LOCUS       NM_001191947            2803 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus dishevelled-binding antagonist of beta-catenin 3
            (Dact3), mRNA.
ACCESSION   NM_001191947 XM_574375
VERSION     NM_001191947.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2803)
  AUTHORS   Xue,H., Xiao,Z., Zhang,J., Wen,J., Wang,Y., Chang,Z., Zhao,J.,
            Gao,X., Du,J. and Chen,Y.G.
  TITLE     Disruption of the Dapper3 gene aggravates ureteral
            obstruction-mediated renal fibrosis by amplifying Wnt/beta-catenin
            signaling
  JOURNAL   J Biol Chem 288 (21), 15006-15014 (2013)
   PUBMED   23580654
REFERENCE   2  (bases 1 to 2803)
  AUTHORS   Kivimae,S., Yang,X.Y. and Cheyette,B.N.
  TITLE     All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit
            conserved interactions with Vangl, Dvl, and serine/threonine
            kinases
  JOURNAL   BMC Biochem 12, 33 (2011)
   PUBMED   21718540
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2803)
  AUTHORS   Jiang,X., Tan,J., Li,J., Kivimae,S., Yang,X., Zhuang,L., Lee,P.L.,
            Chan,M.T., Stanton,L.W., Liu,E.T., Cheyette,B.N. and Yu,Q.
  TITLE     DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in
            colorectal cancer and is a therapeutic target of histone
            modifications
  JOURNAL   Cancer Cell 13 (6), 529-541 (2008)
   PUBMED   18538736
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jun 30, 2017 this sequence version replaced NM_001191947.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.305840.1,
                                           SRR21887622.3795154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               JAXUCZ010000001.1  86674993-86675343
            352-448             JAXUCZ010000001.1  86682791-86682887
            449-601             JAXUCZ010000001.1  86683014-86683166
            602-2803            JAXUCZ010000001.1  86684521-86686722
FEATURES             Location/Qualifiers
     source          1..2803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2803
                     /gene="Dact3"
                     /gene_synonym="RGD1563892"
                     /note="dishevelled-binding antagonist of beta-catenin 3"
                     /db_xref="GeneID:499088"
                     /db_xref="RGD:1563892"
     exon            1..351
                     /gene="Dact3"
                     /gene_synonym="RGD1563892"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1935
                     /gene="Dact3"
                     /gene_synonym="RGD1563892"
                     /note="dapper, antagonist of beta-catenin, homolog 3"
                     /codon_start=1
                     /product="dapper homolog 3"
                     /protein_id="NP_001178876.2"
                     /db_xref="GeneID:499088"
                     /db_xref="RGD:1563892"
                     /translation="MIRAFSFPVSPERGRLRGWLEGSLAGLCELHWLRERQEYRVQQA
                     LRLAQPGMGGAEAEDEEDAEEDEDAAAARRAAAALEEQLEALPGLIWDLGQQLGDLSL
                     ESGGLDQESGRSSGFYEDPSSTGGPDSPPSTFCGDSGFSGSGSYGRLGPSDPRGIYAS
                     ERPKSLGDASPSVPESVGARVAVPRSFSAPYPTAAAGAETCSSAERRARAGPFLTPSP
                     LHAVALRSPRPSGRVPCGSPDGAASRPLDGYISALLRRRRRRGAGQPRTSPGGADGGA
                     RRQNGARPRPPEASPPPGGARPAREPSTERAWAAAWEAEVPPEPTPPAAASPPSSPAE
                     GRLVKAQYIPGAPAASRGLPGRAARRRAPPLTRGRSVEQSPPRERPRAAGRRGRLAEP
                     SGRRGSPRARKAARSQSETSLLGRAHAAPPPKYPTAERDEPRPPRPRRGPAPTPTVQA
                     CRRWRSTAEIDAPDVRRPRARVPAPRGPAPSPSAPPRRLLYGCAGSDSECSAAGRPVP
                     LGRRMPSGCAPGGYGESESSASEGESPAFSSASSDSDGSGGLVWPQQLVAAAGASPSG
                     PGGAAGGGTPAGPAKVFVKIKASHALKKKILRFRSGSLKVMTTV"
     exon            352..448
                     /gene="Dact3"
                     /gene_synonym="RGD1563892"
                     /inference="alignment:Splign:2.1.0"
     exon            449..601
                     /gene="Dact3"
                     /gene_synonym="RGD1563892"
                     /inference="alignment:Splign:2.1.0"
     exon            602..2803
                     /gene="Dact3"
                     /gene_synonym="RGD1563892"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcccggc cagcgggcgg gcgggctgct ggggcgggga ggtgggaccg gcgagagggg
       61 cggccgtggg gcccggccgg gctggggcgg ggggccgcag ccatgatccg ggccttctcg
      121 ttcccggtga gcccggagcg gggtcggctg cggggatggt tggaaggcag cctggccggg
      181 ctctgcgagt tgcattggct ccgagagagg caggaatacc gcgtgcagca ggcgctgcgg
      241 ctggcccagc ccgggatggg gggcgccgag gcggaggacg aggaggacgc cgaggaggac
      301 gaggatgcgg cagcggcgcg tagggccgcg gcagccctgg aggagcagct ggaggccctg
      361 cctgggctca tctgggacct gggccagcag ctgggagacc tgagcctgga gtctggtggc
      421 ctggaccagg agagtgggcg cagctcaggc ttttatgaag accccagttc taccggaggc
      481 ccagattcac caccctccac cttctgcggg gacagtggct tctccggatc tggctcctat
      541 ggacgcctag gtccctcgga ccccaggggc atctatgcca gcgagagacc caagtcctta
      601 ggcgacgcca gtcccagcgt tccggagtcc gtgggtgcca gggtcgcagt gcctcgatcc
      661 ttctcagctc cctatccgac cgcagcagcg ggagctgaga cctgctcgtc cgcggaacgg
      721 cgggctcgtg ccgggccctt cctgacacct agcccgctgc acgcggtggc tctgcgcagc
      781 ccacggccaa gtggacgtgt accctgcggc tcccccgacg gggcggccag ccggcccctg
      841 gacggctaca tctcggcgct cctgcgcagg cgccgccgcc ggggggcggg ccaaccgcgc
      901 acgagtcccg ggggcgcaga cgggggcgcg cggcgccaga acggcgcgcg cccgcggccg
      961 cccgaagcgt ccccgccccc cggaggcgcg cgacccgcgc gggagccgtc gacggagcgt
     1021 gcctgggctg cggcgtggga ggcggaggtt ccacccgaac ccacgcctcc ggccgccgcg
     1081 tcgccgccct ccagtccggc ggagggtcgc ctggtgaagg cacagtacat cccgggcgcg
     1141 cccgcggcct ctaggggcct cccgggccgc gccgcgcgtc gccgggctcc gccgctcacg
     1201 cgaggtcgca gcgtggagca gtccccgcca cgagagcggc cacgcgctgc gggccgtcgg
     1261 ggccgcctgg cagagccgtc cgggcgtcgg ggatcgccga gggcgcgcaa agcggcgcgc
     1321 tcgcagtctg agaccagtct actgggccgc gcgcacgccg ctccgccgcc caagtacccc
     1381 acggctgagc gagacgagcc ccgaccgccc cggccccgcc gtggcccagc gcccacgccc
     1441 acggtccagg cctgccgtcg gtggcgatcc acagctgaga tcgacgcgcc cgatgtccgc
     1501 cgtccccgag cccgcgtgcc cgcgccgcgc ggccccgcgc cctcaccgtc cgcgcccccg
     1561 cgtcggctgc tgtacggctg cgcaggcagc gactccgagt gctcggcggc cgggcgaccc
     1621 gtgccgctcg gccgtcggat gccgtctgga tgcgcaccgg gaggctatgg cgagagcgag
     1681 tcgagcgcca gcgagggcga gtcgcccgcc ttcagctctg cctccagcga ctccgacggc
     1741 agcggaggcc tcgtgtggcc gcagcagctg gtggcggccg caggagcctc gccgtcgggg
     1801 ccagggggtg cggcgggtgg tgggacgccc gcgggtcccg ccaaggtctt cgtgaaaatc
     1861 aaggcatcgc acgcgctgaa gaaaaagatc cttcgttttc ggtcgggttc tctaaaggtc
     1921 atgacgactg tgtgagttgg ggcgggatgg gcttgaactt cacctccatg gcctccgcac
     1981 ccccacactt ctcatcctcc aacctcctcc acacccacct tccaaagacc accgttttct
     2041 ctgcttccaa agaccctcct cactcactgc ccgccgtcca tagcagtcct ggagaggccg
     2101 cccctctcct cccactggga ggcgcccaga ttgtcccagt acagctggtt ttcaaagcct
     2161 tgaaccagaa ggcgcccctc tgtgggccac actctcccca tctgtacaat gggtgtccat
     2221 gtatgcaaat gcagtaattc cgttccattc gggtctcccc tcctctaccc cgttttaatt
     2281 ttagaagctt agtctgttct ctctccactt ctctcacata gccttctcat tcctcttttc
     2341 cttgcccaga tagggcaccc ttctcattca caaagtgccc cctccatgtc cctggaccct
     2401 taggatatcc cctgggggcc cccgagtcag agaccgtctg actcaggttt tgcctacaga
     2461 gtgccctgaa agaggaaatg gcactgtctt cggggctttg agggtcaagt aggagttgcc
     2521 aacacctgga aaggactctt tctgctccat ccctggacag tcatggagga ttgggaggtt
     2581 agagagagga aggaagatgg tttcaatctc gtgcctctcc ccacggggag tgggggaagc
     2641 tgaatgaccc tcagctgttc caatccagtg ggttttttta atttgttttt ttgattaaaa
     2701 aattactgta tttattatga caatggtgac tccccggtgc atggggggcc agattctgtg
     2761 tgtttctcta acctctttgt aaataaatgc acaatgttac ata
//
