LOCUS       NM_145675               2796 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytochrome P450, family 4, subfamily x,
            polypeptide 1 (Cyp4x1), mRNA.
ACCESSION   NM_145675
VERSION     NM_145675.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2796)
  AUTHORS   Carver,K.A., Lourim,D., Tryba,A.K. and Harder,D.R.
  TITLE     Rhythmic expression of cytochrome P450 epoxygenases CYP4x1 and
            CYP2c11 in the rat brain and vasculature
  JOURNAL   Am J Physiol Cell Physiol 307 (11), C989-C998 (2014)
   PUBMED   25055826
  REMARK    GeneRIF: These data suggest there is circadian regulation of Cyp4x1
            and Cyp2c11 gene expression, and that eicosanoid production may
            contribute to circadian changes in blood flow and alter the risk of
            adverse cardiovascular events throughout the day.
REFERENCE   2  (bases 1 to 2796)
  AUTHORS   Stark,K., Dostalek,M. and Guengerich,F.P.
  TITLE     Expression and purification of orphan cytochrome P450 4X1 and
            oxidation of anandamide
  JOURNAL   FEBS J 275 (14), 3706-3717 (2008)
   PUBMED   18549450
REFERENCE   3  (bases 1 to 2796)
  AUTHORS   Bylund,J., Zhang,C. and Harder,D.R.
  TITLE     Identification of a novel cytochrome P450, CYP4X1, with unique
            localization specific to the brain
  JOURNAL   Biochem Biophys Res Commun 296 (3), 677-684 (2002)
   PUBMED   12176035
  REMARK    GeneRIF: molecular cloning & specific localization of Cyp4x1 to the
            brain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 8, 2022 this sequence version replaced NM_145675.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF439343.1, SRR26643298.28408.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               JAXUCZ010000005.1  133919357-133919642 c
            287-428             JAXUCZ010000005.1  133906970-133907111 c
            429-473             JAXUCZ010000005.1  133906080-133906124 c
            474-601             JAXUCZ010000005.1  133904090-133904217 c
            602-729             JAXUCZ010000005.1  133902407-133902534 c
            730-884             JAXUCZ010000005.1  133902175-133902329 c
            885-985             JAXUCZ010000005.1  133901015-133901115 c
            986-1176            JAXUCZ010000005.1  133900349-133900539 c
            1177-1310           JAXUCZ010000005.1  133893705-133893838 c
            1311-1375           JAXUCZ010000005.1  133892531-133892595 c
            1376-1458           JAXUCZ010000005.1  133890960-133891042 c
            1459-2796           JAXUCZ010000005.1  133888439-133889776 c
FEATURES             Location/Qualifiers
     source          1..2796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2796
                     /gene="Cyp4x1"
                     /note="cytochrome P450, family 4, subfamily x, polypeptide
                     1"
                     /db_xref="GeneID:246767"
                     /db_xref="RGD:628719"
     exon            1..286
                     /gene="Cyp4x1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1633
                     /gene="Cyp4x1"
                     /EC_number="1.14.14.1"
                     /note="CYPIVX1"
                     /codon_start=1
                     /product="cytochrome P450 4X1"
                     /protein_id="NP_663708.1"
                     /db_xref="GeneID:246767"
                     /db_xref="RGD:628719"
                     /translation="MEASWLENRWARPLHLALVFCLALVLMQAVKLYLRRQRLLRDLR
                     PFPGPTAHWLLGHQKFLQEDNMEKLDEIVKEYPCAFPCWVGPFQAFFYIYDPDYAKIF
                     LSRTDPKTQYLHQLMTPFLGRGLLNLDGPRWFQHRCLLTPAFHQDILKPCVDMMAHSV
                     NMMLDKWEKTWTTQETTIEVFEHINLMTLDIIMKCAFGQETNCQINGTYESYVKATFE
                     LGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQCTEKIIQDRKKTLKDQVNQD
                     DTQTSQNFLDIVLSAQAGDEKAFSDADLRSEVNTFMWAGHDASAASISWLLYCLALNP
                     EHQDRCRTEIRSILGDGSSITWEQLDEIPYTTMCIKETLRLIPPIPSISRELSKPLTL
                     PDGHSLPAGMTVVLSIWGLHHNPAVWKDPKVFDPLRFTKENSEQRHPCAFLPFSSGPR
                     NCIGQQFAMLELKVAIALTLLRFRVAADLTRPPAFSSHTVLRPKHGIYLHLKKLPEC"
     exon            287..428
                     /gene="Cyp4x1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..473
                     /gene="Cyp4x1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..601
                     /gene="Cyp4x1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..729
                     /gene="Cyp4x1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..884
                     /gene="Cyp4x1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..985
                     /gene="Cyp4x1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1176
                     /gene="Cyp4x1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1310
                     /gene="Cyp4x1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1375
                     /gene="Cyp4x1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1458
                     /gene="Cyp4x1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..2796
                     /gene="Cyp4x1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgattca tatcagctcc aggctagaga aagctatcgg cttcccacca ccaaccacca
       61 tatccttcac ccacccatcc actgcccgca ggataacgag ctcagagtga tggaggcctc
      121 ctggctggag aatcgctggg cgcggccctt acacctggct ttggtgttct gcctggcgct
      181 ggtgctgatg caggccgtga agctctacct gagaagacag aggctgctgc gcgacctacg
      241 ccccttcccg ggtcctaccg cccactggct cctgggacac cagaagtttc ttcaggagga
      301 taatatggag aagcttgacg agattgtcaa agagtaccct tgcgccttcc cctgctgggt
      361 aggacccttc caagcatttt tctacatcta tgacccagac tatgcaaaga tttttctgag
      421 cagaacagac ccaaagaccc agtacctgca ccagctcatg actccctttc ttggaagagg
      481 actcctgaat ttagatgggc ccaggtggtt ccaacaccgc tgcctcctga ctcctgcgtt
      541 ccatcaggac atcctaaaac catgtgtgga catgatggcc cactctgtga acatgatgct
      601 ggataaatgg gagaagacgt ggaccacgca ggaaacaacc atcgaggttt ttgaacacat
      661 taacttgatg accctggaca taataatgaa atgtgctttt ggccaggaga ccaactgcca
      721 gataaacggc acctatgagt cttatgtgaa ggcaacattt gaacttggtg aaatcatatc
      781 ttctcgcttg tacaatttct ggcatcatca tgacataatt ttcaaactca gtcctaaggg
      841 ccactgcttc caggagttag gcaaagtgat acatcaatgc acagaaaaga ttatccagga
      901 cagaaagaaa accctcaagg atcaagtaaa tcaggatgac actcaaacat ctcaaaattt
      961 tctggatatt gttctttctg cccaggctgg agatgaaaag gccttctcag atgctgacct
     1021 tcggtctgag gtgaacacct tcatgtgggc aggacacgac gcctctgcag ctagcatctc
     1081 ctggctcctt tactgcctgg ctctgaaccc tgagcatcaa gacagatgcc ggacagagat
     1141 caggagcatt ctgggagatg ggtcttccat cacctgggaa cagctggatg agatacctta
     1201 cactacaatg tgcatcaagg agacactccg cttgattcct cccatcccat ccatctccag
     1261 ggaactcagc aaacccctta ccctcccaga tggacactcg ctgcctgcag gaatgactgt
     1321 ggtccttagt atttggggtc tccaccacaa tcctgctgtc tggaaagacc caaaggtctt
     1381 tgaccctttg agattcacta aggagaattc tgaacagaga cacccctgcg ccttcctacc
     1441 attctccagt ggtccaagga actgcatcgg gcagcagttt gccatgctgg agttaaaggt
     1501 ggccattgcc ttgactctgc tccgcttccg agtagctgca gacctcacca ggcctcctgc
     1561 cttctccagc cacactgtgc tcagacccaa gcatgggatc tatttgcacc tgaagaaact
     1621 ccctgaatgt tagggaccag ggggagtgac tagatttctg tgtgttaagt taagtttaca
     1681 gccgatggtc caggcagatg gtgaagactc taagactgat gggagagttg gaggactgtg
     1741 ggttggggca tttctacagc tgcgtattac ccaaagacat tttccagtaa cacatgtgat
     1801 cctggctgtg tataacatgg agagattgtc aaattatttt ctaagcttat ctgaagtggg
     1861 aatttctggt ttcaccggag actcggttat gccaagtgat gctttcctgg aagctgtctt
     1921 atgagaggtt gttttgctga agcaggcacc tggtgctttt ctgaaggctg tctggtgaaa
     1981 atgcatgtga cgttttgctg gatgggatgc ttgagagggt acgtgatgga cagagtttaa
     2041 ctcagcagac tgtggacagc actggcattg gttcgccgtg ctttcttcac tgatcttcgc
     2101 ctgttgtgac tctgtagaga gaaactcgcc caagagcttg tggtggtgtt tcagctgctt
     2161 cttgccacgt cagtggactc actccaggtt ctactggatc aaatcgctgc tgattcacgt
     2221 ctggtgtttt gctagtggac ggggctgccg acaatgaaga ttggaatcac ctcaaagaat
     2281 tatttccaaa caggtccaca cccccttgtc ctattaacca tcttcccctc ccccaccttt
     2341 ggtcagtagg atataaggga gattgaagaa ttaagaactt ttattaaata gactctgaaa
     2401 aatctaagct aacacctatc atgggtgacg cctgtgcatt ttttgtttta attatctttg
     2461 gaattataca agtaacagga tttgtgctga atgaaaaatg tttccagtac tatgagtgta
     2521 cataaaatcc caccttcccc gggccactac cctgacagag tctactgtat tccttaaaac
     2581 agaactggta tgcattcttc ctctgtcctg catatttcat aaataatgtt tgtgcgtgtt
     2641 cttagacaca tgatcgtatt tatattgttc ttgcttttcc tcacttaata aaaaattcac
     2701 cttaatcttt ataacaaggt tgtgatatat gagtgttgca tgatttttta aatgtttttc
     2761 tgctattgga aaattaaatc agttataatt tttaaa
//
