LOCUS       NP_037074                503 aa            linear   ROD 04-JUN-2024
DEFINITION  cytochrome P450 7A1 [Rattus norvegicus].
ACCESSION   NP_037074
VERSION     NP_037074.1
DBSOURCE    REFSEQ: accession NM_012942.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Duan,Y., Zhang,F., Yuan,W., Wei,Y., Wei,M., Zhou,Y., Yang,Y.,
            Chang,Y. and Wu,X.
  TITLE     Hepatic cholesterol accumulation ascribed to the activation of
            ileum Fxr-Fgf15 pathway inhibiting hepatic Cyp7a1 in high-fat
            diet-induced obesity rats
  JOURNAL   Life Sci 232, 116638 (2019)
   PUBMED   31288013
  REMARK    GeneRIF: The increased CDCAs concentrations activated Fxr-Fgf15
            pathway in ileum to result in the mRNA expression of Cyp7a1 in
            liver down-regulation, which inhibited cholesterol metabolizing
            into primary BAs to contribute to the cholesterol level increase in
            liver tissue in HFD-induced obesity rats.
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Hao,C.L., Lin,H.L., Ke,L.Y., Yen,H.W. and Shen,K.P.
  TITLE     Pre-germinated brown rice extract ameliorates high-fat diet-induced
            metabolic syndrome
  JOURNAL   J Food Biochem 43 (3), e12769 (2019)
   PUBMED   31353547
REFERENCE   3  (residues 1 to 503)
  AUTHORS   Hu,Y.B., Liu,X.Y. and Zhan,W.
  TITLE     Farnesoid X receptor agonist INT-767 attenuates liver steatosis and
            inflammation in rat model of nonalcoholic steatohepatitis
  JOURNAL   Drug Des Devel Ther 12, 2213-2221 (2018)
   PUBMED   30038487
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Huo,X.K., Liu,J., Yu,Z.L., Wang,Y.F., Wang,C., Tian,X.G., Ning,J.,
            Feng,L., Sun,C.P., Zhang,B.J. and Ma,X.C.
  TITLE     Alisma orientale extract exerts the reversing cholestasis effect by
            activation of farnesoid X receptor
  JOURNAL   Phytomedicine 42, 34-42 (2018)
   PUBMED   29655695
REFERENCE   5  (residues 1 to 503)
  AUTHORS   Han,H., Xu,L., Xiong,K., Zhang,T. and Wang,Z.
  TITLE     Exploration of Hepatoprotective Effect of Gentiopicroside on
            Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in
            Rats by Comprehensive Proteomic and Metabolomic Signatures
  JOURNAL   Cell Physiol Biochem 49 (4), 1304-1319 (2018)
   PUBMED   30223280
REFERENCE   6  (residues 1 to 503)
  AUTHORS   Chiang,J.Y., Yang,T.P. and Wang,D.P.
  TITLE     Cloning and 5'-flanking sequence of a rat cholesterol 7
            alpha-hydroxylase gene
  JOURNAL   Biochim Biophys Acta 1132 (3), 337-339 (1992)
   PUBMED   1420318
REFERENCE   7  (residues 1 to 503)
  AUTHORS   Nishimoto,M., Gotoh,O., Okuda,K. and Noshiro,M.
  TITLE     Structural analysis of the gene encoding rat cholesterol
            alpha-hydroxylase, the key enzyme for bile acid biosynthesis
  JOURNAL   J Biol Chem 266 (10), 6467-6471 (1991)
   PUBMED   2007596
REFERENCE   8  (residues 1 to 503)
  AUTHORS   Jelinek,D.F. and Russell,D.W.
  TITLE     Structure of the rat gene encoding cholesterol 7 alpha-hydroxylase
  JOURNAL   Biochemistry 29 (34), 7781-7785 (1990)
   PUBMED   2261433
REFERENCE   9  (residues 1 to 503)
  AUTHORS   Li,Y.C., Wang,D.P. and Chiang,J.Y.
  TITLE     Regulation of cholesterol 7 alpha-hydroxylase in the liver.
            Cloning, sequencing, and regulation of cholesterol 7
            alpha-hydroxylase mRNA
  JOURNAL   J Biol Chem 265 (20), 12012-12019 (1990)
   PUBMED   1694852
REFERENCE   10 (residues 1 to 503)
  AUTHORS   Noshiro,M., Nishimoto,M. and Okuda,K.
  TITLE     Rat liver cholesterol 7 alpha-hydroxylase. Pretranslational
            regulation for circadian rhythm
  JOURNAL   J Biol Chem 265 (17), 10036-10041 (1990)
   PUBMED   1693613
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J05460.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05460.1, J05430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Rattus norvegicus"
                     /strain="WKA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     Protein         1..503
                     /product="cytochrome P450 7A1"
                     /EC_number="1.14.14.23"
                     /EC_number="1.14.14.26"
                     /note="cholesterol 7-alpha-monooxygenase; CYPVII;
                     cholesterol 7-alpha-hydroxylase; cytochrome P450
                     (cholesterol hydroxylase 7 alpha); cytochrome P450, 7a1;
                     cytochrome P450, family 7, subfamily a, polypeptide 1;
                     24-hydroxycholesterol 7-alpha-hydroxylase"
                     /calculated_mol_wt=56752
     Site            4..24
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P18125.1)"
     Region          55..497
                     /region_name="CYP7A1"
                     /note="cytochrome P450 family 7, subfamily A, polypeptide
                     1; cd20631"
                     /db_xref="CDD:410724"
     Site            order(101,129,285..286,289..290,293,360,362,436..437,442,
                     444..446,449..450,453,488)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:410724"
     Site            order(101,104..105,114,125,129,260,281,284..285,289,
                     360..361,485..487)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:410724"
     CDS             1..503
                     /gene="Cyp7a1"
                     /gene_synonym="CHAP; CYP7; CYP7S1"
                     /coded_by="NM_012942.2:35..1546"
                     /db_xref="GeneID:25428"
                     /db_xref="RGD:2482"
ORIGIN      
        1 mmtisliwgi avlvscciwf ivgirrrkag epplenglip ylgcalkfgs npleflranq
       61 rkhghvftck lmgkyvhfit nslsyhkvlc hgkyfdwkkf hyttsakafg hrsidpndgn
      121 tteninntft ktlqgdalcs lseammqnlq svmrppglpk sksnawvteg myafcyrvmf
      181 eagyltlfgr disktdtqka lilnnldnfk qfdqvfpalv aglpihlfkt ahkareklae
      241 glkhknlcvr dqvselirlr mflndtlstf ddmekakthl ailwasqant ipatfwslfq
      301 mirspeamka aseevsgalq sagqelssgg saiyldqvql ndlpvldsii kealrlssas
      361 lnirtakedf tlhledgsyn irkddmialy pqlmhldpei ypdpltfkyd ryldesgkak
      421 ttfysngnkl kcfympfgsg aticpgrlfa vqeikqflil mlscfelefv esqvkcppld
      481 qsraglgilp plhdiefkyk lkh
//
