LOCUS       NM_031241               1971 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cytochrome P450 family 8 subfamily B member 1
            (Cyp8b1), mRNA.
ACCESSION   NM_031241
VERSION     NM_031241.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1971)
  AUTHORS   Zhu,L., Wang,L., Cao,F., Liu,P., Bao,H., Yan,Y., Dong,X., Wang,D.,
            Wang,Z. and Gong,P.
  TITLE     Modulation of transport and metabolism of bile acids and bilirubin
            by chlorogenic acid against hepatotoxicity and cholestasis in bile
            duct ligation rats: involvement of SIRT1-mediated deacetylation of
            FXR and PGC-1alpha
  JOURNAL   J Hepatobiliary Pancreat Sci 25 (3), 195-205 (2018)
   PUBMED   29360226
REFERENCE   2  (bases 1 to 1971)
  AUTHORS   Eggink,H.M., Oosterman,J.E., de Goede,P., de Vries,E.M., Foppen,E.,
            Koehorst,M., Groen,A.K., Boelen,A., Romijn,J.A., la Fleur,S.E.,
            Soeters,M.R. and Kalsbeek,A.
  TITLE     Complex interaction between circadian rhythm and diet on bile acid
            homeostasis in male rats
  JOURNAL   Chronobiol Int 34 (10), 1339-1353 (2017)
   PUBMED   29028359
  REMARK    GeneRIF: It has been demonstrated that hepatic gene expression of
            Cyp8b1 is directed by day/night rhythm but not daily rhythm in food
            intake. Combining an high-fat diet with feeding in the
            light/inactive period annulled Cyp8b1 gene expression rhythms.
REFERENCE   3  (bases 1 to 1971)
  AUTHORS   Cote,I., Chapados,N.A. and Lavoie,J.M.
  TITLE     Impaired VLDL assembly: a novel mechanism contributing to hepatic
            lipid accumulation following ovariectomy and
            high-fat/high-cholesterol diets?
  JOURNAL   Br J Nutr 112 (10), 1592-1600 (2014)
   PUBMED   25263431
REFERENCE   4  (bases 1 to 1971)
  AUTHORS   Yang,Y., Eggertsen,G., Gafvels,M., Andersson,U., Einarsson,C.,
            Bjorkhem,I. and Chiang,J.Y.
  TITLE     Mechanisms of cholesterol and sterol regulatory element binding
            protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1)
  JOURNAL   Biochem Biophys Res Commun 320 (4), 1204-1210 (2004)
   PUBMED   15249218
  REMARK    GeneRIF: Cholesterol loading reduces SREBP-1 mRNA expression in
            addition to reducing functional SREBP-1 protein, and results in
            decreasing CYP8B1 gene transcription.
REFERENCE   5  (bases 1 to 1971)
  AUTHORS   Ishida,H., Kuruta,Y., Gotoh,O., Yamashita,C., Yoshida,Y. and
            Noshiro,M.
  TITLE     Structure, evolution, and liver-specific expression of sterol
            12alpha-hydroxylase P450 (CYP8B)
  JOURNAL   J Biochem 126 (1), 19-25 (1999)
   PUBMED   10393316
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031241.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB009686.1, AB018596.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1971              JAXUCZ010000008.1  130455622-130457592 c
FEATURES             Location/Qualifiers
     source          1..1971
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1971
                     /gene="Cyp8b1"
                     /note="cytochrome P450 family 8 subfamily B member 1"
                     /db_xref="GeneID:81924"
                     /db_xref="RGD:71016"
     exon            1..1971
                     /gene="Cyp8b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1533
                     /gene="Cyp8b1"
                     /EC_number="1.14.14.139"
                     /note="cytochrome P450, 8b1, sterol 12 alpha-hydrolase;
                     cytochrome P450, family 8, subfamily b, polypeptide 1"
                     /codon_start=1
                     /product="7-alpha-hydroxycholest-4-en-3-one
                     12-alpha-hydroxylase"
                     /protein_id="NP_112520.2"
                     /db_xref="GeneID:81924"
                     /db_xref="RGD:71016"
                     /translation="MLWGSVLGALLMAVGCLCLSLLPRHRRPWEPPLDKGFVPWLGHT
                     MAFRKNMFEFLKGMRAKHGDVFTLQLGGQYFTFVMDPLSFGPIIKSTQKVLDFVTYAR
                     ELVFKVFGYQSMDEDHQMLHIASTKHLMGQGLEDLNRAMLDSLSLVMLGPKGRSLGAR
                     SWCEDGLFHFCYSILFKAGFLSLFGCTKDKEQDLDEADELFRKFRRFDLLFPRFVYSL
                     LGPREWVEVSQLQRLFHQRLSVEQNLEKDGISNWLGFMLRFLRERGMASSMQDKFNFM
                     MLWASQGNTGPTCFWALLFLLKHQDAMKAVREEATRVLGEARLEAETSFAFTLSALKC
                     TPVLDSVMEETLRLCATPTLLRVVQEDYVLKMASGQEYQIRRGDKVALFPYLSVHMDP
                     DIHPEPTTFKYNRFLNPDGTRKVDFYKSGKKIHHYNMPWGSGVSICPGRFFALSEMKT
                     FVLLMVMYFDFELVDPDVPVPPIDPRRWGFGTSQPSHEVRFRYRLKPMQ"
ORIGIN      
        1 gtgcggagct cagactgctg gagcctagcc acgatgctgt ggggttcagt gctaggggcc
       61 ctgctcatgg ctgtcggttg cctctgcctc tccttgctgc ccaggcaccg caggccctgg
      121 gagccacctc tggacaaggg gtttgtgccc tggctgggtc acaccatggc cttccggaag
      181 aatatgtttg aattcctgaa gggaatgcgg gccaagcacg gggacgtgtt cacactgcag
      241 ctgggaggcc agtacttcac ctttgtcatg gatcccctct cctttggccc catcattaag
      301 agcacgcaga aagtgctaga cttcgtgacg tacgctcggg aactggtgtt caaggtgttt
      361 gggtaccagt ccatggatga ggaccaccag atgctgcaca tagccagtac caagcatctg
      421 atgggacaag gcttggagga cctcaaccgg gccatgctgg acagcctgtc cttggtgatg
      481 ctaggaccca aaggccggag tctgggtgcc aggtcctggt gtgaggacgg cctcttccac
      541 ttctgctaca gcatcctgtt taaggctggc ttcctgagct tgtttggctg caccaaggac
      601 aaggagcagg acctggatga ggccgatgag ctgttcagga agttccgcag atttgaccta
      661 cttttcccca ggtttgtcta ctccctgctg gggccccggg agtgggtaga agtgagccag
      721 ctgcagcgtc tcttccacca gagactctct gtggagcaaa acctggagaa agacggcata
      781 agtaactggt tgggcttcat gcttcggttt ctgagggagc gagggatggc ttcatccatg
      841 caggacaaat ttaactttat gatgctctgg gcctcccagg ggaacacggg gcccacctgt
      901 ttctgggccc tcctgttcct gctgaagcat caggacgcca tgaaggctgt gcgagaggaa
      961 gccactcggg tcctgggtga ggccaggttg gaagccgaga catccttcgc tttcactctc
     1021 agtgccctga aatgcactcc agtgctggac agcgtgatgg aagagactct tcgtctctgt
     1081 gccaccccca ccctcctcag ggtggtgcag gaggattatg tcctaaagat ggccagtggg
     1141 caagagtacc agatccgccg tggagataag gtggctctct tcccctatct ctcagtacac
     1201 atggaccccg acatccatcc cgagcccacg accttcaagt acaatcggtt cctcaaccct
     1261 gatggcaccc ggaaagtgga cttctacaag tcaggcaaga agatccacca ctacaacatg
     1321 ccctgggggt cgggtgtctc catatgtccc ggcaggttct ttgccctcag tgagatgaag
     1381 acctttgtcc tccttatggt catgtacttt gactttgaac tggtggaccc tgacgtgcct
     1441 gtgcccccta tcgacccaag gcgctggggc ttcggcacct cccagcccag ccacgaggta
     1501 cgctttcgct accgcctgaa gcccatgcag tgagctcaga cctgagcaca ccctgcagcc
     1561 cagagcggca ctgaacaccc atcctctggc tccaaagcac ccctacctct ccccggcatc
     1621 cctgccatct tgcctcctag acatcatgca tcctagaggt ctgccatgct ccctgtaaga
     1681 tgccatcccc ccagtggttt ccgcctgacc cacctctcag gaggaaaacc tgtggtcagt
     1741 tcgatttaca gctggttacc cacccaagtt tgactcatcc cggaggacag taccagctcc
     1801 catgagtcaa acagtatctt gcaaatgctg cctcagccca tcctacctgc cttacttgat
     1861 gcccttactc caaatcctat cgattcagac tccagagatg ttactcaatg gaatcaagcc
     1921 atgtgtgcaa ttgttaagtt cttaatagat atgcactaaa agaaaaggat t
//
