LOCUS       NM_001395735            1794 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus death-associated protein kinase 2 (Dapk2),
            transcript variant 1, mRNA.
ACCESSION   NM_001395735 XM_039081123
VERSION     NM_001395735.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1794)
  AUTHORS   Shen,M., Wu,Y., Li,L., Zhang,L., Liu,G. and Wang,R.
  TITLE     CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic
            cardiomyopathy by regulating miR-22-3p/DAPK2 Axis
  JOURNAL   J Diabetes 16 (1), e13471 (2024)
   PUBMED   37735821
  REMARK    GeneRIF: CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic
            cardiomyopathy by regulating miR-22-3p/DAPK2 Axis.
REFERENCE   2  (bases 1 to 1794)
  AUTHORS   Li,S., Xiao,F.Y., Shan,P.R., Su,L., Chen,D.L., Ding,J.Y. and
            Wang,Z.Q.
  TITLE     Overexpression of microRNA-133a inhibits
            ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting
            DAPK2
  JOURNAL   J Hum Genet 60 (11), 709-716 (2015)
   PUBMED   26334104
  REMARK    GeneRIF: MiR-133a overexpression may inhibit I/R injury-mediated
            cardiomyocyte apoptosis by targeting DAPK2, leading to reduced
            DAPK2 protein.
REFERENCE   3  (bases 1 to 1794)
  AUTHORS   Geering,B., Stoeckle,C., Rozman,S., Oberson,K., Benarafa,C. and
            Simon,H.U.
  TITLE     DAPK2 positively regulates motility of neutrophils and eosinophils
            in response to intermediary chemoattractants
  JOURNAL   J Leukoc Biol 95 (2), 293-303 (2014)
   PUBMED   24163421
REFERENCE   4  (bases 1 to 1794)
  AUTHORS   Li,H., Ray,G., Yoo,B.H., Erdogan,M. and Rosen,K.V.
  TITLE     Down-regulation of death-associated protein kinase-2 is required
            for beta-catenin-induced anoikis resistance of malignant epithelial
            cells
  JOURNAL   J Biol Chem 284 (4), 2012-2022 (2009)
   PUBMED   18957423
REFERENCE   5  (bases 1 to 1794)
  AUTHORS   Shani,G., Henis-Korenblit,S., Jona,G., Gileadi,O., Eisenstein,M.,
            Ziv,T., Admon,A. and Kimchi,A.
  TITLE     Autophosphorylation restrains the apoptotic activity of DRP-1
            kinase by controlling dimerization and calmodulin binding
  JOURNAL   EMBO J 20 (5), 1099-1113 (2001)
   PUBMED   11230133
REFERENCE   6  (bases 1 to 1794)
  AUTHORS   Inbal,B., Shani,G., Cohen,O., Kissil,J.L. and Kimchi,A.
  TITLE     Death-associated protein kinase-related protein 1, a novel
            serine/threonine kinase involved in apoptosis
  JOURNAL   Mol Cell Biol 20 (3), 1044-1054 (2000)
   PUBMED   10629061
REFERENCE   7  (bases 1 to 1794)
  AUTHORS   Kawai,T., Nomura,F., Hoshino,K., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Akira,S.
  TITLE     Death-associated protein kinase 2 is a new
            calcium/calmodulin-dependent protein kinase that signals apoptosis
            through its catalytic activity
  JOURNAL   Oncogene 18 (23), 3471-3480 (1999)
   PUBMED   10376525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Aug 3, 2021 this sequence version replaced XM_039081123.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.1356983.1,
                                           SRR26360194.1167831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000008.1  75601672-75601814
            144-241             JAXUCZ010000008.1  75608903-75609000
            242-463             JAXUCZ010000008.1  75668125-75668346
            464-602             JAXUCZ010000008.1  75679649-75679787
            603-732             JAXUCZ010000008.1  75694734-75694863
            733-781             JAXUCZ010000008.1  75698491-75698539
            782-808             JAXUCZ010000008.1  75699171-75699197
            809-961             JAXUCZ010000008.1  75702974-75703126
            962-1007            JAXUCZ010000008.1  75704095-75704140
            1008-1097           JAXUCZ010000008.1  75717079-75717168
            1098-1181           JAXUCZ010000008.1  75717266-75717349
            1182-1794           JAXUCZ010000008.1  75720007-75720619
FEATURES             Location/Qualifiers
     source          1..1794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1794
                     /gene="Dapk2"
                     /note="death-associated protein kinase 2"
                     /db_xref="GeneID:300799"
                     /db_xref="RGD:1304708"
     exon            1..143
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            144..241
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1262
                     /gene="Dapk2"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     death-associated kinase 2"
                     /codon_start=1
                     /product="death-associated protein kinase 2 isoform 1"
                     /protein_id="NP_001382664.1"
                     /db_xref="GeneID:300799"
                     /db_xref="RGD:1304708"
                     /translation="MRSPNMETFKQQKVEDFYDIGEELGSGQFAIVRKCREQSTGLEY
                     AAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIITLHDVYENRTDVVLILELVS
                     GGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIP
                     HIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSG
                     ASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALR
                     HPWIMPVDNQQAMVRRESVVNLENFKKQYVRRRWKLSFSIVSLCNHLTRSLMKKVHLR
                     TSEDLRNCESDTEENIARRKALHPRRRSSTS"
     exon            242..463
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..602
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..732
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            733..781
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..808
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..961
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1007
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1097
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1181
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1794
                     /gene="Dapk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggccgct ccgccccctg ggctcctcgg tggctctgcg ggcggacgcc gggctcaggg
       61 agcagagctg agaggatcgc cgcgcacccc gccgcgcccc ggcgcacgtc ctgccctccg
      121 cacatgcagc gcagcctctc gccgattgcg tggtccaggc ctcaatgagg agtccaaata
      181 tggagacatt caaacagcag aaggtggagg acttctatga catcggagag gagctgggca
      241 gtggccagtt cgccatcgtg aggaagtgcc gggagcagag cacggggcta gagtacgcag
      301 ccaaattcat caagaagagg cagagccggg ccagccgtcg gggcgtgtgc cgggaggaaa
      361 tcgagcggga ggtgagcatc ctgcggcagg tgctgcaccc caacatcatc acgctgcacg
      421 acgtctatga gaaccgcacc gatgtggtgc tcatccttga gctagtttcc ggaggagaac
      481 tgttcgattt cttggcccag aaggagtcgt taagtgagga ggaagccacc agcttcatta
      541 agcagatcct ggatggggtg aattaccttc atacaaagaa aattgctcac tttgatctca
      601 agccagaaaa cattatgttg ttagacaaga atatccccat tccacacatc aagctgattg
      661 actttggctt ggctcacgaa atagaagatg gagttgaatt taaaaacatt tttgggacac
      721 ctgaatttgt tgctccagaa atcgtgaact atgagccact gggactggag gcagacatgt
      781 ggagcatcgg agtcatcacc tacatccttc taagtggagc atcccccttc ctgggagaca
      841 caaagcaaga aaccctggca aacatcactg ctgtgagtta cgactttgac gaggaattct
      901 tcagccagac cagtgagctg gccaaggact tcattcggaa gcttcttgtg aaggagaccc
      961 ggaaacggct taccatccaa gaggctctca ggcatccctg gatcatgcca gtggacaacc
     1021 agcaagccat ggtgcgcaga gagtctgtgg tcaacctgga gaactttaag aagcagtatg
     1081 tccgcaggcg gtggaagctg tccttcagca tcgtctccct gtgcaaccac ctcactcgct
     1141 ccctgatgaa gaaggtgcac ttgaggacaa gtgaggacct gaggaactgc gagagtgaca
     1201 cggaggagaa cattgccagg aggaaagccc ttcacccccg gaggaggagc agtacctcct
     1261 aactgatccg gcacctgctt gtcaccagga tccagacatt ttgtgttcct gagcactttg
     1321 caagagagag gagtctgcag gactcagaac tttcaggaga ccctgggagt tgtggctatc
     1381 tcctggtggg gagcctccag cattcctcaa gctcttagtt ctccagaaaa ctggctttca
     1441 tctgtctgct aacctcagaa gctgggaatg ggtgtggact gaggaaatgg atctcaagga
     1501 atatcgtggt tgttgttgtt gttgttgttt ttaccacagg ttaaaggtca gatttaggca
     1561 gctttcctca caaggtgaca gagtacagaa ccaactggtg tagcagccat accaggaaga
     1621 caagcctacc ctatcagagt aaagactctc tagagtgagg gaccaatcct gtgactttac
     1681 aagaatccat aaggagtcag gctgtctcat gtcagactgt gtctgccagc ctcttgccag
     1741 ctcactgtgt tgtttttttt ctcattttta ttattaaact tcttgtttat ctaa
//
