LOCUS       NM_001005886            5567 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus diacylglycerol lipase, alpha (Dagla), mRNA.
ACCESSION   NM_001005886 XM_219575
VERSION     NM_001005886.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5567)
  AUTHORS   Murray,C.H., Gaulden,A.D., Kawa,A.B., Milovanovic,M.,
            Caccamise,A.J., Funke,J.R., Patel,S. and Wolf,M.E.
  TITLE     CaMKII Modulates Diacylglycerol Lipase-alpha Activity in the Rat
            Nucleus Accumbens after Incubation of Cocaine Craving
  JOURNAL   eNeuro 8 (5) (2021)
   PUBMED   34544759
  REMARK    GeneRIF: CaMKII Modulates Diacylglycerol Lipase-alpha Activity in
            the Rat Nucleus Accumbens after Incubation of Cocaine Craving.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5567)
  AUTHORS   Zhou,Y., Howell,F.V., Glebov,O.O., Albrecht,D., Williams,G. and
            Doherty,P.
  TITLE     Regulated endosomal trafficking of Diacylglycerol lipase alpha
            (DAGLalpha) generates distinct cellular pools; implications for
            endocannabinoid signaling
  JOURNAL   Mol Cell Neurosci 76, 76-86 (2016)
   PUBMED   27595600
REFERENCE   3  (bases 1 to 5567)
  AUTHORS   Dai,J., Zhu,M., Wang,C., Shen,W., Zhou,W., Sun,J., Liu,J., Jin,G.,
            Ma,H., Hu,Z., Lin,D. and Shen,H.
  TITLE     Systematical analyses of variants in CTCF-binding sites identified
            a novel lung cancer susceptibility locus among Chinese population
  JOURNAL   Sci Rep 5, 7833 (2015)
   PUBMED   25592173
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5567)
  AUTHORS   Shonesy,B.C., Wang,X., Rose,K.L., Ramikie,T.S., Cavener,V.S.,
            Rentz,T., Baucum,A.J. 2nd, Jalan-Sakrikar,N., Mackie,K.,
            Winder,D.G., Patel,S. and Colbran,R.J.
  TITLE     CaMKII regulates diacylglycerol lipase-alpha and striatal
            endocannabinoid signaling
  JOURNAL   Nat Neurosci 16 (4), 456-463 (2013)
   PUBMED   23502535
REFERENCE   5  (bases 1 to 5567)
  AUTHORS   Jung,K.M., Sepers,M., Henstridge,C.M., Lassalle,O., Neuhofer,D.,
            Martin,H., Ginger,M., Frick,A., DiPatrizio,N.V., Mackie,K.,
            Katona,I., Piomelli,D. and Manzoni,O.J.
  TITLE     Uncoupling of the endocannabinoid signalling complex in a mouse
            model of fragile X syndrome
  JOURNAL   Nat Commun 3, 1080 (2012)
   PUBMED   23011134
REFERENCE   6  (bases 1 to 5567)
  AUTHORS   Suarez,J., Rivera,P., Llorente,R., Romero-Zerbo,S.Y.,
            Bermudez-Silva,F.J., de Fonseca,F.R. and Viveros,M.P.
  TITLE     Early maternal deprivation induces changes on the expression of
            2-AG biosynthesis and degradation enzymes in neonatal rat
            hippocampus
  JOURNAL   Brain Res 1349, 162-173 (2010)
   PUBMED   20599824
  REMARK    GeneRIF: Maternal deprivation induced a significant increase in
            DAGLalpha immunoreactivity in the rat both males and females.
REFERENCE   7  (bases 1 to 5567)
  AUTHORS   Tanimura,A., Yamazaki,M., Hashimotodani,Y., Uchigashima,M.,
            Kawata,S., Abe,M., Kita,Y., Hashimoto,K., Shimizu,T., Watanabe,M.,
            Sakimura,K. and Kano,M.
  TITLE     The endocannabinoid 2-arachidonoylglycerol produced by
            diacylglycerol lipase alpha mediates retrograde suppression of
            synaptic transmission
  JOURNAL   Neuron 65 (3), 320-327 (2010)
   PUBMED   20159446
REFERENCE   8  (bases 1 to 5567)
  AUTHORS   Gao,Y., Vasilyev,D.V., Goncalves,M.B., Howell,F.V., Hobbs,C.,
            Reisenberg,M., Shen,R., Zhang,M.Y., Strassle,B.W., Lu,P., Mark,L.,
            Piesla,M.J., Deng,K., Kouranova,E.V., Ring,R.H., Whiteside,G.T.,
            Bates,B., Walsh,F.S., Williams,G., Pangalos,M.N., Samad,T.A. and
            Doherty,P.
  TITLE     Loss of retrograde endocannabinoid signaling and reduced adult
            neurogenesis in diacylglycerol lipase knock-out mice
  JOURNAL   J Neurosci 30 (6), 2017-2024 (2010)
   PUBMED   20147530
REFERENCE   9  (bases 1 to 5567)
  AUTHORS   Liu,L., Heneghan,J.F., Michael,G.J., Stanish,L.F., Egertova,M. and
            Rittenhouse,A.R.
  TITLE     L- and N-current but not M-current inhibition by M1 muscarinic
            receptors requires DAG lipase activity
  JOURNAL   J Cell Physiol 216 (1), 91-100 (2008)
   PUBMED   18247369
  REMARK    GeneRIF: Data show that L- and N-type calcium channel current, but
            not M-current inhibition by M1 muscarinic receptors requires DAG
            lipase activity.
REFERENCE   10 (bases 1 to 5567)
  AUTHORS   Bisogno,T., Howell,F., Williams,G., Minassi,A., Cascio,M.G.,
            Ligresti,A., Matias,I., Schiano-Moriello,A., Paul,P.,
            Williams,E.J., Gangadharan,U., Hobbs,C., Di Marzo,V. and Doherty,P.
  TITLE     Cloning of the first sn1-DAG lipases points to the spatial and
            temporal regulation of endocannabinoid signaling in the brain
  JOURNAL   J Cell Biol 163 (3), 463-468 (2003)
   PUBMED   14610053
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001005886.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY275375.1, SRR26643298.7170.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000001.1  216372062-216372111 c
            51-188              JAXUCZ010000001.1  216340269-216340406 c
            189-400             JAXUCZ010000001.1  216339657-216339868 c
            401-502             JAXUCZ010000001.1  216338377-216338478 c
            503-641             JAXUCZ010000001.1  216337847-216337985 c
            642-729             JAXUCZ010000001.1  216334419-216334506 c
            730-864             JAXUCZ010000001.1  216332524-216332658 c
            865-942             JAXUCZ010000001.1  216331920-216331997 c
            943-1067            JAXUCZ010000001.1  216330119-216330243 c
            1068-1221           JAXUCZ010000001.1  216326995-216327148 c
            1222-1305           JAXUCZ010000001.1  216326448-216326531 c
            1306-1383           JAXUCZ010000001.1  216326274-216326351 c
            1384-1464           JAXUCZ010000001.1  216325607-216325687 c
            1465-1607           JAXUCZ010000001.1  216324741-216324883 c
            1608-1676           JAXUCZ010000001.1  216324372-216324440 c
            1677-1749           JAXUCZ010000001.1  216324019-216324091 c
            1750-1949           JAXUCZ010000001.1  216322507-216322706 c
            1950-2079           JAXUCZ010000001.1  216321317-216321446 c
            2080-2267           JAXUCZ010000001.1  216320653-216320840 c
            2268-5567           JAXUCZ010000001.1  216315516-216318815 c
FEATURES             Location/Qualifiers
     source          1..5567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..5567
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /note="diacylglycerol lipase, alpha"
                     /db_xref="GeneID:309207"
                     /db_xref="RGD:1359461"
     exon            1..50
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            51..188
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..3228
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /EC_number="3.1.1.116"
                     /note="sn1-specific diacylglycerol lipase alpha;
                     DGL-alpha; neural stem cell-derived dendrite regulator"
                     /codon_start=1
                     /product="diacylglycerol lipase-alpha"
                     /protein_id="NP_001005886.1"
                     /db_xref="GeneID:309207"
                     /db_xref="RGD:1359461"
                     /translation="MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLV
                     YNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRL
                     AILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPT
                     GRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEI
                     AYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTK
                     YLDLKNSHEMLRYKEVCYYMLFALAAYGWPMYLMRKPTCGLCQLARSCSCCLCPARPR
                     FAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKK
                     VVISIRGTLSPKDALTDLTGDAERLPVEGHRGTWLGHKGMVLSAEYIKKKLEQEMVLS
                     QAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDA
                     MEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKS
                     ELPEDQVEVTALASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQE
                     EPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMV
                     SPTEVDLTPELIFQQQPLPTGPPLPTGLALELPATEHRNSSVRSKSQSEMSLEGFSEG
                     RLLSPVAAASAARQDPVELLLLSTQERLAAELQSRRAPLATMESLSDTESLYSFDSRR
                     SSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQ
                     PLEAALGSGGVTPERPPSAANDEEEAAGGSEGGGVAPRGELALHNGRLGDSPSPQVLE
                     FAEFIDSLFNLDSKSSSFQDLYCMMVPESPTSDYTEGPKSPSQQEILLRAQFEPNLVP
                     KPPRLFAGSAEPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLATDKIRTSTPTGHG
                     ASPTKQDDLVISAR"
     exon            189..400
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            401..502
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            503..641
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            642..729
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            730..864
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            865..942
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1067
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1221
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1305
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1383
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1464
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1607
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1676
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1749
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1949
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2079
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2267
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..5567
                     /gene="Dagla"
                     /gene_synonym="Nsddr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggcggtc gcagtggccg cggcgggcca agccctgcgg cgggccggag gaggtgagcg
       61 cctggcccgc tgagcctccc agagctgcca gccatgcccg ggatcgtggt gttccggcgg
      121 cgctggtctg tgggcagcga tgacctcgtg ctgcctgcta tcttcctctt cctgctgcac
      181 accacctggt ttgtgatcct gtctgtggtg ctcttcggcc tggtctacaa cccgcacgag
      241 gcctgctccc tgaacctggt ggaccacggc cgaggctacc tgggcatcct tctgagctgt
      301 atgattgctg agatggctat catttggctg agcatgcgtg ggggtatcct ctacacagaa
      361 ccccgggact ccatgcagta cgtgctctac gtgcgcctgg ccattttggt gatcgagttc
      421 atctacgcta tcgtgggcat cgtctggctt acacagtact acacctcctg caatgacctc
      481 actgctaaga atgtcactct cgggatggtc gtctgcaact gggtggtcat cctcagcgtc
      541 tgcatcactg tcctctgtgt ctttgacccc actggccgca ccttcgtcaa gctgagagcc
      601 accaagagga ggcagcgcaa cctgcggact tacaacctgc ggcatcggtt agaggagggt
      661 caggccacca gctggtcccg ccgtctaaaa gtgttcctct gttgcacccg gacaaaggat
      721 tcccagtcag atgcctattc agaaattgcc tacctctttg ctgaattttt ccgtgacctc
      781 gacatagtgc cctccgacat cattgctggc ctggtgctgc ttaggcagcg gcagcgagcc
      841 aagcgcaatg cggtgctgga tgaggcaaac aatgacatct tggctttcct gtctgggatg
      901 ccagtgacca gaaacaccaa gtacctcgac ctcaagaact cgcacgagat gctacgctac
      961 aaagaagtct gctactacat gctctttgcc ctcgctgcct atggctggcc catgtacctg
     1021 atgaggaagc ccacctgtgg cctctgccag ctggctcggt cctgctcgtg ttgtctctgc
     1081 cctgcacgcc cccgattcgc ccctggggtc accattgagg aagacaactg ttgtggctgc
     1141 aatgcaattg ccatccgccg tcacttcctg gatgagaaca tgactgctgt agacatcgtc
     1201 tatacctcct gtcatgatgc ggtctatgaa actcccttct acgtagctgt ggaccatgac
     1261 aagaagaagg tggtgatcag tatccgggga acactgtccc ccaaggatgc cctgactgac
     1321 ctgacaggag atgctgagcg tctccctgtg gagggacacc gaggcacctg gttgggccac
     1381 aagggcatgg tactctcagc tgagtacatc aagaagaagc tggagcagga gatggtcctg
     1441 tcccaggcct ttgggcgaga cctgggccgt ggaaccaaac actatggcct gattgtggta
     1501 ggccactcct tgggagcagg cacagccgcc attctctcct tcctcctgcg ccctcagtac
     1561 ccgaccctca agtgcttcgc ctactcccct ccaggaggcc tgctgagtga ggatgccatg
     1621 gagtactcca aagagtttgt gactgctgtg gttctgggca aagaccttgt tcccaggatc
     1681 ggcctttccc agctcgaagg tttccgccgg cagcttctgg atgtcctgca gcgaagcacc
     1741 aagcccaaat ggcggatcat cgtgggggcc accaagtgta tccccaagtc ggagctgcct
     1801 gaggatcagg tggaagtgac tgccttggcc agcacacggc tctggacaca ccccagtgat
     1861 ctgaccatcg ccctttcagc cagcacccca ctctacccac ctggccgtat catccatgtg
     1921 gtccataacc accctgctga acagtgctgc tgctgtgaac aggaagagcc cacatacttt
     1981 gccatctggg gtgacaacaa agcctttaat gaggtgatca tctcaccagc catgctccat
     2041 gagcacctgc cctacgtggt catggagggg ctcaataagg tgctggagaa ttacaacaag
     2101 ggaaagacag cgctgctctc tgctgcaaag gtcatggtga gccccactga ggtagacctc
     2161 actcctgagc tcatcttcca gcaacagccg ctgcccacgg ggccacctct gcccactggg
     2221 ctggctctgg agctgcctgc cacagagcat cgcaacagca gtgtcaggag caagtctcag
     2281 tctgagatga gtctagaggg cttctctgaa ggacggctgc tgtccccagt ggctgctgcc
     2341 tcagcagccc ggcaagaccc tgtagagctg ttgctgctgt ccacccagga acgactggcc
     2401 gcggagctgc agtcccggcg ggcaccactg gccactatgg agagcctctc agacactgag
     2461 tcactgtaca gctttgactc acgccgttcc tcaggcttcc gcagcatcag aggctcaccc
     2521 agcctccatg cagtactgga gcgtgatgag ggccacctgt tttacatcga cccagccatt
     2581 ccagaggaga acccatccct cagctcccgc acagagctgc tggcagctga cagtctgtcc
     2641 aagcactcgc aggacaccca acccctggag gcagcactag gcagcggggg tgtgactcct
     2701 gagcgaccac caagtgcagc caatgacgag gaggaggcag ccggtggcag tgagggtggt
     2761 ggggtggccc cacgaggaga gctggcactg cacaatgggc gcctggggga ttcgcccagc
     2821 cctcaggtgc tagaattcgc tgagttcatt gacagcctct tcaacctgga cagcaagagc
     2881 agctccttcc aggacctgta ctgcatgatg gtgcctgaga gccccactag tgactacaca
     2941 gagggcccca agtcccccag ccaacaggaa atcttgcttc gggctcagtt tgagcccaat
     3001 ctggtaccca agccccccag gctctttgca ggatctgccg aaccctcctc tggcatctca
     3061 ctctcaccct ccttcccact cagctcctca ggggagctca tggacctgac acccacgggc
     3121 ctcagcagcc aggagtgtct ggccacagac aagatccgga cttccacccc cacaggccat
     3181 ggggccagcc ctaccaagca ggatgacctg gtcatctcag cacgctagca cttggcagtg
     3241 gtcgtcagct cctccccaac cagaactcaa ggccctgtgg gtacctaatg gctgctcagg
     3301 gcccagtagc tgtggggaga ggctcccaga ggccaaatgg tctcaggccc tgaagcactg
     3361 ctgctgagca gggggtccac atccctacct cagcctagga cccccagaac caagatgtct
     3421 gggaaaagcg ggggtagttt cggtaacagg gaggagattt caggttggat ggtcagtcct
     3481 cagccctctc ggcctgactc ctctgtgtgg gcagcatggt atctctgttc tggtatggca
     3541 ctaggcaagc tagcttcctg tcactgctac tctcctggaa ccgtggcaga atgcagcccc
     3601 cacccccaca tgtcctcaca tgtagttcaa gttggcacct tgccctggcc actctccccc
     3661 agatctggtg cctgcaggcc agccccctgg ggtaatcccc accaaggtgg tccgcagtgc
     3721 tgggtatgtt tacagaatct gctgggcttg gctcaggttg tatcctgagc tcataagccc
     3781 caactcccaa tcatgtgttt agttatcccc tctgagtggg acctgaggac cagaggagcc
     3841 ctgaagggag gtggggtcag ggatgccgct tctttgcctg gtgcccctta tcttcatggg
     3901 tcctggccac tgggcctgcc tgcctacctg ccacttcctg gcttcctggc tcaccttcta
     3961 ctcccaggac tctgaccatt caaagggtgg tggacactcc tgtgacatca cccctggctg
     4021 cagagtcagg gccctgggag gaaagaaggc atccaaagcc ctgtctcctt ggtgtcctgc
     4081 ctgacccctt ctaacccccc accatgccta ggcagctctg ggccctgggg tctgaaacca
     4141 aacacgcctc tgcccacttg ctctcctggc tgcctcactc ctttctgggt ctgggctcca
     4201 actccccact gtgtcctgcc cataagaaga ggggccaaga gtagggtatt ctgggacctg
     4261 gctggaaacc cctgcccact gccaagggga ggggtccggg actcaggggc tgtcccaggt
     4321 tagcctgagg ccttcatagg ttttcctatg ctttggagaa gcagttcagg aggtaggagc
     4381 ccagcccttt ccccaggctg gggggagggg gaggttgtgc atggtagtgt caggtgtgtg
     4441 tgtgcatgtg catgaatgtg caccactcct gaggaaaggg gctgcagagg gctgcctgcc
     4501 tcctgctcct cctaacctga caagaatata gcctgtgaag tgaagacttg ggacaagcca
     4561 gtcactgggg tgtgcaggca agcaactgcc cacccttgtg cccttgtctc cttggaagca
     4621 tggtcccttc cactccagcc ccactcccaa cctctctgag ctgcctaggt tcccctgacc
     4681 acctcatgat cactggtatc cgggcctgag tcctgactct taacccccac agctggggtg
     4741 gcctggatag ctatccaccc taacagatga ggccagagac ctgggagctg ggcctcccct
     4801 tactctgtga ctcccccatc cccaactgac tcctggtcac cctgtcccct gccaaggcag
     4861 tgcctcagcc tagcacagaa atacaattaa aaaaaaatca ctggttctta gaactcaaat
     4921 attagacaaa aatcttaaat cagaggaata acccagcaag taccccagct ggcacaagga
     4981 gagttgtggg tctggccttt taactctttt tctctgtcag ggtaggtctg ggggggtccc
     5041 tctggggtgt gcccctatgc ccaggactga gccatcaggg acatcccccc acccccaagg
     5101 ctgcagccat actgtgttac aggcttgggg ctggggcagg cttggactca gccctagaca
     5161 cgaagggcca gcccacccct ccctgttccc tccctgatgc acgttccctt cactccatgc
     5221 cacctctggg ggggtctgag ccaccccctt catcccagtt cagattgatc ccccacactg
     5281 tcccccagac ccgcagcaca agctctccca gccgtgtgct ggcctgtcct cccagggatc
     5341 tgggtgactt ccatatgcaa ctagtagtga acagctagcc ccccatgcac cctctgcact
     5401 ccacgtgcca ttctcccacg acctttttgt acctaatgta tgaaagatcc acactaatat
     5461 cgctgtaaag agaagagaca aattaatata gcttattcta tgaatatatc tgtatataaa
     5521 gttttctgta tattgtatag agctgtgtat aaactgaatg tagaagc
//
