LOCUS       NM_001411819            5491 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus DAB adaptor protein 1 (Dab1), transcript variant
            2, mRNA.
ACCESSION   NM_001411819
VERSION     NM_001411819.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5491)
  AUTHORS   Vazquez-Carretero,M.D., Garcia-Miranda,P., Balda,M.S., Matter,K.,
            Peral,M.J. and Ilundain,A.A.
  TITLE     Small and large intestine express a truncated Dab1 isoform that
            assembles in cell-cell junctions and co-localizes with proteins
            involved in endocytosis
  JOURNAL   Biochim Biophys Acta Biomembr 1860 (5), 1231-1241 (2018)
   PUBMED   29470947
  REMARK    GeneRIF: In intestine a truncated Dab1 variant transmits the reelin
            signal and may play a role in clathrin-mediated apical endocytosis
            and in the control of cell-to-cell junction assembly. Dab1 variant
            may be a nucleocytoplasmic shuttling protein, inferred from its
            sequence and nuclear location.
REFERENCE   2  (bases 1 to 5491)
  AUTHORS   Hu,C., Wang,P., Zhang,S., Ren,L., Lv,Y., Yin,R. and Bi,J.
  TITLE     Neuroprotective effect of melatonin on soluble Abeta1-42-induced
            cortical neurodegeneration via Reelin-Dab1 signaling pathway
  JOURNAL   Neurol Res 39 (7), 621-631 (2017)
   PUBMED   28385118
  REMARK    GeneRIF: Melatonin ameliorated the neurotoxiciy and astrocyte
            activation induced by Abeta1-42 in the cerebral cortex. Melatonin
            also blocked the reduction in Reelin and Dab1 expression induced by
            Abeta1-42. Using in vitro study, Reelin inactivation completely
            abolished the protective effect of melatonin against
            Abeta1-42-induced neurotoxicity.
REFERENCE   3  (bases 1 to 5491)
  AUTHORS   Gao,Z., Chen,X., Zhu,K., Zeng,P. and Ding,G.
  TITLE     Dab1 Contributes to Angiotensin II-Induced Apoptosis via p38
            Signaling Pathway in Podocytes
  JOURNAL   Biomed Res Int 2017, 2484303 (2017)
   PUBMED   28676854
  REMARK    GeneRIF: These results indicated that Dab1 mediated Ang II-induced
            podocyte apoptosis via p38 signaling pathway.
REFERENCE   4  (bases 1 to 5491)
  AUTHORS   Simo,S. and Cooper,J.A.
  TITLE     Rbx2 regulates neuronal migration through different cullin 5-RING
            ligase adaptors
  JOURNAL   Dev Cell 27 (4), 399-411 (2013)
   PUBMED   24210661
REFERENCE   5  (bases 1 to 5491)
  AUTHORS   Matsuki,T., Matthews,R.T., Cooper,J.A., van der Brug,M.P.,
            Cookson,M.R., Hardy,J.A., Olson,E.C. and Howell,B.W.
  TITLE     Reelin and stk25 have opposing roles in neuronal polarization and
            dendritic Golgi deployment
  JOURNAL   Cell 143 (5), 826-836 (2010)
   PUBMED   21111240
REFERENCE   6  (bases 1 to 5491)
  AUTHORS   Wang,Z., Tseng,C.P., Pong,R.C., Chen,H., McConnell,J.D., Navone,N.
            and Hsieh,J.T.
  TITLE     The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate
            cancer. Characterization of a novel GTPase-activating protein
            associated with N-terminal domain of DOC-2/DAB2
  JOURNAL   J Biol Chem 277 (15), 12622-12631 (2002)
   PUBMED   11812785
REFERENCE   7  (bases 1 to 5491)
  AUTHORS   Ohshima,T., Ogawa,M., Veeranna, Hirasawa,M., Longenecker,G.,
            Ishiguro,K., Pant,H.C., Brady,R.O., Kulkarni,A.B. and Mikoshiba,K.
  TITLE     Synergistic contributions of cyclin-dependant kinase 5/p35 and
            Reelin/Dab1 to the positioning of cortical neurons in the
            developing mouse brain
  JOURNAL   Proc Natl Acad Sci U S A 98 (5), 2764-2769 (2001)
   PUBMED   11226314
REFERENCE   8  (bases 1 to 5491)
  AUTHORS   Alvarez-Dolado,M., Ruiz,M., Del Rio,J.A., Alcantara,S., Burgaya,F.,
            Sheldon,M., Nakajima,K., Bernal,J., Howell,B.W., Curran,T.,
            Soriano,E. and Munoz,A.
  TITLE     Thyroid hormone regulates reelin and dab1 expression during brain
            development
  JOURNAL   J Neurosci 19 (16), 6979-6993 (1999)
   PUBMED   10436054
REFERENCE   9  (bases 1 to 5491)
  AUTHORS   Howell,B.W., Hawkes,R., Soriano,P. and Cooper,J.A.
  TITLE     Neuronal position in the developing brain is regulated by mouse
            disabled-1
  JOURNAL   Nature 389 (6652), 733-737 (1997)
   PUBMED   9338785
REFERENCE   10 (bases 1 to 5491)
  AUTHORS   Sweet,H.O., Bronson,R.T., Johnson,K.R., Cook,S.A. and Davisson,M.T.
  TITLE     Scrambler, a new neurological mutation of the mouse with
            abnormalities of neuronal migration
  JOURNAL   Mamm Genome 7 (11), 798-802 (1996)
   PUBMED   8875886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.28098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               JAXUCZ010000005.1  124369504-124369845
            343-544             JAXUCZ010000005.1  124485863-124486064
            545-684             JAXUCZ010000005.1  124607586-124607725
            685-783             JAXUCZ010000005.1  124612932-124613030
            784-915             JAXUCZ010000005.1  124676130-124676261
            916-1035            JAXUCZ010000005.1  124676882-124677001
            1036-1074           JAXUCZ010000005.1  124677490-124677528
            1075-1140           JAXUCZ010000005.1  124678988-124679053
            1141-1200           JAXUCZ010000005.1  124685669-124685728
            1201-1263           JAXUCZ010000005.1  124717036-124717098
            1264-1372           JAXUCZ010000005.1  124719334-124719442
            1373-1921           JAXUCZ010000005.1  124726012-124726560
            1922-2049           JAXUCZ010000005.1  124729620-124729747
            2050-2160           JAXUCZ010000005.1  124730061-124730171
            2161-5491           JAXUCZ010000005.1  124739254-124742584
FEATURES             Location/Qualifiers
     source          1..5491
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33-q34"
     gene            1..5491
                     /gene="Dab1"
                     /note="DAB adaptor protein 1"
                     /db_xref="GeneID:266729"
                     /db_xref="RGD:628770"
     exon            1..342
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..544
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..2145
                     /gene="Dab1"
                     /note="Dab, reelin signal transducer, homolog 1; DAB1,
                     reelin adaptor protein"
                     /codon_start=1
                     /product="disabled homolog 1"
                     /protein_id="NP_001398748.1"
                     /db_xref="GeneID:266729"
                     /db_xref="RGD:628770"
                     /translation="MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKA
                     KLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTG
                     ALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQL
                     IYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEEN
                     IYQVPTSQKKEGVYDVPKSQPVSAVTQLELFGDMSTPPDITSPPTPATPGDAFLPAPS
                     QTLPGSADVFGSMSFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQIAMGAQPPVAQVIP
                     GAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPG
                     TNDSARSSPQSDKPRQKMGKEMFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKV
                     GVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHVSDPTADDI
                     FEEGFESPSKSEEQEAPDGSQASSTSDPFGEPSGEPSGDNISPQDGS"
     exon            545..684
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..783
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..915
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1035
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1074
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1140
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1200
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1263
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1372
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1921
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2049
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2160
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..5491
                     /gene="Dab1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actggagaaa cgcggagtcc gggaggaggc tgcagcggct gcctaggaac gtggcccgct
       61 cgcagcgcaa tccccctacc ccctgcgacg aacggcaggg cggggacccc aggttctcgg
      121 ctccaatcgg tctctactcc cgggatgggg ggcgagcgag aggactggag aagcgcgacc
      181 gcgagccgcg gcgcccccgc tcgcccgctc gttggctctt ccccttcgtc ggcgccgcgg
      241 cgactccact gagctgtcgc tcggaacgcg ttctggcggc gaacagagag cccgggcggg
      301 agagggagcc ggcgaggaag ggcttgggac gctcagtggc agcactccga cagagtgaat
      361 gacatgtgcg gcccggggtg tcctttctga agggaggagc ctttctcttg gagaggatcc
      421 tcgatgagcc tggccaaggc ccggggtctg tgtgaagagg actaaggatt aagtaggatg
      481 tcaactgaga cagaacttca agtagctgtg aaaaccagcg ccaagaaaga ctccaggaag
      541 aaaggtcagg atcgcagcga agccactttg ataaagaggt ttaaaggcga aggggtccgg
      601 tacaaagcca agctgattgg gatcgatgaa gtgtccgcag ctcggggaga caagttatgt
      661 caagattcca tgatgaagct caagggtgtt gttgctggcg ctcgttccaa aggagaacac
      721 aaacagaaaa tctttttaac catctccttt ggaggaatca agatctttga tgagaagacc
      781 ggggcccttc agcatcacca tgctgttcac gaaatttcct acattgcgaa ggacatcaca
      841 gatcaccggg cttttggata cgtttgtggg aaggaaggga atcacagatt tgtggccatc
      901 aaaacagccc aggcggctga gcccgttatc ctggacttga gagatctctt tcaactcatc
      961 tatgagctga agcaaagaga agaattggaa aaaaaggcac agaaggataa gcagtgtgaa
     1021 caagccgtgt accagaccat tttggaagag gatgttgaag atcccgtgta ccagtacatt
     1081 gtgtttgagg ctggacatga gccaatccgt gatcctgaaa cagaagaaaa catttaccag
     1141 gttcccacca gccaaaagaa ggaaggtgtt tatgatgtgc caaaaagtca acctgtaagt
     1201 gctgtgaccc aactagaact ttttggagac atgtccaccc ctcctgatat aacctctccc
     1261 cccactcctg caaccccagg tgatgccttt ctcccggcgc catcccagac acttccgggg
     1321 agtgcagatg tgtttggctc tatgtctttt ggcactgctg ctgtaccctc aggttatgtc
     1381 gctatgggcg ccgtcctccc atccttctgg ggccagcagc cccttgttca acagcagatc
     1441 gccatgggtg ctcagccacc cgttgctcag gtgataccag gagctcagcc catcgcatgg
     1501 ggccagccag gtctctttcc tgcaacccag caaccctggc caactgtggc cgggcagttc
     1561 ccgccagccg ccttcatgcc cacacaaact gttatgcctt taccagctgc catgttccaa
     1621 ggtcccctca ccccccttgc aaccgtccca ggcacgaatg actctgccag gtcaagtcca
     1681 cagagtgaca agcccaggca gaaaatgggg aaggaaatgt ttaaggattt ccagatggcc
     1741 cagcctccac ccgtaccctc ccgaaaacct gaccagccct ccctgacctg tacctcagag
     1801 gccttctcca gttacttcaa caaagtcggg gtggcacagg atacagacga ctgtgatgac
     1861 tttgacatct cccaattgaa cttgacccct gtgacttcta ccacaccatc taccaactca
     1921 cctccaaccc cggcccctag gcagagctct ccatccaaat catcagcttc ccacgtcagt
     1981 gatccgaccg cagatgacat ctttgaagaa ggctttgaaa gtcccagcaa gagtgaagaa
     2041 caagaagctc ctgatggatc acaggcctcc tccaccagtg atccatttgg ggagcccagt
     2101 ggtgagccca gtggtgataa tataagtcca caagacggta gctagatagc gcaggtctgg
     2161 gagccagagc ctctctatgc gcagatcaac agacctaaga aatagcatca atgcgagctc
     2221 atggtgggtg cttcatgact gacatgggaa tccacagtgc aacaggctct cttgggctct
     2281 cacttcacct catcccacag aaaaaactca acaatcgccc agtgaaatcg cccgaagagg
     2341 gaacagagtg ttttttggca accaatggca gatacctatg gcagcacaaa acaaaataaa
     2401 caaacaaaca aacaaaccaa aacacaacac cccaaaaatg tacctgaaca aacagaaccc
     2461 aacattaatc accagtcaag ccaacgctta accaacaaat accttgagct ctctcatcca
     2521 ggtctaagac acccctggat ttgaaaccgt tactgtgttt tccttttgct acctgttgac
     2581 tactgtagag accacagatt ggagtggcag gcatcagaga attacgacaa ggttggcacg
     2641 gacttatttt aggccaaagc aagggatcct ctgtgaccac agtgtcatcc tccatatgcc
     2701 ttccggctgt ggcgacgtgc gtgcgtggcg tctctccaca gggcctggtc tgccatcctg
     2761 tttcccctgt cctttctttg tcatgtttga gaattaatgg gtgtacaaat ttttgtattg
     2821 cttttgactt ttttagaaat gggtgaagaa atctaaatgg ggaagggaaa gcctcttacg
     2881 aagtgaatga acttgaaatc gcaaagcaat taagtggttg gtgattccat atgatcaaga
     2941 atgttgccaa aacaactctt tagttgtcct gcatcctggt gaagaaagaa ggcttttgga
     3001 tagaaccttc attctggggg tagcaaagga catcaaatcc cattgatgag aaatatggaa
     3061 aatgcatccg gtttcctcag aaattctgaa ctcttgagta caataaaatg atgtctttat
     3121 ttttctgata cttcgctgct gtgatactat gcagacaagt gtcttttcca tgcgccattt
     3181 tcaaagaaaa gtcatttgcc aaataattct ggtacaattc tggtaatgag gttttggatc
     3241 ttagaaacca actttctaat ggtaacataa atattccatg taacaaactg attctgtggt
     3301 caaatggttc atctctatct ctttttgtac atcagaaaat tcaaatggga cttttttttt
     3361 tattttctaa cttgaaaagg aaaaccttac cattaaactc tttaactatt taagggaaat
     3421 ggctttaagg agttctaatg aaaaagatcc tttttttttt tgtaaatata aatgtcagta
     3481 aagatgcttt ttaataacgc cattacactg tagagaaggt agcagatgga gcataaggta
     3541 caagggacat gaggtgggac tcccgcgccg gccgtgtttc tgggaagact gggaggaagc
     3601 tagagttcag acacaggcag gagccctggg ccaatagcag ctcgagaaca ggaggaggtg
     3661 gggctccgct ccatagtcag tttctctgga gagttttcac cctctaccca acagaagaga
     3721 aaggaagctc acatgggaaa ggtttgacct tcagatttga gaagtcgctc acttctccac
     3781 tcccacttac tcgcccataa gtcacgggac tggttgtatg tgaaccagaa ggattttact
     3841 tcctgatttt acacatatgg gacaaagttc tagtgttcaa tcctatgttt agcacacagc
     3901 tttcataaag aatctatata tttttaccct atagagaact gttatacagg tcagatacgt
     3961 tttcctgact ctcctatgca gttacatgtt ggattcagtg gtttaagaag gacacccaca
     4021 agaatcatgt aattggatct ggaagtgatt actcttacta agttttaaaa cttgagaagc
     4081 caaacttccc ttgctataac tggttgaaat gggccggcat gctttggctt cttcctatcc
     4141 ataggaattt aaatgatttt gaaggtgatt gtagagtgaa ctcttcacac aaaaatcgca
     4201 atacaatgtc aaagtgatta tcgtcattta gactccacat ttcacactgg aatataattt
     4261 tcccaaacag ataaatgaac catatgtcca ttagaaatta ctaccctact gtggaaatgc
     4321 tacccaagaa ctagacaaga agggttgtcc atcgccctct gaagctgcta cctgtttgta
     4381 cacgattcct ccagaaacat gggtccatgc tgtgatgaag tgaccctctt gtgtaaagca
     4441 gaaatgggga gggataatgg ccacaaattg tcctgaaagc ggtcctgctt ctctgaagtg
     4501 ttctcaagat aagcggttgc cacgggaaac agcttcagtg gctatggtgt catggggctg
     4561 gtggtgctgt cacctccctc agtgtggctg tctgagtttg tccatcagtg tcacaccttt
     4621 atccccttcc tttgggttac catgacacga agtgaactct ggtgttgctg ttgtcgggtg
     4681 taccaaccac aatcagtttt ctagcagggg gtgacagccc agcctgctag agcatcccat
     4741 ccttcactga gcatgactga agtctaactg gatcggaact taaggaagat gcccagacga
     4801 cacattcaaa tgagtcaaga ttttaaactg ccacctatat tttcattggc agaatactgt
     4861 ttcttttttc cttcccaagc accatttggt aaattcagaa ccactgtacc cctctcccgg
     4921 gattatagtg acatgtctga acaggagctg aggtatcaat accaaaagag catggggagt
     4981 ctgcacagtt cctcttagat cgataggaag gttcacttgt acaatgcctg cttcctcatc
     5041 ttctattagc actaaattcg tcactttaaa ttttgaaacc agggaaacgc cacctgtcat
     5101 tctgtcccca ttccccatag ctctttgatc tttacatacc accagacttt tttggtaact
     5161 tgtatccatc ccagtgtctg cagaaacccc atcatgtaat gtaccgggca ccttctttta
     5221 agaaaatgtt tactcagtgg gtttggttcc tttcaatttc tgtgttctga cacctatttt
     5281 tttaataaag atgagaaaga gaaaatgact gttgcagtac gtttctagac ctactttacc
     5341 tcagatgaca gtttgttaac atatatggac acattatttt taactttatg tacaatacat
     5401 tcaacagaac agcaaaattt ttagaaattt tccattaatt tctgtaacac gccatgtaaa
     5461 acggttacaa ataaacacgt ttgagaacaa c
//
