LOCUS       NM_053697               5169 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus dystroglycan 1 (Dag1), mRNA.
ACCESSION   NM_053697 XM_001074892 XM_343483
VERSION     NM_053697.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5169)
  AUTHORS   Figiel,I., Baczynska,E., Wojtowicz,T., Magnowska,M., Buszka,A.,
            Bijata,M. and Wlodarczyk,J.
  TITLE     The cell adhesion protein dystroglycan affects the structural
            remodeling of dendritic spines
  JOURNAL   Sci Rep 12 (1), 2506 (2022)
   PUBMED   35169214
  REMARK    GeneRIF: The cell adhesion protein dystroglycan affects the
            structural remodeling of dendritic spines.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5169)
  AUTHORS   Dou,Y., Tan,Y., Yu,T., Ma,X., Zhou,Y., Zhao,Y., Zhao,Y. and Liu,X.
  TITLE     MiR-132 down-regulates high glucose-induced beta-dystroglycan
            degradation through Matrix Metalloproteinases-9 up-regulation in
            primary neurons
  JOURNAL   J Cell Mol Med 25 (16), 7783-7795 (2021)
   PUBMED   34160889
  REMARK    GeneRIF: MiR-132 down-regulates high glucose-induced
            beta-dystroglycan degradation through Matrix Metalloproteinases-9
            up-regulation in primary neurons.
REFERENCE   3  (bases 1 to 5169)
  AUTHORS   Fruh,S., Romanos,J., Panzanelli,P., Burgisser,D., Tyagarajan,S.K.,
            Campbell,K.P., Santello,M. and Fritschy,J.M.
  TITLE     Neuronal Dystroglycan Is Necessary for Formation and Maintenance of
            Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells
  JOURNAL   J Neurosci 36 (40), 10296-10313 (2016)
   PUBMED   27707967
REFERENCE   4  (bases 1 to 5169)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   5  (bases 1 to 5169)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   6  (bases 1 to 5169)
  AUTHORS   Tian,M., Jacobson,C., Gee,S.H., Campbell,K.P., Carbonetto,S. and
            Jucker,M.
  TITLE     Dystroglycan in the cerebellum is a laminin alpha 2-chain binding
            protein at the glial-vascular interface and is expressed in
            Purkinje cells
  JOURNAL   Eur J Neurosci 8 (12), 2739-2747 (1996)
   PUBMED   8996823
REFERENCE   7  (bases 1 to 5169)
  AUTHORS   Belkin,A.M. and Smalheiser,N.R.
  TITLE     Localization of cranin (dystroglycan) at sites of cell-matrix and
            cell-cell contact: recruitment to focal adhesions is dependent upon
            extracellular ligands
  JOURNAL   Cell Adhes Commun 4 (4-5), 281-296 (1996)
   PUBMED   9117347
REFERENCE   8  (bases 1 to 5169)
  AUTHORS   Biral,D., Senter,L. and Salviati,G.
  TITLE     Increased expression of dystrophin, beta-dystroglycan and adhalin
            in denervated rat muscles
  JOURNAL   J Muscle Res Cell Motil 17 (5), 523-532 (1996)
   PUBMED   8906620
REFERENCE   9  (bases 1 to 5169)
  AUTHORS   Jimi,T., Wakayama,Y., Takeda,A., Kobayashi,T., Kumagai,T.,
            Suzuki,Y., Hasegawa,O., Yamashita,S., Shibuya,S., Kuroiwa,Y. et al.
  TITLE     Altered distribution of beta-dystroglycan in sarcolemma of human
            dystrophic muscles: an immunohistochemical study
  JOURNAL   Muscle Nerve 18 (8), 910-913 (1995)
   PUBMED   7630355
REFERENCE   10 (bases 1 to 5169)
  AUTHORS   Cullen,M.J., Walsh,J. and Nicholson,L.V.
  TITLE     Immunogold localization of the 43-kDa dystroglycan at the plasma
            membrane in control and dystrophic human muscle
  JOURNAL   Acta Neuropathol 87 (4), 349-354 (1994)
   PUBMED   8017170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before May 12, 2012 this sequence version replaced
            XM_001074892.2, XM_343483.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.32104.1,
                                           SRR26643289.24082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               JAXUCZ010000008.1  117781802-117782199 c
            399-5169            JAXUCZ010000008.1  117769517-117774287 c
FEATURES             Location/Qualifiers
     source          1..5169
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..5169
                     /gene="Dag1"
                     /note="dystroglycan 1"
                     /db_xref="GeneID:114489"
                     /db_xref="RGD:621890"
     exon            1..398
                     /gene="Dag1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2801
                     /gene="Dag1"
                     /note="beta-dystroglycan; dystroglycan 1
                     (dystrophin-associated glycoprotein 1);
                     alpha-dystroglycan"
                     /codon_start=1
                     /product="dystroglycan 1 precursor"
                     /protein_id="NP_446149.1"
                     /db_xref="GeneID:114489"
                     /db_xref="RGD:621890"
                     /translation="MSVDNWLLHPLWGQTFLLLLSVAVAQAHWPSEPSEAVRDWKNQL
                     EASMHSVLSDFQEAVPTVVGIPDGTAVVGRSFRVSIPTDLIASSGEIIKVSAAGKEAL
                     PSWLHWDPHSHILEGLPLDTDKGVHYISVSAARLGANGSHVPQTASVFSIEVYPEDHS
                     EPQSVRAASSDPGEVVSSACAADEPVTVLTVILDADLTKMTPKQRIDLLNRMQSFSEV
                     ELNNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKLGCSLNQNSVPDIRGVE
                     TPAREGTMSAHLGYPVVGWHIANKKPTLPKRIRRQIHATPTPVTAIGPPTTAIQEPPS
                     RIVPTPTSPAIAPPTETMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPIPPTRVSEAG
                     TTVPGQIRPTLTIPGYVEPTAVVTPPTTTTKKPRVSTPKPATPSTDSSTTTTRRPTKK
                     PRTPRPVPRVTTKAPITRLETASPPTRIRTTTSAVPRGGEANQRPELKNHIDRVDAWV
                     GTYFEVKIPSDTFYDNEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSS
                     HVGKHEYFMHATDKGGLSAVDAFEIHVHKRPQGDKAPARFKAKLAGDPAPVVNDIHKK
                     IALVKKLAFAFGDRNCSSITLQNITRGSIVVEWTNNTLPLEPCPKEQIVGLSRRIADE
                     NGKPRPAFSNALEPDFKALSVAVAGSGSCRHLQFIPVAPPSPGTSAAPATEVPDRDPE
                     KSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRKGKLTLEDQATFIKKGVPIIF
                     ADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSVPETTPLNQDTVGEYTPLRDEDP
                     NAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP"
     exon            399..5169
                     /gene="Dag1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctctgggtg ctgcaggatg gaacagctgt gccgagggtg aggatccaac cctgggacca
       61 catcatttgc ttccttcctt agcaactgtt ggcttgagca aaccctagcc tgggtgagca
      121 tgtctgtgga caactggcta ctgcaccccc tctggggaca gacctttctc ctcctactgt
      181 ctgtggctgt ggctcaagcc cactggccca gtgaaccctc agaggctgtg agggactgga
      241 agaaccagct tgaggcgtcc atgcactcag ttctctcgga cttccaggag gctgttccca
      301 ccgtggttgg catcccagat ggcacggctg ttgttgggcg ctcattccga gtgagcattc
      361 caacagattt aattgcctcc agtggagaaa ttatcaaggt gtctgcagca gggaaggagg
      421 ccctgccgtc ctggctacac tgggatccac acagtcatat tttggaaggc cttcctcttg
      481 acactgataa aggtgtccat tacatctcag tgagtgctgc acgcctggga gcaaatggaa
      541 gccacgtgcc gcagacggcc agcgtgttct ctattgaggt ctaccctgaa gaccacagtg
      601 agccacagtc tgtccgggca gcctcatcag accctggtga agtagtgtca tctgcttgtg
      661 cagctgatga gccagtgact gtccttacag tgattctgga tgctgacctc accaagatga
      721 ccccaaagca aaggattgat ctactgaaca gaatgcagag cttctcagaa gtagaactta
      781 acaacatgaa gttggtgcct gtagtcaata atagactatt tgacatgtca gccttcatgg
      841 ctggcccagg aaatgcaaag aaagtggtag agaatggggc tctgctgtcc tggaaactag
      901 ggtgctcctt gaatcagaat agcgtccctg acatccgcgg tgtagaaacc cctgctaggg
      961 agggtaccat gtctgcccac cttggttatc ctgtggtggg ttggcacatt gccaataaga
     1021 agcccactct ccccaaacga atccggaggc agatccatgc cactcctaca cctgttactg
     1081 ccattggacc cccaactacc gccattcagg agccaccatc taggatagtg cctactccca
     1141 catctccagc cattgcacct ccaacagaga ccatggctcc tcctgttagg gatcctgtcc
     1201 cagggaagcc cacggtcacc attcggactc gaggtgccat tattcagacc ccaactctgg
     1261 gccctatccc tcctactcgg gtgtcagaag ctggtaccac agttcctggc cagattcgcc
     1321 caacactgac aattcctggt tatgtagagc ccacagcagt tgttactcct ccaacaacta
     1381 ccacaaagaa gccacgagta tctacgccaa aaccagcaac gccttcaact gattcgtcaa
     1441 ctaccacaac tcgaaggcca accaaaaaac cacggacacc ccgaccagtg ccccgggtca
     1501 ccaccaaagc accgatcacc agattggaga ccgcttcccc acccactcga atccgcacta
     1561 ccaccagtgc agtgccccgt gggggagaag ctaaccagcg gccagagctt aagaaccaca
     1621 tcgacagggt tgatgcctgg gtaggaacct actttgaggt aaagattcca tcagacacct
     1681 tctatgacaa tgaggacacc actacggaca agctcaagct gaccctgaag ctgcgagagc
     1741 agcagttggt aggtgagaaa tcttgggttc agtttaacag caacagccag ctcatgtatg
     1801 gtctgcctga cagcagccat gtcggaaaac atgagtattt catgcacgcc acggacaaag
     1861 ggggcctttc tgctgtggat gccttcgaga tccatgttca caagcgccca caaggggaca
     1921 aagctcccgc gcgattcaag gccaaacttg caggggatcc cgcacctgtg gtgaacgata
     1981 tccacaagaa gatcgctttg gtaaagaagc tggcttttgc ctttggggat aggaactgca
     2041 gctccatcac ccttcagaac atcacccggg gctctattgt ggtcgagtgg accaacaaca
     2101 ctctgcccct ggagccctgc cccaaggagc agatcgtagg gctgagccgc aggattgctg
     2161 atgaaaacgg gaagcctcgt cctgccttct ccaatgctct ggagcctgac ttcaaggctc
     2221 tgagtgttgc tgtggcgggc tctggcagtt gtcggcacct ccaatttatc cccgtggcac
     2281 caccctctcc tggaacctca gcagcaccgg ccacagaggt tccagacagg gaccctgaga
     2341 agagcagtga ggatgacgtt tacttgcaca cagtcatccc agctgttgtg gttgcagcca
     2401 tcctgctcat tgctggaatc attgctatga tctgctatcg caagaagagg aagggcaaac
     2461 tgaccctgga ggaccaggcc acctttatca agaagggggt gcctattatc tttgcagatg
     2521 agctggatga ctctaagccc ccgccctctt ccagcatgcc gctcatcctg caggaagaga
     2581 aggctcccct ccctcctcct gagtacccta accagagtgt gcccgagacc actcctctga
     2641 accaggacac tgtgggagag tacacacccc tgcgggatga ggatcctaat gcacctccct
     2701 accagccacc cccacccttc acagctccca tggagggcaa gggctcccgt cccaagaaca
     2761 tgaccccata ccgatcaccc cctccatatg taccccctta acccacaagc gcctgggtgg
     2821 aggcaggggt agggcagagg cctggagaca actcggtgtt gtctgtagag accggtggcc
     2881 cacagaccat tgcccaccgg tacccaacac ctgacctagc acactgacac acggggcctg
     2941 gacaagcccg ccctctctgg tcctcccaaa ccccaaagct gctggagaga ctttggggga
     3001 cttttttatt tttatttttt gcctaacagc tttttgtttg ttcatagaaa agtcttcgct
     3061 gcgtttttga tggctctgaa agcgctgttt gagtagaggt aggaggaggg agcgaggaac
     3121 cgtgaatgaa ctcgcaggca gtgctgggtg gcccccagct ctctgcattt tgcctttaac
     3181 actaactgta ctgtcttttc tattcacgtg tgtctagctg caggatgtaa catggaaaac
     3241 agtagctaaa gattaaattc aaaggacttt cagaaattaa ggttaagttt ttacatttaa
     3301 tctgctgttt acctaaactt gtatgtataa tttttgggtg ggtatgggga attgctttgc
     3361 taaaaataag ctcccagggt gtttcagact tagagaagac caagggacag tattttttat
     3421 caaaggaatc ctattttttc acactatgtc accttggttg ctctgatatc ccagagcctg
     3481 actgagggcc tcctgggcct ggctcaggtg ccgggccctg gtgctggctc tgttctcccg
     3541 ctattgccag gggctggaag ctggaggggc ctcttgggcc atggacatcc tgacctctac
     3601 cccctgcacg ctagtggcct accaccaagg gggtcttcat ttctgtggga aagggactcc
     3661 aaaaggcatt ggtggctgtg gcctccaacc taggtgctcc aaggtgggcc agctgctcgt
     3721 aggggcacct gggaaggtcg aaggactcca cctcatcaac ctttcttttc ccctttctct
     3781 gtgggttcag ttttgttttg ttttgttttt cctttcctct taaaaggaat accatggtct
     3841 ttgaaacact cagtggggga cattttggtg aagatgcaat atttttatgt catgtgatgc
     3901 tctttcctca cttgaccttg gccactttgt cccaacagtc cacagcccta cctaccccat
     3961 acaccctgcc ccctcttctc tggcgctcca gtcctgggcc ttgggcctga acaactggaa
     4021 aaggtctggt ggctggggag gagtgccagc aatagttcat agtaaaaatc tgtgggctct
     4081 caaagctaat tttttactaa agtttttata cagcctcaaa ttgttttatt aaaaaaaaaa
     4141 gattaaaaaa tggtgatgct taacagcagt ttgtacaagc tcctagtgtt gactccatgg
     4201 aactgatggc tttgctcatt ttgaccctcc ccggcccctt cttttcctaa tgggttaaat
     4261 tctggattac atagaggctt cctttgcctt ttttagcaga acattgtcca tctgtctgcg
     4321 tctctgtccc atgactcagg ggcacccact ctgctttatt ctcctccttt ggaagaaacc
     4381 attttgagca tgccttttct tgatgtctga gttattttgg gtacctttta gggaggaatg
     4441 ccttttgcaa taatgtatcc cttccctgat ggagggtggg tgggtggacc caggctccct
     4501 ttgcacacgg agcagtaact tctaagccat atcgactgtt tagcagaggg cgtgctgtct
     4561 caggaaggga agcctgtagg acaggagcat tgcttccaaa cagtggttcc ttctgcattc
     4621 tccacaaggc ctacccttcc tgctcagccc ctaggagggt tctaggggag cagtgcccca
     4681 tgggggagtc tgccgatgag tgcttcatgg atggctggtg actgggcctg atgtcccaag
     4741 agcagggatc tgacctgatg aaattatttc tggtgacctc atcaaaaatc aatcaatcaa
     4801 tcccagtatt ccaggtgagg gctttggaaa gccttccaga taactgttgt tgctcttagc
     4861 aacaccacca ttgggcattg ccatgtagag aggaggctgg cccagagtgg cttgttgtca
     4921 tagcaactgg aggcagtggg gcagtgaaca gaataacaag agcaacaatg cctttgcagg
     4981 cagcctcctc cctaagccct gagctgccga tggccatcag actctgagac agagagccaa
     5041 tctcacattc aagtgttcac caaccactga cgtgtcttta tttccttcta tatgatttta
     5101 agatgtgttt tctgcattct gtatagaaac atatcaaact aaataaaagc agtgtcttta
     5161 ttacaatgc
//
