LOCUS       NM_001107464            2731 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus dishevelled-binding antagonist of beta-catenin 2
            (Dact2), mRNA.
ACCESSION   NM_001107464 XM_001055394 XM_218002
VERSION     NM_001107464.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2731)
  AUTHORS   Huang,S., Qian,X., Jiang,T., Xiao,J., Yin,M., Xiong,M. and Wen,Z.
  TITLE     Mechanism of dact2 gene inhibiting the occurrence and development
            of liver fibrosis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (6), 33-39 (2022)
   PUBMED   35818217
  REMARK    GeneRIF: Mechanism of dact2 gene inhibiting the occurrence and
            development of liver fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2731)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 2731)
  AUTHORS   Kivimae,S., Yang,X.Y. and Cheyette,B.N.
  TITLE     All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit
            conserved interactions with Vangl, Dvl, and serine/threonine
            kinases
  JOURNAL   BMC Biochem 12, 33 (2011)
   PUBMED   21718540
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2731)
  AUTHORS   Lee,W.C., Hough,M.T., Liu,W., Ekiert,R., Lindstrom,N.O.,
            Hohenstein,P. and Davies,J.A.
  TITLE     Dact2 is expressed in the developing ureteric bud/collecting duct
            system of the kidney and controls morphogenetic behavior of
            collecting duct cells
  JOURNAL   Am J Physiol Renal Physiol 299 (4), F740-F751 (2010)
   PUBMED   20685821
REFERENCE   5  (bases 1 to 2731)
  AUTHORS   Meng,F., Cheng,X., Yang,L., Hou,N., Yang,X. and Meng,A.
  TITLE     Accelerated re-epithelialization in Dpr2-deficient mice is
            associated with enhanced response to TGFbeta signaling
  JOURNAL   J Cell Sci 121 (Pt 17), 2904-2912 (2008)
   PUBMED   18716284
REFERENCE   6  (bases 1 to 2731)
  AUTHORS   Su,Y., Zhang,L., Gao,X., Meng,F., Wen,J., Zhou,H., Meng,A. and
            Chen,Y.G.
  TITLE     The evolutionally conserved activity of Dapper2 in antagonizing
            TGF-beta signaling
  JOURNAL   FASEB J 21 (3), 682-690 (2007)
   PUBMED   17197390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 11, 2021 this sequence version replaced NM_001107464.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on orthologous transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.690.1, SRR26643298.987.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               JAXUCZ010000001.1  63862856-63863098   c
            244-376             JAXUCZ010000001.1  63858078-63858210   c
            377-652             JAXUCZ010000001.1  63856763-63857038   c
            653-2731            JAXUCZ010000001.1  63854182-63856260   c
FEATURES             Location/Qualifiers
     source          1..2731
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2731
                     /gene="Dact2"
                     /note="dishevelled-binding antagonist of beta-catenin 2"
                     /db_xref="GeneID:308212"
                     /db_xref="RGD:1310742"
     exon            1..243
                     /gene="Dact2"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..2334
                     /gene="Dact2"
                     /note="dapper homolog 2, antagonist of beta-catenin;
                     dapper, antagonist of beta-catenin, homolog 2"
                     /codon_start=1
                     /product="dapper homolog 2"
                     /protein_id="NP_001100934.2"
                     /db_xref="GeneID:308212"
                     /db_xref="RGD:1310742"
                     /translation="MWAPSGPGPAGWDRRRVGARLRAALAGLQELQGLRATQQARVRG
                     ALGLHPAPGPRGQELRLEAALAALREQLSRLRRQDAGLKTHLDQLDQQISELQLDVSR
                     SPCEALDSDSRPSSGFYELSDAGSCSLSTSCASVCSDRLSPSLGSWLPVLQPSKSRSG
                     MGDWRPRSADETTVPAWSPQRTEDSRLLHGAEDTGRLRGMFRPRPVSTGDLERVLPAD
                     TGLQNAGTDASSLLCQGIEIPAHALDPKYQRDLVARGGQEVYPYPSPLHAVALQSPLF
                     ALPKEAPCFDIYSPPEEPPLVPADQNGTQPEPEPEPTRELGSAEAYIHRLLRLRGQEL
                     PLREVGQEQGGDAAAFPQKSCGQRSDGMGQLEKPACGADWGGMKPSRGAAKDSLRQQG
                     PVSLVGTETLSSPLKEETIPWNPCVRGDNTVSSSPASQIQQPYTDCGQGPVLSPSRVL
                     GPESPPLAPVPFAYTSSTTNETSPLRLRMGSPQNKAMKVKRRVSEKVPRLGKQLPPQP
                     EKQRGIHAAWSTELDPSSRPPQGGLNRRPTLAREPPGRSCSESTLYPVPLLVPLVVTQ
                     RESYPASSQALFPMETALLSSAARRKQRRWQSTMEISAKSRSVSRPGPNLGPPKSPAK
                     RTGGPRAQSRPSLARQDACARSESDPSEHSAECASLFHSTIAETSEDEEASDHTANRF
                     GDESSSNDSEDCAQSSRRGLAIGSAEAAQGGWAWPPVPLQQVSRAPGGTRPSLPPVPK
                     LCRIKASKALKKKIRRFQPAALKVMTMV"
     exon            244..376
                     /gene="Dact2"
                     /inference="alignment:Splign:2.1.0"
     exon            377..652
                     /gene="Dact2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..2731
                     /gene="Dact2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtgcggc ggttgagcgt ccgggagatg tgggcaccga gcggcccggg gcccgcgggc
       61 tgggaccgcc gcagggtggg cgcgcgacta cgagcagcac tggcggggct gcaggagctt
      121 caggggctgc gcgccacgca gcaagcgcga gtgcggggag ccctgggcct gcacccagcg
      181 ccagggcccc gcggccagga gctgaggctg gaggcggcgc tggccgcgct acgggagcag
      241 ctgtcacggc taaggagaca ggatgctggc ctgaagaccc acttggacca gctggaccag
      301 cagataagtg aactgcagct ggatgtaagc aggtcaccct gcgaggcctt agacagtgac
      361 agcaggccca gctcaggttt ctatgagctg agtgatgccg gttcctgctc cctgtccacc
      421 tcctgtgcat ctgtctgcag cgaccgtcta tccccctccc tgggaagctg gctgcctgtg
      481 ctccagccct ccaagtccag gtctggcatg ggggactggc gaccccgctc tgctgatgag
      541 accactgtcc ctgcgtggag cccacagcgc acagaagata gcaggctcct gcatggtgca
      601 gaggacacag gtcggctgag gggcatgttc cggcccagac cggtgtctac aggcgacctc
      661 gagagagtcc ttccagctga cacggggctc cagaatgctg gcactgatgc ctcatccctc
      721 ctatgccagg ggatagagat cccagcccat gcactggacc ccaagtacca gcgtgatctg
      781 gtggccaggg gaggccagga ggtgtacccg tatcccagcc ccctccatgc agtggctctg
      841 cagagccctc tttttgcttt gcctaaagaa gctccgtgtt tcgacatcta ctcaccccct
      901 gaggagcccc ctctggtccc tgctgaccag aacgggactc agcctgagcc tgagccagag
      961 cccacccgtg agctgggctc agccgaagcc tacatccaca gactactgcg tctgcggggc
     1021 caagagctcc ccctgagaga ggtggggcag gagcagggag gagacgcagc tgcttttcca
     1081 cagaagtcct gtggccagag gtcagacggg atgggtcagc tggagaagcc agcctgtggg
     1141 gctgactggg gaggaatgaa accaagtagg ggtgctgcca aggacagcct caggcaacag
     1201 gggcctgtgt cccttgtggg tactgagacc ctcagcagcc ccctaaagga ggaaaccata
     1261 ccttggaatc cctgtgtccg tggagacaat actgttagtt cctctcccgc ctcccagatc
     1321 cagcagcctt acactgactg tggccaaggg ccagtcctat caccatcaag ggtgttggga
     1381 ccagaaagcc cgcctctggc cccggttccc tttgcttaca catcctccac tactaatgaa
     1441 acctccccat tgaggctgag gatgggctct ccccaaaaca aggccatgaa ggtcaaaaga
     1501 agagttagcg agaaagtacc acggctgggg aagcagctcc caccacaacc ggagaaacag
     1561 cggggcattc atgccgcgtg gtccacagag ctggacccct cctccagacc cccgcaggga
     1621 ggtctcaata ggagacccac actggccaga gagcctcctg gacgctcctg ctctgagtcc
     1681 accctctacc ctgtgcccct cctcgtcccc ctagtggtga cccagaggga aagttacccc
     1741 gcctcatccc aagctctctt cccaatggag acagccctcc tcagctccgc agccaggcgg
     1801 aagcagcgca ggtggcaatc cactatggag atctcagcta aatcccgttc ggtcagccga
     1861 cctgggccca atttggggcc ccctaagtcc ccagccaaga gaacaggtgg tccccgagcc
     1921 cagagcaggc cctcgcttgc ccgccaggat gcctgtgcga ggagtgagtc agacccctca
     1981 gagcactctg cagagtgcgc ctcgttattt cactctacca ttgccgaaac cagcgaggac
     2041 gaggaggcta gcgaccacac tgccaaccgc tttggggacg agtccagcag taacgattca
     2101 gaagactgtg cccagagcag ccgccgcggc ctggcaatag gcagtgcaga ggctgcgcaa
     2161 gggggatggg cctggcctcc ggtgccactc cagcaggtct cgcgggcacc aggaggcacc
     2221 aggccatccc tgccccctgt gcccaaactg tgccgcataa aggcctccaa ggccctgaag
     2281 aagaagatcc gaaggttcca gccagcagcc ctgaaggtca tgaccatggt gtgataccag
     2341 cgtttcagga caagccctgg accctagaaa gtgccatgag atgtggtatc ccgtgccatg
     2401 tgatgagtag gcaaaggatt gtaccaacct gctattttgc ttaggtttct cagataccct
     2461 tcttactgtg gttgtgtcat ctggagtgac attccctcca gccctcttca ttgcatgatc
     2521 tcaaccacaa tttggttccc caccatactc tgcctgcttt gtggggagag gtctctaaca
     2581 ttcctcccca gagacttcct agaatcacgg catcctgttg ggggaggggg ggttagattt
     2641 gcatttaact ccatattaca gttgtctgaa taaacaccta caccatgctg ctagaactcc
     2701 aaataaaaga accacatttc ctttcacctc a
//
