LOCUS       NM_012941               3020 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 51 (Cyp51), mRNA.
ACCESSION   NM_012941
VERSION     NM_012941.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3020)
  AUTHORS   Weng,X., Ma,X., Wang,Q., Xu,K., Hu,X., Liu,W. and Zhang,C.
  TITLE     Effect of hypothyroidism on CYP51 and FSHR expression in rat ovary
  JOURNAL   Theriogenology 138, 145-151 (2019)
   PUBMED   31352176
  REMARK    GeneRIF: Hypothyroidism changes CYP51 and FSHR expression in ovary,
            which are regulated by gonadotropin. Moreover, genes changes in
            ovary are at least partially attributed to steroids biosynthesis.
REFERENCE   2  (bases 1 to 3020)
  AUTHORS   Keber,R., Motaln,H., Wagner,K.D., Debeljak,N., Rassoulzadegan,M.,
            Acimovic,J., Rozman,D. and Horvat,S.
  TITLE     Mouse knockout of the cholesterogenic cytochrome P450 lanosterol
            14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome
  JOURNAL   J Biol Chem 286 (33), 29086-29097 (2011)
   PUBMED   21705796
REFERENCE   3  (bases 1 to 3020)
  AUTHORS   Tamboli,I.Y., Barth,E., Christian,L., Siepmann,M., Kumar,S.,
            Singh,S., Tolksdorf,K., Heneka,M.T., Lutjohann,D., Wunderlich,P.
            and Walter,J.
  TITLE     Statins promote the degradation of extracellular amyloid
            {beta}-peptide by microglia via stimulation of exosome-associated
            insulin-degrading enzyme (IDE) secretion
  JOURNAL   J Biol Chem 285 (48), 37405-37414 (2010)
   PUBMED   20876579
REFERENCE   4  (bases 1 to 3020)
  AUTHORS   Strushkevich,N., Usanov,S.A. and Park,H.W.
  TITLE     Structural basis of human CYP51 inhibition by antifungal azoles
  JOURNAL   J Mol Biol 397 (4), 1067-1078 (2010)
   PUBMED   20149798
REFERENCE   5  (bases 1 to 3020)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3020)
  AUTHORS   Stromstedt,M., Waterman,M.R., Haugen,T.B., Tasken,K., Parvinen,M.
            and Rozman,D.
  TITLE     Elevated expression of lanosterol 14alpha-demethylase (CYP51) and
            the synthesis of oocyte meiosis-activating sterols in postmeiotic
            germ cells of male rats
  JOURNAL   Endocrinology 139 (5), 2314-2321 (1998)
   PUBMED   9564839
  REMARK    Erratum:[Endocrinology 1998 Sep;139(9):3771]
REFERENCE   7  (bases 1 to 3020)
  AUTHORS   Noshiro,M., Aoyama,Y., Kawamoto,T., Gotoh,O., Horiuchi,T. and
            Yoshida,Y.
  TITLE     Structural and evolutionary studies on sterol 14-demethylase P450
            (CYP51), the most conserved P450 monooxygenase: I. Structural
            analyses of the gene and multiple sizes of mRNA
  JOURNAL   J Biochem 122 (6), 1114-1121 (1997)
   PUBMED   9498553
REFERENCE   8  (bases 1 to 3020)
  AUTHORS   Sloane,D.L., So,O.Y., Leung,R., Scarafia,L.E., Saldou,N.,
            Jarnagin,K. and Swinney,D.C.
  TITLE     Cloning and functional expression of the cDNA encoding rat
            lanosterol 14-alpha demethylase
  JOURNAL   Gene 161 (2), 243-248 (1995)
   PUBMED   7665087
REFERENCE   9  (bases 1 to 3020)
  AUTHORS   Sonoda,Y., Amano,C., Endo,M., Sato,Y., Sekigawa,Y. and Fukuhara,M.
  TITLE     Lanosterol 14 alpha-demethylase (cytochrome P-45014DM): modulation
            of its enzyme activity by cholesterol feeding
  JOURNAL   Biol Pharm Bull 18 (7), 1009-1011 (1995)
   PUBMED   7581240
REFERENCE   10 (bases 1 to 3020)
  AUTHORS   Aoyama,Y., Funae,Y., Noshiro,M., Horiuchi,T. and Yoshida,Y.
  TITLE     Occurrence of a P450 showing high homology to yeast lanosterol
            14-demethylase (P450(14DM)) in the rat liver
  JOURNAL   Biochem Biophys Res Commun 201 (3), 1320-1326 (1994)
   PUBMED   8024575
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012941.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087033.1, AY724494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               JAXUCZ010000004.1  30991693-30991930
            239-337             JAXUCZ010000004.1  30993492-30993590
            338-514             JAXUCZ010000004.1  30995665-30995841
            515-641             JAXUCZ010000004.1  30996764-30996890
            642-816             JAXUCZ010000004.1  30997890-30998064
            817-936             JAXUCZ010000004.1  30999979-31000098
            937-1132            JAXUCZ010000004.1  31000448-31000643
            1133-1228           JAXUCZ010000004.1  31004335-31004430
            1229-1397           JAXUCZ010000004.1  31006421-31006589
            1398-3020           JAXUCZ010000004.1  31008525-31010147
FEATURES             Location/Qualifiers
     source          1..3020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..3020
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; RATCP14DM"
                     /note="cytochrome P450, family 51"
                     /db_xref="GeneID:25427"
                     /db_xref="RGD:2481"
     exon            1..238
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; RATCP14DM"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1576
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; RATCP14DM"
                     /EC_number="1.14.14.154"
                     /note="cytochrome P450 Lanosterol 14 alpha-demethylase;
                     LDM; CYPLI; P450LI; P45014DM; P450-14DM; cytochrome P450
                     51A1; sterol 14-alpha demethylase; cytochrome P450LI;
                     cytochrome P45014DM; cytochrome P450-14DM; Cytochrom P450
                     Lanosterol 14 alpha-demethylase; cytochrome P450,
                     subfamily 51; sterol 14-alpha demethylase P450"
                     /codon_start=1
                     /product="lanosterol 14-alpha demethylase"
                     /protein_id="NP_037073.1"
                     /db_xref="GeneID:25427"
                     /db_xref="RGD:2481"
                     /translation="MVLLGLLQSGGSVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLF
                     RLAVGHMVQLPAGAKSPPYIYSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVG
                     KTFTYLLGSDAAALLFNSKNEDLNAEEVYGRLTTPVFGKGVAYDVPNAVFLEQKKILK
                     SGLNIAHFKQYVSIIEKEAKEYFKSWGESGERNVFEALSELIILTASHCLHGKEIRSQ
                     LNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKNIFYKAIQKRRLSKE
                     PAEDILQTLLDSTYKDGRPLTDDEIAGMLIGLLLAGQHTSSTTSAWMGFFLARDKPLQ
                     DKCYLEQKTVCGEDLPPLTYEQLKDLNLLDRCIKETLRLRPPIMTMMRMAKTPQTVAG
                     YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCI
                     GENFAYVQIKTIWSTMLRLYEFDLINGYFPSVNYTTMIHTPENPVIRYKRRSK"
     exon            239..337
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; RATCP14DM"
                     /inference="alignment:Splign:2.1.0"
     exon            338..514
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; RATCP14DM"
                     /inference="alignment:Splign:2.1.0"
     exon            515..641
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; RATCP14DM"
                     /inference="alignment:Splign:2.1.0"
     exon            642..816
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; RATCP14DM"
                     /inference="alignment:Splign:2.1.0"
     exon            817..936
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; RATCP14DM"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1132
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; RATCP14DM"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1228
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; RATCP14DM"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1397
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; RATCP14DM"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..3020
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; RATCP14DM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttcccgaga agcggcaggg acctcggcct ccagcttacc gggcggatcg aagcagcggt
       61 cgggatggta ctgctgggct tgctgcagtc aggcggctcg gtgctcgggc aggcgatgga
      121 gcaggtgaca ggaggcaacc tgctttccac gctgctcatc gcctgcgcct tcacgcttag
      181 ccttgtctac ctgttccgcc tcgcagtggg ccacatggtc cagctgcccg ctggagcgaa
      241 aagtccgcca tatatttact ctccaattcc gttccttggc cacgcgatag catttgggaa
      301 aagtccaatt gagttcctgg aaaatgcata tgagaagtac ggacctgtgt ttagctttac
      361 catggtgggc aagactttca cttacctttt ggggagtgac gcagccgccc tgctcttcaa
      421 cagtaagaac gaagacctga atgcggaaga ggtctacggt cggctgacaa cgcccgtgtt
      481 tgggaaggga gttgcatacg acgtgccaaa tgcagttttc ctggaacaga agaaaatact
      541 aaaaagcggc cttaacatag cccacttcaa gcagtatgtt tctatcattg aaaaagaagc
      601 gaaggagtac tttaaaagtt ggggagaaag cggagaaaga aatgtgtttg aagcgctgtc
      661 tgagctcata attttaacag ctagccattg cttacatgga aaggaaatta gaagtcagct
      721 caacgagaag gtggctcagc tgtacgcaga cctggatgga ggctttagcc atgccgcctg
      781 gctgttgcca ggctggctgc ccctgccgag tttcaggcgc agggacagag cccatcgaga
      841 gatcaagaat attttctaca aggccatcca gaaacgtagg ctgtcaaaag aaccagccga
      901 ggacattctt caaactttac tggattctac atacaaggat gggcgtcctc tgacggacga
      961 cgagatcgca gggatgctca tcggactgct gctggccgga cagcacacat cctccaccac
     1021 cagtgcctgg atgggcttct ttctggccag agataaacca cttcaagaca aatgctactt
     1081 agaacagaaa acggtgtgcg gggaggatct gcctccctta acttatgagc agttgaagga
     1141 tctgaattta cttgatagat gcataaaaga aacactaaga ctgaggcctc ctataatgac
     1201 catgatgaga atggccaaga cccctcagac tgtggctggg tacaccattc ctccaggaca
     1261 tcaggtgtgt gtttctccaa ctgtcaatca aagactgaaa gactcctggg tagaacgctt
     1321 ggacttcaat cctgaccgct acctacagga caacccagcg tcgggagaga agtttgccta
     1381 tgtgccgttt ggagccgggc gccatcgttg tattggagaa aattttgcct atgttcaaat
     1441 taagacaatt tggtccacta tgcttcgttt atatgaattt gacctcatca atggatattt
     1501 tcccagtgtg aattatacaa caatgattca taccccagaa aacccagtaa tccgttacaa
     1561 acgaagatca aaatgaagaa aggaacaagg agccagtgtg gagacgggac tgcaagctgc
     1621 agcttggcag agaatgaagc tttgacacag ctttcatact gtactgtttt ttaagtgtgt
     1681 ggttctgaaa gccagtttga ttttaatgtt ttattaactc ggtgattttt gtcagaccta
     1741 atggcatttg aaacagttat aatagttctg ataggatttc agggaagcca agtttatgtt
     1801 agaaatcgtt taggggagcc tcggtattca gagatgatac agaatatagc atccaggtaa
     1861 ctaacttcag aagcacacgt tgccgtaggg agattccggc ttggaactag tttgggaagt
     1921 tttaagcctg gtcagatgct acagaggcaa tgggtcattg gtgtggttgg gccacttctg
     1981 tgcgtaaaga tgtgagaggg tgaaggataa gttttctgcg aagctctaga tggtgtgagt
     2041 gccctttgta gtgttaactg agagcaccac tccagcgaga tggcagcaat cttggacctt
     2101 atcttgataa ccttatttcc taaaaataat aaatactaaa gagtacttat gttattggtt
     2161 ccagaaaaat ccaaaatcaa atccttgtgg aatttttaat tttaattaaa aaaaaaaaaa
     2221 aacaagtacc atgattttaa aagtgtatga ttctgagctt agtgaattct ggccttgaga
     2281 ttgaggaatg gggacatggt atcattgccc gtgttctttg gaggctgtgc tcaggagcca
     2341 acctaacaga ttgttaccat gggcctaatt ctgacctgcc cataatctgt attaggaatc
     2401 aagagatctg ttgctgggtg tggtgctgca cacctgtaat actagtgctc gggctgaggc
     2461 aggaggattg agagtttgag gccaacctag gctacatagc aagacttaac accctcccca
     2521 aaataaaacc ttttttctct aaagtatgtg tactggctgg tcttaggtga caacctgaca
     2581 cacgctaggg tcatcagaga aaagggaacc tcagttgagg aaatgctgta aggatgctta
     2641 gtggtcaatg agagagggcc cagcccactg tgggtggttc cacccctagg ctggtcatcc
     2701 tgggtcctaa gaaagcaggc tgactaagac accaggagca agacagtaag cagcatcctt
     2761 catggcctct gcatcagctc ctgccttagg ttcctgaccc gcttgagttc ccgtcctgac
     2821 tttctttgat aatgaacagt agtatggaag tgtaagccaa ataacccacc cccaccctcc
     2881 caacttgctt tttgctcatg gtgttttgta gcaatagaaa ccctaactgt tacagctgta
     2941 agaggctttt gaagactctt caaatgaagg cccaaatctc tgctgttaaa ggtttcagat
     3001 taaaattctc tatgagaaaa
//
