LOCUS       NM_001107120            3019 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus diacylglycerol lipase, beta (Daglb), mRNA.
ACCESSION   NM_001107120 XM_001072224 XM_221911
VERSION     NM_001107120.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3019)
  AUTHORS   Ma,M., Zeng,G., Tan,B., Zhao,G., Su,Q., Zhang,W., Song,Y.,
            Liang,J., Xu,B., Wang,Z., Chen,J., Hou,M., Yang,C., Yun,J.,
            Huang,Y., Lin,Y., Chen,D., Han,Y., DeMorrow,S., Liang,L., Lai,J.
            and Huang,L.
  TITLE     DAGLbeta is the principal synthesizing enzyme of 2-AG and promotes
            aggressive phenotype of intrahepatic cholangiocarcinoma via
            AP-1/DAGLbeta/miR4516 feedforward circuitry
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 325 (3), G213-G229 (2023)
   PUBMED   37366545
  REMARK    GeneRIF: DAGLbeta is the principal synthesizing enzyme of 2-AG and
            promotes aggressive phenotype of intrahepatic cholangiocarcinoma
            via AP-1/DAGLbeta/miR4516 feedforward circuitry.
REFERENCE   2  (bases 1 to 3019)
  AUTHORS   Shin,M., Ware,T.B. and Hsu,K.L.
  TITLE     DAGL-Beta Functions as a PUFA-Specific Triacylglycerol Lipase in
            Macrophages
  JOURNAL   Cell Chem Biol 27 (3), 314-321 (2020)
   PUBMED   31991095
REFERENCE   3  (bases 1 to 3019)
  AUTHORS   Hsu,K.L., Tsuboi,K., Adibekian,A., Pugh,H., Masuda,K. and
            Cravatt,B.F.
  TITLE     DAGLbeta inhibition perturbs a lipid network involved in macrophage
            inflammatory responses
  JOURNAL   Nat Chem Biol 8 (12), 999-1007 (2012)
   PUBMED   23103940
REFERENCE   4  (bases 1 to 3019)
  AUTHORS   Gao,Y., Vasilyev,D.V., Goncalves,M.B., Howell,F.V., Hobbs,C.,
            Reisenberg,M., Shen,R., Zhang,M.Y., Strassle,B.W., Lu,P., Mark,L.,
            Piesla,M.J., Deng,K., Kouranova,E.V., Ring,R.H., Whiteside,G.T.,
            Bates,B., Walsh,F.S., Williams,G., Pangalos,M.N., Samad,T.A. and
            Doherty,P.
  TITLE     Loss of retrograde endocannabinoid signaling and reduced adult
            neurogenesis in diacylglycerol lipase knock-out mice
  JOURNAL   J Neurosci 30 (6), 2017-2024 (2010)
   PUBMED   20147530
REFERENCE   5  (bases 1 to 3019)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   6  (bases 1 to 3019)
  AUTHORS   Jung,K.M., Mangieri,R., Stapleton,C., Kim,J., Fegley,D.,
            Wallace,M., Mackie,K. and Piomelli,D.
  TITLE     Stimulation of endocannabinoid formation in brain slice cultures
            through activation of group I metabotropic glutamate receptors
  JOURNAL   Mol Pharmacol 68 (5), 1196-1202 (2005)
   PUBMED   16051747
REFERENCE   7  (bases 1 to 3019)
  AUTHORS   Bisogno,T., Howell,F., Williams,G., Minassi,A., Cascio,M.G.,
            Ligresti,A., Matias,I., Schiano-Moriello,A., Paul,P.,
            Williams,E.J., Gangadharan,U., Hobbs,C., Di Marzo,V. and Doherty,P.
  TITLE     Cloning of the first sn1-DAG lipases points to the spatial and
            temporal regulation of endocannabinoid signaling in the brain
  JOURNAL   J Cell Biol 163 (3), 463-468 (2003)
   PUBMED   14610053
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474012.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_221911.4, XM_001072224.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212319.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3019
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..3019
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /note="diacylglycerol lipase, beta"
                     /db_xref="GeneID:304289"
                     /db_xref="RGD:1310193"
     exon            1..177
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2089
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /EC_number="3.1.1.3"
                     /EC_number="3.1.1.116"
                     /note="sn1-specific diacylglycerol lipase beta; DGL-beta;
                     DAGL-beta; PUFA-specific triacylglycerol lipase"
                     /codon_start=1
                     /product="diacylglycerol lipase-beta"
                     /protein_id="NP_001100590.1"
                     /db_xref="GeneID:304289"
                     /db_xref="RGD:1310193"
                     /translation="MPGMVLFGRRWSLASDDLVFPGSFELFLRVLWWIASLTLYLMHR
                     RKLDCPGGVLLSTYLIVLLVLLAVIIGIVLAIVCVSMRGTICNPGPRKSMSKLLYIRL
                     ALFLPEMVWASLGAAWVAKGIQCDRTVVIGIIATVIVSWIVIAATMVTIVFVFDPLGG
                     KMAPYPPCIPEHLDSNSSNHLLTGLRTAAKSVWETRVQCCCCCIGQDDNTRVAFSSTA
                     DLFSTYFSDTDLVPSDIAAGFTLLHQQQDKISHSREPSEVVTHTPGQPQETELDAEVE
                     NCHHYMPFAAAAYGWPLYIYRNPFTGLCRIGGDCCRGRDIEYDAVEGDEHHCHFASIL
                     KTTGLQYRDFIHVSFHDKVYELPFIVVLDHRKESVVVAVRGTMSLQDVLTDLSAESEN
                     LELDIELQDCVAHKGIAQAARYIYRRLVNDGILSQAFSVAPEYRLVVVGHSLGAGAAA
                     LLAIMLRGAYPQVRAYAFSPPRGLLSKSLFEYSKDFVVSLILGMDVIPRLSVANMEDL
                     KRRILRVIANCNKPKYKILLHGCWYSVFGGSPDNFPTELDEGNQGALTQPLLGEQTLL
                     TRCSPGYCSGDSPLDSPKYPTLYPPGRIIHLEEEGGSGRFGCCSAAQYRARWAHETEF
                     SKILIGPKMLIDHMPDVMIRALDRVVADRTACVSCPGQGGSNVP"
     exon            178..329
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            330..501
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            502..760
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            761..883
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1011
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1138
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1222
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1300
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1381
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1509
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1578
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1651
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1896
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..3019
                     /gene="Daglb"
                     /gene_synonym="RGD1310193"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgccgct agggaccccc tccggacaag cgcagagtca gaagggcgcg cgcggctgag
       61 gcggcgcggt gggaggtgca ccatgccggg gatggtgctg ttcggccggc gctggtccct
      121 agctagcgac gacctggtgt tccccgggtc ttttgagctg ttcctgcgtg tgctgtggtg
      181 gatcgccagt ctgacgttat acctcatgca cagaaggaag ctggactgtc ctggtggggt
      241 cttgctcagc acgtacctga tcgtcctcct tgttctcctg gctgttatta taggcatcgt
      301 gctggccatc gtgtgtgtca gcatgagagg aaccatttgt aaccctggac ctcggaagtc
      361 tatgtctaag ctgctctata tccgactggc cctcttcctg ccagagatgg tctgggcttc
      421 tctgggggct gcctgggtgg caaaaggtat ccaatgtgac aggacagttg tgattggcat
      481 catcgccacc gtcattgtca gttggattgt catcgctgcc actatggtca ccatcgtctt
      541 tgtctttgac ccgctgggtg ggaaaatggc tccgtatccc ccatgcatcc ctgaacacct
      601 ggacagtaac agttcaaacc atttattgac cggcctgagg acggctgcaa agagcgtgtg
      661 ggagacccgg gtgcaatgct gctgctgctg cattgggcag gacgacaaca ccagagtcgc
      721 cttttccagc acggccgacc tgttctccac ctacttctct gacacagacc tggtgcccag
      781 cgatattgca gccggcttca cccttctcca ccagcaacag gacaagatca gccacagccg
      841 ggagccttcg gaggtcgtga cccacacacc agggcaacct caggaaacag agctggacgc
      901 ggaagtggaa aactgccatc actacatgcc gtttgcagca gctgcctacg gatggcccct
      961 ctacatctac aggaacccgt tcacggggct gtgcaggatc ggtggtgact gctgcagagg
     1021 cagagacata gagtatgatg ccgtggaagg tgacgagcac cactgccact tcgcctccat
     1081 cctgaagacg acggggctgc agtacagaga cttcatccac gttagctttc acgacaaggt
     1141 gtacgagctg cccttcatag tggttctgga tcacaggaag gagtctgttg tggttgccgt
     1201 gagagggacc atgtctctcc aggacgtcct gaccgatctg tctgccgaga gcgagaacct
     1261 agagctggat atcgagctac aggactgcgt ggcccacaag ggaattgctc aagcggccag
     1321 atacatttat cgaagactgg tcaacgatgg gattcttagc caagccttca gtgttgctcc
     1381 ggagtaccgg ctcgttgtgg tggggcacag cctgggagct ggagctgcgg ccctgttagc
     1441 catcatgctc cgcggggcct acccacaagt ccgtgcttat gccttctccc cgcccagggg
     1501 gctgctgagc aaatccctct ttgagtactc caaggacttc gtggtgtcgc tgatcctagg
     1561 gatggatgtg atccccaggt taagcgtggc caacatggag gatctcaaga ggaggatcct
     1621 gcgagtgatc gccaactgca ataagccaaa gtacaagatc ttgctgcacg gctgttggta
     1681 cagcgtgttt ggaggaagcc ctgataactt tccaaccgaa ctggatgagg gcaaccaggg
     1741 ggccctgact cagcctcttc taggggagca gactctgcta acacggtgct ccccaggcta
     1801 ctgctccggc gactccccac tggattctcc caagtacccc actctgtatc cacccggcag
     1861 gatcatccac ctggaagagg agggtggttc agggaggttt ggctgctgct ctgctgccca
     1921 gtacagagcg aggtgggcac atgaaacaga attcagcaag atcctgatag gcccaaagat
     1981 gctgattgac catatgcccg acgtcatgat tcgggccctg gacagagtgg tcgccgacag
     2041 aacagcctgt gtctcgtgcc ctggccaagg cggctctaac gtcccttagt cagccctaca
     2101 ggacactgac gagcacaatg gacttgcatt ttttggaggt tcttttgttg tgcttttgtt
     2161 ttttgttttt cttaagactg attgactgtg agtggcttct gtgaggctgg tatggtgggg
     2221 tctgtccatc agtagtaacc tgaggggtct cagcagagcg atcaatatga ccatacaatt
     2281 tacacaacct ttttgttttg gtttgttttt ttcaagacgg ggtttctctg tgtagccctg
     2341 gctgtcctgg aactcaccct gtaggccagg ctggccttga atttagatcg gcctgcctct
     2401 gcacctgagt gctgggatta acaacgtgtg tcaccgctga ctggcctatg gaactatttt
     2461 taaccacagt attaacagga tccagagttg gggacatgca taggtgttgg tacttctagg
     2521 ccagctcgtg gagcaagcct cccgtggcca cctaagaagt ctacacctga agacttctca
     2581 gtggatctgc agcgccccca ctcctgctag gatccccttc tgtttacagc gtctgaactt
     2641 aagacaacgg acatgcactt tatgcttacc cgcattcttc cgggggcact aggacagccg
     2701 agcttcctcc gaggccggca ctgcagctcc tgcctcatga atacacgagc tgatcactaa
     2761 ctcttaggta tgcttaattc tcacactatt ctacccgagc cgggtgggag gctcggggga
     2821 tttaacaata aataaagaag ttggtaaact atcaagtgcc tcaaggaagg tgtgtattcc
     2881 tgggagccag gagctggccg agttccagtg tgccatttcc atgctgggat tacaagcgtg
     2941 tactactgta cccagctggt actgaacttc tgcctttcta ccctaaacca agttgtctgg
     3001 taacactctg gttactaag
//
