LOCUS       NM_001108030            5722 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Rattus norvegicus dishevelled associated activator of morphogenesis
            1 (Daam1), transcript variant 1, mRNA.
ACCESSION   NM_001108030 XM_001080564 XM_234275
VERSION     NM_001108030.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5722)
  AUTHORS   Venditti,M., Santillo,A., Falvo,S., Fiore,M.M.D., Baccari,G.C. and
            Minucci,S.
  TITLE     D-Aspartate Upregulates DAAM1 Protein Levels in the Rat Testis and
            Induces Its Localization in Spermatogonia Nucleus
  JOURNAL   Biomolecules 10 (5), 677 (2020)
   PUBMED   32353957
  REMARK    GeneRIF: D-Aspartate Upregulates DAAM1 Protein Levels in the Rat
            Testis and Induces Its Localization in Spermatogonia Nucleus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5722)
  AUTHORS   Chemek,M., Venditti,M., Boughamoura,S., Mimouna,S.B., Messaoudi,I.
            and Minucci,S.
  TITLE     Involvement of testicular DAAM1 expression in zinc protection
            against cadmium-induced male rat reproductive toxicity
  JOURNAL   J Cell Physiol 233 (1), 630-640 (2018)
   PUBMED   28332181
  REMARK    GeneRIF: Zinc chloride could prevent cadmium chloride-induced
            testicular toxicity and sperm quality alteration in adult male rat
            after gestational and lactational exposure, probably via the
            restoration of the testicular DAAM1 expression inhibited by Cd.
REFERENCE   3  (bases 1 to 5722)
  AUTHORS   Pariante,P., Dotolo,R., Venditti,M., Ferrara,D., Donizetti,A.,
            Aniello,F. and Minucci,S.
  TITLE     First Evidence of DAAM1 Localization During the Post-Natal
            Development of Rat Testis and in Mammalian Sperm
  JOURNAL   J Cell Physiol 231 (10), 2172-2184 (2016)
   PUBMED   26831620
  REMARK    GeneRIF: a role for DAAM1 in cytoskeletal organization during
            Mammalian testis morphogenesis and gamete progression
REFERENCE   4  (bases 1 to 5722)
  AUTHORS   Yasunaga,T., Hoff,S., Schell,C., Helmstadter,M., Kretz,O.,
            Kuechlin,S., Yakulov,T.A., Engel,C., Muller,B., Bensch,R.,
            Ronneberger,O., Huber,T.B., Lienkamp,S.S. and Walz,G.
  TITLE     The polarity protein Inturned links NPHP4 to Daam1 to control the
            subapical actin network in multiciliated cells
  JOURNAL   J Cell Biol 211 (5), 963-973 (2015)
   PUBMED   26644512
REFERENCE   5  (bases 1 to 5722)
  AUTHORS   Wagh,D., Terry-Lorenzo,R., Waites,C.L., Leal-Ortiz,S.A., Maas,C.,
            Reimer,R.J. and Garner,C.C.
  TITLE     Piccolo Directs Activity Dependent F-Actin Assembly from
            Presynaptic Active Zones via Daam1
  JOURNAL   PLoS One 10 (4), e0120093 (2015)
   PUBMED   25897839
  REMARK    GeneRIF: Similar to Piccolo and Profilin, Daam1 loss of function
            impairs presynaptic-F-actin assembly in neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5722)
  AUTHORS   Salomon,S.N., Haber,M., Murai,K.K. and Dunn,R.J.
  TITLE     Localization of the Diaphanous-related formin Daam1 to neuronal
            dendrites
  JOURNAL   Neurosci Lett 447 (1), 62-67 (2008)
   PUBMED   18832009
REFERENCE   7  (bases 1 to 5722)
  AUTHORS   Higashi,T., Ikeda,T., Shirakawa,R., Kondo,H., Kawato,M.,
            Horiguchi,M., Okuda,T., Okawa,K., Fukai,S., Nureki,O., Kita,T. and
            Horiuchi,H.
  TITLE     Biochemical characterization of the Rho GTPase-regulated actin
            assembly by diaphanous-related formins, mDia1 and Daam1, in
            platelets
  JOURNAL   J Biol Chem 283 (13), 8746-8755 (2008)
   PUBMED   18218625
REFERENCE   8  (bases 1 to 5722)
  AUTHORS   Liu,W., Sato,A., Khadka,D., Bharti,R., Diaz,H., Runnels,L.W. and
            Habas,R.
  TITLE     Mechanism of activation of the Formin protein Daam1
  JOURNAL   Proc Natl Acad Sci U S A 105 (1), 210-215 (2008)
   PUBMED   18162551
REFERENCE   9  (bases 1 to 5722)
  AUTHORS   Jones,C. and Chen,P.
  TITLE     Planar cell polarity signaling in vertebrates
  JOURNAL   Bioessays 29 (2), 120-132 (2007)
   PUBMED   17226800
  REMARK    Review article
REFERENCE   10 (bases 1 to 5722)
  AUTHORS   Aspenstrom,P., Richnau,N. and Johansson,A.S.
  TITLE     The diaphanous-related formin DAAM1 collaborates with the Rho
            GTPases RhoA and Cdc42, CIP4 and Src in regulating cell
            morphogenesis and actin dynamics
  JOURNAL   Exp Cell Res 312 (12), 2180-2194 (2006)
   PUBMED   16630611
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_234275.4, XM_001080564.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760400, SAMEA5760476
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5722
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..5722
                     /gene="Daam1"
                     /note="dishevelled associated activator of morphogenesis
                     1"
                     /db_xref="GeneID:314212"
                     /db_xref="RGD:1305119"
     exon            1..294
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..514
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..3238
                     /gene="Daam1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     disheveled-associated activator of morphogenesis 1"
                     /codon_start=1
                     /product="disheveled-associated activator of morphogenesis
                     1 isoform 1"
                     /protein_id="NP_001101500.1"
                     /db_xref="GeneID:314212"
                     /db_xref="RGD:1305119"
                     /translation="MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPA
                     LPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSW
                     PEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSC
                     ILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIK
                     TKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVS
                     LKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDF
                     FEMLRNEDELEFAKRFELVHIDTKSATQMFELTRRRLTHSEAYPHFMSILHHCLQMPY
                     KRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTPLENFNIKNVVRMLVNENEVKQWKE
                     QAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQV
                     ADLTAQLHELNRNKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQKEADAIDDAL
                     SSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKF
                     VPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKP
                     KVEAIRSSSEEVLRSSALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSI
                     DKNITLLHYLITIVENKYPKVLNLSEELRDIPQAAKVNMTELDKEISTLRSGLKAVET
                     ELEYQKSQPPQPGDKFVSVVSQFITLASFSFSDVEDLLAEAKELFTKAVKHFGEEAGK
                     IQPDEFFGIFDQFLQAVTEAKQENENMRKRKEEEERRARLEAQLKEQRERERKMRKAK
                     ESSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRISNQVTDSSRERPITKLNF"
     exon            515..604
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..676
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..771
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..1105
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1216
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1320
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1387
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1505
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1644
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1703
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1891
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1999
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2106
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2191
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2298
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2387
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2556
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2664
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2725
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2857
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..3028
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..5722
                     /gene="Daam1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcttcctcaa gcttctccag tggctccggc ctcctcagct tcatctttcc agaggtgacg
       61 ggaaaaggtt ctgggtgtga cgtgcttgga gaagcagttg gatctgtgct cagtgaagtg
      121 cttgaggggg agagagcctg tgcaagtggc tcctgcctga gaggtcaagt ggatgattgc
      181 tttaacttcc tgttttgatc tgtatctggg gatgcggctc tgagaagtgg ccatccaaat
      241 atgtggatga actggctgcc agttggacat ctcagctatc tctgtgcatc atggagtgtt
      301 gtaatatcaa gaaataggag aaaattcaac catggcccca aggaagagag gcggaagggg
      361 gatttcattt atcttttgct gtttccgaaa caatgaccac ccagaaatca catatcggct
      421 taggaatgat agcaactttg cacttcagac aatggagcca gcactgccca tgccccctgt
      481 ggaggagctg gatgtcatgt tcagtgaact tgtggatgaa ctcgacctca cagacaaaca
      541 tagggaggcc atgtttgcac ttccagcaga gaaaaagtgg cagatatact gtagcaagaa
      601 aaaggaccag gaagaaaaca agggagcaac aagttggccc gagttctaca ttgatcagct
      661 caattccatg gctgctagaa aatctctgct ggctttagag aaggaagaag aagaagagag
      721 gagtaaaacc atcgagagtc taaagacagc actgaggaca aagcccatga ggtttgtaac
      781 cagattcatc gacttggatg gcctgtcatg tattctcaac tttctgaaga ccatggacta
      841 tgagacctcc gagtctcgga tacatacctc cctcattggc tgtataaagg cactaatgaa
      901 caactctcaa ggccgggccc acgtcctggc tcattctgag agtattaatg taattgctca
      961 gagtctgagc acagagaaca ttaaaacaaa ggtggccgtg ctggaaatcc tgggcgctgt
     1021 gtgcctggtt cctgggggcc acaagaaagt tctgcaggct atgctgcact atcagaagta
     1081 tgccagcgag agaacccgct tccagacgtt aatcaacgac ttggataaaa gcactgggcg
     1141 ctatcgggat gaagtgagtc tcaagactgc catcatgtcg ttcatcaatg cagtgctgag
     1201 ccagggagcc ggagtggaga gtttggactt cagactccat cttcgctacg aatttctgat
     1261 gctaggaatt cagcctgtta tagataaatt aagggaacat gagaattcaa cactagacag
     1321 gcacttagac ttttttgaaa tgctccgaaa tgaagatgaa ctagaatttg ccaaaagatt
     1381 tgaactggtt cacatagaca caaaaagcgc cactcagatg tttgagctga ccaggaggag
     1441 gctcacccac agcgaagcct acccccactt catgtccatt ctgcaccatt gcctgcagat
     1501 gccttacaag aggagtggta acacagtcca gtactggctg ctgctagaca gaatcataca
     1561 gcagatagtt atccagaatg acaaaggaca agaccccgac tccacacctc tggaaaactt
     1621 taatattaag aacgtcgtaa gaatgctggt taatgaaaac gaagttaagc aatggaaaga
     1681 gcaagcagag aagatgagga aagagcacaa tgagctacaa cagaagctgg agaagaaaga
     1741 gagagaatgt gatgccaaga cccaagagaa ggaagaaatg atgcagacct taaacaagat
     1801 gaaggagaag ctggagaagg agaccactga gcacaagcag gttaagcagc aggtggcaga
     1861 cctcacggcg cagctccacg agctcaacag gaacaaattg gaaggaacag tatggactga
     1921 aatcgatgat acaaaagtct tcaaaattct agaccttgaa gacctagaaa gaacattctc
     1981 tgcctaccaa agacagcaga aagaagcaga tgccattgat gacgcactga gttccaaact
     2041 taaagtcaaa gagctgtcag tgattgatgg tcggagagct cagaattgca acatccttct
     2101 gtcgaggttg aagttatcca atgacgaaat caagcgagca attctaacaa tggatgaaca
     2161 ggaggacctg cccaaggaca tgttagaaca gcttttgaaa ttcgtgcctg agaaaagcga
     2221 cattgacctg ctagaagaac ataaacatga gttggaccgg atggccaagg ctgatcgctt
     2281 cctgtttgag atgagcagaa ttaatcatta ccagcaacga ctgcaatcac tgtacttcaa
     2341 aaagaagttt gcagagcgtg tggccgaagt gaagcccaaa gtagaagcga tccgctccag
     2401 ctcagaggag gtactcagga gcagtgccct caagcagctc ctggaggtgg ttctggcttt
     2461 tggaaattat atgaataaag gacaaagagg caatgcatat ggattcaaga tctccagcct
     2521 caacaagatt gcagatacaa aatccagtat tgacaagaac attaccctct tgcactatct
     2581 aataaccatt gtggagaata agtaccccaa ggtcctgaat ctcagcgaag agttgcggga
     2641 tattcctcaa gcagcgaaag tgaacatgac tgagctggac aaagagatca gcaccttgag
     2701 gagtggcctg aaagctgtgg agacggaact tgagtatcaa aagtctcagc ccccgcagcc
     2761 tggagacaag tttgtgtctg ttgtcagcca gtttatcacc ctggcgagct tcagcttctc
     2821 agacgtagaa gatcttctag cagaagctaa agagctgttc actaaagcag tgaagcactt
     2881 tggggaagag gctggcaaaa tccagccaga tgagttcttt gggatctttg atcagtttct
     2941 tcaggctgtg acagaagcga aacaggaaaa tgagaacatg aggaaaagga aggaggagga
     3001 ggagcggagg gctcgcctgg aagctcagct caaagagcag cgggagaggg agcggaagat
     3061 gaggaaggcc aaggagagca gtgaagagag tggcgagttt gacgacctgg tctcggctct
     3121 gcgctcagga gaggtgttcg acaaagacct ttcaaaactc aaacggaacc ggaaacgcat
     3181 ttccaaccag gtgacggaca gcagccgcga gcgaccaatc acgaaactta atttttagtt
     3241 tccttgcatc tttttctaga aagcgccgta gcagcccttt ggagtgacta gaacttttca
     3301 ttacactgcc tttcgatcca aaacagtggc gatttcttct ctcatctgtg agtgaaggtg
     3361 tgaatgtgtg tgtaaatgta tgtgtatata tgtgaaaatg tacatacaag tcttaagtgt
     3421 tgtccgggga cctatgtgta tgcttaaaaa gttcatgtta atgtgtgcac ccagaaactc
     3481 tttgtgtatg cattcatatt tccctgaaca ccatgcctgt tcagaagcac aatactctct
     3541 cctgaaacag atgacagaca ttcctttaaa ggggggtggg gggaggaaag aagaagttaa
     3601 gagaagcttg tcttgtgaag tattttatgg ttcccacagt tgatgtagtg aggcgatttt
     3661 cactggtgga aaaggaattg gaacagactg ggctgagctc agcgctcgtg ggcgaggcac
     3721 cgcgcccaca tcagtgagtg actagcgagc ggaacagctc tgaggttccg atgctgctgt
     3781 tggggtacac acttgcctgg ggtacaaacg tctgttgaga acatcttgca cacattcata
     3841 tcatgtaggg tgtcattcac acttcgttta tacatttaaa acttgaacac caatttcccc
     3901 ctaatttcat cgatttttct gccaagtgct cttgatgact tcttcctttg gttttgtttt
     3961 tgtttttttg gaaacacact ttctaaatga tgcctcctgg atcctgggtt agggccagaa
     4021 ttgccagagc ctcctcactg acctaacaat acagttctgt agacctgaca aatgaaattt
     4081 cccaccgaga cttagtggaa gaaccctgaa gagtgttctt aaaggcatag gggtgcttta
     4141 tggggtgtct tctgttttct gtataggccg agctgcatgt cctgggataa agggcattca
     4201 tatggacacg aaatgtcaac agtatctaca gggatgctca gatctattta tctcaaaaat
     4261 atttgaagtg atcgctgtta cgtgttgtca ttttaaattg tgtgtcagtg acgctacctg
     4321 tacaatttca gtccaaaaaa taaagctctc agggagaaat gataaaaaaa aaaaaaaaca
     4381 aaaaaaaaaa aacaatgagc agtagaaaat aaaatatgga cgcttaccac tggcctgcca
     4441 actcctagta tccttaactt atgtggtatg taaagaggac tgttactact tttcttttgc
     4501 tttatttatt tgtaccaggg tgtggggagg gactagcgtt ttctctttgt tctccttctg
     4561 tccttctgtg gctgggtttc ctgtggagag agtagttttc cctattgcac tacaatatta
     4621 tttactcact aaactgaggt tttcagtaaa gtatcaactg tttattaagc acttactatg
     4681 taccgggcat agtagagcta tagtggtagt aagcaagaca gagtccctgc ccaccaatga
     4741 attctcactc taaatggggt tttcagggac ggtagaatac cagtgtgcat agtacacagg
     4801 aaccatacta tttaaaaaat aatctctatg gactatattg tttagtgcag atggcaaggg
     4861 atctgtgctg tgtgaaagct gtgaaacagt gctctaagaa ttgtcaagag ctgtggtttt
     4921 tacatttttt gtttttcttc atcacatact tagcaacttt tctacccatt atgtagaagc
     4981 aaatagctct tcactaaggc agtcacaggt gcaaagcaga gctgactctc ccagccccga
     5041 gctaacccca gtctgcaagc atcctggcag tggtgccgat gcagacctgg ctcgggccag
     5101 cctggggagg aggagcgggg tggagtgatg gatttcactg ttcctgatct aaagtgcctc
     5161 tttgtatatt cttttctatt gatagcagga aaagtttggt ccagctcagt tttggaactg
     5221 tggaaagaga ctcacaccag agagcaagtc tgtgtcgcat gtccccttgc ctttcttaga
     5281 atcctcctca cttccatgta gccctcctgg taggccacct ttgcccttcc cagcttccgg
     5341 tttattttcc taaagactgt gcaggtaact tcatgtgcca ttgttacaaa aaaaaaaaaa
     5401 tggacttttt agactggtgc tggtgtaagt agtcactttt ctctcttgag tatgtatttt
     5461 aaagattttt ttaaataatg ccaaaaaaag aaaagcatta taatttctaa acttaatcaa
     5521 tgtctcgtat cttactagct tagtagttgg acccatttag tctttagatg caagactgtt
     5581 gttacagaac caagggaaaa aaaggtgtcg tgtgtgctat gagactgtac atttttttaa
     5641 atagcaatat gcaataaaga tgacttcact gggtttacgg atgtgttttc tatgtattat
     5701 taaaatagca aggttagaca tc
//
