LOCUS       NM_001024325            1654 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cell cycle regulator of NHEJ (Cyren), mRNA.
ACCESSION   NM_001024325 XM_575427
VERSION     NM_001024325.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1654)
  AUTHORS   Arnoult,N., Correia,A., Ma,J., Merlo,A., Garcia-Gomez,S., Maric,M.,
            Tognetti,M., Benner,C.W., Boulton,S.J., Saghatelian,A. and
            Karlseder,J.
  TITLE     Regulation of DNA repair pathway choice in S and G2 phases by the
            NHEJ inhibitor CYREN
  JOURNAL   Nature 549 (7673), 548-552 (2017)
   PUBMED   28959974
REFERENCE   2  (bases 1 to 1654)
  AUTHORS   Slavoff,S.A., Heo,J., Budnik,B.A., Hanakahi,L.A. and Saghatelian,A.
  TITLE     A human short open reading frame (sORF)-encoded polypeptide that
            stimulates DNA end joining
  JOURNAL   J Biol Chem 289 (16), 10950-10957 (2014)
   PUBMED   24610814
REFERENCE   3  (bases 1 to 1654)
  AUTHORS   Agarwal,S., Harada,J., Schreifels,J., Lech,P., Nikolai,B.,
            Yamaguchi,T., Chanda,S.K. and Somia,N.V.
  TITLE     Isolation, characterization, and genetic complementation of a
            cellular mutant resistant to retroviral infection
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15933-15938 (2006)
   PUBMED   17043244
  REMARK    GeneRIF: Characterizes the hamster ortholog and suggests that it
            may modulate the ability of the proteasome to degrade retroviral
            cores upon cellular infection.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079043.1.
            
            On May 27, 2005 this sequence version replaced XM_575427.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079043.1, CK470463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN06680432
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1654
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..1654
                     /gene="Cyren"
                     /gene_synonym="Mri"
                     /note="cell cycle regulator of NHEJ"
                     /db_xref="GeneID:500077"
                     /db_xref="RGD:1563238"
     exon            1..307
                     /gene="Cyren"
                     /gene_synonym="Mri"
                     /inference="alignment:Splign:2.1.0"
     exon            308..555
                     /gene="Cyren"
                     /gene_synonym="Mri"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..898
                     /gene="Cyren"
                     /gene_synonym="Mri"
                     /note="modulator of retrovirus infection homolog"
                     /codon_start=1
                     /product="cell cycle regulator of non-homologous end
                     joining"
                     /protein_id="NP_001019496.1"
                     /db_xref="GeneID:500077"
                     /db_xref="RGD:1563238"
                     /translation="METLKSDNKKRVLPSWMTAPGNERKVVSVKTAKRKQTAAIRVGA
                     ATRAPAKETVYCMNEAEMVDVALGILIEGRKQEKPWEQPSLVAPDKLQLSPPCSESPH
                     TSSPGSSSEEEDSRTDSPALGLSPARGPEASNSPCSRSPEEGKEEEDELKYVREIFFS
                     "
     exon            556..631
                     /gene="Cyren"
                     /gene_synonym="Mri"
                     /inference="alignment:Splign:2.1.0"
     exon            632..1617
                     /gene="Cyren"
                     /gene_synonym="Mri"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcggcca gcaccgggct agtgcagcga cagcccgcgt gtgccttctg agtgagattt
       61 tcctgggatc caaccggcct gaccccatca gcgctgagtt ccagaaacct tgcggtgggc
      121 aggacctggc tcgatggttg atgttcagtt tgctgcgact ctgtgcccgt taacgcgtaa
      181 ctgcgcctgt ttcttgtcta taaaatggac gtgatggtac aagtactgcc cggtctgatt
      241 catttctgaa cactggcact cactggatgg tgttcatctt actgacttct gttctgtggc
      301 tgaacaggca ttcaagatcg gctcccactg gggtcagata agcccggtgt gatgagagtg
      361 tgatttttgg tcctgctgta gagaagcaag tccctgagtg tggaaaacca tagcaatgga
      421 aaccctaaaa tccgataaca aaaagagggt cctcccctcg tggatgacag cccctgggaa
      481 tgagagaaag gttgtatcag tgaagacagc caagaggaag cagacagcag ccattcgagt
      541 tggggcagca acaagagccc cggccaagga gacagtgtac tgcatgaatg aagctgaaat
      601 ggtcgatgtg gcgctgggga tcctgattga gggccgaaaa caggaaaagc cctgggaaca
      661 gccgtctctg gtggcccctg ataagctgca gctttcccct ccctgttccg agtcccctca
      721 caccagctcc ccagggagca gcagtgagga agaagacagc agaaccgact ctcctgcact
      781 aggtctcagc cctgcccggg gaccagaagc ttctaactct ccctgtagca gaagcccgga
      841 ggagggaaag gaggaggaag acgagttaaa gtacgtcagg gagatatttt tcagttagta
      901 tgaactgttc gctgcttctg cggagagtct ttaggatgtg cggagagccg tgggcacttc
      961 ctgcccctgc cacccatgaa aacccagact ttgctcccaa cttccagtcc caggaggctg
     1021 tcagtttggg tgggactaat tctgtagcag gatgcagaca tgcatcctct tatagtctta
     1081 tcctgcacca ccctctggct ctgagggttt gcaatgccag ccctatgttt tagtcacagt
     1141 aaaaaaaaca aagtcttggg ctagaagcaa agaaaactag agctgcagag aacgtgggta
     1201 ttggagatgg gcagccagac ttaaagagac ctgtgaacag tctccctcat gatacagtcc
     1261 agcagcaagc ttccaccctt ccaaccaaac acgctggcag ctgcccacag ttccctgcca
     1321 tatccgagag caggaggctc tatcagactg ctgagtcaaa taggtcctgt ctaccaccag
     1381 tcacctccct tctacctggg gcctccacct tggtccctgt agagctgtag gggagagtag
     1441 ggaagggaaa cagaacaaag gatcacacca gagtccacgt ttctttgggt tcactttggc
     1501 ttactgatga gcacagagtg aagaactcgt taccacttag ggtttttttt ggtacacaca
     1561 ctgaaaagat acatactgaa gccccaatgc ataataaaga ccgtgcttct aagccttaaa
     1621 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
