LOCUS       NM_053626               1646 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus D-amino-acid oxidase (Dao), mRNA.
ACCESSION   NM_053626 XM_001080433
VERSION     NM_053626.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1646)
  AUTHORS   Fukushima,T., Kansaku,A., Umino,M., Sakamoto,T. and Onozato,M.
  TITLE     Evaluation of D-amino acid oxidase activity in rat kidney using a
            D-kynurenine derivative, 6-methylthio-D-kynurenine: An in vivo
            microdialysis study
  JOURNAL   Drug Discov Ther 17 (6), 434-439 (2024)
   PUBMED   38044118
  REMARK    GeneRIF: Evaluation of D-amino acid oxidase activity in rat kidney
            using a D-kynurenine derivative, 6-methylthio-D-kynurenine: An in
            vivo microdialysis study.
REFERENCE   2  (bases 1 to 1646)
  AUTHORS   Jiang,H., Zhang,H., Jiang,X. and Wu,S.
  TITLE     Overexpression of D-amino acid oxidase prevents retinal
            neurovascular pathologies in diabetic rats
  JOURNAL   Diabetologia 64 (3), 693-706 (2021)
   PUBMED   33319325
  REMARK    GeneRIF: Overexpression of D-amino acid oxidase prevents retinal
            neurovascular pathologies in diabetic rats.
REFERENCE   3  (bases 1 to 1646)
  AUTHORS   Shimizu,Y., Ishii,C., Yanobu-Takanashi,R., Nakano,K., Imaike,A.,
            Mita,M., Hamase,K. and Okamura,T.
  TITLE     d-Amino acid oxidase deficiency is caused by a large deletion in
            the Dao gene in LEA rats
  JOURNAL   Biochim Biophys Acta Proteins Proteom 1868 (9), 140463 (2020)
   PUBMED   32512180
  REMARK    GeneRIF: d-Amino acid oxidase deficiency is caused by a large
            deletion in the Dao gene in LEA rats.
REFERENCE   4  (bases 1 to 1646)
  AUTHORS   Luks,L., Sacchi,S., Pollegioni,L. and Dietrich,D.R.
  TITLE     Novel insights into renal D-amino acid oxidase accumulation:
            propiverine changes DAAO localization and peroxisomal size in vivo
  JOURNAL   Arch Toxicol 91 (1), 427-437 (2017)
   PUBMED   26961980
REFERENCE   5  (bases 1 to 1646)
  AUTHORS   Paul,P., Murphy,T., Oseni,Z., Sivalokanathan,S. and de
            Belleroche,J.S.
  TITLE     Pathogenic effects of amyotrophic lateral sclerosis-linked mutation
            in D-amino acid oxidase are mediated by D-serine
  JOURNAL   Neurobiol Aging 35 (4), 876-885 (2014)
   PUBMED   24138986
  REMARK    GeneRIF: Its toxic effect on motor neurons can be mediated by
            expression in motor neurons and it promotes autophagy.
REFERENCE   6  (bases 1 to 1646)
  AUTHORS   Schumacher,J., Jamra,R.A., Freudenberg,J., Becker,T., Ohlraun,S.,
            Otte,A.C., Tullius,M., Kovalenko,S., Bogaert,A.V., Maier,W.,
            Rietschel,M., Propping,P., Nothen,M.M. and Cichon,S.
  TITLE     Examination of G72 and D-amino-acid oxidase as genetic risk factors
            for schizophrenia and bipolar affective disorder
  JOURNAL   Mol Psychiatry 9 (2), 203-207 (2004)
   PUBMED   14966479
REFERENCE   7  (bases 1 to 1646)
  AUTHORS   Chumakov,I., Blumenfeld,M., Guerassimenko,O., Cavarec,L.,
            Palicio,M., Abderrahim,H., Bougueleret,L., Barry,C., Tanaka,H., La
            Rosa,P., Puech,A., Tahri,N., Cohen-Akenine,A., Delabrosse,S.,
            Lissarrague,S., Picard,F.P., Maurice,K., Essioux,L., Millasseau,P.,
            Grel,P., Debailleul,V., Simon,A.M., Caterina,D., Dufaure,I.,
            Malekzadeh,K., Belova,M., Luan,J.J., Bouillot,M., Sambucy,J.L.,
            Primas,G., Saumier,M., Boubkiri,N., Martin-Saumier,S., Nasroune,M.,
            Peixoto,H., Delaye,A., Pinchot,V., Bastucci,M., Guillou,S.,
            Chevillon,M., Sainz-Fuertes,R., Meguenni,S., Aurich-Costa,J.,
            Cherif,D., Gimalac,A., Van Duijn,C., Gauvreau,D., Ouellette,G.,
            Fortier,I., Raelson,J., Sherbatich,T., Riazanskaia,N., Rogaev,E.,
            Raeymaekers,P., Aerssens,J., Konings,F., Luyten,W., Macciardi,F.,
            Sham,P.C., Straub,R.E., Weinberger,D.R., Cohen,N. and Cohen,D.
  TITLE     Genetic and physiological data implicating the new human gene G72
            and the gene for D-amino acid oxidase in schizophrenia
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13675-13680 (2002)
   PUBMED   12364586
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Dec 24;99(26):17221.
            Ouelette, G [corrected to Ouellette, G]; Realson, J [corrected to
            Raelson, J]]
REFERENCE   8  (bases 1 to 1646)
  AUTHORS   Konno,R.
  TITLE     Rat D-amino-acid oxidase cDNA: rat D-amino-acid oxidase as an
            intermediate form between mouse and other mammalian D-amino-acid
            oxidases
  JOURNAL   Biochim Biophys Acta 1395 (2), 165-170 (1998)
   PUBMED   9473656
REFERENCE   9  (bases 1 to 1646)
  AUTHORS   Wanders,R.J., Romeyn,G.J., Schutgens,R.B. and Tager,J.M.
  TITLE     L-pipecolate oxidase: a distinct peroxisomal enzyme in man
  JOURNAL   Biochem Biophys Res Commun 164 (1), 550-555 (1989)
   PUBMED   2572224
REFERENCE   10 (bases 1 to 1646)
  AUTHORS   Angermuller,S. and Fahimi,H.D.
  TITLE     Heterogenous staining of D-amino acid oxidase in peroxisomes of rat
            liver and kidney. A light and electron microscopic study
  JOURNAL   Histochemistry 88 (3-6), 277-285 (1988)
   PUBMED   2896644
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB003400.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001080433.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB003400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1646
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1646
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /note="D-amino-acid oxidase"
                     /db_xref="GeneID:114027"
                     /db_xref="RGD:621138"
     exon            1..87
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..287
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1137
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /EC_number="1.4.3.3"
                     /note="DAAO; DAMOX; D-amino acid oxidase 1"
                     /codon_start=1
                     /product="D-amino-acid oxidase"
                     /protein_id="NP_446078.1"
                     /db_xref="GeneID:114027"
                     /db_xref="RGD:621138"
                     /translation="MRVAVIGAGVIGLSTALCIHERYHPAQPLHMKIYADRFTPFTTS
                     DVAAGLWQPYLSDPSNPQEAEWNQQTFDHLQSCLHSPNAEKMGLALISGYNLFRDEVP
                     DPFWKSTVLGFRKLTPSELDMFPDYSYGWFNTSLLLEGKSYLSWLTERLTERGVKFIH
                     RKVASFEEVVRGGVDVIINCTGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDP
                     SLGIYNSPYIIPGSKTVTLGGVFQLGNWSELNSVHDHNTIWKSCCQLEPTLKNARIMG
                     ELTGFRPVRPQVRLERERLRFGSSSAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILE
                     EKNLSRMPPSHL"
     exon            288..402
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..479
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..545
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..600
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            601..705
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..788
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..906
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1005
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1646
                     /gene="Dao"
                     /gene_synonym="Dao1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1646
                     /gene="Dao"
                     /gene_synonym="Dao1"
ORIGIN      
        1 caacgcagcc cagaatcagg agcaatcctg ctggagacag gttcctgcac ccccaggcca
       61 tttttctcta gacacttggc accagcggct ggggtgatgc gcgtggccgt gattggagcg
      121 ggagtcatcg gactgtctac agccctctgc attcatgaac gttaccaccc agcccaacct
      181 ctgcacatga agatctatgc ggatcgcttc acgccgttca ctaccagcga tgtggctgcg
      241 ggactctggc agccttatct ctctgacccc agcaacccgc aggaggcgga gtggaaccag
      301 caaactttcg atcaccttca gagctgcctc cattctccaa acgctgagaa aatgggcttg
      361 gccctaatct caggctacaa cctcttccga gacgaagtcc cggacccttt ctggaaaagc
      421 acagttctgg gattccggaa gctgaccccc agcgagttgg acatgttccc tgattatagc
      481 tatggctggt tcaacacgag cctccttctt gaggggaaga gctacctatc atggctgact
      541 gagaggttaa ctgagagggg agtgaagttc atccatcgga aggtggcatc tttcgaagag
      601 gtggtgagag gaggcgtgga tgtgattatc aactgcaccg gggtgtgggc cggggctctg
      661 caagcagacg cctccctgca gccaggccgg ggccagatca tccaggtgga ggccccttgg
      721 ataaagcact tcatcctcac ccatgatccc agccttggca tctacaactc tccatacatc
      781 atcccaggtt ccaagacagt tacactcgga ggtgtattcc agctggggaa ctggagcgag
      841 ctaaacagcg tccatgacca caacaccatt tggaagagct gctgtcaact ggagcccacc
      901 ctgaagaatg caagaatcat gggtgaactc actggcttcc ggccagtccg acctcaggtc
      961 cggctagaaa gagaacgcct tcgctttgga tcttcaagtg cagaggtcat ccataactat
     1021 ggtcatggag gttacgggct cacgattcac tggggttgtg caatggaggc agccaacctc
     1081 tttgggaaaa ttctagaaga aaagaacttg tccaggatgc ctccatccca cctctgagga
     1141 ctctggtgaa taccacttgc cccaagacga catcccaacc ccttcagcca gttgacacca
     1201 tccttgatga ttccctcccc cagccccagc ccctcctcca gcaccccctt ggcaaaggcc
     1261 tgaagggagg aaatcctgct gttccctctc tgcctagtcc ttccagggca gtgatgctgg
     1321 ttggttctaa ccaaggctgc atgagacagg cgagatctac aaccatgatg caattcttct
     1381 cacgctgcaa cgactgtact aaggctggtc ctactgggtg gcagggtctg tgttcagtct
     1441 gatagagtag tctggaatct tttgcttaga actctgatga acggttcacg acactatcca
     1501 tgtctatttg tagtgatgga gtgatgggag gagagggagg aagaagagga ggagggggag
     1561 ggggaggagg gggaggaggg ggaggaggag gagggctccc tcttcagcac tctgctggtc
     1621 aacatcatta aagcactgaa tatcca
//
