LOCUS       NM_001399171            3630 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus dishevelled-binding antagonist of beta-catenin 1
            (Dact1), mRNA.
ACCESSION   NM_001399171 XM_002729635
VERSION     NM_001399171.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3630)
  AUTHORS   Zhang,Z., Yang,P., Wang,C. and Tian,R.
  TITLE     LncRNA CRNDE hinders the progression of osteoarthritis by
            epigenetic regulation of DACT1
  JOURNAL   Cell Mol Life Sci 79 (8), 405 (2022)
   PUBMED   35802196
  REMARK    GeneRIF: LncRNA CRNDE hinders the progression of osteoarthritis by
            epigenetic regulation of DACT1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3630)
  AUTHORS   Jardim,D.P., Poco,P.C.E. and Campos,A.H.
  TITLE     Dact1, a Wnt-Pathway Inhibitor, Mediates Human Mesangial Cell
            TGF-beta1-Induced Apoptosis
  JOURNAL   J Cell Physiol 232 (8), 2104-2111 (2017)
   PUBMED   27714812
  REMARK    GeneRIF: mRNA/protein levels are increased in kidney remnants from
            5/6 nephrectomized rats and strongly correlate with TGF-beta1
            expression.
REFERENCE   3  (bases 1 to 3630)
  AUTHORS   Ma,B., Liu,B., Cao,W., Gao,C., Qi,Z., Ning,Y. and Chen,Y.G.
  TITLE     The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2
            Degradation via Promoting Its Ubiquitination and Aggregate-induced
            Autophagy
  JOURNAL   J Biol Chem 290 (19), 12346-12354 (2015)
   PUBMED   25825496
  REMARK    GeneRIF: Dpr1 promotes the ubiquitination of Dvl2 by pVHL and
            mediates the protein aggregate-elicited autophagy initiation
REFERENCE   4  (bases 1 to 3630)
  AUTHORS   Hagenmueller,M., Riffel,J.H., Bernhold,E., Fan,J., Katus,H.A. and
            Hardt,S.E.
  TITLE     Dapper-1 is essential for Wnt5a induced cardiomyocyte hypertrophy
            by regulating the Wnt/PCP pathway
  JOURNAL   FEBS Lett 588 (14), 2230-2237 (2014)
   PUBMED   24879894
  REMARK    GeneRIF: Dpr1 (Dact1) is essential for execution of the Wnt5a/PCP
            pathway.
REFERENCE   5  (bases 1 to 3630)
  AUTHORS   Shi,Y., Ding,Y., Lei,Y.P., Yang,X.Y., Xie,G.M., Wen,J., Cai,C.Q.,
            Li,H., Chen,Y., Zhang,T., Wu,B.L., Jin,L., Chen,Y.G. and Wang,H.Y.
  TITLE     Identification of novel rare mutations of DACT1 in human neural
            tube defects
  JOURNAL   Hum Mutat 33 (10), 1450-1455 (2012)
   PUBMED   22610794
REFERENCE   6  (bases 1 to 3630)
  AUTHORS   Lagathu,C., Christodoulides,C., Virtue,S., Cawthorn,W.P.,
            Franzin,C., Kimber,W.A., Nora,E.D., Campbell,M., Medina-Gomez,G.,
            Cheyette,B.N., Vidal-Puig,A.J. and Sethi,J.K.
  TITLE     Dact1, a nutritionally regulated preadipocyte gene, controls
            adipogenesis by coordinating the Wnt/beta-catenin signaling network
  JOURNAL   Diabetes 58 (3), 609-619 (2009)
   PUBMED   19073771
REFERENCE   7  (bases 1 to 3630)
  AUTHORS   Gao,X., Wen,J., Zhang,L., Li,X., Ning,Y., Meng,A. and Chen,Y.G.
  TITLE     Dapper1 is a nucleocytoplasmic shuttling protein that negatively
            modulates Wnt signaling in the nucleus
  JOURNAL   J Biol Chem 283 (51), 35679-35688 (2008)
   PUBMED   18936100
REFERENCE   8  (bases 1 to 3630)
  AUTHORS   Su,Y., Zhang,L., Gao,X., Meng,F., Wen,J., Zhou,H., Meng,A. and
            Chen,Y.G.
  TITLE     The evolutionally conserved activity of Dapper2 in antagonizing
            TGF-beta signaling
  JOURNAL   FASEB J 21 (3), 682-690 (2007)
   PUBMED   17197390
REFERENCE   9  (bases 1 to 3630)
  AUTHORS   Zhang,L., Gao,X., Wen,J., Ning,Y. and Chen,Y.G.
  TITLE     Dapper 1 antagonizes Wnt signaling by promoting dishevelled
            degradation
  JOURNAL   J Biol Chem 281 (13), 8607-8612 (2006)
   PUBMED   16446366
REFERENCE   10 (bases 1 to 3630)
  AUTHORS   Yau,T.O., Chan,C.Y., Chan,K.L., Lee,M.F., Wong,C.M., Fan,S.T. and
            Ng,I.O.
  TITLE     HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is
            frequently downregulated in hepatocellular carcinoma: involvement
            of methylation-mediated gene silencing
  JOURNAL   Oncogene 24 (9), 1607-1614 (2005)
   PUBMED   15580286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jan 4, 2022 this sequence version replaced XM_002729635.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.35892.1,
                                           SRR21887622.1297067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-423               JAXUCZ010000006.1  95526690-95527112
            424-556             JAXUCZ010000006.1  95529817-95529949
            557-712             JAXUCZ010000006.1  95530778-95530933
            713-3630            JAXUCZ010000006.1  95534379-95537296
FEATURES             Location/Qualifiers
     source          1..3630
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3630
                     /gene="Dact1"
                     /gene_synonym="RGD1564008"
                     /note="dishevelled-binding antagonist of beta-catenin 1"
                     /db_xref="GeneID:500666"
                     /db_xref="RGD:1564008"
     exon            1..423
                     /gene="Dact1"
                     /gene_synonym="RGD1564008"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2436
                     /gene="Dact1"
                     /gene_synonym="RGD1564008"
                     /note="dapper homolog 1, antagonist of beta-catenin;
                     dapper, antagonist of beta-catenin, homolog 1"
                     /codon_start=1
                     /product="dapper homolog 1"
                     /protein_id="NP_001386100.1"
                     /db_xref="GeneID:500666"
                     /db_xref="RGD:1564008"
                     /translation="MKPDSAREPEPLSPGRGAEAEGRWRERGEADTERQRTRERQEAT
                     LAGLAELGYLRQRQELLVRGALRCSGAVGTVAPRAGELRGDAAQRSRLEEKFLEENIL
                     LLRRQLNCLRRRDAGLLNQLQELDKQISDLRLDVEKTSEEHLETDSRPSSGFYELSDG
                     ASGSLSNSSNSVFSECLSSCHSSTCFCSPLEAALTISDGCPKSADVNPKYQCDLVSKN
                     GNDVYRYPSPLHAVAVQSPMFLLCLTGNSLREEEGLGNHASDICIGSELNATKMDNSL
                     PSPSSLWPASQPASSKKMDGYILSLVQKKTHPVRTNKPRTSVNADPTKGLLRNGSVCV
                     RAPSSVPQGSNVNLKNTKQMCLPCGGIPSLENGPFSPPKQRSKDSKTDQSESKRLALQ
                     EGCSVGTAMEPQSKHLPKIAKAASQELVRCQAGLGESMKESNQVSAVSPKTSPGGGPV
                     ASTESKALQLQKKMPQKSSLQALPAVDRPSLDFKSEGSSQSLEEGHLVKAQFIPGQQA
                     GARPHRAHRNPGVARSATLKARGQAATEHGLPTVREKPRAVGKKCRFPDDLDTNKKLR
                     KASSKGRRSSGLPDASLPGRPLGTGGHRAGSRAHAHGREPVVAKPKHKRTDYRRWKSS
                     AEVSYEEALRRARRARREHGGAYPVAVAVPYPSPYAYVASDSEYSAECESLFHSTVVD
                     TSEDDQSNYTTNCFGDSESSVSEGDFVGESTTTSDSEESGGLIWSQFVQTLPIQTVTA
                     PDLHTRPTKTFVKIKASHNLKKKILRFRSGSLKLMTTV"
     exon            424..556
                     /gene="Dact1"
                     /gene_synonym="RGD1564008"
                     /inference="alignment:Splign:2.1.0"
     exon            557..712
                     /gene="Dact1"
                     /gene_synonym="RGD1564008"
                     /inference="alignment:Splign:2.1.0"
     exon            713..3630
                     /gene="Dact1"
                     /gene_synonym="RGD1564008"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactggagc agcgcgggat gcgagtgcgg gcggcatgag ctcccggccg ggaccctagc
       61 gcgtgctgct gctctcgggc tggccgggcc tcgggggtca tgaagcccga ctcagcgcgc
      121 gagcccgagc cgctgagccc cggcaggggc gcagaggccg aggggcgctg gcgcgagagg
      181 ggcgaggcgg acacggagcg gcagcgcacc cgcgagcgcc aggaggccac gctggcgggg
      241 ctggcggagc tggggtacct gcggcaacgc caggagctgc tggtgcgcgg tgcgctgcgc
      301 tgctccgggg ccgtggggac cgtcgcgccg cgcgccgggg agctgcgggg ggacgcggcg
      361 cagcgcagcc gcctggagga gaagttcctg gaggagaaca tcttgctgct gcggaggcag
      421 ttgaattgtt tgaggagaag agatgccggt ttgttgaatc agttgcaaga acttgacaag
      481 cagataagtg acctgagact ggatgttgag aagacatctg aggagcacct ggagacggac
      541 agccggccta gctcagggtt ttatgagctg agtgatgggg cttccgggtc cctttctaac
      601 tcctctaact ccgtgttcag tgaatgtttg tccagttgcc attccagcac ctgcttctgc
      661 agccccttgg aggcagcctt gaccatctcg gacggttgcc ccaaatctgc agatgtgaat
      721 cctaaatacc agtgtgacct tgtgtctaaa aacgggaatg acgtatatcg gtatcccagt
      781 ccacttcacg ctgtggctgt gcagagccca atgtttctcc tttgtctgac gggcaactct
      841 ctgagggaag aggaggggct tgggaaccac gccagcgaca tttgcattgg atctgaactg
      901 aatgccacca aaatggataa ttccttgcca tctccaagca gtttgtggcc ggcttctcag
      961 cctgcatcca gtaagaaaat ggatgggtat attctgagcc tggtccagaa gaaaacacac
     1021 cctgtaagga ccaataaacc tagaaccagt gtgaacgctg accctaccaa ggggcttctg
     1081 aggaatggaa gtgtgtgtgt cagggcccct agtagtgtcc cacagggcag caatgtgaac
     1141 cttaagaata cgaaacagat gtgtttgccc tgtgggggaa taccctcttt ggaaaatggg
     1201 ccattctctc ctcctaagca gaggtcaaaa gactcgaaga cagaccagtc agaaagtaag
     1261 aggttggctc tgcaggaggg ctgctcggta ggcactgcca tggaacccca aagcaagcat
     1321 ctgcccaaaa tcgccaaggc agcctctcaa gagcttgtaa ggtgtcaagc tgggctggga
     1381 gaatctatga aggaaagcaa tcaggtttca gccgtttctc ctaaaacaag tccgggcgga
     1441 ggccctgtcg cttccacaga gagcaaagct ctgcagctcc agaaaaagat gccacagaag
     1501 agcagtctac aggccttgcc tgcggtggac aggccatcct tggacttcaa aagcgagggc
     1561 tcttctcaaa gcctcgaaga agggcatctg gtaaaagctc agttcatccc agggcagcag
     1621 gcgggcgcca ggcctcaccg tgcacacagg aacccgggtg tcgcaaggag cgccaccttg
     1681 aaggcccgtg gccaggcagc cacagaacat ggccttccca ccgtcaggga gaaaccgcgg
     1741 gcggtgggca agaagtgccg tttcccagac gacttggata caaataagaa actcaggaag
     1801 gcctcctcca agggccggcg cagcagcggg ctgcccgacg cgagccttcc tggcaggcca
     1861 ctgggcaccg gcggccatag ggcaggcagc agggcgcacg cgcacggacg ggagccggtg
     1921 gtggccaaac ctaaacacaa gcgaaccgac taccggaggt ggaagtcgtc ggccgaggtc
     1981 tcctacgaag aggccctgcg gagggcacgg agggctcgca gggagcacgg gggcgcctac
     2041 ccagtggccg tggccgtgcc ctaccccagc ccctacgcct acgtggccag cgactctgag
     2101 tactcggccg agtgtgagtc gctcttccac tccacggtgg tggacaccag cgaggacgat
     2161 cagagcaact acaccaccaa ctgctttggc gacagtgagt ccagcgtgag cgagggcgac
     2221 ttcgtgggtg agagcaccac caccagcgac tctgaggaga gcgggggttt aatctggtcc
     2281 cagtttgtcc agactctccc tattcaaacg gttacggccc cagaccttca cacccgcccc
     2341 acaaaaacct ttgtcaaaat taaggcctcg cacaacctca agaagaagat cctccgcttc
     2401 cggtcaggct ctttgaaact gatgactact gtttgagtag ctgatgtagc gagtgtcttc
     2461 ccctccccca gtctctggaa aagaaaagaa agaaagaaaa aaggtggtgt cttaatattt
     2521 gtgtcatact taaatgatac tttccttcta ctaggataaa cccaagataa attatgtctc
     2581 gccatcatgt atggacgcta gtgcctttaa tggaaggtga aggatgtatc gctagttaga
     2641 agtgaatatt gaggtcttag tggtggtgat aatgaatgaa ttttgattat cagatgtttt
     2701 gtccgagtgt ctggcaaagt acaggtctgt gatgtttcaa gttttatttg gatgagacct
     2761 tttgtttccg aggtctgtgg ataaaatttt taagtcgtga actcgcgcct tgatgtttta
     2821 gggctgtgtc cctgaaaaga ctttccggtt gaggggcatt gcatacaatt gtgtagaata
     2881 ggtagaaaaa aaaatggtca ttgctttctg taaacttttt taatatagtc aacatttctc
     2941 agatgtctct ccatcctatt ttcttcttag aagtacactt tttactggat ttagaaccta
     3001 gtagaccaga ctgtaaatct ggaggtggta aactggatag gaagactgac aggaccttag
     3061 aaggattcac aaaaaccttt gccacgtgta gtgcctcagc cttcgttaca gtaactcttt
     3121 ctgggccagg tatccagcag tttttgatgc ctttctctct gctcctaact tgtatccaat
     3181 acaactgttt gtcccttaga cagcttgcct ttgggataaa atgttggtcc tatggtgcaa
     3241 agaaattcac ccttactggg catgactcca agcccagaat tgctctcacc taagcactgg
     3301 cctaaacagt agtgcagttc actccccact ggaccactga cttgtctgga agggctttac
     3361 attttttaaa aaagtttttg gtaaacagta ttgtgtaaaa tagaattttt taaatactga
     3421 tatatgcatg ttttgtgcat gagtagtagt tatttggatt cctgttttga tattcctgtt
     3481 gttgaattac tgtataatat aaacagtatg tgttttatat atatcattgt gtaaatttaa
     3541 tataacacat tatatgctgt actaaatgat ttgttttatt gctgttaact ttgttatttg
     3601 ttataaaaac cagatgttta cacttataaa
//
