LOCUS       NM_133413               4297 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus cysteinyl leukotriene receptor 2 (Cysltr2),
            transcript variant 1, mRNA.
ACCESSION   NM_133413 XM_003752828 XM_008770843
VERSION     NM_133413.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4297)
  AUTHORS   Yu,S., Yan,J., Chen,X., Zhu,X., Li,X. and Liao,L.
  TITLE     Expression of cysteinyl leukotriene receptor in brain tissues of
            rats with Streptococcus pneumoniae meningitis
  JOURNAL   Int J Clin Exp Pathol 12 (12), 4242-4252 (2019)
   PUBMED   31933824
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4297)
  AUTHORS   Zhao,C.Z., Zhao,B., Zhang,X.Y., Huang,X.Q., Shi,W.Z., Liu,H.L.,
            Fang,S.H., Lu,Y.B., Zhang,W.P., Tang,F.D. and Wei,E.Q.
  TITLE     Cysteinyl leukotriene receptor 2 is spatiotemporally involved in
            neuron injury, astrocytosis and microgliosis after focal cerebral
            ischemia in rats
  JOURNAL   Neuroscience 189, 1-11 (2011)
   PUBMED   21664436
  REMARK    GeneRIF: The spatiotemporal profiles of CysLT2 receptor expression
            suggest that it plays regulatory roles in acute neuron injury, and
            astrocytosis and microgliosis in the late phase.
REFERENCE   3  (bases 1 to 4297)
  AUTHORS   Qi,L.L., Fang,S.H., Shi,W.Z., Huang,X.Q., Zhang,X.Y., Lu,Y.B.,
            Zhang,W.P. and Wei,E.Q.
  TITLE     CysLT2 receptor-mediated AQP4 up-regulation is involved in
            ischemic-like injury through activation of ERK and p38 MAPK in rat
            astrocytes
  JOURNAL   Life Sci 88 (1-2), 50-56 (2011)
   PUBMED   21055410
REFERENCE   4  (bases 1 to 4297)
  AUTHORS   Xu,L., Zhang,L., Liu,L., Fang,S., Lu,Y., Wei,E. and Zhang,W.
  TITLE     Involvement of cysteinyl leukotriene receptors in angiogenesis in
            rat thoracic aortic rings
  JOURNAL   Pharmazie 65 (10), 750-754 (2010)
   PUBMED   21105577
REFERENCE   5  (bases 1 to 4297)
  AUTHORS   Shimbori,C., Shiota,N. and Okunishi,H.
  TITLE     Involvement of leukotrienes in the pathogenesis of silica-induced
            pulmonary fibrosis in mice
  JOURNAL   Exp Lung Res 36 (5), 292-301 (2010)
   PUBMED   20497024
  REMARK    Erratum:[Exp Lung Res. 2010 Sep;36(7):440]
REFERENCE   6  (bases 1 to 4297)
  AUTHORS   Beller,T.C., Maekawa,A., Friend,D.S., Austen,K.F. and Kanaoka,Y.
  TITLE     Targeted gene disruption reveals the role of the cysteinyl
            leukotriene 2 receptor in increased vascular permeability and in
            bleomycin-induced pulmonary fibrosis in mice
  JOURNAL   J Biol Chem 279 (44), 46129-46134 (2004)
   PUBMED   15328359
REFERENCE   7  (bases 1 to 4297)
  AUTHORS   Fukai,H., Ogasawara,Y., Migita,O., Koga,M., Ichikawa,K.,
            Shibasaki,M., Arinami,T. and Noguchi,E.
  TITLE     Association between a polymorphism in cysteinyl leukotriene
            receptor 2 on chromosome 13q14 and atopic asthma
  JOURNAL   Pharmacogenetics 14 (10), 683-690 (2004)
   PUBMED   15454733
REFERENCE   8  (bases 1 to 4297)
  AUTHORS   Pillai,S.G., Cousens,D.J., Barnes,A.A., Buckley,P.T., Chiano,M.N.,
            Hosking,L.K., Cameron,L.A., Fling,M.E., Foley,J.J., Green,A.,
            Sarau,H.M., Schmidt,D.B., Sprankle,C.S., Blumenthal,M.N.,
            Vestbo,J., Kennedy-Wilson,K., Wixted,W.E., Wagner,M.J.,
            Anderson,W.H. and Ignar,D.M.
  CONSRTM   Investigators of the GAIN Network
  TITLE     A coding polymorphism in the CYSLT2 receptor with reduced affinity
            to LTD4 is associated with asthma
  JOURNAL   Pharmacogenetics 14 (9), 627-633 (2004)
   PUBMED   15475736
REFERENCE   9  (bases 1 to 4297)
  AUTHORS   Ogasawara,H., Ishii,S., Yokomizo,T., Kakinuma,T., Komine,M.,
            Tamaki,K., Shimizu,T. and Izumi,T.
  TITLE     Characterization of mouse cysteinyl leukotriene receptors mCysLT1
            and mCysLT2: differential pharmacological properties and tissue
            distribution
  JOURNAL   J Biol Chem 277 (21), 18763-18768 (2002)
   PUBMED   11854273
REFERENCE   10 (bases 1 to 4297)
  AUTHORS   Hui,Y., Yang,G., Galczenski,H., Figueroa,D.J., Austin,C.P.,
            Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Funk,C.D.
  TITLE     The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and
            genomic cloning, alternative splicing, and in vitro
            characterization
  JOURNAL   J Biol Chem 276 (50), 47489-47495 (2001)
   PUBMED   11591709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Sep 13, 2022 this sequence version replaced
            XM_008770843.3, NM_133413.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.1171668.1,
                                           SRR22582416.585328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000015.1  54638227-54638314   c
            89-159              JAXUCZ010000015.1  54606846-54606916   c
            160-286             JAXUCZ010000015.1  54604856-54604982   c
            287-4297            JAXUCZ010000015.1  54599043-54603053   c
FEATURES             Location/Qualifiers
     source          1..4297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..4297
                     /gene="Cysltr2"
                     /gene_synonym="Cyslt2; RSBPT32"
                     /note="cysteinyl leukotriene receptor 2"
                     /db_xref="GeneID:170926"
                     /db_xref="RGD:619797"
     exon            1..88
                     /gene="Cysltr2"
                     /gene_synonym="Cyslt2; RSBPT32"
                     /inference="alignment:Splign:2.1.0"
     exon            89..159
                     /gene="Cysltr2"
                     /gene_synonym="Cyslt2; RSBPT32"
                     /inference="alignment:Splign:2.1.0"
     exon            160..286
                     /gene="Cysltr2"
                     /gene_synonym="Cyslt2; RSBPT32"
                     /inference="alignment:Splign:2.1.0"
     exon            287..4297
                     /gene="Cysltr2"
                     /gene_synonym="Cyslt2; RSBPT32"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..1434
                     /gene="Cysltr2"
                     /gene_synonym="Cyslt2; RSBPT32"
                     /note="cysteinyl leukotriene CysLT2 receptor"
                     /codon_start=1
                     /product="cysteinyl leukotriene receptor 2"
                     /protein_id="NP_596904.1"
                     /db_xref="GeneID:170926"
                     /db_xref="RGD:619797"
                     /translation="MGVTGTPSYYSDKNCTIENFKRDFYPIIYLIIFVWGALGNGFSI
                     YVFLQTYKKSTSVNVFMLNLAISDFLFISTLPFRADYNFRGSDWIFGDWACRIMSYSL
                     YVNMYTSIYFLTVLSIVRFLATAHPFQMLHITSVRSAWILCGIIWVFIMASSGLLLKH
                     GQEKKNNTTLCFELNLQKFKNLVILNYIALGVGFLLPFFILTICYLLIIRVLLKVEIP
                     ESGPRDAQRKALTTIVIAMIIFLLCFLPYHALRTIHLVTWDADSCMDELHKATVITLT
                     LAAANSCFNPFLYYFAGENFKARLRAIFSKDHL"
ORIGIN      
        1 aaataaacaa gctgaattct atgggagaga agccaggagt cagagcggag tcaaacgtcc
       61 gtccaggcag cggaaggcag aagcacagtt gttctgggga aggatgtgcc tctttggcta
      121 aggagaagtc ttggaacttc ttgaattggg aagataaaag atgaagaaga tgatctttta
      181 gaggctactt gtaccaatag tttgagctcc aaaggcattt caattctgat ttggagcctg
      241 aatttgggaa aggaagaatc aacaatagtt gtccaagaga caagatgtcc accgtgcata
      301 tgtctgatgc ctgccaaggt cagaagaggg tgtcggagaa acttgcttct cgccatgtga
      361 gatggagtac ggcaaatgtt tgatcactaa tcaggaagaa aagtggaatt gtatgaagta
      421 actttttggg tttatttctt tttaaactaa tataaagaga aaactttata ttagtccttg
      481 cctctgtcca actccatatt agaaatggga gtaactggga cccccagcta ttatagtgac
      541 aagaactgta caatagaaaa cttcaagagg gacttttacc ctatcatcta cctgataata
      601 tttgtctggg gagccttggg aaatggcttt tccatatatg tcttcctaca gacttacaag
      661 aagtccacat ctgtgaatgt tttcatgctc aacctggcca tttcagattt cctattcata
      721 agcaccctgc ccttcagggc tgactataat ttcagaggtt ctgattggat atttggggac
      781 tgggcctgca gaattatgtc ttattcttta tatgtcaaca tgtatactag catttatttc
      841 ctaactgtgc tgagtattgt gcgcttcctg gccactgccc accccttcca gatgctccat
      901 atcaccagcg ttaggagtgc ctggatcctc tgtgggatta tatgggtctt catcatggct
      961 tcctcaggac tgcttctgaa gcatggccaa gagaagaaaa ataacactac attgtgcttt
     1021 gagctgaatc tccaaaagtt taaaaatctc gtcatcttga actacattgc attaggggtg
     1081 ggcttcttgc ttccattttt catactcacc atctgctacc tgttgatcat ccgggtcttg
     1141 ttaaaggtgg agattccaga atcaggtcca cgggatgctc agaggaaggc actgaccact
     1201 atcgtcattg ccatgatcat cttcctcctc tgttttctgc cataccatgc acttcggacc
     1261 atccacttgg tcacatggga tgcagattca tgtatggatg aattacataa ggccacggtc
     1321 atcactctga ccttggctgc agccaacagc tgcttcaatc cctttctcta ttattttgct
     1381 ggagagaatt tcaaagcacg attaagggct atattcagca aagatcatct atagaaagca
     1441 aagtcaaagt gcagccttcc tatttgtgta ttactgaaga ccagagttaa gagcataagg
     1501 ggctgttctg gaggtacgct catgaacact ggtgtccacc ttcactcact cagggtctcc
     1561 aaattacttc atatctgtgt cataaccgac aagtcttggt tcctgacatt taaatgacca
     1621 caacatttgc taataaagcc tatttcagaa attttattag atgtattttt agtggttggg
     1681 actaaatgag aaattaggaa aaatatttct actggaatct tgcatgctaa aatgtgacat
     1741 tagtaaaaca tgttacacac agtaggccat gttttgcatc agatattatg ctagctcttt
     1801 ggcccagaca ttctaaattc ctaacttgaa gacattctta agcaccctag cttctccaaa
     1861 tcctttctct cttaaagctt ttaagacaca gtcaaatcgc ctggaggcct gagtgcagct
     1921 agaagagcat cccaaggcct ctgggacagg ctttactttg aagaggaaaa ctatcttcta
     1981 atgcaagtca aggtccagac aagattggca agagaaaaag gaggagaagg attaaggcca
     2041 gagagtgaat gatgagtaga agtaaagagt aatttcatct ttgcctccaa gagataggtt
     2101 ccagcagcca aatggaagaa tgtacctttt gtgtcttacc aggaggtagg cagactgagg
     2161 agtggggctg tgttgggatc acatccctag gggatacaag aatcatgtgt ggaataggaa
     2221 tgaggaatag ccatggacat gcatctcatg agactcggga ctgaactgat gtcattgtag
     2281 tcattggccc ctcctattaa cccatggaga tgacaattga aggaggtgga ccatcgggaa
     2341 aggggtgggc agaacgtgag aagtgatgta gaaaaaagtc cttgataata gaaagagacc
     2401 ctttctatcc acagaaactg gctacagata ctaccaatta ttcacatgac ctttgtgttg
     2461 actccaacag tcaagtgctg catccttcag aaatgctgaa gaaagcacag agattccatg
     2521 ggtggagaac ttaagaagtg tgtccaagtc tacacagctg gtgagcactt taaaagccct
     2581 gaggaaatgt taacttggtg ctctccccct aacccctgtg aacctccaaa aagtctgcac
     2641 ggaaacccat ggtcaaagtc tgcatggaaa cccatggtca aagactgcat ggaaacccat
     2701 ggtcaaagac tgcatggaaa cccatggtca aaagtctgca tggagacttt ctctcttgtc
     2761 agacacatat gcctttctca tccttacaag gaaagcaagg tctgggggct ggagagatgc
     2821 ttttggggtt aatagcactt gttgctttta taaaggagtc aagcactgac atggaggctc
     2881 acagccatct ttaactccac aggatttgat gctctcttgt ggctctgtgg gcatgcacac
     2941 agtgtggaga catacgtaca gacaaaacat tcatacatgt aaaaatcctt aacaaccaca
     3001 aaaataataa tgacaatagt cataaaacaa agcaattttt ggctcctggc acagcttggg
     3061 gtggaaggga gattgtgttc tcaagttgga gagtactaca gtagtgttaa tatgaaacta
     3121 caattctgta accttccttt atttagctac cagaatgata gagagatacc agggaagacc
     3181 tagaacatct gcctacaggg caactcctct atcctagaga cgaggctgac agacacttgg
     3241 gaatcctcca attccaaatc tgaatgtcta ctctctcatt tacctaacag caaagcctaa
     3301 aatctacaat agccaacttg gtctagttcc acacttgatt ataaacaagt taatgaccac
     3361 acaattttta gtggaaaacc ccttaacatt taaggcacca acattttttc attttttatt
     3421 ggttattttt taatttacat ttcaaatgtt atcccctttc ccagtttccc ttccataagc
     3481 cccctatccc ataccctctc ccccttcttg tatgagggtg ttcccccacc cacccactta
     3541 ccccttccca cctccccacc ttggtattcc tctatactgg gggatccagc cttggcagga
     3601 ccaagggctt ctcttcccat tggttcccaa caaggccatc ctctgctacg tatgcacttg
     3661 gagatacggg tctgtccatg tgtactcttt ggatggtggt ttagtccctg ggagctctag
     3721 ttggttggta ttgttgttct tatggggttg caaatccctt tagctccttc aattctttct
     3781 ctaactcctc caacagggac cctgttctca gctcaatggt tggctgcaag ccatctgcct
     3841 ctgtatttgt catgctctgg cagagcctct taggagacag ctatatcagg ctcctgccag
     3901 gatgcacttc ttggtattag caatattgtg tgggttcaag gaaccaacaa ttaagagcac
     3961 agagtgtgac attttgatag aaaaggtttc aacattttct tatatcagaa agcactggga
     4021 tactgctcaa aacaaacaag caagcaaaca aacatgagga gacagacaac caagacaatg
     4081 atagcacaac acagtcatta gtatgttaga gaagaaaagt gttagctaag agcgtgagta
     4141 ataactggag tccactgcat agttgagtat tttcacagag catgacacat aggaacacta
     4201 tgatgaattc tcaggaaatg agtgaggagg atagatgtgg ggtaggagga gaggcacaag
     4261 aagcttgggt gtacattctc caccagagaa aagttca
//
