LOCUS       NM_001109597            2964 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus cystin 1 (Cys1), mRNA.
ACCESSION   NM_001109597 XM_001074594
VERSION     NM_001109597.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2964)
  AUTHORS   Hou,J.Y., Wang,Y.G., Ma,S.J., Yang,B.Y. and Li,Q.P.
  TITLE     Identification of a prognostic 5-Gene expression signature for
            gastric cancer
  JOURNAL   J Cancer Res Clin Oncol 143 (4), 619-629 (2017)
   PUBMED   28035468
REFERENCE   2  (bases 1 to 2964)
  AUTHORS   Wu,M., Yang,C., Tao,B., Bu,S. and Guay-Woodford,L.M.
  TITLE     The ciliary protein cystin forms a regulatory complex with necdin
            to modulate Myc expression
  JOURNAL   PLoS One 8 (12), e83062 (2013)
   PUBMED   24349431
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2964)
  AUTHORS   Tao,B., Bu,S., Yang,Z., Siroky,B., Kappes,J.C., Kispert,A. and
            Guay-Woodford,L.M.
  TITLE     Cystin localizes to primary cilia via membrane microdomains and a
            targeting motif
  JOURNAL   J Am Soc Nephrol 20 (12), 2570-2580 (2009)
   PUBMED   19850956
REFERENCE   4  (bases 1 to 2964)
  AUTHORS   Alcalay,N.I., Sharma,M., Vassmer,D., Chapman,B., Paul,B., Zhou,J.,
            Brantley,J.G., Wallace,D.P., Maser,R.L. and Vanden Heuvel,G.B.
  TITLE     Acceleration of polycystic kidney disease progression in cpk mice
            carrying a deletion in the homeodomain protein Cux1
  JOURNAL   Am J Physiol Renal Physiol 295 (6), F1725-F1734 (2008)
   PUBMED   18829740
REFERENCE   5  (bases 1 to 2964)
  AUTHORS   Hou,X., Mrug,M., Yoder,B.K., Lefkowitz,E.J., Kremmidiotis,G.,
            D'Eustachio,P., Beier,D.R. and Guay-Woodford,L.M.
  TITLE     Cystin, a novel cilia-associated protein, is disrupted in the cpk
            mouse model of polycystic kidney disease
  JOURNAL   J Clin Invest 109 (4), 533-540 (2002)
   PUBMED   11854326
REFERENCE   6  (bases 1 to 2964)
  AUTHORS   Cho,H., Buchanan,J., Strong,D., Yamada,Y. and Yoo,T.J.
  TITLE     The molecular and structural basis of hearing impairment in mice
            with the cpk mutant gene
  JOURNAL   Ann N Y Acad Sci 630, 262-264 (1991)
   PUBMED   1952600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001109597.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.34994.1,
                                           SRR26643299.26951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840122 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1089              JAXUCZ010000006.1  47045583-47046671   c
            1090-1142           JAXUCZ010000006.1  47033318-47033370   c
            1143-2964           JAXUCZ010000006.1  47029440-47031261   c
FEATURES             Location/Qualifiers
     source          1..2964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..2964
                     /gene="Cys1"
                     /note="cystin 1"
                     /db_xref="GeneID:690489"
                     /db_xref="RGD:1596023"
     exon            1..1089
                     /gene="Cys1"
                     /inference="alignment:Splign:2.1.0"
     CDS             811..1248
                     /gene="Cys1"
                     /codon_start=1
                     /product="cystin-1"
                     /protein_id="NP_001103067.1"
                     /db_xref="GeneID:690489"
                     /db_xref="RGD:1596023"
                     /translation="MGSGSSRSGRILRRRRSPDRRQTGPGETALEGGAADQAKTAAVQ
                     EECGPDPRPATPPGGREETLRLLDQLLAESEVWGPQEQTPRGPARLPPAVSPEKKVTG
                     NPEDSCASEAPGSSPKRPEGQSAISYDYSEEELMASIEREYCR"
     exon            1090..1142
                     /gene="Cys1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..2964
                     /gene="Cys1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctctcgcac acacacaaaa ctctgattct ccttttctgt ccccctcctc ggctctctgc
       61 ctctgctctc tcagacctgt acctgaagcc ccaacgacct cctttccgtc agcgctactc
      121 cccaactcct gatcttcccc cttcccctgg catccagctc tgctgcaagc attcctccgt
      181 ccttcagccg gtgtcttgct cccctttccc caagcgtgac tcccacccat gctcgcccaa
      241 acttccccaa gaagatctcc taccccgatt tcccttccac cggtctaccc accctgcacc
      301 ctttaaggct ccttcccata caacactaac cctgttacac ctccctcctg tacacaccct
      361 acctcaaact tcccacccgg cgagtcactc ccaccctctc ctcatacctc ttaccctcct
      421 ccccgcagga tcaccttctc tgttctccct gttcccccgc gctccccccg ccccaccccg
      481 tccttcacct cctccacgtc tttcccccat cctccaattc tctcgctgag gagcgtcccc
      541 cgcctcccta gcagcttttt acctcctcca gcctcccaga tcacccttgc ctctccgttt
      601 ctctcatccc cgcgtccccc gtgactccat ccgctccccc accttccata gcccccatcc
      661 cccgtgactc cccccatccc tccatcgcac tctcctccgc tcagtcctcc agaatccccc
      721 ctgctgctcc ctcgccccat cctgctcgcc gcgctcccgc cccagtccgg ctcggcttcc
      781 cggctgcgcg ctccaggtcc ggtacgcgcc atgggcagcg gcagtagccg gagcggccga
      841 atcctgaggc ggcggcgcag tcctgacagg cgccagacag gcccgggaga gacagccttg
      901 gagggcggcg cggctgacca ggccaagaca gccgcggtgc aggaggagtg cggccctgat
      961 ccccgccccg cgacgccccc cggtggccgg gaggagaccc tgcgcctgct ggaccagttg
     1021 ctggccgagt cagaggtctg gggaccccag gagcagaccc cacgaggccc cgcccggctc
     1081 ccacccgcgg tgtccccaga aaagaaggtt acgggcaacc ctgaagacag ctgtgcctct
     1141 gaagccccag gcagcagccc caagagaccc gaggggcagt cggccatctc ctatgattac
     1201 tcggaagagg agctcatggc gagcatcgag cgggaatact gccgctgagc cggataagtg
     1261 gccctggaca ccactgccca ggccttgtag gtctgtgagc tgggctagag ccaaaggcac
     1321 cagcttacct acccacgacc tagccggagg ggaatacagc tatcttccca aactgatctt
     1381 ttaaggttca cggctggagt cctgctgatg gcctggccga ccaagagtga ggggcaagta
     1441 ggtgccaggc cacaggcgtg tgcgtacctc ctcttacttt gaggggtagc ctggccgtgt
     1501 ggttcccctg aatctgaact gtttgtctgc tctgcccagg tgggaaaggg tcgacctgtc
     1561 ttggcatctg tgccacaggc ttctagaagt ttccaccaag gaatgttctc agtctccaca
     1621 ctaagattag tcccgtgcag ttacctccat ggatgtcagt ttccacgggc acacaagggg
     1681 cccaagtata tggatggggg ggcaggtgct gagcgtgtag gtctaggcgg gtccagagat
     1741 tgcatttctg acagcataga ggtagtgaca agctgcaggt gcaaggactt agggcctgag
     1801 tcccttggct tctcccttcc gtatgcggga ggctcctccg agctacggtg taacagcctc
     1861 ccctgcttgg atggaggagg aggagagggg gctgggaacc acagatgctc tggcgtccca
     1921 ctattccatt agcttggtat cacttccctc tgggcctctt ggtttctctc ttggggagaa
     1981 tcctggaggt tctttgaggt ctttcaggcc ctatcagttg ggcggctcta tcttcctacc
     2041 agggcgctgc catcttcgga gggccatcgt gctttatgca tcctactgag agcagggctg
     2101 cattggagct gagagaggtg tgcgtgtaga ggttcgtggc aactcttctc cagtttccct
     2161 tctggctggc agtctggcta acacaaaggg cctcttctcc ttcttcttgc ttgagtggaa
     2221 ggtagtcaca ataatgatgc caaagggacc tcaaacattg acagatggga atagagagag
     2281 cccgtgggaa ggtcctgtgt ggtcctgtag ggcctttcgt ggtcttgctc aggtgtggac
     2341 ggacccagct ggtagacagg gttcgtagat tagtgagtgg aggcacaagt ctgcatccct
     2401 gatatcatca ggctggaggg ctattgaggc cttaaaggct gcatagtgaa ttcaaattca
     2461 gcctggacta tatcgtgagt ctgtcaggaa agggggcaga gaatcgggaa acaacagcaa
     2521 cttttgctaa ggtccaaaca ggcctcagct taggttgcat ctctggacca aggcagtggc
     2581 cttcgccagc atcttccctc tcctgagaac agctgccagc ccatgaatcc tcagagcaca
     2641 acctacatta cagtatctca ggaaccaagg aagaatggtc actgagaccg tccccacacc
     2701 cacagtcctt tgccgtcccc tgcaaatgat tccatgaact tgtgacttga caagagtgcc
     2761 tttgagtgct cagtggggag acttgtgcta cggtgggagc ccagagcctt ggagtgtctg
     2821 ctagtcagct gagggttggg tcaaaacctc ccagagctag cacctgtatc ttactagagc
     2881 ccaaatgact gcttttgcta tgaaaatgaa agctgtttct attttaataa cgcgaatatt
     2941 aaaaatgctt attttaaaag aggt
//
