LOCUS       NM_001395066            2635 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus cytohesin 2 (Cyth2), transcript variant 2, mRNA.
ACCESSION   NM_001395066 XM_006228964
VERSION     NM_001395066.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2635)
  AUTHORS   Hosokawa,H., Dip,P.V., Merkulova,M., Bakulina,A., Zhuang,Z.,
            Khatri,A., Jian,X., Keating,S.M., Bueler,S.A., Rubinstein,J.L.,
            Randazzo,P.A., Ausiello,D.A., Gruber,G. and Marshansky,V.
  TITLE     The N termini of a-subunit isoforms are involved in signaling
            between vacuolar H+-ATPase (V-ATPase) and cytohesin-2
  JOURNAL   J Biol Chem 288 (8), 5896-5913 (2013)
   PUBMED   23288846
  REMARK    GeneRIF: The N termini of a-subunit isoforms are involved in
            signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2
REFERENCE   2  (bases 1 to 2635)
  AUTHORS   Ikenouchi,J. and Umeda,M.
  TITLE     FRMD4A regulates epithelial polarity by connecting Arf6 activation
            with the PAR complex
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 748-753 (2010)
   PUBMED   20080746
REFERENCE   3  (bases 1 to 2635)
  AUTHORS   Hernandez-Deviez,D., Mackay-Sim,A. and Wilson,J.M.
  TITLE     A Role for ARF6 and ARNO in the regulation of endosomal dynamics in
            neurons
  JOURNAL   Traffic 8 (12), 1750-1764 (2007)
   PUBMED   17897316
  REMARK    GeneRIF: endotubin labels a distinct endosomal structure in
            neurons; and ARNO and ARF6 mediate neurite extension through the
            regulation of this compartment
REFERENCE   4  (bases 1 to 2635)
  AUTHORS   DiNitto,J.P., Delprato,A., Gabe Lee,M.T., Cronin,T.C., Huang,S.,
            Guilherme,A., Czech,M.P. and Lambright,D.G.
  TITLE     Structural basis and mechanism of autoregulation in
            3-phosphoinositide-dependent Grp1 family Arf GTPase exchange
            factors
  JOURNAL   Mol Cell 28 (4), 569-583 (2007)
   PUBMED   18042453
REFERENCE   5  (bases 1 to 2635)
  AUTHORS   Hofmann,I., Thompson,A., Sanderson,C.M. and Munro,S.
  TITLE     The Arl4 family of small G proteins can recruit the cytohesin Arf6
            exchange factors to the plasma membrane
  JOURNAL   Curr Biol 17 (8), 711-716 (2007)
   PUBMED   17398095
REFERENCE   6  (bases 1 to 2635)
  AUTHORS   Venkateswarlu,K.
  TITLE     Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds
            cytohesin 2 and modifies its activity
  JOURNAL   J Biol Chem 278 (44), 43460-43469 (2003)
   PUBMED   12920129
  REMARK    GeneRIF: cytohesin 2 binds to IPCEF1, which modifies its activity
REFERENCE   7  (bases 1 to 2635)
  AUTHORS   Hernandez-Deviez,D.J., Casanova,J.E. and Wilson,J.M.
  TITLE     Regulation of dendritic development by the ARF exchange factor ARNO
  JOURNAL   Nat Neurosci 5 (7), 623-624 (2002)
   PUBMED   12032543
REFERENCE   8  (bases 1 to 2635)
  AUTHORS   Kitano,J., Kimura,K., Yamazaki,Y., Soda,T., Shigemoto,R.,
            Nakajima,Y. and Nakanishi,S.
  TITLE     Tamalin, a PDZ domain-containing protein, links a protein complex
            formation of group 1 metabotropic glutamate receptors and the
            guanine nucleotide exchange factor cytohesins
  JOURNAL   J Neurosci 22 (4), 1280-1289 (2002)
   PUBMED   11850456
REFERENCE   9  (bases 1 to 2635)
  AUTHORS   Suzuki,I., Owada,Y., Suzuki,R., Yoshimoto,T. and Kondo,H.
  TITLE     Localization of mRNAs for subfamily of guanine nucleotide-exchange
            proteins (GEP) for ARFs (ADP-ribosylation factors) in the brain of
            developing and mature rats under normal and postaxotomy conditions
  JOURNAL   Brain Res Mol Brain Res 98 (1-2), 41-50 (2002)
   PUBMED   11834294
REFERENCE   10 (bases 1 to 2635)
  AUTHORS   Telemenakis,I., Benseler,F., Stenius,K., Sudhof,T.C. and Brose,N.
  TITLE     Rat homologues of yeast sec7p
  JOURNAL   Eur J Cell Biol 74 (2), 143-149 (1997)
   PUBMED   9352219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jun 1, 2021 this sequence version replaced XM_006228964.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.1673.1,
                                           SRR26643295.2332.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000001.1  105427337-105427542 c
            207-354             JAXUCZ010000001.1  105426308-105426455 c
            355-421             JAXUCZ010000001.1  105426146-105426212 c
            422-540             JAXUCZ010000001.1  105425488-105425606 c
            541-621             JAXUCZ010000001.1  105424828-105424908 c
            622-734             JAXUCZ010000001.1  105424144-105424256 c
            735-883             JAXUCZ010000001.1  105423856-105424004 c
            884-995             JAXUCZ010000001.1  105423359-105423470 c
            996-1072            JAXUCZ010000001.1  105421449-105421525 c
            1073-1144           JAXUCZ010000001.1  105421288-105421359 c
            1145-1299           JAXUCZ010000001.1  105421055-105421209 c
            1300-2635           JAXUCZ010000001.1  105419631-105420966 c
FEATURES             Location/Qualifiers
     source          1..2635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2635
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /note="cytohesin 2"
                     /db_xref="GeneID:116692"
                     /db_xref="RGD:620398"
     exon            1..206
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1387
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /note="isoform 2 is encoded by transcript variant 2; ARF
                     nucleotide binding site opener; SEC7 homolog B; PH, SEC7
                     and coiled-coil domain-containing protein 2; pleckstrin
                     homology, Sec7 and coiled-coil domains 2"
                     /codon_start=1
                     /product="cytohesin-2 isoform 2"
                     /protein_id="NP_001381995.1"
                     /db_xref="GeneID:116692"
                     /db_xref="RGD:620398"
                     /translation="MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAM
                     SEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVEHELLQNTPEEIARFLYK
                     GEGLNKTAIGDYLGEREELNLSVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKI
                     DRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNR
                     GINEGGDLPEDLLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTW
                     KRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLI
                     KACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISV
                     KKKQEQP"
     exon            207..354
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /inference="alignment:Splign:2.1.0"
     exon            355..421
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /inference="alignment:Splign:2.1.0"
     exon            422..540
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /inference="alignment:Splign:2.1.0"
     exon            541..621
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /inference="alignment:Splign:2.1.0"
     exon            622..734
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /inference="alignment:Splign:2.1.0"
     exon            735..883
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /inference="alignment:Splign:2.1.0"
     exon            884..995
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1072
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1144
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1299
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..2635
                     /gene="Cyth2"
                     /gene_synonym="Arno; CLM2; Pscd2; Sec7; Sec7B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggcccca ccggccgggc ggttgggccg tgaagggaga gtcttttcgg cgctgaggac
       61 gggcgctgag gaggcggcgg tggctcctgg ggcgtttgag cgggctcact cgagcccgcg
      121 ggccgacgcg gacgcaggcc cagccggcgg aaacgccccg gactccccgc gggccttcct
      181 agccgccatg gaggacggtg tctacgagcc cccagacttg actccagagg agcgcatgga
      241 gctggagaac atccgtcggc gaaagcagga gctgctggtg gagatccagc gcctccggga
      301 agagctaagt gaagctatga gcgaagtgga gggtctggag gccaatgagg gcagtaagac
      361 cttgcagcgg aaccggaaga tggcaatggg ccggaagaaa ttcaacatgg accccaaaaa
      421 ggggatccaa ttcttggtgg agcatgaact tctacagaac acacctgagg aaattgcccg
      481 cttcctgtac aagggcgagg ggctgaacaa gacagccatt ggggactacc taggggaaag
      541 ggaagagctg aacctgtctg tgctccatgc ttttgtggat ctacatgagt tcaccgacct
      601 caatctggtt caggccctcc ggcaattcct gtggagcttt cgcctccctg gagaggctca
      661 gaaaattgac cgaatgatgg aggcctttgc ccagagatat tgcttatgta atcccggggt
      721 cttccagtcc acagacacct gctacgtgtt gtccttcgct gtgatcatgc tgaacaccag
      781 ccttcacaat cccaatgtca gggacaagcc gggcctggag cgctttgtgg ccatgaaccg
      841 aggcatcaat gagggtgggg acctgcctga ggaccttctc aggaacctct atgacagcat
      901 ccgaaacgag cccttcaaaa tccctgagga tgatgggaat gatctcaccc acaccttctt
      961 caacccagac cgagagggct ggctcctaaa gctggggggc cgggtgaaga cttggaagcg
     1021 tcgctggttc atcctcacag acaactgcct ctactacttt gagtacacta cggacaagga
     1081 gcccagaggg atcatccccc tagagaacct gagcattcgt gaggtggatg atcctcggaa
     1141 gccgaactgc tttgagcttt acattcccaa caataaggga cagctcatca aagcctgcaa
     1201 aacggaggct gatggtcggg tagtagaggg gaaccacatg gtgtaccgaa tctcagcacc
     1261 cacacaggag gagaaagacg agtggatcaa gtccatccag gctgctgtaa gcgtggaccc
     1321 cttctacgag atgttggcag caagaaagaa gcggatttct gtgaagaaga agcaagaaca
     1381 accctgaccc tgtccccaac tccattattt attttggagc tgccccgcct gggtggcagg
     1441 acccctgggc cctggggctg tggatcctgg ttccctgttt ggaaaatcac cacctctagc
     1501 tcctgactcc ttatttgtaa ttaacatgtt ggtaatctta ttaattattt aacccctcgc
     1561 gcctgcagat gccctcattt cttgggtttg ggagagctga gaacccatcc tcctgacatt
     1621 aaccaggaca ctgggcttca tacagcatgg aaggcaggca catcccagac ggtgactcca
     1681 gccctggggg tgccgagtgg agggagaatc taatgtctta gtgtggtttt agactcggcc
     1741 tactctccat gtgctctacc ccactggcct ggccgctatg ttcatgttgg acctgtggtc
     1801 cttgggggac ttagtccagg agactaagac tagaacaaca ggaggctcag gaggagcgag
     1861 tcccaagaaa acctgtgtca gtccctagga actggctgtg ctggccactg agtaccccat
     1921 ggtggcctgg aggggcaagt ggtgtgtgtc atgaggtacg cgggatgcca ttgtgacagt
     1981 ggcttctgac cccacgtcca gccacttgtg gaggtgtttg tttttaactg aaaggcctgg
     2041 gcatgtgtct cctgactcgt gggaggggat ctcagtgaag ggatactgct gagtccccaa
     2101 gtggtcctgt cctcttgtgc ttctggtgga ggagaggata aaggaccaaa tgcctgctgc
     2161 ccacctctag tggcaggaag ctttttgtta ctgttaagag tcaagccttg ccacctcctt
     2221 ccagtgccag catgctagac tgctagctgc cctgccagac aggaagtagt agttgtaaag
     2281 gaatttgcct cttcccagca tgctttagca tgcaggcctg actgggaaga aaggattctg
     2341 ccccagggcc ttctgggact tgagagtcag aaggtgtgtg tggatctgca accctgtggg
     2401 tgtatgcccc aacagcactg atctggataa atgtgagcat ccaggttcta atttaggtgg
     2461 gctttggctc agactactgt caataggctg tagtctccgg ggtatcagct tttctgaagc
     2521 ttaccttgac attgggaaag gagcatgaat tacctctccc cctccctcca ggggctggtg
     2581 tgaaatggag attcccaaat aaaacaacta aagtgtcacc caaagggcca ggaaa
//
