LOCUS       NM_024159               3160 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus DAB adaptor protein 2 (Dab2), mRNA.
ACCESSION   NM_024159 XM_346616
VERSION     NM_024159.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3160)
  AUTHORS   Jing,Z., Jia-Jun,W. and Wei-Jie,Y.
  TITLE     Phosphorylation of Dab2 is involved in inhibited VEGF-VEGFR-2
            signaling induced by downregulation of syndecan-1 in glomerular
            endothelial cell
  JOURNAL   Cell Biol Int 44 (3), 894-904 (2020)
   PUBMED   31868265
  REMARK    GeneRIF: Phosphorylation of Dab2 is involved in inhibited
            VEGF-VEGFR-2 signaling induced by downregulation of syndecan-1 in
            glomerular endothelial cell.
REFERENCE   2  (bases 1 to 3160)
  AUTHORS   Schutte-Nutgen,K., Edeling,M., Mendl,G., Krahn,M.P., Edemir,B.,
            Weide,T., Kremerskothen,J., Michgehl,U. and Pavenstadt,H.
  TITLE     Getting a Notch closer to renal dysfunction: activated Notch
            suppresses expression of the adaptor protein Disabled-2 in tubular
            epithelial cells
  JOURNAL   FASEB J 33 (1), 821-832 (2019)
   PUBMED   30052485
  REMARK    GeneRIF: showed that Dab2 expression in cultured tubular epithelial
            cells is involved in endocytic regulation and that it also protects
            cells from TGF-beta-induced epithelial-to-mesenchymal transition
REFERENCE   3  (bases 1 to 3160)
  AUTHORS   Lam,J., van den Bosch,M., Wegrzyn,J., Parker,J., Ibrahim,R.,
            Slowski,K., Chang,L., Martinez-Hoyer,S., Condorelli,G., Boldin,M.,
            Deng,Y., Umlandt,P., Fuller,M. and Karsan,A.
  TITLE     miR-143/145 differentially regulate hematopoietic stem and
            progenitor activity through suppression of canonical TGFbeta
            signaling
  JOURNAL   Nat Commun 9 (1), 2418 (2018)
   PUBMED   29925839
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3160)
  AUTHORS   Ahn,M., Moon,C., Park,C., Kim,J., Sim,K.B. and Shin,T.
  TITLE     Transient activation of an adaptor protein, disabled-2, in rat
            spinal cord injury
  JOURNAL   Acta Histochem 117 (1), 56-61 (2015)
   PUBMED   25432322
  REMARK    GeneRIF: these findings suggest that both isoforms of Dab-2 are
            transiently upregulated in response to SCI and that the increased
            expression of Dab-2 is associated with the early activation of
            macrophages and astrogliosis
REFERENCE   5  (bases 1 to 3160)
  AUTHORS   Vazquez-Carretero,M.D., Palomo,M., Garcia-Miranda,P.,
            Sanchez-Aguayo,I., Peral,M.J., Calonge,M.L. and Ilundain,A.A.
  TITLE     Dab2, megalin, cubilin and amnionless receptor complex might
            mediate intestinal endocytosis in the suckling rat
  JOURNAL   J Cell Biochem 115 (3), 510-522 (2014)
   PUBMED   24122887
  REMARK    GeneRIF: We conclude that the megalin/cubilin/amnionless/Dab2
            complex/es participate in intestinal processes, mainly during the
            lactation period and that Dab2 may act as an adaptor in intestinal
            processes mediated by ApoER2 and VLDLR.
REFERENCE   6  (bases 1 to 3160)
  AUTHORS   Zhou,J. and Hsieh,J.T.
  TITLE     The inhibitory role of DOC-2/DAB2 in growth factor
            receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of
            ERK phosphorylation via binding to Grb2
  JOURNAL   J Biol Chem 276 (30), 27793-27798 (2001)
   PUBMED   11371563
REFERENCE   7  (bases 1 to 3160)
  AUTHORS   Morris,S.M. and Cooper,J.A.
  TITLE     Disabled-2 colocalizes with the LDLR in clathrin-coated pits and
            interacts with AP-2
  JOURNAL   Traffic 2 (2), 111-123 (2001)
   PUBMED   11247302
  REMARK    Erratum:[Traffic 2002 Mar;3(3):236]
REFERENCE   8  (bases 1 to 3160)
  AUTHORS   Cho,S.Y., Jeon,J.W., Lee,S.H. and Park,S.S.
  TITLE     p67 isoform of mouse disabled 2 protein acts as a transcriptional
            activator during the differentiation of F9 cells
  JOURNAL   Biochem J 352 Pt 3 (Pt 3), 645-650 (2000)
   PUBMED   11104669
REFERENCE   9  (bases 1 to 3160)
  AUTHORS   Oleinikov,A.V., Zhao,J. and Makker,S.P.
  TITLE     Cytosolic adaptor protein Dab2 is an intracellular ligand of
            endocytic receptor gp600/megalin
  JOURNAL   Biochem J 347 Pt 3 (Pt 3), 613-621 (2000)
   PUBMED   10769163
REFERENCE   10 (bases 1 to 3160)
  AUTHORS   Tseng,C.P., Ely,B.D., Li,Y., Pong,R.C. and Hsieh,J.T.
  TITLE     Regulation of rat DOC-2 gene during castration-induced rat ventral
            prostate degeneration and its growth inhibitory function in human
            prostatic carcinoma cells
  JOURNAL   Endocrinology 139 (8), 3542-3553 (1998)
   PUBMED   9681506
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_024159.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U95177.1, BC097314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                JAXUCZ010000002.1  57272300-57272396
            98-237              JAXUCZ010000002.1  57273332-57273471
            238-336             JAXUCZ010000002.1  57274774-57274872
            337-468             JAXUCZ010000002.1  57277835-57277966
            469-549             JAXUCZ010000002.1  57278475-57278555
            550-576             JAXUCZ010000002.1  57279313-57279339
            577-630             JAXUCZ010000002.1  57279586-57279639
            631-693             JAXUCZ010000002.1  57280033-57280095
            694-1347            JAXUCZ010000002.1  57284619-57285272
            1348-1507           JAXUCZ010000002.1  57286273-57286432
            1508-2143           JAXUCZ010000002.1  57290552-57291187
            2144-2250           JAXUCZ010000002.1  57291664-57291770
            2251-2322           JAXUCZ010000002.1  57292260-57292331
            2323-3160           JAXUCZ010000002.1  57292959-57293796
FEATURES             Location/Qualifiers
     source          1..3160
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..3160
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /note="DAB adaptor protein 2"
                     /db_xref="GeneID:79128"
                     /db_xref="RGD:621007"
     exon            1..97
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..2313
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /note="C9; mitogen-responsive phosphoprotein; disabled
                     homolog 2 mitogen-responsive phosphoprotein; adaptor
                     molecule disabled-2; differentially expressed in ovarian
                     carcinoma 2; disabled 2, mitogen-responsive
                     phosphoprotein; DAB2, clathrin adaptor protein"
                     /codon_start=1
                     /product="disabled homolog 2"
                     /protein_id="NP_077073.1"
                     /db_xref="GeneID:79128"
                     /db_xref="RGD:621007"
                     /translation="MSNEVETSTTNGQPDQQAAPKAPSKKEKKKGSEKTDEYLLARFK
                     GDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGI
                     KIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVV
                     DLKDLFQVIYNVKKKEEEKKKVEEANKAEENGSEALMTLDDQANKLKLGVDQMDLFGD
                     MSTPPDLNNPTESRDILLVDLNSEIDTNQNSLRENPFLTNGVTSCSLPRPKPQASFLP
                     ESAFSANLNFFPTPNPDPFRDDPFAQPDQSAPSSFHSLTSADQKKANPGSLSTPQSKG
                     PLNGDTDYFGQQFDQISNRTGKQEAQGGPWPYPSSQTQQAVRTQNGVSEKEQNGFHIK
                     SSPNPFVGSPPKGLSVPNGVKQDLESSVQSSAHDSIAIIPPPQSTKPGRGRRTAKSSA
                     NDLLASDIFASEPPGQMSPTGQPAVPQANFMDLFKTSAPAPMGSGPLVGLGTVPVTPP
                     QAGPWTPVVFTPSTTVVPGAIISGQPSGFGQPLVFGTTPAVQVWNQPSSFATAASPPP
                     PAVWCPTTSVAPNTWSSTSPLGNPFQSSNIFPPSTISTQSFPQPMMSSVLVTPPQPPP
                     RNGPLKDTLSDAFTGLDPLGDKEVKEVKEMFKDFQLRQPPLVPSRKGETPSSGTSSAF
                     SSYFNNKVGIPQEHVDHDDFDANQLLNKINEPPKPAPRQGVLSGTKSADNSLENPFSK
                     GFSSTNPSVVSQPASSDAHRSPFGNPFA"
     exon            98..237
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     exon            238..336
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     exon            337..468
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     exon            469..549
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..576
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..630
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..693
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     exon            694..1347
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1507
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..2143
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2250
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2322
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..3160
                     /gene="Dab2"
                     /gene_synonym="Doc-2; Doc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgtcatgt ctaatgaagt agagacaagc acaaccaatg gtcagcctga ccaacaggct
       61 gcaccgaaag caccatcaaa gaaggaaaag aagaaaggtt ctgaaaagac agatgagtat
      121 ctgttggcca ggttcaaagg tgatggtgta aaatacaagg ccaagctaat cggtattgat
      181 gatgtgcctg atgcgagggg agacaaaatg agtcaggatt ctatgatgaa actcaaggga
      241 atggcagcag ctggtcgctc tcagggacag cacaagcaaa ggatctgggt caacatttcc
      301 ctgtctggca taaaaattat tgatgagaaa accggggtaa tagagcatga acatccagta
      361 aataagattt ccttcattgc tcgtgatgtg acagacaata gagcatttgg ttatgtgtgt
      421 ggaggagaag gccagcatca attttttgct ataaaaacag ggcaacaggc tgaaccatta
      481 gtcgtcgatc ttaaagacct ttttcaagtt atctataatg taaagaaaaa ggaagaagaa
      541 aagaaaaagg ttgaagaagc caacaaagcg gaagagaatg ggagtgaggc cctaatgacc
      601 cttgatgatc aagctaacaa actgaagctg ggtgttgacc agatggattt gtttggggac
      661 atgtctacac ctcctgacct aaataatcca acagaaagca gagatatcct gttagtggat
      721 ctaaactctg aaatcgacac caatcagaac tctttaagag aaaatccatt cttaacaaat
      781 ggagtcacct cctgttctct ccctcgacca aagcctcagg catccttctt gcctgaaagt
      841 gccttttctg ccaatctcaa cttctttccc acccctaatc ctgatccttt ccgtgatgat
      901 cctttcgcac agccagacca atcggcaccc tcttcgtttc attctctcac atctgcagat
      961 cagaagaaag cgaatccggg tagcttgtct actccacaga gtaaagggcc cttgaacggt
     1021 gatactgatt actttggtca gcaatttgac cagatctcta accggactgg caaacaggaa
     1081 gctcagggag gcccatggcc ctatccaagt tcgcaaaccc agcaagcagt gagaactcaa
     1141 aatggggtat ctgaaaaaga acagaacggc ttccatatca aatcttcccc gaaccctttt
     1201 gtgggaagcc ctcccaaagg actatcggta ccgaatggcg taaagcagga cttggaaagc
     1261 tctgtccagt cctcagcgca tgactccata gccattatcc cacctccaca aagtaccaaa
     1321 ccaggaagag gcaggaggac cgctaagtct tcagcaaacg acctgcttgc ttcagatatc
     1381 tttgcctcag aacctccagg ccagatgtcc cccacaggac aacctgcagt cccacaggcg
     1441 aactttatgg atctcttcaa aaccagtgct cctgccccaa tggggtcggg gcccctcgta
     1501 ggtctaggta ctgtcccagt aacacccccc caagcaggac cttggacacc tgttgtcttc
     1561 actccttcta caactgtggt cccaggagcc ataataagtg gccagccttc cggttttggt
     1621 cagccactcg tctttggtac aaccccagca gtgcaagttt ggaatcagcc ttcatcattt
     1681 gcaactgcag cttcccctcc acccccggca gtttggtgtc ctaccacatc tgtggcaccc
     1741 aacacttggt catccacaag tcccctgggg aatccttttc agagtagtaa tatctttcca
     1801 ccttccacca tatccactca gtcctttcct cagcctatga tgtcctctgt tctggtcaca
     1861 cctccccaac cacctccccg aaatggccca ctaaaggaca ctcttagtga tgccttcact
     1921 ggcttagacc cacttgggga taaagaggtc aaggaagtga aagaaatgtt taaggacttc
     1981 cagctgcggc agccacctct tgtaccctcg aggaaggggg agacaccttc ctctgggacc
     2041 tcaagcgcct tctccagtta cttcaacaat aaagttggca ttcctcagga gcatgtagac
     2101 catgatgatt ttgatgccaa tcaactgttg aacaagatta atgaaccacc aaagccagcc
     2161 cccagacaag gtgtcctctc gggtaccaaa tctgctgaca attcactcga gaaccctttc
     2221 tctaaagggt tcagctcaac aaacccctcc gtggtctctc agcctgcatc ttctgatgcc
     2281 cacaggagcc cttttggaaa tccttttgcc taacttcttt ctgaagttgt aatgctgact
     2341 gactatccag atgagcaaaa ggctggcttt ggtcaaggat taagcagata gccagaaacg
     2401 tgctgacctc tgtccttgct ccagctttga tgtattacct gttaccctac ttgtctttgc
     2461 ctcatgtact tgtaaaaagc ctttcactct ctctaggcta aagctacact gaaacaatgg
     2521 ctttacataa attaaactcc taagctctct agctccaata taaatgaagt agcttcccta
     2581 ccaaatcctt gtctgtcgtg ctcctagaac cttccagaat attctccgtt ttaccctcaa
     2641 tttgggaggt gtggccacct ttacccttaa tatcacactg ccttgagtaa atgtccaaat
     2701 ccttgtagct ctcaaggtca tttgtgattc ctggtgtgca tcataaatct aaacattaat
     2761 attaacatta ataggaaagc aagacacctt gcttcccatt cccactcaga caagtttttt
     2821 tatgataaaa tgaaagcaag actaacttct cgaatccacc caaggaccat ttcgagatgg
     2881 tctttctcag ctaattgcat catttaccaa tcctactcca agtggtgttt acatttgact
     2941 tgaaaaggag aaaggtctaa ctcaaaacat aaggcattat tcaaagctaa taaaacaatt
     3001 tctccctggg gccccacatt gttttcattc cagacacttt gcagctgttt gaccctgatg
     3061 atattatgcc ctacattttc cttgaagatt ctgattttat ttcatgtgat tcttttttct
     3121 caataaagat gattattgtg tgcattacta aacaaacaaa
//
