LOCUS       NM_001106926            3588 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus D-2-hydroxyglutarate dehydrogenase (D2hgdh),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001106926 XM_217474 XR_008638
VERSION     NM_001106926.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3588)
  AUTHORS   Achouri,Y., Noel,G., Vertommen,D., Rider,M.H., Veiga-Da-Cunha,M.
            and Van Schaftingen,E.
  TITLE     Identification of a dehydrogenase acting on D-2-hydroxyglutarate
  JOURNAL   Biochem J 381 (Pt 1), 35-42 (2004)
   PUBMED   15070399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Dec 3, 2020 this sequence version replaced NM_001106926.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1210004.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840124, SAMN13663631
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               JAXUCZ010000009.1  101797934-101798278
            346-684             JAXUCZ010000009.1  101799025-101799363
            685-742             JAXUCZ010000009.1  101801954-101802011
            743-882             JAXUCZ010000009.1  101802528-101802667
            883-1076            JAXUCZ010000009.1  101804638-101804831
            1077-1245           JAXUCZ010000009.1  101807881-101808049
            1246-1389           JAXUCZ010000009.1  101810289-101810432
            1390-1532           JAXUCZ010000009.1  101811356-101811498
            1533-1698           JAXUCZ010000009.1  101812544-101812709
            1699-3588           JAXUCZ010000009.1  101813838-101815727
FEATURES             Location/Qualifiers
     source          1..3588
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..3588
                     /gene="D2hgdh"
                     /gene_synonym="RGD1307976"
                     /note="D-2-hydroxyglutarate dehydrogenase"
                     /db_xref="GeneID:301624"
                     /db_xref="RGD:1307976"
     exon            1..345
                     /gene="D2hgdh"
                     /gene_synonym="RGD1307976"
                     /inference="alignment:Splign:2.1.0"
     exon            346..684
                     /gene="D2hgdh"
                     /gene_synonym="RGD1307976"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..1958
                     /gene="D2hgdh"
                     /gene_synonym="RGD1307976"
                     /EC_number="1.1.99.39"
                     /codon_start=1
                     /product="D-2-hydroxyglutarate dehydrogenase,
                     mitochondrial"
                     /protein_id="NP_001100396.2"
                     /db_xref="GeneID:301624"
                     /db_xref="RGD:1307976"
                     /translation="MVLHLVPRWSASLFRASPRWKKTYSQRASAQLKWLGCPRSVYSP
                     LACRAYSKVSGSPEVMLTPERYPVQRLPFSTVSEEDLAAFECIIPGRVITDPEQLQTC
                     NVDWLRTVRGCSKVLLRPQTSEEVSQILRHCYKRNLAVNPQGGNTGMVGGSVPVFDEV
                     ILSTALMNQVISFHDVSGILVCQAGCVLEELSRYVQERDFIMPLDLGAKGSCHIGGNV
                     ATNAGGLRFLRYGSLRGTVLGLEVVLADGTILNCLTSLRKDNTGYDLKQMFIGSEGTL
                     GVITAVSIVCPPRPKAVNVAFLGCPGFTEVLQTFRTCKGQLGEILSAFEFMDAECMQL
                     VGQHLHLTNPVQESPFYVLVETSGSSAGHDAEKLTNVLEQVLNSGLVIDGTMATDQRK
                     VQMLWALRERITEALSRDGYVFKYDLSLPVERLYDLVIDLRTRLGPRAKHVVGYGHLG
                     DGNLHLNVTAEAFSQELLGALEPYVYAWTAEQRGSVSAEHGLGFKKKNVLGYSKPPVA
                     VKLMQQLKAMLDPKGILNPYKTLPARA"
     exon            685..742
                     /gene="D2hgdh"
                     /gene_synonym="RGD1307976"
                     /inference="alignment:Splign:2.1.0"
     exon            743..882
                     /gene="D2hgdh"
                     /gene_synonym="RGD1307976"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1076
                     /gene="D2hgdh"
                     /gene_synonym="RGD1307976"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1245
                     /gene="D2hgdh"
                     /gene_synonym="RGD1307976"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1389
                     /gene="D2hgdh"
                     /gene_synonym="RGD1307976"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1532
                     /gene="D2hgdh"
                     /gene_synonym="RGD1307976"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1698
                     /gene="D2hgdh"
                     /gene_synonym="RGD1307976"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..3588
                     /gene="D2hgdh"
                     /gene_synonym="RGD1307976"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagcggaggc ctacggttgt gcaaggggtt gggaaccagg gtgcgggtgc ggactcggtg
       61 tttgcactcg gacggaagct agggtgcgta gtgggctggc tgtagctcct gggtggaggg
      121 cgctggtgtc tgggtccgtg cagtccgggc tgtggcctgt caaatgatgg cacagatcag
      181 gtgcgagccg agatggccgg cgaggcgagg atactcgcac tgcttctcac ctacacccac
      241 gggctgcaat tggctgggaa tgcaaatagt tgctcctctt tgacgtcacg gcacagggcg
      301 catgcgcaat ctgtgcgcat gtcgtgctgt gtttttccgt ctcaggagca atggtgctcc
      361 atttggtgcc cagatggtct gcaagcctct tcagggcatc tccaagatgg aaaaagacct
      421 acagccagag agcttctgcg cagttgaagt ggctgggttg ccctcggagt gtgtacagcc
      481 ccttggcttg cagagcatac tccaaggtct ctggcagccc tgaggtgatg ctgacccctg
      541 agcgataccc agtgcaacgg ctgccgtttt ctaccgtgtc agaggaggac ctggctgcat
      601 ttgaatgcat catacctggc agagttatca cagatccaga gcaactgcag acttgcaatg
      661 tggactggct gaggaccgtg cggggctgta gtaaggtgct gctgagaccc cagacctcag
      721 aggaagtctc ccagattctt aggcactgct ataagaggaa cttggctgtg aacccacagg
      781 gcggaaacac tggcatggtg ggtggcagtg tccctgtctt tgatgaagtc atcctgtcca
      841 ctgccctcat gaatcaagtc atcagctttc atgatgtgtc tggaattctg gtttgccagg
      901 caggctgcgt gctggaggag ctgagcaggt acgtgcagga gcgggacttc atcatgccac
      961 tggacttggg tgcaaagggc agctgccaca ttgggggtaa tgtcgcaacg aacgctgggg
     1021 gtctgcggtt tctgcggtac ggctctcttc gagggactgt cctgggcctg gaagtggtac
     1081 ttgctgatgg aaccatcctg aactgcctga cctctttgag gaaggacaac actggctatg
     1141 acctgaagca gatgttcatt gggtcagagg gcaccctggg agtcatcact gctgtatcca
     1201 tcgtgtgccc accgaggccc aaggctgtga atgtggcttt ccttggctgc cctgggttta
     1261 ctgaggttct gcagaccttc cgcacctgca aggggcaact gggcgagatc ctgtctgcct
     1321 ttgagtttat ggatgccgaa tgcatgcagt tggttggaca gcacctccac ctgaccaacc
     1381 cagtacaaga gagtccattc tatgtcctgg ttgagacctc aggctccagt gccgggcacg
     1441 atgctgagaa actgaccaac gtcctggagc aagtgctgaa ttctggcctg gtgatcgatg
     1501 gcactatggc caccgaccag aggaaagtcc agatgctgtg ggccttgcgg gaaaggatca
     1561 cagaggcact cagtcgtgac ggctacgtgt tcaagtatga cttatccctc cccgtggagc
     1621 ggctctatga ccttgtgatc gacctgcgca cccgccttgg ccctcgagcc aagcatgtgg
     1681 tgggatatgg gcacttgggg gatggcaacc ttcacctgaa cgtgacagca gaggccttta
     1741 gccaggagct gcttggtgcc ttggagcctt atgtgtacgc ctggacagcg gaacagcggg
     1801 gcagcgtcag tgctgagcac ggcctgggct tcaagaagaa gaatgtactc ggctatagca
     1861 agccacctgt ggctgtgaag cttatgcaac agctgaaggc catgctggac cccaaaggca
     1921 tcctgaaccc ctataagact ctacctgctc gggcctaact agagcttttc agcttcttgt
     1981 gcaagaggct aggaccttgg gcatgcaggc ttggtgggcc ctggaggtct cccagctgat
     2041 ggcccgtgca gtagaccctc tgggctcgac tgcctttctg tgaggatgag cagagagcag
     2101 atagagctgc ccagcccttc tctggtctcc taccagctca tggtggacgg aataagtggg
     2161 tggggggttg ccccactccc aaacaagcca gatctcacct gctctgtggt ggtctgtgga
     2221 gacctgatgc atctctgtag cgtgtcattt taaaaacata ctaccttgtc tgctgctgca
     2281 acccgtgctc tgagctaggc tcagggatca gtcaccgctg gtctcactta ggtgcaccaa
     2341 tggcctggcc atttttcctg agagcctcga ttgttccccg agaccctcat ggccagctta
     2401 gccaagctgc caacaactgt cctggccgcc atctttctcc ttctgcccag tttactgcca
     2461 tgggtggaaa acactagact actggccaga taactcaatg actgggcaaa gaatttcctg
     2521 ccccaatctt atcaactaga tcccttcgtc ctccttggcc cctgctcaac atggaggcta
     2581 caaactctag gagccccaag acctacatgt ctgcagttta ctacttgcct gggctgaatt
     2641 cctctttctt tgcgtccttt ctcttcctcc tgggtcctgg aagtcccgtc ttttctcctt
     2701 ctcccaaaaa ttggcttctg cctcctttat tgacacaatc gagagtcaat tagggagtca
     2761 atacctctcc ctacagatct ctggaagagt gccacgtggt gtcttggatg gatcttcctg
     2821 gatggtttgc cgtgtggcgt gtaccctgtg agggctgcag ccccagatca gttaccatga
     2881 tgacccagaa caccacagct cattcccatg agtggaattt gctgtcatat caagcaggcc
     2941 ttggattggt aactgtggtc cacctgacca ggtcattccc ttgggttttg ttcatttttg
     3001 ggcagggtct ttccacatag ccctggctgt tcaggaactt acgatgtaga ccagattgac
     3061 ctttatctca cagtgatccg ctgtgcctct gcctttcctt ctgtcccccg agcgctggga
     3121 ttaaaggcaa gtgccgctac acccagcttg ccttgctctt gaagacctga tggttgttca
     3181 gcaggtgcag agattgcctg cagagcctga cctttctgga tatgggacag tcccccaact
     3241 gaatcgattc atggattcag tcatgggagt actatcctct aggatttgac ctgtcaaatg
     3301 atctggggtt ccggcagtct gggaggttga atacacctac cgtgactttt cttttctttt
     3361 ttctgttatc agtttccaga aaaaaaattg aactacaacc tggaagagag cgagaggaag
     3421 caagagcaag agagtgaggg ggtggggcaa gcagcaccgt ttatagtgtc aggggaacct
     3481 gactgttgcc aggtaacggt ggggtacagc ttagacagaa agctaacttt ccccctgctt
     3541 tggcttctgc tgctagaaaa ttactcacat aaagctgatt gcaaagtt
//
