LOCUS       NM_001126267            1913 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus CYFIP related Rac1 interactor B (Cyrib), mRNA.
ACCESSION   NM_001126267 XM_001066035 XM_216922
VERSION     NM_001126267.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1913)
  AUTHORS   Yuki KE, Marei H, Fiskin E, Eva MM, Gopal AA, Schwartzentruber JA,
            Majewski J, Cellier M, Mandl JN, Vidal SM, Malo D and Dikic I.
  TITLE     CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal
            remodelling and protects against bacterial infection
  JOURNAL   Nat Microbiol 4 (9), 1516-1531 (2019)
   PUBMED   31285585
REFERENCE   2  (bases 1 to 1913)
  AUTHORS   Fort L, Batista JM, Thomason PA, Spence HJ, Whitelaw JA, Tweedy L,
            Greaves J, Martin KJ, Anderson KI, Brown P, Lilla S, Neilson MP,
            Tafelmeyer P, Zanivan S, Ismail S, Bryant DM, Tomkinson NCO,
            Chamberlain LH, Mastick GS, Insall RH and Machesky LM.
  TITLE     Fam49/CYRI interacts with Rac1 and locally suppresses protrusions
  JOURNAL   Nat Cell Biol 20 (10), 1159-1171 (2018)
   PUBMED   30250061
REFERENCE   3  (bases 1 to 1913)
  AUTHORS   Chattaragada MS, Riganti C, Sassoe M, Principe M, Santamorena MM,
            Roux C, Curcio C, Evangelista A, Allavena P, Salvia R, Rusev B,
            Scarpa A, Cappello P and Novelli F.
  TITLE     FAM49B, a novel regulator of mitochondrial function and integrity
            that suppresses tumor metastasis
  JOURNAL   Oncogene 37 (6), 697-709 (2018)
   PUBMED   29059164
REFERENCE   4  (bases 1 to 1913)
  AUTHORS   Nagarajan NA, Gonzalez F and Shastri N.
  TITLE     Nonclassical MHC class Ib-restricted cytotoxic T cells monitor
            antigen processing in the endoplasmic reticulum
  JOURNAL   Nat Immunol 13 (6), 579-586 (2012)
   PUBMED   22522492
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1913)
  AUTHORS   Ishikawa H, Thompson J, Yates JR 3rd and Marshall WF.
  TITLE     Proteomic analysis of mammalian primary cilia
  JOURNAL   Curr Biol 22 (5), 414-419 (2012)
   PUBMED   22326026
REFERENCE   6  (bases 1 to 1913)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   7  (bases 1 to 1913)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166469.1.
            
            On May 11, 2008 this sequence version replaced NM_001126267.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166469.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1913
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /note="CYFIP related Rac1 interactor B"
                     /db_xref="GeneID:299909"
                     /db_xref="RGD:1307697"
     exon            1..143
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
     exon            144..196
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
     exon            197..235
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
     exon            236..318
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1220
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /note="family with sequence similarity 49, member B"
                     /codon_start=1
                     /product="CYFIP-related Rac1 interactor B"
                     /protein_id="NP_001119739.1"
                     /db_xref="GeneID:299909"
                     /db_xref="RGD:1307697"
                     /translation="MGNLLKVLTCTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLK
                     DAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEA
                     ALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYR
                     RTLSRMRINNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIE
                     NTTDCLSTMASVCRVMLETPEYRSRFTNEETVSFCLRVMVGVIILYDHVHPVGAFAKT
                     SKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIRSMLQ"
     exon            319..440
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
     exon            441..546
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
     exon            547..683
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
     exon            684..761
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
     exon            762..878
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
     exon            879..958
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1085
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1156
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1894
                     /gene="Cyrib"
                     /gene_synonym="Fam49b; RGD1307697"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgctgctg ctgcttgccg ctgcggcggg gccgctcgcg aacctgcggc ggggacgcgc
       61 gagccgccga cccggaagcg gcgtgtgtgc accgcaggct cccgccgcca gctcgcccgc
      121 tcgcccgccc gtcggacagc caggagaagg caccgaggcc cggaatctgg gtaatccttt
      181 caaggctgcc gcattgatag aaggacgagg acagaatcac cagcactggc tgaaggtacc
      241 ttaacatggg gaatcttctt aaagttttga catgcacaga ccttgagcag gggccaaatt
      301 ttttccttga ttttgaaaat gcccagccta cagagtctga gaaggaaata tataatcagg
      361 tgaatgtagt gttaaaagat gcagaaggca tcttggagga cttgcagtca tacagaggag
      421 ctggccacga aatacgagag gcaatccagc atccagccga tgagaagttg caagagaagg
      481 catggggtgc agtcgtgcca ctagtaggca aattaaagaa attttacgaa ttttctcaga
      541 gattagaagc agcattaaga ggccttctgg gagccttgac aagcacacca tactccccca
      601 cccagcatct agagcgagag caggctctgg ctaaacagtt tgcagagatt cttcacttca
      661 cactccggtt tgatgaactc aagatgacaa atcctgccat acaaaatgat ttcagctact
      721 atagaagaac attgagtcgt atgagaatta ataacgtccc ggcagaagga gaaaatgaag
      781 taaataatga attggcaaat cggatgtctt tgttttatgc tgaggccacc ccaatgctga
      841 aaaccttaag tgacgcaaca acaaaatttg tatcagagaa taaaaatttg ccaatagaaa
      901 ataccacaga ctgcttaagc accatggcaa gtgtatgcag agtcatgctg gagacgccgg
      961 aatatagaag cagatttacc aatgaagaaa cagtatcatt ctgcttgagg gtaatggtgg
     1021 gtgtcataat actctatgac cacgtccatc cagtgggagc atttgccaaa acttctaaaa
     1081 ttgatatgaa aggttgtatc aaagttctta aggatcaacc tcctaatagt gtagaaggtc
     1141 ttctcaatgc tctcaggtac acaacaaaac atttgaacga tgagactacc tccaagcaaa
     1201 ttaggtccat gctgcagtaa gagctgtggt gcaagcccct gccgcggatg gagcacacag
     1261 tgttcttagt gaccgagaat gcacagtcct agtgaatgcc attaaatttc cttattcttg
     1321 ctttggtttc tttcctctgt tcctcttccc acttttttaa tcatgttctt gttcttaaga
     1381 cttcttttct gtgccaaaat cagtaaagtt atactttgaa agggattttg tcctttcaaa
     1441 acaggccatc taaggcagct aattacgcat tgcattgagg tctctactga gaaaagttct
     1501 gtgacttgaa ctaaatattt ttaaatgtgg attttttttg aaaactaata tttaatattg
     1561 cttctcctgc atggcaaaac tgcctattct gctatttaaa accctcataa atttattttc
     1621 tactgccgct ttttcatgtg cagccaaaat gaaaatgttt aaattaactg tgttgtacaa
     1681 atggtaccca acacaaactt tttttaaatt agtaagactt ttgtttaaag ttttaagttt
     1741 gcattttgac ttttttttgt aagtttgtat gttgtgtgtt taacctttat taactaacgt
     1801 taaaaactgt gatgtgtgcg tagattatta cgtatgcatg ttcatgttta agaatggctg
     1861 ttgataaaat aaaattcagc tttccttttt ctaaaaaaaa aaaaaaaaaa aaa
//
