LOCUS       NM_053641               4922 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cysteinyl leukotriene receptor 1 (Cysltr1), mRNA.
ACCESSION   NM_053641 XM_006257158
VERSION     NM_053641.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4922)
  AUTHORS   Yu,S., Yan,J., Chen,X., Zhu,X., Li,X. and Liao,L.
  TITLE     Expression of cysteinyl leukotriene receptor in brain tissues of
            rats with Streptococcus pneumoniae meningitis
  JOURNAL   Int J Clin Exp Pathol 12 (12), 4242-4252 (2019)
   PUBMED   31933824
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4922)
  AUTHORS   Osman,J., Savari,S., Chandrashekar,N.K., Bellamkonda,K., Douglas,D.
            and Sjolander,A.
  TITLE     Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a
            mouse model of colitis-associated colon cancer
  JOURNAL   Oncotarget 8 (21), 34773-34786 (2017)
   PUBMED   28410235
REFERENCE   3  (bases 1 to 4922)
  AUTHORS   Said,M.M. and Bosland,M.C.
  TITLE     The anti-inflammatory effect of montelukast, a cysteinyl
            leukotriene receptor-1 antagonist, against estradiol-induced
            nonbacterial inflammation in the rat prostate
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 390 (2), 197-205 (2017)
   PUBMED   27909742
  REMARK    GeneRIF: Cysteinyl leukotriene receptor-1 antagonist montelukast
            prevents estradiol-induced nonbacterial inflammation in the rat
            prostate.
REFERENCE   4  (bases 1 to 4922)
  AUTHORS   Shigematsu,M., Koga,T., Ishimori,A., Saeki,K., Ishii,Y.,
            Taketomi,Y., Ohba,M., Jo-Watanabe,A., Okuno,T., Harada,N.,
            Harayama,T., Shindou,H., Li,J.D., Murakami,M., Hoka,S. and
            Yokomizo,T.
  TITLE     Leukotriene B4 receptor type 2 protects against
            pneumolysin-dependent acute lung injury
  JOURNAL   Sci Rep 6, 34560 (2016)
   PUBMED   27703200
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4922)
  AUTHORS   Yuan,Y., Yang,B., Ye,Z., Zhang,M., Yang,X., Xin,C., Lin,M. and
            Huang,P.
  TITLE     Sceptridium ternatum extract exerts antiasthmatic effects by
            regulating Th1/Th2 balance and the expression levels of leukotriene
            receptors in a mouse asthma model
  JOURNAL   J Ethnopharmacol 149 (3), 701-706 (2013)
   PUBMED   23933317
REFERENCE   6  (bases 1 to 4922)
  AUTHORS   Ragab,S., Parikh,A., Darby,Y.C. and Scadding,G.K.
  TITLE     An open audit of montelukast, a leukotriene receptor antagonist, in
            nasal polyposis associated with asthma
  JOURNAL   Clin Exp Allergy 31 (9), 1385-1391 (2001)
   PUBMED   11591188
REFERENCE   7  (bases 1 to 4922)
  AUTHORS   Ichinose,F., Zapol,W.M., Sapirstein,A., Ullrich,R., Tager,A.M.,
            Coggins,K., Jones,R. and Bloch,K.D.
  TITLE     Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia
            requires 5-lipoxygenase in mice
  JOURNAL   Circ Res 88 (8), 832-838 (2001)
   PUBMED   11325876
REFERENCE   8  (bases 1 to 4922)
  AUTHORS   Maekawa,A., Kanaoka,Y., Lam,B.K. and Austen,K.F.
  TITLE     Identification in mice of two isoforms of the cysteinyl leukotriene
            1 receptor that result from alternative splicing
  JOURNAL   Proc Natl Acad Sci U S A 98 (5), 2256-2261 (2001)
   PUBMED   11226226
REFERENCE   9  (bases 1 to 4922)
  AUTHORS   Spector,S.L., Smith,L.J. and Glass,M.
  TITLE     Effects of 6 weeks of therapy with oral doses of ICI 204,219, a
            leukotriene D4 receptor antagonist, in subjects with bronchial
            asthma. ACCOLATE Asthma Trialists Group
  JOURNAL   Am J Respir Crit Care Med 150 (3), 618-623 (1994)
   PUBMED   8087328
REFERENCE   10 (bases 1 to 4922)
  AUTHORS   Piechuta,H., Ford-Hutchinson,A.W. and Letts,L.G.
  TITLE     Inhibition of allergen-induced bronchoconstriction in hyperreactive
            rats as a model for testing 5-lipoxygenase inhibitors and
            leukotriene D4 receptor antagonists
  JOURNAL   Agents Actions 22 (1-2), 69-74 (1987)
   PUBMED   2825489
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Aug 31, 2022 this sequence version replaced
            XM_006257158.3, NM_053641.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.45005.1,
                                           SRR26360190.554378.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676785,
                                           SAMN16676806 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               JAXUCZ010000021.1  75762406-75762873   c
            469-555             JAXUCZ010000021.1  75741904-75741990   c
            556-4922            JAXUCZ010000021.1  75734281-75738647   c
FEATURES             Location/Qualifiers
     source          1..4922
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..4922
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1"
                     /note="cysteinyl leukotriene receptor 1"
                     /db_xref="GeneID:114099"
                     /db_xref="RGD:619796"
     exon            1..468
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..555
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..4922
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             582..1601
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1"
                     /codon_start=1
                     /product="cysteinyl leukotriene receptor 1"
                     /protein_id="NP_446093.1"
                     /db_xref="GeneID:114099"
                     /db_xref="RGD:619796"
                     /translation="MVGAENMTASFSNNRCHDTIDEFRNQVYSTMYSMISVVGFFGNS
                     FVLYVLIKTYHEKSAFQVYMINLAIADLLCVCTLPLRVVYYVHKGKWFFGDFLCRLTT
                     YALYVNLYCSIFFMTAMSFFRCVAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPF
                     LLSKSYQDEKNNTKCFEPPQDKQTKKYVLVLHYVSLIFGFIIPFVTIIVCYTMIILTL
                     LKNTMKKNLPSRRKAIGMIIVVTAAFLVSFMPYHIQRAIHLHFLHSETRSCDSVLRMQ
                     KSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTFRKHSLSSMTYIPKKKASLPEKGE
                     EMCKE"
ORIGIN      
        1 cctccttact tcccacctca gagcagctgc atgacttcct gagggttcta ctgcagtagc
       61 cagagataaa cactcatttg tgcacataac ctgcaagtct ccagtttcta agtttctagg
      121 cttcttccct ctctgttctt ttccttcccc cactttgaac caggaaagct aaactctggt
      181 gggcttgaag cagcttgaga actactaaga aagaggaaga agagtcggtg tatattgttt
      241 agcaaatgtg ccatgccctg acctctctcc tctggaaaag aaacgttcct aaaaagcggg
      301 agccctgtga atggagtgga ccatccagag tatccagatt tcttctgcag ctcaccatcc
      361 agggttagct caccagggga ctagcaggtt ggattttctg aagatctgga tgttgcttca
      421 gggagcaact tcaaaaggac cttaaactgt gaagcttgga accagcagct tgaacgtacc
      481 ctgacactac aacgtaagga cagtggccac agtaagaagg aaaatttgtg aaaggtgctg
      541 tggggccaaa aagaggcacc aagcagacat tcctggagaa catggttgga gctgaaaata
      601 tgacagcatc tttcagtaat aacagatgtc atgacacaat tgatgaattc cgaaatcagg
      661 tgtactccac aatgtactct atgatctccg ttgtgggttt ctttggcaat agctttgtcc
      721 tctatgtcct cataaaaaca taccatgaga aatcagcctt ccaagtatac atgattaatc
      781 tagccatagc agatctactc tgtgtatgta cattgcctct ccgtgtggtc tactatgttc
      841 acaaaggcaa gtggttcttt ggtgactttt tgtgccgcct caccacctat gccttatatg
      901 ttaacctcta ttgtagcatc ttctttatga cagccatgag ctttttccgg tgtgttgcaa
      961 ttgtctttcc agtccagaac attaatttgg ttacacagaa aaaagccagg tttgtgtgtg
     1021 ttggaatttg gatttttgtg attttgacaa gttctccatt tttactgagc aaatcttacc
     1081 aagatgagaa aaacaatact aaatgttttg agcctccaca ggacaaacaa actaaaaaat
     1141 atgttttggt cttgcattat gtgtcattaa tctttggttt catcatccct tttgtcacca
     1201 taattgtctg ttacacaatg atcattctga ccttactaaa aaatacaatg aagaaaaacc
     1261 tgccaagtcg aaggaaggct ataggaatga tcatagttgt gacagctgcc tttttagtca
     1321 gcttcatgcc atatcatatt caacgagcta tccaccttca ctttttacac agtgaaacta
     1381 gatcctgtga ctctgtcctt aggatgcaga agtcagtggt cataacctta tctctagctg
     1441 catcaaattg ttgctttgat cctctgctat atttcttttc aggtggaaac tttaggagaa
     1501 ggctgtctac atttagaaag cattctttgt ccagtatgac ttacataccc aaaaagaaag
     1561 cttccttgcc agaaaaagga gaagaaatgt gtaaagaata attcagaccc atttccagtg
     1621 cagagcaatg aaaagtaaat tcctgacaag cattttttta aatcacaatt ttaaaaaagt
     1681 ttcccatgag tagtttacaa atcattatat gtatgacatt tataaatacc attatttgat
     1741 attttaagtg ttcaaaattc agtttctaac tgtgaaccaa cccttcggtt tttcaatgac
     1801 tcaccagaaa gtggagaatg tttgtggttc tgaactataa aactgagtat gaaatcaaga
     1861 atatcaaaag ggttacaaaa gttatgtact agacttttga gtccagcttt taaatatagc
     1921 ttggaaatta gcaaatagtc atcagtcacc ctaacatatc cctttgcatg catgccatga
     1981 gatgagacct ggagatgacc caggacctac agaaatgtac ggtcatggtt tcctttgtag
     2041 tacagactag ctaggtaaag cagtgcactg tcttccagaa gagaatgttc aagtgctaga
     2101 acacaccaag attcagccaa gagctccgca ggctgcagga aatttaccat ctgaaaagta
     2161 aggaagataa atccgatcaa aggccagttt gtttcttaat tttcttctgc ctttgactca
     2221 agctgtccac tccccccccc caaagaatga ttttgttctt gctcactaca gttcaatccc
     2281 aattctacat gtaatccttc cttaatgagt aaggcaactg gcatttccat atatgagcag
     2341 aagcaatcaa aattcatctg aagtaaagga aataggtcta ctattctaca caagttttgt
     2401 tggaatcaaa attaactatg tcagatacca gaagaaaatt tgaatatcca tgtcattaat
     2461 tctttaataa gtatatgcac ttatgtatat atataaatat aagtaatata tcttgttcta
     2521 tgacatgcat ttatagtaag ttaattatga aatatatttt tgttttatac ttcctgcttt
     2581 tttcattagc atgttgaaag taataattgt ttatagtgat tttcatatta tagcagaaac
     2641 tttgttctta aagcaaacca ttgaaaacaa cttgattgtt tgatatgata ttcattggca
     2701 aagttttgct gaaggccact ttgccccaac tctgagtttc aaaagtcaca ttacatcaga
     2761 aggaataaat gataatagag atggaataaa gaaaaaccat gaatggagtt ctatctgcac
     2821 cagccacatg taaacttttt aaatttcact tctgctggac cccttgggaa aaaatttaaa
     2881 gcataatgaa gagaggactc tgaggatcaa aactaactgg aactcattga tttctgttga
     2941 acatgtctga aaattgacag tgcctattac tcttgttacc tcttgcttga gacaaatatg
     3001 aaacatattt gtcataagac ttcaggcctc attttctaca tttctgcttt gtagtagaag
     3061 ggcccaacac tggaagccaa gatgtctgca tgctaacctg gtctctttta acttttaaca
     3121 aagttaacgt aactatgacc aaatcttata agcctaaaac cttaactttc tcagctgtaa
     3181 gatgagaatg atacttgttt tgctttctta tggacatttg caggattcaa atatgggcag
     3241 atatgttaaa attgtatcct aaaatgtatt ataagatgcc attttaaagt atttttagga
     3301 gagttgttaa atatgctaac tcatatctat tgtatccatt ttaattttga aagaatgaga
     3361 acaaaatact gccacaattt aattctaatg catataatca tgttgctcat ttattcctat
     3421 gtccaagctt ttgtctgtat ttgcaatttc actcacatat gtacccatat gtaccatata
     3481 gatattccac aaaacttcag ccacatgcaa acgtacaatg aatgtattgt tctttcttga
     3541 actatgcctt tatagctgat accatacaac ttacttctta ctactttttc cagtttctcc
     3601 atgtgtctta gtattttctc ataaagggaa gtgctctgtg tagaagtatc aattccttga
     3661 ggttaaaaat tacatccttg aggtaaaaat acattatata tatatataat tttttatttt
     3721 aaaagctttt caaatgtttt aaatgcttta tctgtgccaa ttcataagta caaaagcctc
     3781 attttgtcag caagctttaa ccaagattga actctaggca ttctgttgct aaactatatt
     3841 cttaatttgc taggtatctg tgccatcatt ttcatgtaca aagtgtcagg tatacatgat
     3901 aaataagttc tagaggttta ctatgtaaaa ttatgccttc cattatcact gtgcctttat
     3961 ttttttaata ggacagatat gctttgctct tactgcaaac agatgagaaa tacatgattg
     4021 agcaatgaga gacagagaga gaaattggat gaatcgatga taaattaaag tgtatgcttt
     4081 ttaacgcttt ttaaaatatt ttacttatac atatgtatct gcatgaattt ttagttttta
     4141 tttatgctct catatattat atcccaactc cagtttctcc tcctttccct catcccagtt
     4201 ctccctctcc ccaattcctg tgttccctag atcctctcct cctcaacttc ttttcagaaa
     4261 aaagcaggtt tcccagtgat ttcaaacaaa cataccatga aatacaataa gacttagcat
     4321 aaaccctgat atcaacccag taagaaaaag ggatcccaag aacaggcaag agagtcagaa
     4381 acaaccccac tcctactgtt aggactccca taaaaaagac aaagctatac aaccataatg
     4441 taatatgcag tggacctagc tcagacccat acacattcaa ctgcttccct gatctccatt
     4501 tcagttctgt gagcccctat gagccctgcg tagttgattc tgtgggccac gttctcctgg
     4561 tgtctttgaa tgcttaaatg tgtaaattat atgatgagca ttacacatac ttatgattta
     4621 gcccaaagaa tgctgtaaaa gtcacttaga atattgaaat tagaaggtgc ttcatatttg
     4681 caattcctag tagcaaaata ataataatct atagcattaa cactccacag tctttacata
     4741 tatccctatg gtcactagca gccttttcaa atctcatcag gtagtcaaaa ctgtttatca
     4801 ttgtatactt aactttttat ttcattcagc aagtattgta tgtatcccta aaatgcattt
     4861 ctggtcttaa gcaaatgttc tgtatgttaa gttttaaaat aaacaattga ttttgtgggt
     4921 tc
//
