc ggggcgtccc cattcctggg ggagaccaag
      781 caggaaacgc tgacaaacat ctcggctgtg aactatgact ttgatgaaga gtacttcagc
      841 agcaccagtg aactggccaa ggacttcatc cgaaggctgc tggtcaaaga tcccaagagg
      901 aggatgacca tcgcacagag cctggagcat tcctggatca aggttcgccg gcgtgaggac
      961 ggcgcccgga agccagagcg acgccgactg cgcgcggcgc gcctgcgcga gtacagtctc
     1021 aagtcgcact caagcatgcc gcgaaacacg agctacgcca gcttcgagcg cttctcgcgc
     1081 gtgctggagg acgtggcggc ggcggagcag gggctgcgcg agctgcagcg gggccggcgg
     1141 cagtgccggg agcgcgtgtg cgcgctgcgc gtggctgcgg aacagcggga ggcgcgctgc
     1201 cgcgacggga gcgccgggct aggccgcgac ctgcgacgcc tgcgcacgga gctgggtcgc
     1261 accgaggctc tgcgcacgcg cgcgcaggag gaggcacggg cagcgctctt gggcgctggt
     1321 ggcctgaaac gtcgcctgtg tcgccttgag aaccgctacg acgcgctagc cgcacaggtg
     1381 gctgctgagg tgcagttcgt gcgcgatctg gtacgcgcgc tggagcagga gcggctgcag
     1441 gccgagtgcg gcgtgcgcta ggctgcgaca cccccagatc tcggcccatc cccagaataa
     1501 agctactttc cacgc
//
