LOCUS       NM_198685                693 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus cystatin S (Cyss), mRNA.
ACCESSION   NM_198685 XM_215879
VERSION     NM_198685.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 693)
  AUTHORS   Kajikawa,S., Kigami,D., Nakayama,H. and Doi,K.
  TITLE     Changes in submaxillary gland gene expression in F344 rats by
            multiple dosing of theophylline
  JOURNAL   Exp Anim 55 (2), 143-146 (2006)
   PUBMED   16651698
REFERENCE   2  (bases 1 to 693)
  AUTHORS   Iseki,S., Kim,J.G., Kudo,Y., Naito,Y. and Hipkaeo,W.
  TITLE     Impaired induction of cystatin S gene expression by isoproterenol
            in the submandibular gland of hypophysectomized rats
  JOURNAL   Arch Oral Biol 50 (7), 653-660 (2005)
   PUBMED   15892951
REFERENCE   3  (bases 1 to 693)
  AUTHORS   Shaw,P.A. and Yu,W.H.
  TITLE     Sympathetic and parasympathetic regulation of cystatin S gene
            expression
  JOURNAL   Life Sci 70 (3), 301-313 (2001)
   PUBMED   12005263
REFERENCE   4  (bases 1 to 693)
  AUTHORS   Nishiura,T. and Abe,K.
  TITLE     Postnatal changes of gene expression for tissue inhibitors of
            metalloproteinase-1 and -2 and cystatins S and C, in rat
            submandibular gland demonstrated by quantitative reverse
            transcription-polymerase chain reaction
  JOURNAL   Arch Oral Biol 44 (1), 15-26 (1999)
   PUBMED   10075146
REFERENCE   5  (bases 1 to 693)
  AUTHORS   Abe,K., Okina,A., Yano,T., Gao,C., Ohmori,H., Ishibashi,K.,
            Nishiura,T. and Letic-Gavrilovic,A.
  TITLE     Abnormally high levels of cystatin S in submandibular glands,
            saliva, and gingiva of plaque-resistant rats
  JOURNAL   J Dent Res 77 (11), 1913-1919 (1998)
   PUBMED   9823730
REFERENCE   6  (bases 1 to 693)
  AUTHORS   Takahashi,M., Honda,Y., Ogawa,K. and Barka,T.
  TITLE     Immunofluorescence localization of cystatins in human lacrimal
            gland and in the exorbital lacrimal gland of the rat
  JOURNAL   Acta Ophthalmol (Copenh) 70 (5), 625-631 (1992)
   PUBMED   1471486
REFERENCE   7  (bases 1 to 693)
  AUTHORS   Cox,J.L. and Shaw,P.A.
  TITLE     Structure, organization and regulation of a rat cysteine proteinase
            inhibitor-encoding gene
  JOURNAL   Gene 110 (2), 175-180 (1992)
   PUBMED   1537554
REFERENCE   8  (bases 1 to 693)
  AUTHORS   Bedi,G.S.
  TITLE     The effects of autonomic drugs on the concentration of
            kallikrein-like proteases and cysteine-proteinase inhibitor
            (cystatin) in rat whole saliva
  JOURNAL   J Dent Res 70 (5), 924-930 (1991)
   PUBMED   2022776
REFERENCE   9  (bases 1 to 693)
  AUTHORS   Bedi,G.S.
  TITLE     The effect of adrenergic agonists and antagonists on
            cysteine-proteinase inhibitor (cystatin) in rat saliva
  JOURNAL   Arch Oral Biol 36 (8), 611-618 (1991)
   PUBMED   1685882
REFERENCE   10 (bases 1 to 693)
  AUTHORS   Shaw,P.A., Barka,T., Woodin,A., Schacter,B.S. and Cox,J.L.
  TITLE     Expression and induction by beta-adrenergic agonists of the
            cystatin S gene in submandibular glands of developing rats
  JOURNAL   Biochem J 265 (1), 115-120 (1990)
   PUBMED   1967932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Oct 27, 2022 this sequence version replaced NM_198685.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04206.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840122,
                                           SAMN12840129 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               JAXUCZ010000003.1  157896994-157897265 c
            273-386             JAXUCZ010000003.1  157893968-157894081 c
            387-693             JAXUCZ010000003.1  157892660-157892966 c
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..693
                     /gene="Cyss"
                     /gene_synonym="Cst4"
                     /note="cystatin S"
                     /db_xref="GeneID:296234"
                     /db_xref="RGD:735160"
     exon            1..272
                     /gene="Cyss"
                     /gene_synonym="Cst4"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..470
                     /gene="Cyss"
                     /gene_synonym="Cst4"
                     /note="LM protein; cystatin-1; protein LM"
                     /codon_start=1
                     /product="cystatin-S precursor"
                     /protein_id="NP_941958.1"
                     /db_xref="GeneID:296234"
                     /db_xref="RGD:735160"
                     /translation="MAYLLHAQLFLLTTFILVLNMRLCPVLGHFLGGIEKSSMEEEGA
                     SEALNYAVNEYNEKNSDLYLSRVVEVKDVQKQVVAGTKFFFDVILGKTICLKTQGDLT
                     NCPLNEEADQQEHEFCSFVVHDIPWENYIVLLSSSCHSI"
     exon            273..386
                     /gene="Cyss"
                     /gene_synonym="Cst4"
                     /inference="alignment:Splign:2.1.0"
     exon            387..693
                     /gene="Cyss"
                     /gene_synonym="Cst4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcctctcc ttgtcttgga tcctagtcca tttctaagaa gatcatggcc tacctgctcc
       61 atgctcaact atttctactg actaccttta tattagtttt gaacatgaga ctttgtcctg
      121 ttctaggtca ctttctgggt ggcatagaga agtctagcat ggaggaggaa ggagcctcag
      181 aagcattgaa ctatgctgtc aatgaatata atgaaaagaa cagtgacttg tacctgagcc
      241 gtgtggtgga agtgaaggat gtccaaaagc aggtggtggc tggaaccaaa tttttctttg
      301 atgtgattct aggcaaaaca atatgtttga agacacaggg tgacttgacc aactgtccct
      361 taaatgaaga ggctgatcag caggagcatg aattctgctc tttcgtggtt catgatatcc
      421 catgggagaa ttatattgtc ttgctgagct ccagctgtca tagtatatga attagtgtca
      481 agtgttactg tgtaggatgc agatgtctct ggcaatgcct catcactcca gtggatgatc
      541 tttccttgat ggatgcttac cagcatggat attagcaatg gaatagactg ctgtgcactt
      601 agagttagac ccaagcacct ctccctttat tcttcctcta caaatgccca tatttgcttg
      661 ctcattcctt gctcaataaa atgtccaaca gct
//
