LOCUS       NM_053910               1399 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytohesin 1 (Cyth1), mRNA.
ACCESSION   NM_053910
VERSION     NM_053910.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1399)
  AUTHORS   Mohanan,V., Nakata,T., Desch,A.N., Levesque,C., Boroughs,A.,
            Guzman,G., Cao,Z., Creasey,E., Yao,J., Boucher,G., Charron,G.,
            Bhan,A.K., Schenone,M., Carr,S.A., Reinecker,H.C., Daly,M.J.,
            Rioux,J.D., Lassen,K.G. and Xavier,R.J.
  TITLE     C1orf106 is a colitis risk gene that regulates stability of
            epithelial adherens junctions
  JOURNAL   Science 359 (6380), 1161-1166 (2018)
   PUBMED   29420262
REFERENCE   2  (bases 1 to 1399)
  AUTHORS   Ikenouchi,J. and Umeda,M.
  TITLE     FRMD4A regulates epithelial polarity by connecting Arf6 activation
            with the PAR complex
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 748-753 (2010)
   PUBMED   20080746
REFERENCE   3  (bases 1 to 1399)
  AUTHORS   DiNitto,J.P., Delprato,A., Gabe Lee,M.T., Cronin,T.C., Huang,S.,
            Guilherme,A., Czech,M.P. and Lambright,D.G.
  TITLE     Structural basis and mechanism of autoregulation in
            3-phosphoinositide-dependent Grp1 family Arf GTPase exchange
            factors
  JOURNAL   Mol Cell 28 (4), 569-583 (2007)
   PUBMED   18042453
REFERENCE   4  (bases 1 to 1399)
  AUTHORS   Hofmann,I., Thompson,A., Sanderson,C.M. and Munro,S.
  TITLE     The Arl4 family of small G proteins can recruit the cytohesin Arf6
            exchange factors to the plasma membrane
  JOURNAL   Curr Biol 17 (8), 711-716 (2007)
   PUBMED   17398095
REFERENCE   5  (bases 1 to 1399)
  AUTHORS   Stricker,R., Vandekerckhove,J., Krishna,M.U., Falck,J.R., Hanck,T.
            and Reiser,G.
  TITLE     Oligomerization controls in tissue-specific manner ligand binding
            of native, affinity-purified p42(IP4)/centaurin alpha1 and
            cytohesins-proteins with high affinity for the messengers
            D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol
            3,4,5-trisphosphate
  JOURNAL   Biochim Biophys Acta 1651 (1-2), 102-115 (2003)
   PUBMED   14499594
  REMARK    GeneRIF: Data suggest that oligomerization of inositol
            phosphate/phosphatidylinositol binding proteins such as cytoadhesin
            1 and centaurin alpha 1 can modulate their function in a
            tissue-dependent manner.
REFERENCE   6  (bases 1 to 1399)
  AUTHORS   Boehm,T., Hofer,S., Winklehner,P., Kellersch,B., Geiger,C.,
            Trockenbacher,A., Neyer,S., Fiegl,H., Ebner,S., Ivarsson,L.,
            Schneider,R., Kremmer,E., Heufler,C. and Kolanus,W.
  TITLE     Attenuation of cell adhesion in lymphocytes is regulated by CYTIP,
            a protein which mediates signal complex sequestration
  JOURNAL   EMBO J 22 (5), 1014-1024 (2003)
   PUBMED   12606567
REFERENCE   7  (bases 1 to 1399)
  AUTHORS   Ogasawara,M., Kim,S.C., Adamik,R., Togawa,A., Ferrans,V.J.,
            Takeda,K., Kirby,M., Moss,J. and Vaughan,M.
  TITLE     Similarities in function and gene structure of cytohesin-4 and
            cytohesin-1, guanine nucleotide-exchange proteins for
            ADP-ribosylation factors
  JOURNAL   J Biol Chem 275 (5), 3221-3230 (2000)
   PUBMED   10652308
REFERENCE   8  (bases 1 to 1399)
  AUTHORS   Ashery,U., Koch,H., Scheuss,V., Brose,N. and Rettig,J.
  TITLE     A presynaptic role for the ADP ribosylation factor (ARF)-specific
            GDP/GTP exchange factor msec7-1
  JOURNAL   Proc Natl Acad Sci U S A 96 (3), 1094-1099 (1999)
   PUBMED   9927699
REFERENCE   9  (bases 1 to 1399)
  AUTHORS   Telemenakis,I., Benseler,F., Stenius,K., Sudhof,T.C. and Brose,N.
  TITLE     Rat homologues of yeast sec7p
  JOURNAL   Eur J Cell Biol 74 (2), 143-149 (1997)
   PUBMED   9352219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U83895.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U83895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1399
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.2-q32.3"
     gene            1..1399
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /note="cytohesin 1"
                     /db_xref="GeneID:116691"
                     /db_xref="RGD:620397"
     exon            1..97
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1272
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /note="rSec7-1; SEC7 homolog A; PH, SEC7 and coiled-coil
                     domain-containing protein 1; pleckstrin homology, Sec7 and
                     coiled-coil domains 1; pleckstrin homology, Sec7 and
                     coiled/coil domains 1(cytohesin 1)"
                     /codon_start=1
                     /product="cytohesin-1"
                     /protein_id="NP_446362.1"
                     /db_xref="GeneID:116691"
                     /db_xref="RGD:620397"
                     /translation="MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEV
                     ANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLY
                     KGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQK
                     IDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMN
                     RGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVK
                     TWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQ
                     VIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKV
                     SSTKRH"
     exon            98..180
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
     exon            181..245
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
     exon            246..312
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
     exon            313..431
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
     exon            432..512
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
     exon            513..625
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
     exon            626..774
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
     exon            775..887
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
     exon            888..966
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1038
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1193
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1399
                     /gene="Cyth1"
                     /gene_synonym="Pscd1; Sec7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagctggt gtctggcagg acgcgggctg cgggaggtca gtggcggtcg gtggccggag
       61 tcggtcgccg gcaccatgga ggacgatgac agctatgtcc ccagtgacct gactgcagag
      121 gagcgtcaag aactggagaa catccggcgg aggaagcagg agctgctggc tgacatccag
      181 aggctgaagg aagagatagc agaggttgct aatgaaattg aaagcctggg atccacagag
      241 gaacggaaaa acatgcagag gaacaaacag gtagccatgg gcagaaagaa attcaacatg
      301 gatcctaaga aggggatcca gttcttaatc gagaatggcc tgctgaaaaa cacttgtgag
      361 gacattgccc agttcctgta taaaggggaa gggctcaaca aaacagccat cggtgactac
      421 cttggggaga gagatgagtt cagcatccag gtcttgcatg catttgtgga gctgcacgag
      481 ttcaccgacc tgaacctcgt ccaggccttg cggcagttcc tgtggagctt ccggctccct
      541 ggagaggccc agaagattga ccggatgatg gaggcctttg cgcagcggta ctgtcagtgc
      601 aatactgggg tgttccagtc tacagacact tgctatgtcc tgtcctttgc aatcatcatg
      661 ctgaacacca gcctacacaa ccccaacgtc aaagacaagc ctacggtgga gaggttcatc
      721 gccatgaacc gaggcatcaa tgacggagga gacctgcccg aggagctgct gcggaatctc
      781 tatgagagca tcaaaaacga accctttaaa atcccagaag atgacggcaa tgatctcact
      841 cacactttct tcaatccaga ccgagagggc tggctactaa agctcggagg tggcagggta
      901 aagacttgga agaggcgctg gttcattctg actgacaact gcctttacta ctttgaatac
      961 accacggaca aagagccccg cgggatcatc cccctggaga acctgagtat ccgagaggtg
     1021 gaagactcca agaagccgaa ctgctttgag ctttatatcc ctgacaataa agaccaggtg
     1081 attaaggcct gcaagacaga ggctgacgga cgagtggtgg aagggaacca cactgtgtac
     1141 cgcatctcgg cccccactcc tgaggagaag gaagactgga tcaagtgcat caaagccgcc
     1201 atcagcagag acccgttcta cgagatgctt gcagcacgga aaaagaaggt ctcctccaca
     1261 aagaggcact gagggtgcac cagggcacgg ccagcccgtg aagctgtggc cccttctcct
     1321 gcctcccctg agggcgctgt ggagcccagc agaggagagc agagggcttc tctgccagtt
     1381 cctgcccact ccgctccta
//
